|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 201 to 257 out of 257 for Pak3

<< First    < Previous  |  Next >    Last >>
0.016s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Publication
25053427 | J:214095
First Author: Osipovich AB
Year: 2014
Journal: Development
Title: Insm1 promotes endocrine cell differentiation by modulating the expression of a network of genes that includes Neurog3 and Ripply3.
Volume: 141
Issue: 15
Pages: 2939-49
•
•
•
•
•
Publication
19386638 | J:173286
 
First Author: Long JE
Year: 2009
Journal: Cereb Cortex
Title: Dlx1&2 and Mash1 transcription factors control MGE and CGE patterning and differentiation through parallel and overlapping pathways.
Volume: 19 Suppl 1
Pages: i96-106
•
•
•
•
•
Publication
19521500 | J:149737
First Author: Sansom SN
Year: 2009
Journal: PLoS Genet
Title: The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis.
Volume: 5
Issue: 6
Pages: e1000511
•
•
•
•
•
Publication
20436479 | J:157819
First Author: Shimogori T
Year: 2010
Journal: Nat Neurosci
Title: A genomic atlas of mouse hypothalamic development.
Volume: 13
Issue: 6
Pages: 767-75
•
•
•
•
•
Publication
- | J:94338
     
First Author: NIH Mouse Knockout Inventory
Year: 2004
Journal: MGI Direct Data Submission
Title: Information obtained from the NIH Mouse Knockout Inventory
•
•
•
•
•
Publication
15226823 | J:93300
First Author: Blackshaw S
Year: 2004
Journal: PLoS Biol
Title: Genomic analysis of mouse retinal development.
Volume: 2
Issue: 9
Pages: E247
•
•
•
•
•
Publication
- | J:342608
       
First Author: GO Central curators, GOA curators, Rhea curators
Year: 2020
Title: Automatic Gene Ontology annotation based on Rhea mapping
•
•
•
•
•
Publication
- | J:72245
       
First Author: GOA curators, MGI curators
Year: 2001
Title: Gene Ontology annotation based on Enzyme Commission mapping
•
•
•
•
•
Publication
- | J:346132
       
First Author: The Gene Ontology Consortium
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
•
•
•
•
•
Publication
34321999 | J:313619
 
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
•
•
•
•
•
Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
•
•
•
•
•
Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
•
•
•
•
•
Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
•
•
•
•
•
Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
•
•
•
•
•
Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
•
•
•
•
•
Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
•
•
•
•
•
Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
•
•
•
•
•
Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
•
•
•
•
•
Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
•
•
•
•
•
Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
•
•
•
•
•
Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
•
•
•
•
•
Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
•
•
•
•
•
Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
•
•
•
•
•
Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
•
•
•
•
•
Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
•
•
•
•
•
Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
•
•
•
•
•
Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
•
•
•
•
•
Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
•
•
•
•
•
Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
•
•
•
•
•
Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
•
•
•
•
•
Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
•
•
•
•
•
Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
•
•
•
•
•
Publication
24236816 | J:227963
First Author: Dai X
Year: 2014
Journal: Eur J Neurosci
Title: Dlx1 transcription factor regulates dendritic growth and postsynaptic differentiation through inhibition of neuropilin-2 and PAK3 expression.
Volume: 39
Issue: 4
Pages: 531-47
•
•
•
•
•
UniProt Feature
UniProt Feature
Begin: 339
Description: Phosphoserine; by PAK1, PAK2 and PAK3
Type: modified residue
End: 339
•
•
•
•
•
UniProt Feature
UniProt Feature
Begin: 338
Description: Phosphoserine; by PAK1, PAK2, PAK3 and PAK5
Type: modified residue
End: 338
•
•
•
•
•
UniProt Feature
UniProt Feature
Begin: 189
Description: Phosphoserine; by PAK1, PAK2 and PAK3
Type: modified residue
End: 189
•
•
•
•
•
UniProt Feature
UniProt Feature
Begin: 186
Description: Phosphoserine; by PAK1, PAK2 and PAK3
Type: modified residue
End: 186
•
•
•
•
•
Publication
9065412 | J:231211
First Author: Siow YL
Year: 1997
Journal: J Biol Chem
Title: Identification of two essential phosphorylated threonine residues in the catalytic domain of Mekk1. Indirect activation by Pak3 and protein kinase C.
Volume: 272
Issue: 12
Pages: 7586-94
•
•
•
•
•
Publication
18523455 | -
First Author: Rejeb I
Year: 2008
Journal: Eur J Hum Genet
Title: A novel splice mutation in PAK3 gene underlying mental retardation with neuropsychiatric features.
Volume: 16
Issue: 11
Pages: 1358-63
•
•
•
•
•
Allele
Pak3<tm1.1Rpo> | MGI:6466590
Name: p21 (RAC1) activated kinase 3; targeted mutation 1.1, Roseline Poirier
Allele Type: Targeted
Attribute String: Humanized sequence
•
•
•
•
•
Publication
15574732 | -
First Author: Boda B
Year: 2004
Journal: J Neurosci
Title: The mental retardation protein PAK3 contributes to synapse formation and plasticity in hippocampus.
Volume: 24
Issue: 48
Pages: 10816-25
•
•
•
•
•
Publication
17105769 | -
First Author: Nodé-Langlois R
Year: 2006
Journal: J Cell Sci
Title: Sequential implication of the mental retardation proteins ARHGEF6 and PAK3 in spine morphogenesis.
Volume: 119
Issue: Pt 23
Pages: 4986-93
•
•
•
•
•
Publication
20540949 | -
First Author: Ouyang Y
Year: 2010
Journal: J Mol Biol
Title: Structural and kinetic effects of PAK3 phosphorylation mimic of cTnI(S151E) on the cTnC-cTnI interaction in the cardiac thin filament.
Volume: 400
Issue: 5
Pages: 1036-45
•
•
•
•
•
Genotype
Genotype
Symbol: Pak3/?
Background: B6.129S2(Cg)-Pak3
Zygosity: ot
Has Mutant Allele: true
•
•
•
•
•
DO Term
DOID:0112051 | non-syndromic X-linked intellectual disability 30
•
•
•
•
•
Publication
15581714 | -
 
First Author: van Galen EJ
Year: 2005
Journal: Prog Brain Res
Title: Rho proteins, mental retardation and the neurobiological basis of intelligence.
Volume: 147
Pages: 295-317
•
•
•
•
•
Publication
21949127 | -
First Author: Thévenot E
Year: 2011
Journal: J Biol Chem
Title: p21-Activated kinase 3 (PAK3) protein regulates synaptic transmission through its interaction with the Nck2/Grb4 protein adaptor.
Volume: 286
Issue: 46
Pages: 40044-59
•
•
•
•
•
Protein Domain
IPR035063 | STK_PAK3
Type: Domain
Description: This entry represents the catalytic domain of serine/threonine kinase p21-activated kinase (PAK) 3.PAK3 is highly expressed in the brain. It is implicated in neuronal plasticity, synapse formation, dendritic spine morphogenesis, cell cycle progression, neuronal migration, and apoptosis [, ]. Inactivating mutations in the PAK3 gene cause X-linked non-syndromic mental retardation, the severity of which depends on the site of the mutation [, ]. PAK3 belongs to the group I PAKs.Group I PAKs contain a PBD (p21-binding domain) overlapping with an AID (autoinhibitory domain), a C-terminal catalytic domain, SH3 binding sites and a non-classical SH3 binding site for PIX (PAK-interacting exchange factor). PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac [].
•
•
•
•
•
Publication
29912324 | J:290113
First Author: Shen W
Year: 2019
Journal: Cereb Cortex
Title: Foxg1 Regulates the Postnatal Development of Cortical Interneurons.
Volume: 29
Issue: 4
Pages: 1547-1560
•
•
•
•
•
Publication
15800193 | J:98630
First Author: Zhang H
Year: 2005
Journal: J Neurosci
Title: A GIT1/PIX/Rac/PAK signaling module regulates spine morphogenesis and synapse formation through MLC.
Volume: 25
Issue: 13
Pages: 3379-88
•
•
•
•
•
Publication
37326884 | J:358596
First Author: Zhang M
Year: 2023
Journal: Neurosci Bull
Title: Neuronal Histone Methyltransferase EZH2 Regulates Neuronal Morphogenesis, Synaptic Plasticity, and Cognitive Behavior in Mice.
Volume: 39
Issue: 10
Pages: 1512-1532
•
•
•
•
•
Publication
28765528 | J:263577
First Author: Zhao M
Year: 2017
Journal: Sci Rep
Title: Pdx1-Cre-driven conditional gene depletion suggests PAK4 as dispensable for mouse pancreas development.
Volume: 7
Issue: 1
Pages: 7031
•
•
•
•
•
Publication
31051214 | J:276346
 
First Author: Wu HY
Year: 2019
Journal: Cancer Lett
Title: p21-Activated kinase 3 promotes cancer stem cell phenotypes through activating the Akt-GSK3β-β-catenin signaling pathway in pancreatic cancer cells.
Volume: 456
Pages: 13-22
•
•
•
•
•
Publication
11950587 | -
First Author: Jaffer ZM
Year: 2002
Journal: Int J Biochem Cell Biol
Title: p21-activated kinases: three more join the Pak.
Volume: 34
Issue: 7
Pages: 713-7
•
•
•
•
•
Protein
Q61036
Organism: Mus musculus/domesticus
Length: 559  
Fragment?: false
•
•
•
•
•
Protein
B1GX80
Organism: Mus musculus/domesticus
Length: 565  
Fragment?: false
•
•
•
•
•
Protein
B1GX81
Organism: Mus musculus/domesticus
Length: 580  
Fragment?: false
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom