Type |
Details |
Score |
Publication |
First Author: |
Lohr KM |
Year: |
2014 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Increased vesicular monoamine transporter enhances dopamine release and opposes Parkinson disease-related neurodegeneration in vivo. |
Volume: |
111 |
Issue: |
27 |
Pages: |
9977-82 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hattori N |
Year: |
1998 |
Journal: |
Genomics |
Title: |
Genotype in the 24-kDa subunit gene (NDUFV2) of mitochondrial complex I and susceptibility to Parkinson disease. |
Volume: |
49 |
Issue: |
1 |
Pages: |
52-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Thiruchelvam M |
Year: |
2005 |
Journal: |
J Biol Chem |
Title: |
Overexpression of superoxide dismutase or glutathione peroxidase protects against the paraquat + maneb-induced Parkinson disease phenotype. |
Volume: |
280 |
Issue: |
23 |
Pages: |
22530-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Alvarez-Fischer D |
Year: |
2013 |
Journal: |
PLoS One |
Title: |
Bee venom and its component apamin as neuroprotective agents in a Parkinson disease mouse model. |
Volume: |
8 |
Issue: |
4 |
Pages: |
e61700 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rekaik H |
Year: |
2015 |
Journal: |
FEBS Lett |
Title: |
Dissecting the role of Engrailed in adult dopaminergic neurons--Insights into Parkinson disease pathogenesis. |
Volume: |
589 |
Issue: |
24 Pt A |
Pages: |
3786-94 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhao F |
Year: |
2019 |
Journal: |
Mol Neurobiol |
Title: |
Conditional Haploinsufficiency of β-Catenin Aggravates Neuronal Damage in a Paraquat-Based Mouse Model of Parkinson Disease. |
Volume: |
56 |
Issue: |
7 |
Pages: |
5157-5166 |
|
•
•
•
•
•
|
Publication |
First Author: |
Khasnavis S |
Year: |
2013 |
Journal: |
J Biol Chem |
Title: |
Castration induces Parkinson disease pathologies in young male mice via inducible nitric-oxide synthase. |
Volume: |
288 |
Issue: |
29 |
Pages: |
20843-20855 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li X |
Year: |
2012 |
Journal: |
PLoS One |
Title: |
Evaluation of TorsinA as a target for Parkinson disease therapy in mouse models. |
Volume: |
7 |
Issue: |
11 |
Pages: |
e50063 |
|
•
•
•
•
•
|
Publication |
First Author: |
Komnig D |
Year: |
2016 |
Journal: |
J Neurochem |
Title: |
Mice lacking Faim2 show increased cell death in the MPTP mouse model of Parkinson disease. |
Volume: |
139 |
Issue: |
5 |
Pages: |
848-857 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nuber S |
Year: |
2021 |
Journal: |
Ann Neurol |
Title: |
A Stearoyl-Coenzyme A Desaturase Inhibitor Prevents Multiple Parkinson Disease Phenotypes in α-Synuclein Mice. |
Volume: |
89 |
Issue: |
1 |
Pages: |
74-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fishman-Jacob T |
Year: |
2009 |
Journal: |
J Biol Chem |
Title: |
A sporadic Parkinson disease model via silencing of the ubiquitin-proteasome/E3 ligase component SKP1A. |
Volume: |
284 |
Issue: |
47 |
Pages: |
32835-45 |
|
•
•
•
•
•
|
Publication |
First Author: |
Han X |
Year: |
2019 |
Journal: |
Autophagy |
Title: |
Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiquitination and autophagy: implications for Parkinson disease. |
Volume: |
15 |
Issue: |
11 |
Pages: |
1860-1881 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang J |
Year: |
2019 |
Journal: |
Glia |
Title: |
SIRPα deficiency accelerates the pathologic process in models of Parkinson disease. |
Volume: |
67 |
Issue: |
12 |
Pages: |
2343-2359 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tagliaferro P |
Year: |
2015 |
Journal: |
Neurobiol Dis |
Title: |
An early axonopathy in a hLRRK2(R1441G) transgenic model of Parkinson disease. |
Volume: |
82 |
|
Pages: |
359-371 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lin QS |
Year: |
2020 |
Journal: |
Lab Invest |
Title: |
RIP1/RIP3/MLKL mediates dopaminergic neuron necroptosis in a mouse model of Parkinson disease. |
Volume: |
100 |
Issue: |
3 |
Pages: |
503-511 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shi SY |
Year: |
2015 |
Journal: |
Nat Commun |
Title: |
DJ-1 links muscle ROS production with metabolic reprogramming and systemic energy homeostasis in mice. |
Volume: |
6 |
|
Pages: |
7415 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chien CH |
Year: |
2016 |
Journal: |
BMC Cancer |
Title: |
Growth hormone is increased in the lungs and enhances experimental lung metastasis of melanoma in DJ-1 KO mice. |
Volume: |
16 |
Issue: |
1 |
Pages: |
871 |
|
•
•
•
•
•
|
Publication |
First Author: |
Goldberg MS |
Year: |
2005 |
Journal: |
Neuron |
Title: |
Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1. |
Volume: |
45 |
Issue: |
4 |
Pages: |
489-96 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lee KP |
Year: |
2018 |
Journal: |
Pflugers Arch |
Title: |
DJ-1 is involved in epigenetic control of sphingosine-1-phosphate receptor expression in vascular neointima formation. |
Volume: |
470 |
Issue: |
7 |
Pages: |
1103-1113 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang J |
Year: |
2020 |
Journal: |
J Biol Chem |
Title: |
Deficiency in the anti-apoptotic protein DJ-1 promotes intestinal epithelial cell apoptosis and aggravates inflammatory bowel disease via p53. |
Volume: |
295 |
Issue: |
13 |
Pages: |
4237-4251 |
|
•
•
•
•
•
|
Publication |
First Author: |
Parker PJ |
Year: |
2001 |
Journal: |
Biochem Soc Trans |
Title: |
AGC protein kinase phosphorylation and protein kinase C. |
Volume: |
29 |
Issue: |
Pt 6 |
Pages: |
860-3 |
|
•
•
•
•
•
|
Author |
|
•
•
•
•
•
|
Author |
|
•
•
•
•
•
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DO Term |
|
•
•
•
•
•
|
DO Term |
|
•
•
•
•
•
|
DO Term |
|
•
•
•
•
•
|
Publication |
First Author: |
Wilhelm M |
Year: |
2007 |
Journal: |
J Biol Chem |
Title: |
Proapoptotic Nix activates the JNK pathway by interacting with POSH and mediates death in a Parkinson disease model. |
Volume: |
282 |
Issue: |
2 |
Pages: |
1288-95 |
|
•
•
•
•
•
|
Publication |
First Author: |
Brochard V |
Year: |
2009 |
Journal: |
J Clin Invest |
Title: |
Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease. |
Volume: |
119 |
Issue: |
1 |
Pages: |
182-92 |
|
•
•
•
•
•
|
Publication |
First Author: |
Harms AS |
Year: |
2018 |
Journal: |
Exp Neurol |
Title: |
Peripheral monocyte entry is required for alpha-Synuclein induced inflammation and Neurodegeneration in a model of Parkinson disease. |
Volume: |
300 |
|
Pages: |
179-187 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu CW |
Year: |
2005 |
Journal: |
J Biol Chem |
Title: |
A precipitating role for truncated alpha-synuclein and the proteasome in alpha-synuclein aggregation: implications for pathogenesis of Parkinson disease. |
Volume: |
280 |
Issue: |
24 |
Pages: |
22670-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhou W |
Year: |
2011 |
Journal: |
J Biol Chem |
Title: |
Phenylbutyrate up-regulates the DJ-1 protein and protects neurons in cell culture and in animal models of Parkinson disease. |
Volume: |
286 |
Issue: |
17 |
Pages: |
14941-51 |
|
•
•
•
•
•
|
Publication |
First Author: |
Requejo-Aguilar R |
Year: |
2015 |
Journal: |
Biochem J |
Title: |
DJ1 represses glycolysis and cell proliferation by transcriptionally up-regulating Pink1. |
Volume: |
467 |
Issue: |
2 |
Pages: |
303-10 |
|
•
•
•
•
•
|
Publication |
First Author: |
Alvarez-Castelao B |
Year: |
2014 |
Journal: |
Front Aging Neurosci |
Title: |
Epitope Mapping of Antibodies to Alpha-Synuclein in LRRK2 Mutation Carriers, Idiopathic Parkinson Disease Patients, and Healthy Controls. |
Volume: |
6 |
|
Pages: |
169 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ghosh A |
Year: |
2013 |
Journal: |
J Biol Chem |
Title: |
The peptidyl-prolyl isomerase Pin1 up-regulation and proapoptotic function in dopaminergic neurons: relevance to the pathogenesis of Parkinson disease. |
Volume: |
288 |
Issue: |
30 |
Pages: |
21955-71 |
|
•
•
•
•
•
|
Publication |
First Author: |
Haque ME |
Year: |
2012 |
Journal: |
J Biol Chem |
Title: |
Inactivation of Pink1 gene in vivo sensitizes dopamine-producing neurons to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and can be rescued by autosomal recessive Parkinson disease genes, Parkin or DJ-1. |
Volume: |
287 |
Issue: |
27 |
Pages: |
23162-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tamma R |
Year: |
2013 |
Journal: |
Lab Invest |
Title: |
Effects of prednisolone on the dystrophin-associated proteins in the blood-brain barrier and skeletal muscle of dystrophic mdx mice. |
Volume: |
93 |
Issue: |
5 |
Pages: |
592-610 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zeng N |
Year: |
2022 |
Journal: |
EMBO Rep |
Title: |
DJ-1 depletion prevents immunoaging in T-cell compartments. |
Volume: |
23 |
Issue: |
3 |
Pages: |
e53302 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shi H |
Year: |
2017 |
Journal: |
Hum Mol Genet |
Title: |
Sirt3 protects dopaminergic neurons from mitochondrial oxidative stress. |
Volume: |
26 |
Issue: |
10 |
Pages: |
1915-1926 |
|
•
•
•
•
•
|
Publication |
First Author: |
Beilina A |
Year: |
2014 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease. |
Volume: |
111 |
Issue: |
7 |
Pages: |
2626-31 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen YH |
Year: |
2019 |
Journal: |
Int J Mol Sci |
Title: |
Delayed Dopamine Dysfunction and Motor Deficits in Female Parkinson Model Mice. |
Volume: |
20 |
Issue: |
24 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Fishbein I |
Year: |
2014 |
Journal: |
Brain |
Title: |
Augmentation of phenotype in a transgenic Parkinson mouse heterozygous for a Gaucher mutation. |
Volume: |
137 |
Issue: |
Pt 12 |
Pages: |
3235-47 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lozovaya N |
Year: |
2018 |
Journal: |
Nat Commun |
Title: |
GABAergic inhibition in dual-transmission cholinergic and GABAergic striatal interneurons is abolished in Parkinson disease. |
Volume: |
9 |
Issue: |
1 |
Pages: |
1422 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fanning S |
Year: |
2019 |
Journal: |
Mol Cell |
Title: |
Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment. |
Volume: |
73 |
Issue: |
5 |
Pages: |
1001-1014.e8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wu DC |
Year: |
2002 |
Journal: |
J Neurosci |
Title: |
Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease. |
Volume: |
22 |
Issue: |
5 |
Pages: |
1763-71 |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion H, Nick Parkinson |
Allele Type: |
Transgenic |
Attribute String: |
Humanized sequence, Inserted expressed sequence |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion L, Nick Parkinson |
Allele Type: |
Transgenic |
Attribute String: |
Humanized sequence, Inserted expressed sequence |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 6928, Fiona Parkinson |
Allele Type: |
Transgenic |
Attribute String: |
Humanized sequence, Inserted expressed sequence |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion P, Nick Parkinson |
Allele Type: |
Transgenic |
Attribute String: |
Humanized sequence, Inserted expressed sequence |
|
•
•
•
•
•
|
Publication |
First Author: |
Im JY |
Year: |
2010 |
Journal: |
Neurosci Res |
Title: |
DJ-1 protects against oxidative damage by regulating the thioredoxin/ASK1 complex. |
Volume: |
67 |
Issue: |
3 |
Pages: |
203-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jung SH |
Year: |
2014 |
Journal: |
Atherosclerosis |
Title: |
DJ-1 protein regulates CD3+ T cell migration via overexpression of CXCR4 receptor. |
Volume: |
235 |
Issue: |
2 |
Pages: |
503-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tai-Nagara I |
Year: |
2014 |
Journal: |
Blood |
Title: |
Mortalin and DJ-1 coordinately regulate hematopoietic stem cell function through the control of oxidative stress. |
Volume: |
123 |
Issue: |
1 |
Pages: |
41-50 |
|
•
•
•
•
•
|
Publication |
First Author: |
De Miguel C |
Year: |
2019 |
Journal: |
J Am Heart Assoc |
Title: |
Uncoupling Protein 2 Increases Blood Pressure in DJ -1 Knockout Mice. |
Volume: |
8 |
Issue: |
9 |
Pages: |
e011856 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lin Z |
Year: |
2021 |
Journal: |
Cell Death Dis |
Title: |
DJ-1 inhibits microglial activation and protects dopaminergic neurons in vitro and in vivo through interacting with microglial p65. |
Volume: |
12 |
Issue: |
8 |
Pages: |
715 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xu S |
Year: |
2018 |
Journal: |
J Neurochem |
Title: |
Parkinson's disease-related DJ-1 modulates the expression of uncoupling protein 4 against oxidative stress. |
Volume: |
145 |
Issue: |
4 |
Pages: |
312-322 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lee DY |
Year: |
2015 |
Journal: |
Biochim Biophys Acta |
Title: |
DJ-1 regulates the expression of renal (pro)renin receptor via reactive oxygen species-mediated epigenetic modification. |
Volume: |
1850 |
Issue: |
2 |
Pages: |
426-34 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lev N |
Year: |
2015 |
Journal: |
PLoS One |
Title: |
A DJ-1 Based Peptide Attenuates Dopaminergic Degeneration in Mice Models of Parkinson's Disease via Enhancing Nrf2. |
Volume: |
10 |
Issue: |
5 |
Pages: |
e0127549 |
|
•
•
•
•
•
|
Publication |
First Author: |
Won KJ |
Year: |
2014 |
Journal: |
Cardiovasc Res |
Title: |
DJ-1/park7 modulates vasorelaxation and blood pressure via epigenetic modification of endothelial nitric oxide synthase. |
Volume: |
101 |
Issue: |
3 |
Pages: |
473-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim YC |
Year: |
2010 |
Journal: |
FEBS Lett |
Title: |
DJ-1, an oncogene and causative gene for familial Parkinson's disease, is essential for SV40 transformation in mouse fibroblasts through up-regulation of c-Myc. |
Volume: |
584 |
Issue: |
18 |
Pages: |
3891-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim JM |
Year: |
2016 |
Journal: |
Sci Rep |
Title: |
DJ-1 deficiency impairs glutamate uptake into astrocytes via the regulation of flotillin-1 and caveolin-1 expression. |
Volume: |
6 |
|
Pages: |
28823 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sivasubramaniyam T |
Year: |
2021 |
Journal: |
Sci Rep |
Title: |
Dj1 deficiency protects against atherosclerosis with anti-inflammatory response in macrophages. |
Volume: |
11 |
Issue: |
1 |
Pages: |
4723 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schriever SC |
Year: |
2017 |
Journal: |
Neuroscience |
Title: |
Alterations in neuronal control of body weight and anxiety behavior by glutathione peroxidase 4 deficiency. |
Volume: |
357 |
|
Pages: |
241-254 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ho CC |
Year: |
2009 |
Journal: |
J Neurosci |
Title: |
The Parkinson disease protein leucine-rich repeat kinase 2 transduces death signals via Fas-associated protein with death domain and caspase-8 in a cellular model of neurodegeneration. |
Volume: |
29 |
Issue: |
4 |
Pages: |
1011-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gao J |
Year: |
2022 |
Journal: |
Brain Res Bull |
Title: |
Asparagine endopeptidase deletion ameliorates cognitive impairments by inhibiting proinflammatory microglial activation in MPTP mouse model of Parkinson disease. |
Volume: |
178 |
|
Pages: |
120-130 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
220
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Lopez-Fabuel I |
Year: |
2017 |
Journal: |
Neurochem Int |
Title: |
Mitochondrial respiratory chain disorganization in Parkinson's disease-relevant PINK1 and DJ1 mutants. |
Volume: |
109 |
|
Pages: |
101-105 |
|
•
•
•
•
•
|
HT Experiment |
Series Id: |
GSE60413 |
Experiment Type: |
transcription profiling by array |
Study Type: |
WT vs. Mutant |
Source: |
ArrayExpress |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
Aberrant interaction between Parkinson disease-associated mutant UCH-L1 and the lysosomal receptor for chaperone-mediated autophagy. |
|
•
•
•
•
•
|
Publication |
First Author: |
Jin H |
Year: |
2014 |
Journal: |
J Biol Chem |
Title: |
Histone hyperacetylation up-regulates protein kinase Cδ in dopaminergic neurons to induce cell death: relevance to epigenetic mechanisms of neurodegeneration in Parkinson disease. |
Volume: |
289 |
Issue: |
50 |
Pages: |
34743-67 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kuo YM |
Year: |
2010 |
Journal: |
Hum Mol Genet |
Title: |
Extensive enteric nervous system abnormalities in mice transgenic for artificial chromosomes containing Parkinson disease-associated alpha-synuclein gene mutations precede central nervous system changes. |
Volume: |
19 |
Issue: |
9 |
Pages: |
1633-50 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shaltiel-Karyo R |
Year: |
2013 |
Journal: |
J Biol Chem |
Title: |
A blood-brain barrier (BBB) disrupter is also a potent α-synuclein (α-syn) aggregation inhibitor: a novel dual mechanism of mannitol for the treatment of Parkinson disease (PD). |
Volume: |
288 |
Issue: |
24 |
Pages: |
17579-88 |
|
•
•
•
•
•
|
Publication |
First Author: |
She H |
Year: |
2011 |
Journal: |
J Clin Invest |
Title: |
Direct regulation of complex I by mitochondrial MEF2D is disrupted in a mouse model of Parkinson disease and in human patients. |
Volume: |
121 |
Issue: |
3 |
Pages: |
930-40 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chartier-Harlin MC |
Year: |
2011 |
Journal: |
Am J Hum Genet |
Title: |
Translation initiator EIF4G1 mutations in familial Parkinson disease. |
Volume: |
89 |
Issue: |
3 |
Pages: |
398-406 |
|
•
•
•
•
•
|
Publication |
First Author: |
Han H |
Year: |
2020 |
Journal: |
EMBO Rep |
Title: |
PINK1 phosphorylates Drp1S616 to regulate mitophagy-independent mitochondrial dynamics. |
Volume: |
21 |
Issue: |
8 |
Pages: |
e48686 |
|
•
•
•
•
•
|
Publication |
First Author: |
Martella G |
Year: |
2011 |
Journal: |
Neuroscience |
Title: |
Altered profile and D2-dopamine receptor modulation of high voltage-activated calcium current in striatal medium spiny neurons from animal models of Parkinson's disease. |
Volume: |
177 |
|
Pages: |
240-51 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu Y |
Year: |
2019 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
DJ-1 regulates the integrity and function of ER-mitochondria association through interaction with IP3R3-Grp75-VDAC1. |
Volume: |
116 |
Issue: |
50 |
Pages: |
25322-25328 |
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•
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Publication |
First Author: |
Tan LH |
Year: |
2018 |
Journal: |
Sci Rep |
Title: |
The cytoprotective role of DJ-1 and p45 NFE2 against human primary alveolar type II cell injury and emphysema. |
Volume: |
8 |
Issue: |
1 |
Pages: |
3555 |
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•
•
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•
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Publication |
First Author: |
Yamaguchi S |
Year: |
2012 |
Journal: |
PLoS One |
Title: |
Transcriptional activation of low-density lipoprotein receptor gene by DJ-1 and effect of DJ-1 on cholesterol homeostasis. |
Volume: |
7 |
Issue: |
5 |
Pages: |
e38144 |
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•
•
•
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Publication |
First Author: |
Giaime E |
Year: |
2010 |
Journal: |
Cell Death Differ |
Title: |
Loss of function of DJ-1 triggered by Parkinson's disease-associated mutation is due to proteolytic resistance to caspase-6. |
Volume: |
17 |
Issue: |
1 |
Pages: |
158-69 |
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•
•
•
•
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Publication |
First Author: |
Xiong H |
Year: |
2009 |
Journal: |
J Clin Invest |
Title: |
Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation. |
Volume: |
119 |
Issue: |
3 |
Pages: |
650-60 |
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•
•
•
•
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Publication |
First Author: |
Xu M |
Year: |
2021 |
Journal: |
Cell Mol Gastroenterol Hepatol |
Title: |
DJ-1 Deficiency in Hepatocytes Improves Liver Ischemia-Reperfusion Injury by Enhancing Mitophagy. |
Volume: |
12 |
Issue: |
2 |
Pages: |
567-584 |
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•
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•
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Publication |
First Author: |
Levin J |
Year: |
2022 |
Journal: |
EBioMedicine |
Title: |
Safety, tolerability and pharmacokinetics of the oligomer modulator anle138b with exposure levels sufficient for therapeutic efficacy in a murine Parkinson model: A randomised, double-blind, placebo-controlled phase 1a trial. |
Volume: |
80 |
|
Pages: |
104021 |
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•
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•
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Publication |
First Author: |
Ho PW |
Year: |
2020 |
Journal: |
Autophagy |
Title: |
Age-dependent accumulation of oligomeric SNCA/α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA). |
Volume: |
16 |
Issue: |
2 |
Pages: |
347-370 |
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Allele |
Name: |
phospholipase A2, group VI; targeted mutation 1.1, Hung-Li Wang |
Allele Type: |
Targeted |
Attribute String: |
Humanized sequence |
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•
•
•
•
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Publication |
First Author: |
Shim JH |
Year: |
2011 |
Journal: |
Mitochondrion |
Title: |
The antioxidant Trolox helps recovery from the familial Parkinson's disease-specific mitochondrial deficits caused by PINK1- and DJ-1-deficiency in dopaminergic neuronal cells. |
Volume: |
11 |
Issue: |
5 |
Pages: |
707-15 |
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•
•
•
•
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Gene |
Type: |
gene |
Organism: |
human |
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•
•
•
•
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Publication |
First Author: |
Parsanejad M |
Year: |
2014 |
Journal: |
J Neurosci |
Title: |
Regulation of the VHL/HIF-1 pathway by DJ-1. |
Volume: |
34 |
Issue: |
23 |
Pages: |
8043-50 |
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•
•
•
•
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Genotype |
Symbol: |
Pla2g6/Pla2g6 |
Background: |
involves: 129 * C57BL/6J |
Zygosity: |
hm |
Has Mutant Allele: |
true |
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•
•
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•
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Strain |
Attribute String: |
congenic, mutant strain, transgenic |
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•
|
Strain |
Attribute String: |
transgenic, mutant strain, congenic |
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•
•
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Strain |
Attribute String: |
mutant stock, transgenic |
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•
•
•
•
|
Strain |
Attribute String: |
mutant stock, transgenic |
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•
•
•
•
|
Publication |
First Author: |
Nakamura K |
Year: |
2021 |
Journal: |
PLoS Biol |
Title: |
Extracellular DJ-1 induces sterile inflammation in the ischemic brain. |
Volume: |
19 |
Issue: |
5 |
Pages: |
e3000939 |
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•
•
•
•
•
|
Publication |
First Author: |
Cremer JN |
Year: |
2015 |
Journal: |
Neuroscience |
Title: |
Changes in the expression of neurotransmitter receptors in Parkin and DJ-1 knockout mice--A quantitative multireceptor study. |
Volume: |
311 |
|
Pages: |
539-51 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hauser DN |
Year: |
2015 |
Journal: |
eNeuro |
Title: |
The Polg Mutator Phenotype Does Not Cause Dopaminergic Neurodegeneration in DJ-1-Deficient Mice. |
Volume: |
2 |
Issue: |
1 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Aron L |
Year: |
2010 |
Journal: |
PLoS Biol |
Title: |
Pro-survival role for Parkinson's associated gene DJ-1 revealed in trophically impaired dopaminergic neurons. |
Volume: |
8 |
Issue: |
4 |
Pages: |
e1000349 |
|
•
•
•
•
•
|
Publication |
First Author: |
Billia F |
Year: |
2013 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Parkinson-susceptibility gene DJ-1/PARK7 protects the murine heart from oxidative damage in vivo. |
Volume: |
110 |
Issue: |
15 |
Pages: |
6085-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jiang L |
Year: |
2021 |
Journal: |
Acta Pharmacol Sin |
Title: |
The C terminus of DJ-1 determines its homodimerization, MGO detoxification activity and suppression of ferroptosis. |
Volume: |
42 |
Issue: |
7 |
Pages: |
1150-1159 |
|
•
•
•
•
•
|
Publication |
First Author: |
Carr L |
Year: |
2017 |
Journal: |
PLoS One |
Title: |
Expression patterns of Slit and Robo family members in adult mouse spinal cord and peripheral nervous system. |
Volume: |
12 |
Issue: |
2 |
Pages: |
e0172736 |
|
•
•
•
•
•
|
Publication |
First Author: |
Forkert PG |
Year: |
1996 |
Journal: |
Carcinogenesis |
Title: |
Alterations in expression of CYP1A1 and NADPH-cytochrome P450 reductase during lung tumor development in SWR/J mice. |
Volume: |
17 |
Issue: |
1 |
Pages: |
127-32 |
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Author |
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