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Search results 201 to 300 out of 1772 for Parkinson

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Type Details Score
Publication
First Author: Lohr KM
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Increased vesicular monoamine transporter enhances dopamine release and opposes Parkinson disease-related neurodegeneration in vivo.
Volume: 111
Issue: 27
Pages: 9977-82
Publication
First Author: Hattori N
Year: 1998
Journal: Genomics
Title: Genotype in the 24-kDa subunit gene (NDUFV2) of mitochondrial complex I and susceptibility to Parkinson disease.
Volume: 49
Issue: 1
Pages: 52-8
Publication
First Author: Thiruchelvam M
Year: 2005
Journal: J Biol Chem
Title: Overexpression of superoxide dismutase or glutathione peroxidase protects against the paraquat + maneb-induced Parkinson disease phenotype.
Volume: 280
Issue: 23
Pages: 22530-9
Publication
First Author: Alvarez-Fischer D
Year: 2013
Journal: PLoS One
Title: Bee venom and its component apamin as neuroprotective agents in a Parkinson disease mouse model.
Volume: 8
Issue: 4
Pages: e61700
Publication
First Author: Rekaik H
Year: 2015
Journal: FEBS Lett
Title: Dissecting the role of Engrailed in adult dopaminergic neurons--Insights into Parkinson disease pathogenesis.
Volume: 589
Issue: 24 Pt A
Pages: 3786-94
Publication
First Author: Zhao F
Year: 2019
Journal: Mol Neurobiol
Title: Conditional Haploinsufficiency of β-Catenin Aggravates Neuronal Damage in a Paraquat-Based Mouse Model of Parkinson Disease.
Volume: 56
Issue: 7
Pages: 5157-5166
Publication
First Author: Khasnavis S
Year: 2013
Journal: J Biol Chem
Title: Castration induces Parkinson disease pathologies in young male mice via inducible nitric-oxide synthase.
Volume: 288
Issue: 29
Pages: 20843-20855
Publication
First Author: Li X
Year: 2012
Journal: PLoS One
Title: Evaluation of TorsinA as a target for Parkinson disease therapy in mouse models.
Volume: 7
Issue: 11
Pages: e50063
Publication
First Author: Komnig D
Year: 2016
Journal: J Neurochem
Title: Mice lacking Faim2 show increased cell death in the MPTP mouse model of Parkinson disease.
Volume: 139
Issue: 5
Pages: 848-857
Publication
First Author: Nuber S
Year: 2021
Journal: Ann Neurol
Title: A Stearoyl-Coenzyme A Desaturase Inhibitor Prevents Multiple Parkinson Disease Phenotypes in α-Synuclein Mice.
Volume: 89
Issue: 1
Pages: 74-90
Publication
First Author: Fishman-Jacob T
Year: 2009
Journal: J Biol Chem
Title: A sporadic Parkinson disease model via silencing of the ubiquitin-proteasome/E3 ligase component SKP1A.
Volume: 284
Issue: 47
Pages: 32835-45
Publication
First Author: Han X
Year: 2019
Journal: Autophagy
Title: Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiquitination and autophagy: implications for Parkinson disease.
Volume: 15
Issue: 11
Pages: 1860-1881
Publication
First Author: Wang J
Year: 2019
Journal: Glia
Title: SIRPα deficiency accelerates the pathologic process in models of Parkinson disease.
Volume: 67
Issue: 12
Pages: 2343-2359
Publication  
First Author: Tagliaferro P
Year: 2015
Journal: Neurobiol Dis
Title: An early axonopathy in a hLRRK2(R1441G) transgenic model of Parkinson disease.
Volume: 82
Pages: 359-371
Publication
First Author: Lin QS
Year: 2020
Journal: Lab Invest
Title: RIP1/RIP3/MLKL mediates dopaminergic neuron necroptosis in a mouse model of Parkinson disease.
Volume: 100
Issue: 3
Pages: 503-511
Publication  
First Author: Shi SY
Year: 2015
Journal: Nat Commun
Title: DJ-1 links muscle ROS production with metabolic reprogramming and systemic energy homeostasis in mice.
Volume: 6
Pages: 7415
Publication
First Author: Chien CH
Year: 2016
Journal: BMC Cancer
Title: Growth hormone is increased in the lungs and enhances experimental lung metastasis of melanoma in DJ-1 KO mice.
Volume: 16
Issue: 1
Pages: 871
Publication
First Author: Goldberg MS
Year: 2005
Journal: Neuron
Title: Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1.
Volume: 45
Issue: 4
Pages: 489-96
Publication
First Author: Lee KP
Year: 2018
Journal: Pflugers Arch
Title: DJ-1 is involved in epigenetic control of sphingosine-1-phosphate receptor expression in vascular neointima formation.
Volume: 470
Issue: 7
Pages: 1103-1113
Publication
First Author: Zhang J
Year: 2020
Journal: J Biol Chem
Title: Deficiency in the anti-apoptotic protein DJ-1 promotes intestinal epithelial cell apoptosis and aggravates inflammatory bowel disease via p53.
Volume: 295
Issue: 13
Pages: 4237-4251
Publication
First Author: Parker PJ
Year: 2001
Journal: Biochem Soc Trans
Title: AGC protein kinase phosphorylation and protein kinase C.
Volume: 29
Issue: Pt 6
Pages: 860-3
Author
Author
DO Term
DO Term
DO Term
Publication
First Author: Wilhelm M
Year: 2007
Journal: J Biol Chem
Title: Proapoptotic Nix activates the JNK pathway by interacting with POSH and mediates death in a Parkinson disease model.
Volume: 282
Issue: 2
Pages: 1288-95
Publication
First Author: Brochard V
Year: 2009
Journal: J Clin Invest
Title: Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease.
Volume: 119
Issue: 1
Pages: 182-92
Publication  
First Author: Harms AS
Year: 2018
Journal: Exp Neurol
Title: Peripheral monocyte entry is required for alpha-Synuclein induced inflammation and Neurodegeneration in a model of Parkinson disease.
Volume: 300
Pages: 179-187
Publication
First Author: Liu CW
Year: 2005
Journal: J Biol Chem
Title: A precipitating role for truncated alpha-synuclein and the proteasome in alpha-synuclein aggregation: implications for pathogenesis of Parkinson disease.
Volume: 280
Issue: 24
Pages: 22670-8
Publication
First Author: Zhou W
Year: 2011
Journal: J Biol Chem
Title: Phenylbutyrate up-regulates the DJ-1 protein and protects neurons in cell culture and in animal models of Parkinson disease.
Volume: 286
Issue: 17
Pages: 14941-51
Publication
First Author: Requejo-Aguilar R
Year: 2015
Journal: Biochem J
Title: DJ1 represses glycolysis and cell proliferation by transcriptionally up-regulating Pink1.
Volume: 467
Issue: 2
Pages: 303-10
Publication  
First Author: Alvarez-Castelao B
Year: 2014
Journal: Front Aging Neurosci
Title: Epitope Mapping of Antibodies to Alpha-Synuclein in LRRK2 Mutation Carriers, Idiopathic Parkinson Disease Patients, and Healthy Controls.
Volume: 6
Pages: 169
Publication
First Author: Ghosh A
Year: 2013
Journal: J Biol Chem
Title: The peptidyl-prolyl isomerase Pin1 up-regulation and proapoptotic function in dopaminergic neurons: relevance to the pathogenesis of Parkinson disease.
Volume: 288
Issue: 30
Pages: 21955-71
Publication
First Author: Haque ME
Year: 2012
Journal: J Biol Chem
Title: Inactivation of Pink1 gene in vivo sensitizes dopamine-producing neurons to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and can be rescued by autosomal recessive Parkinson disease genes, Parkin or DJ-1.
Volume: 287
Issue: 27
Pages: 23162-70
Publication
First Author: Tamma R
Year: 2013
Journal: Lab Invest
Title: Effects of prednisolone on the dystrophin-associated proteins in the blood-brain barrier and skeletal muscle of dystrophic mdx mice.
Volume: 93
Issue: 5
Pages: 592-610
Publication
First Author: Zeng N
Year: 2022
Journal: EMBO Rep
Title: DJ-1 depletion prevents immunoaging in T-cell compartments.
Volume: 23
Issue: 3
Pages: e53302
Publication
First Author: Shi H
Year: 2017
Journal: Hum Mol Genet
Title: Sirt3 protects dopaminergic neurons from mitochondrial oxidative stress.
Volume: 26
Issue: 10
Pages: 1915-1926
Publication
First Author: Beilina A
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease.
Volume: 111
Issue: 7
Pages: 2626-31
Publication  
First Author: Chen YH
Year: 2019
Journal: Int J Mol Sci
Title: Delayed Dopamine Dysfunction and Motor Deficits in Female Parkinson Model Mice.
Volume: 20
Issue: 24
Publication
First Author: Fishbein I
Year: 2014
Journal: Brain
Title: Augmentation of phenotype in a transgenic Parkinson mouse heterozygous for a Gaucher mutation.
Volume: 137
Issue: Pt 12
Pages: 3235-47
Publication
First Author: Lozovaya N
Year: 2018
Journal: Nat Commun
Title: GABAergic inhibition in dual-transmission cholinergic and GABAergic striatal interneurons is abolished in Parkinson disease.
Volume: 9
Issue: 1
Pages: 1422
Publication
First Author: Fanning S
Year: 2019
Journal: Mol Cell
Title: Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment.
Volume: 73
Issue: 5
Pages: 1001-1014.e8
Publication
First Author: Wu DC
Year: 2002
Journal: J Neurosci
Title: Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease.
Volume: 22
Issue: 5
Pages: 1763-71
Allele
Name: transgene insertion H, Nick Parkinson
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
Allele
Name: transgene insertion L, Nick Parkinson
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
Allele
Name: transgene insertion 6928, Fiona Parkinson
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
Allele
Name: transgene insertion P, Nick Parkinson
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
Publication
First Author: Im JY
Year: 2010
Journal: Neurosci Res
Title: DJ-1 protects against oxidative damage by regulating the thioredoxin/ASK1 complex.
Volume: 67
Issue: 3
Pages: 203-8
Publication
First Author: Jung SH
Year: 2014
Journal: Atherosclerosis
Title: DJ-1 protein regulates CD3+ T cell migration via overexpression of CXCR4 receptor.
Volume: 235
Issue: 2
Pages: 503-9
Publication
First Author: Tai-Nagara I
Year: 2014
Journal: Blood
Title: Mortalin and DJ-1 coordinately regulate hematopoietic stem cell function through the control of oxidative stress.
Volume: 123
Issue: 1
Pages: 41-50
Publication
First Author: De Miguel C
Year: 2019
Journal: J Am Heart Assoc
Title: Uncoupling Protein 2 Increases Blood Pressure in DJ -1 Knockout Mice.
Volume: 8
Issue: 9
Pages: e011856
Publication
First Author: Lin Z
Year: 2021
Journal: Cell Death Dis
Title: DJ-1 inhibits microglial activation and protects dopaminergic neurons in vitro and in vivo through interacting with microglial p65.
Volume: 12
Issue: 8
Pages: 715
Publication
First Author: Xu S
Year: 2018
Journal: J Neurochem
Title: Parkinson's disease-related DJ-1 modulates the expression of uncoupling protein 4 against oxidative stress.
Volume: 145
Issue: 4
Pages: 312-322
Publication
First Author: Lee DY
Year: 2015
Journal: Biochim Biophys Acta
Title: DJ-1 regulates the expression of renal (pro)renin receptor via reactive oxygen species-mediated epigenetic modification.
Volume: 1850
Issue: 2
Pages: 426-34
Publication
First Author: Lev N
Year: 2015
Journal: PLoS One
Title: A DJ-1 Based Peptide Attenuates Dopaminergic Degeneration in Mice Models of Parkinson's Disease via Enhancing Nrf2.
Volume: 10
Issue: 5
Pages: e0127549
Publication
First Author: Won KJ
Year: 2014
Journal: Cardiovasc Res
Title: DJ-1/park7 modulates vasorelaxation and blood pressure via epigenetic modification of endothelial nitric oxide synthase.
Volume: 101
Issue: 3
Pages: 473-81
Publication
First Author: Kim YC
Year: 2010
Journal: FEBS Lett
Title: DJ-1, an oncogene and causative gene for familial Parkinson's disease, is essential for SV40 transformation in mouse fibroblasts through up-regulation of c-Myc.
Volume: 584
Issue: 18
Pages: 3891-5
Publication  
First Author: Kim JM
Year: 2016
Journal: Sci Rep
Title: DJ-1 deficiency impairs glutamate uptake into astrocytes via the regulation of flotillin-1 and caveolin-1 expression.
Volume: 6
Pages: 28823
Publication
First Author: Sivasubramaniyam T
Year: 2021
Journal: Sci Rep
Title: Dj1 deficiency protects against atherosclerosis with anti-inflammatory response in macrophages.
Volume: 11
Issue: 1
Pages: 4723
Publication  
First Author: Schriever SC
Year: 2017
Journal: Neuroscience
Title: Alterations in neuronal control of body weight and anxiety behavior by glutathione peroxidase 4 deficiency.
Volume: 357
Pages: 241-254
Publication
First Author: Ho CC
Year: 2009
Journal: J Neurosci
Title: The Parkinson disease protein leucine-rich repeat kinase 2 transduces death signals via Fas-associated protein with death domain and caspase-8 in a cellular model of neurodegeneration.
Volume: 29
Issue: 4
Pages: 1011-6
Publication  
First Author: Gao J
Year: 2022
Journal: Brain Res Bull
Title: Asparagine endopeptidase deletion ameliorates cognitive impairments by inhibiting proinflammatory microglial activation in MPTP mouse model of Parkinson disease.
Volume: 178
Pages: 120-130
Protein
Organism: Mus musculus/domesticus
Length: 220  
Fragment?: false
Publication  
First Author: Lopez-Fabuel I
Year: 2017
Journal: Neurochem Int
Title: Mitochondrial respiratory chain disorganization in Parkinson's disease-relevant PINK1 and DJ1 mutants.
Volume: 109
Pages: 101-105
HT Experiment
Series Id: GSE60413
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
Interaction Experiment
Description: Aberrant interaction between Parkinson disease-associated mutant UCH-L1 and the lysosomal receptor for chaperone-mediated autophagy.
Publication
First Author: Jin H
Year: 2014
Journal: J Biol Chem
Title: Histone hyperacetylation up-regulates protein kinase Cδ in dopaminergic neurons to induce cell death: relevance to epigenetic mechanisms of neurodegeneration in Parkinson disease.
Volume: 289
Issue: 50
Pages: 34743-67
Publication
First Author: Kuo YM
Year: 2010
Journal: Hum Mol Genet
Title: Extensive enteric nervous system abnormalities in mice transgenic for artificial chromosomes containing Parkinson disease-associated alpha-synuclein gene mutations precede central nervous system changes.
Volume: 19
Issue: 9
Pages: 1633-50
Publication
First Author: Shaltiel-Karyo R
Year: 2013
Journal: J Biol Chem
Title: A blood-brain barrier (BBB) disrupter is also a potent α-synuclein (α-syn) aggregation inhibitor: a novel dual mechanism of mannitol for the treatment of Parkinson disease (PD).
Volume: 288
Issue: 24
Pages: 17579-88
Publication
First Author: She H
Year: 2011
Journal: J Clin Invest
Title: Direct regulation of complex I by mitochondrial MEF2D is disrupted in a mouse model of Parkinson disease and in human patients.
Volume: 121
Issue: 3
Pages: 930-40
Publication
First Author: Chartier-Harlin MC
Year: 2011
Journal: Am J Hum Genet
Title: Translation initiator EIF4G1 mutations in familial Parkinson disease.
Volume: 89
Issue: 3
Pages: 398-406
Publication
First Author: Han H
Year: 2020
Journal: EMBO Rep
Title: PINK1 phosphorylates Drp1S616 to regulate mitophagy-independent mitochondrial dynamics.
Volume: 21
Issue: 8
Pages: e48686
Publication  
First Author: Martella G
Year: 2011
Journal: Neuroscience
Title: Altered profile and D2-dopamine receptor modulation of high voltage-activated calcium current in striatal medium spiny neurons from animal models of Parkinson's disease.
Volume: 177
Pages: 240-51
Publication
First Author: Liu Y
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: DJ-1 regulates the integrity and function of ER-mitochondria association through interaction with IP3R3-Grp75-VDAC1.
Volume: 116
Issue: 50
Pages: 25322-25328
Publication
First Author: Tan LH
Year: 2018
Journal: Sci Rep
Title: The cytoprotective role of DJ-1 and p45 NFE2 against human primary alveolar type II cell injury and emphysema.
Volume: 8
Issue: 1
Pages: 3555
Publication
First Author: Yamaguchi S
Year: 2012
Journal: PLoS One
Title: Transcriptional activation of low-density lipoprotein receptor gene by DJ-1 and effect of DJ-1 on cholesterol homeostasis.
Volume: 7
Issue: 5
Pages: e38144
Publication
First Author: Giaime E
Year: 2010
Journal: Cell Death Differ
Title: Loss of function of DJ-1 triggered by Parkinson's disease-associated mutation is due to proteolytic resistance to caspase-6.
Volume: 17
Issue: 1
Pages: 158-69
Publication
First Author: Xiong H
Year: 2009
Journal: J Clin Invest
Title: Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation.
Volume: 119
Issue: 3
Pages: 650-60
Publication
First Author: Xu M
Year: 2021
Journal: Cell Mol Gastroenterol Hepatol
Title: DJ-1 Deficiency in Hepatocytes Improves Liver Ischemia-Reperfusion Injury by Enhancing Mitophagy.
Volume: 12
Issue: 2
Pages: 567-584
Publication  
First Author: Levin J
Year: 2022
Journal: EBioMedicine
Title: Safety, tolerability and pharmacokinetics of the oligomer modulator anle138b with exposure levels sufficient for therapeutic efficacy in a murine Parkinson model: A randomised, double-blind, placebo-controlled phase 1a trial.
Volume: 80
Pages: 104021
Publication
First Author: Ho PW
Year: 2020
Journal: Autophagy
Title: Age-dependent accumulation of oligomeric SNCA/α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA).
Volume: 16
Issue: 2
Pages: 347-370
Allele
Name: phospholipase A2, group VI; targeted mutation 1.1, Hung-Li Wang
Allele Type: Targeted
Attribute String: Humanized sequence
Publication
First Author: Shim JH
Year: 2011
Journal: Mitochondrion
Title: The antioxidant Trolox helps recovery from the familial Parkinson's disease-specific mitochondrial deficits caused by PINK1- and DJ-1-deficiency in dopaminergic neuronal cells.
Volume: 11
Issue: 5
Pages: 707-15
Gene
Type: gene
Organism: human
Publication
First Author: Parsanejad M
Year: 2014
Journal: J Neurosci
Title: Regulation of the VHL/HIF-1 pathway by DJ-1.
Volume: 34
Issue: 23
Pages: 8043-50
Genotype
Symbol: Pla2g6/Pla2g6
Background: involves: 129 * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
Strain
Attribute String: congenic, mutant strain, transgenic
Strain
Attribute String: transgenic, mutant strain, congenic
Strain
Attribute String: mutant stock, transgenic
Strain
Attribute String: mutant stock, transgenic
Publication
First Author: Nakamura K
Year: 2021
Journal: PLoS Biol
Title: Extracellular DJ-1 induces sterile inflammation in the ischemic brain.
Volume: 19
Issue: 5
Pages: e3000939
Publication  
First Author: Cremer JN
Year: 2015
Journal: Neuroscience
Title: Changes in the expression of neurotransmitter receptors in Parkin and DJ-1 knockout mice--A quantitative multireceptor study.
Volume: 311
Pages: 539-51
Publication  
First Author: Hauser DN
Year: 2015
Journal: eNeuro
Title: The Polg Mutator Phenotype Does Not Cause Dopaminergic Neurodegeneration in DJ-1-Deficient Mice.
Volume: 2
Issue: 1
Publication
First Author: Aron L
Year: 2010
Journal: PLoS Biol
Title: Pro-survival role for Parkinson's associated gene DJ-1 revealed in trophically impaired dopaminergic neurons.
Volume: 8
Issue: 4
Pages: e1000349
Publication
First Author: Billia F
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Parkinson-susceptibility gene DJ-1/PARK7 protects the murine heart from oxidative damage in vivo.
Volume: 110
Issue: 15
Pages: 6085-90
Publication
First Author: Jiang L
Year: 2021
Journal: Acta Pharmacol Sin
Title: The C terminus of DJ-1 determines its homodimerization, MGO detoxification activity and suppression of ferroptosis.
Volume: 42
Issue: 7
Pages: 1150-1159
Publication
First Author: Carr L
Year: 2017
Journal: PLoS One
Title: Expression patterns of Slit and Robo family members in adult mouse spinal cord and peripheral nervous system.
Volume: 12
Issue: 2
Pages: e0172736
Publication
First Author: Forkert PG
Year: 1996
Journal: Carcinogenesis
Title: Alterations in expression of CYP1A1 and NADPH-cytochrome P450 reductase during lung tumor development in SWR/J mice.
Volume: 17
Issue: 1
Pages: 127-32
Author