| Type |
Details |
Score |
| Publication |
| First Author: |
Liu XD |
| Year: |
2020 |
| Journal: |
Nat Commun |
| Title: |
PBRM1 loss defines a nonimmunogenic tumor phenotype associated with checkpoint inhibitor resistance in renal carcinoma. |
| Volume: |
11 |
| Issue: |
1 |
| Pages: |
2135 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gao W |
| Year: |
2017 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Inactivation of the PBRM1 tumor suppressor gene amplifies the HIF-response in VHL-/- clear cell renal carcinoma. |
| Volume: |
114 |
| Issue: |
5 |
| Pages: |
1027-1032 |
|
•
•
•
•
•
|
| HT Experiment |
|
| Experiment Type: |
RNA-Seq |
| Study Type: |
WT vs. Mutant |
| Source: |
GEO |
|
•
•
•
•
•
|
| Allele |
| Name: |
polybromo 1; endonuclease-mediated mutation 2, Shanghai Model Organisms Center |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Varela I |
| Year: |
2011 |
| Journal: |
Nature |
| Title: |
Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. |
| Volume: |
469 |
| Issue: |
7331 |
| Pages: |
539-42 |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
| Allele |
| Name: |
polybromo 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Porter EG |
| Year: |
2017 |
| Journal: |
J Biol Chem |
| Title: |
Individual Bromodomains of Polybromo-1 Contribute to Chromatin Association and Tumor Suppression in Clear Cell Renal Carcinoma. |
| Volume: |
292 |
| Issue: |
7 |
| Pages: |
2601-2610 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
The human protein polybromo-1 (PBRM1, also known as BAF180) is part of a SWI/SNF chromatin-remodeling complex []. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine [, ]. Polybromo contains 6 bromodomains. This entry represents the fifth one (BD5). Mutations in BD5 moderately affect PBRM1 chromatin association []. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Owen DJ |
| Year: |
2000 |
| Journal: |
EMBO J |
| Title: |
The structural basis for the recognition of acetylated histone H4 by the bromodomain of histone acetyltransferase gcn5p. |
| Volume: |
19 |
| Issue: |
22 |
| Pages: |
6141-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
de Castro RO |
| Year: |
2022 |
| Journal: |
Development |
| Title: |
PBAF chromatin remodeler complexes that mediate meiotic transitions in mouse. |
| Volume: |
149 |
| Issue: |
18 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kishore S |
| Year: |
2010 |
| Journal: |
Hum Mol Genet |
| Title: |
The snoRNA MBII-52 (SNORD 115) is processed into smaller RNAs and regulates alternative splicing. |
| Volume: |
19 |
| Issue: |
7 |
| Pages: |
1153-64 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Peña-Llopis S |
| Year: |
2013 |
| Journal: |
Cancer Res |
| Title: |
Cooperation and antagonism among cancer genes: the renal cancer paradigm. |
| Volume: |
73 |
| Issue: |
14 |
| Pages: |
4173-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Liao L |
| Year: |
2015 |
| Journal: |
Cancer Genet |
| Title: |
The roles of chromatin-remodelers and epigenetic modifiers in kidney cancer. |
| Volume: |
208 |
| Issue: |
5 |
| Pages: |
206-14 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
860
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
856
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
931
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zeng L |
| Year: |
2002 |
| Journal: |
FEBS Lett |
| Title: |
Bromodomain: an acetyl-lysine binding domain. |
| Volume: |
513 |
| Issue: |
1 |
| Pages: |
124-8 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1085
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1634
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1689
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1652
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1704
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1460
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1582
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1582
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1597
 |
| Fragment?: |
false |
|
•
•
•
•
•
|