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Search results 201 to 246 out of 246 for Pcdh15

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Type Details Score
Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Allele
Pcdh15<tm1.1Ugds> | MGI:5566900
Name: protocadherin 15; targeted mutation 1.1, Unite de Genetique des Deficits Sensoriels
Allele Type: Targeted
Attribute String: Conditional ready
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Allele
Pcdh15<tm2.1Ugds> | MGI:6389238
Name: protocadherin 15; targeted mutation 2.1, Unite de Genetique des Deficits Sensoriels
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Pcdh15<tm3.1Ugds> | MGI:6389239
Name: protocadherin 15; targeted mutation 3.1, Unite de Genetique des Deficits Sensoriels
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Pcdh15<av-Jfb> | MGI:2448714
 
Name: protocadherin 15; Ames waltzer James F Battey
Allele Type: Spontaneous
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Allele
Pcdh15<av-J> | MGI:1855958
 
Name: protocadherin 15; Ames waltzer Jackson
Allele Type: Spontaneous
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Allele
Pcdh15<av-3J> | MGI:1856394
 
Name: protocadherin 15; Ames waltzer 3 Jackson
Allele Type: Spontaneous
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Allele
Pcdh15<roda> | MGI:5704141
 
Name: protocadherin 15; rodador
Allele Type: Chemically induced (ENU)
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Genotype
Genotype
Symbol: Pcdh15/Pcdh15
Background: involves: 129X1/SvJ * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Pcdh15/Pcdh15
Background: C57BL/6J-Pcdh15/J
Zygosity: hm
Has Mutant Allele: true
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DO Term
DOID:0110481 | autosomal recessive nonsyndromic deafness 23
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DO Term
DOID:0110832 | Usher syndrome type 1F
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Strain
MGI:2161820 | B6.BKS-Pcdh15<av-J>/J
Attribute String: congenic, mutant strain, spontaneous mutation
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Strain
MGI:5651107 | B6.BKS-Pcdh15<av-J> x CASA/Rk
Attribute String: congenic, mutant strain, wild-derived, spontaneous mutation
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Strain
MGI:2164307 | B6.BKS-Pcdh15<av-J>
Attribute String: congenic, mutant strain, spontaneous mutation
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Genotype
Genotype
Symbol: Pcdh15/Pcdh15
Background: B6.BKS-Pcdh15/J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Pcdh15/Pcdh15
Background: BALB/c-Pcdh15
Zygosity: hm
Has Mutant Allele: true
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Allele
Pcdh15<m1Btlr> | MGI:3814568
 
Name: protocadherin 15; mutation 1 Bruce Beutler
Allele Type: Chemically induced (ENU)
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Publication
28238533 | -
First Author: Powers RE
Year: 2017
Journal: Structure
Title: A Partial Calcium-Free Linker Confers Flexibility to Inner-Ear Protocadherin-15.
Volume: 25
Issue: 3
Pages: 482-495
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Protein Domain
IPR041149 | EC_dom
Type: Domain
Description: This is an extracellular cadherin (EC) domain which can be found at the N-terminal region of Protocadherin 15 (Pcdh15). Pcdh15 features exceptionally long extracellular domains containing 11 ECs []. These repeats are structurally similar, but not identical in sequence, often featuring linkers with conserved calcium-binding sites that confer mechanical strength to them [].
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Allele
Pcdh15<av-Tg2742Rpw> | MGI:2151877
 
Name: protocadherin 15; transgenic, nonhomologous insert 2742, Richard P Woychik
Allele Type: Transgenic
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Strain
MGI:3814699 | C57BL/6J-Pcdh15<m1Btlr>
Attribute String: chemically induced mutation, coisogenic
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Genotype
Genotype
Symbol: Pcdh15/Pcdh15
Background: C57BL/6J-Pcdh15
Zygosity: hm
Has Mutant Allele: true
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Strain
MGI:3796752 | FVB/N-Pcdh15<av-Tg2742Rpw>
Attribute String: coisogenic, transgenic
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Genotype
Genotype
Symbol: Pcdh15/Pcdh15
Background: FVB/N-Pcdh15
Zygosity: hm
Has Mutant Allele: true
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Protein Domain
IPR030718 | Protocadherin-15
Type: Family
Description: Protocadherin-15 (Pcdh15) belongs to the epsilon subfamily of nonclustered protocadherins. It is a component of the tip-links, the extracellular filaments that connect the tips of stereocilia and gate hair cell mechano-electrical transduction channels in the inner ear []. Pcdh15 interacts with transmembrane channel-like proteins TMC1 and TMC2, which have been implicated in mechanotransduction in mammalian hair cells []. Mutations in genes coding for Pcdh15 cause deafness in both mice and humans [, ]. Pcdh15 plays an important role in hair-bundle morphogenesis [].The cadherin family consists of a large group of cell adhesion proteins. It can be classified into three subfamilies: classical cadherins, desmosomal cadherins and protocadherins (PCDHs). Based on the genomic structure, the PCDH family can be divided into two groups, clustered PCDHs and non-clustered PCDHs. Non-clustered PCDHs can be further classified into three subgroups: delta1 (PCDH1, PCDH7, PCDH9, PCDH11 and PCDH20), delta2 (PCDH8, PCDH10, PCDH12, PCDH17, PCDH18 and PCDH19) and epsilon (PCDH15, PCDH16, PCDH21 and MUCDHL). Non-clustered PCDHs are expressed predominantly in the nervous system and have spatiotemporally diverse expression patterns [].
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Publication
25467981 | J:217448
First Author: Zhao B
Year: 2014
Journal: Neuron
Title: TMIE is an essential component of the mechanotransduction machinery of cochlear hair cells.
Volume: 84
Issue: 5
Pages: 954-67
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Publication
36191207 | J:344636
First Author: Fettiplace R
Year: 2022
Journal: Proc Natl Acad Sci U S A
Title: The conductance and organization of the TMC1-containing mechanotransducer channel complex in auditory hair cells.
Volume: 119
Issue: 41
Pages: e2210849119
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Publication
18463160 | J:137661
First Author: Jacobson SG
Year: 2008
Journal: Hum Mol Genet
Title: Usher syndromes due to MYO7A, PCDH15, USH2A or GPR98 mutations share retinal disease mechanism.
Volume: 17
Issue: 15
Pages: 2405-15
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Publication
38194445 | J:344637
First Author: Beurg M
Year: 2024
Journal: Proc Natl Acad Sci U S A
Title: LHFPL5 is a key element in force transmission from the tip link to the hair cell mechanotransducer channel.
Volume: 121
Issue: 3
Pages: e2318270121
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Publication
29515374 | J:263973
 
First Author: Morgan CP
Year: 2018
Journal: Front Cell Neurosci
Title: TRPV6, TRPM6 and TRPM7 Do Not Contribute to Hair-Cell Mechanotransduction.
Volume: 12
Pages: 41
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Protein
Q99PJ1
Organism: Mus musculus/domesticus
Length: 1943  
Fragment?: false
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Protein
A0A0A6YY17
Organism: Mus musculus/domesticus
Length: 1783  
Fragment?: false
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Protein
E9Q159
Organism: Mus musculus/domesticus
Length: 1865  
Fragment?: false
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Protein
A0A0A6YXB5
Organism: Mus musculus/domesticus
Length: 1714  
Fragment?: false
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Protein
A0A140T8S2
Organism: Mus musculus/domesticus
Length: 1675  
Fragment?: false
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Protein
A0A0A6YWL3
Organism: Mus musculus/domesticus
Length: 1333  
Fragment?: true
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Publication
21173574 | -
First Author: Kim SY
Year: 2011
Journal: Cell Adh Migr
Title: Non-clustered protocadherin.
Volume: 5
Issue: 2
Pages: 97-105
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