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Search results 201 to 264 out of 264 for Pcdh18

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Type Details Score
Publication
21173574 | -
First Author: Kim SY
Year: 2011
Journal: Cell Adh Migr
Title: Non-clustered protocadherin.
Volume: 5
Issue: 2
Pages: 97-105
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Publication
9651350 | J:48727
First Author: Telo' P
Year: 1998
Journal: J Biol Chem
Title: Identification of a novel cadherin (vascular endothelial cadherin-2) located at intercellular junctions in endothelial cells.
Volume: 273
Issue: 28
Pages: 17565-72
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Publication
18477666 | J:138143
First Author: Rampon C
Year: 2008
Journal: Physiol Genomics
Title: Protocadherin 12 deficiency alters morphogenesis and transcriptional profile of the placenta.
Volume: 34
Issue: 2
Pages: 193-204
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Publication
22205043 | J:309156
First Author: Philibert C
Year: 2012
Journal: Pathol Biol (Paris)
Title: Protocadherin-12 deficiency leads to modifications in the structure and function of arteries in mice.
Volume: 60
Issue: 1
Pages: 34-40
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Protein
A0JNZ2
Organism: Mus musculus/domesticus
Length: 121  
Fragment?: false
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Publication
18848899 | -
First Author: Hulpiau P
Year: 2009
Journal: Int J Biochem Cell Biol
Title: Molecular evolution of the cadherin superfamily.
Volume: 41
Issue: 2
Pages: 349-69
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Publication
15627506 | J:97541
First Author: Makarenkova H
Year: 2005
Journal: Biochim Biophys Acta
Title: Alternatively spliced variants of protocadherin 8 exhibit distinct patterns of expression during mouse development.
Volume: 1681
Issue: 2-3
Pages: 150-6
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Publication
16261259 | -
First Author: Redies C
Year: 2005
Journal: Cell Mol Life Sci
Title: delta-Protocadherins: unique structures and functions.
Volume: 62
Issue: 23
Pages: 2840-52
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Publication
22941331 | -
First Author: Zhang D
Year: 2012
Journal: Oncol Rep
Title: Frequent silencing of protocadherin 8 by promoter methylation, a candidate tumor suppressor for human gastric cancer.
Volume: 28
Issue: 5
Pages: 1785-91
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Publication
18408767 | -
First Author: Yu JS
Year: 2008
Journal: Oncogene
Title: PCDH8, the human homolog of PAPC, is a candidate tumor suppressor of breast cancer.
Volume: 27
Issue: 34
Pages: 4657-65
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Publication
24740680 | -
First Author: Jao TM
Year: 2014
Journal: Int J Cancer
Title: Protocadherin 10 suppresses tumorigenesis and metastasis in colorectal cancer and its genetic loss predicts adverse prognosis.
Volume: 135
Issue: 11
Pages: 2593-603
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Publication
24888369 | -
First Author: Li Z
Year: 2014
Journal: Mol Med Rep
Title: Nuclear factor-κB is involved in the protocadherin-10-mediated pro-apoptotic effect in multiple myeloma.
Volume: 10
Issue: 2
Pages: 832-8
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Publication
21402705 | -
First Author: Bouillot S
Year: 2011
Journal: J Biol Chem
Title: Protocadherin-12 cleavage is a regulated process mediated by ADAM10 protein: evidence of shedding up-regulation in pre-eclampsia.
Volume: 286
Issue: 17
Pages: 15195-204
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Protein Domain
IPR030720 | Protocadherin-12
Type: Family
Description: Protocadherin-12 (Pcdh12), also known as vascular cadherin-2 or VE-cadherin-2, is located at the intercellular junctions of endothelial cells, where it promotes homotypic cellular adhesion []. It is required for placental development [, ]and its deficiency leads to modifications in the structure and function of arteries in adult mice [].The cadherin family consists of a large group of cell adhesion proteins. It can be classified into three subfamilies: classical cadherins, desmosomal cadherins and protocadherins (PCDHs). Based on the genomic structure, the PCDH family can be divided into two groups, clustered PCDHs and non-clustered PCDHs. Non-clustered PCDHs can be further classified into three subgroups: delta1 (PCDH1, PCDH7, PCDH9, PCDH11 and PCDH20), delta2 (PCDH8, PCDH10, PCDH12, PCDH17, PCDH18 and PCDH19) and epsilon (PCDH15, PCDH16, PCDH21 and MUCDHL). Non-clustered PCDHs are expressed predominantly in the nervous system and have spatiotemporally diverse expression patterns [].
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Protein Domain
IPR030712 | Protocadherin-10
Type: Family
Description: Protocadherin-10 (Pcdh10) belongs to the delta-2 subfamily of nonclustered protocadherins []. Pcdh10 is a pivotal tumour suppressor in colorectal cancer []and induces myeloma cell apoptosis, probably by inhibiting the NF-kappaB pathway [].The cadherin family consists of a large group of cell adhesion proteins. It can be classified into three subfamilies: classical cadherins, desmosomal cadherins and protocadherins (PCDHs). Based on the genomic structure, the PCDH family can be divided into two groups, clustered PCDHs and non-clustered PCDHs. Non-clustered PCDHs can be further classified into three subgroups: delta1 (PCDH1, PCDH7, PCDH9, PCDH11 and PCDH20), delta2 (PCDH8, PCDH10, PCDH12, PCDH17, PCDH18 and PCDH19) and epsilon (PCDH15, PCDH16, PCDH21 and MUCDHL). Non-clustered PCDHs are expressed predominantly in the nervous system and have spatiotemporally diverse expression patterns [].
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Protein Domain
IPR030711 | Protocadherin-8
Type: Family
Description: Protocadherin-8 (Pcdh8) belongs to the delta-2 subfamily of nonclustered protocadherins [, ]. It is involved in development [, ]and can act as a tumour suppressor [, ].The cadherin family consists of a large group of cell adhesion proteins. It can be classified into three subfamilies: classical cadherins, desmosomal cadherins and protocadherins (PCDHs). Based on the genomic structure, the PCDH family can be divided into two groups, clustered PCDHs and non-clustered PCDHs. Non-clustered PCDHs can be further classified into three subgroups: delta1 (PCDH1, PCDH7, PCDH9, PCDH11 and PCDH20), delta2 (PCDH8, PCDH10, PCDH12, PCDH17, PCDH18 and PCDH19) and epsilon (PCDH15, PCDH16, PCDH21 and MUCDHL). Non-clustered PCDHs are expressed predominantly in the nervous system and have spatiotemporally diverse expression patterns [].
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Publication
16799054 | J:112247
First Author: Haywood-Watson RJ 2nd
Year: 2006
Journal: Invest Ophthalmol Vis Sci
Title: Ames Waltzer deaf mice have reduced electroretinogram amplitudes and complex alternative splicing of Pcdh15 transcripts.
Volume: 47
Issue: 7
Pages: 3074-84
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Publication
25114259 | J:214830
First Author: Maeda R
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Tip-link protein protocadherin 15 interacts with transmembrane channel-like proteins TMC1 and TMC2.
Volume: 111
Issue: 35
Pages: 12907-12
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Protein
Q3UZU4
Organism: Mus musculus/domesticus
Length: 121  
Fragment?: false
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Protein
Q8CC37
Organism: Mus musculus/domesticus
Length: 283  
Fragment?: true
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Publication
25199687 | J:244222
First Author: Hayashi S
Year: 2014
Journal: Dev Cell
Title: Protocadherin-17 mediates collective axon extension by recruiting actin regulator complexes to interaxonal contacts.
Volume: 30
Issue: 6
Pages: 673-87
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Publication
22927092 | -
First Author: Chen Y
Year: 2013
Journal: Dev Neurobiol
Title: Protocadherin-17 function in Zebrafish retinal development.
Volume: 73
Issue: 4
Pages: 259-73
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Publication
22926751 | -
First Author: Hu X
Year: 2013
Journal: J Pathol
Title: Protocadherin 17 acts as a tumour suppressor inducing tumour cell apoptosis and autophagy, and is frequently methylated in gastric and colorectal cancers.
Volume: 229
Issue: 1
Pages: 62-73
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Publication
20200074 | -
First Author: Haruki S
Year: 2010
Journal: Carcinogenesis
Title: Frequent silencing of protocadherin 17, a candidate tumour suppressor for esophageal squamous cell carcinoma.
Volume: 31
Issue: 6
Pages: 1027-36
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Publication
19616130 | -
First Author: Liu Q
Year: 2009
Journal: Gene Expr Patterns
Title: Expression of protocadherin-9 and protocadherin-17 in the nervous system of the embryonic zebrafish.
Volume: 9
Issue: 7
Pages: 490-6
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Publication
19189440 | -
First Author: Krishna-K
Year: 2009
Journal: J Cereb Blood Flow Metab
Title: Expression of cadherin superfamily genes in brain vascular development.
Volume: 29
Issue: 2
Pages: 224-9
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Publication
23684785 | J:201552
First Author: Hoshina N
Year: 2013
Journal: Neuron
Title: Protocadherin 17 regulates presynaptic assembly in topographic corticobasal Ganglia circuits.
Volume: 78
Issue: 5
Pages: 839-54
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Publication
25612302 | -
First Author: Liu Q
Year: 2015
Journal: J Comp Neurol
Title: Differential expression of protocadherin-19, protocadherin-17, and cadherin-6 in adult zebrafish brain.
Volume: 523
Issue: 9
Pages: 1419-42
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Publication
22267240 | -
First Author: Depienne C
Year: 2012
Journal: Hum Mutat
Title: PCDH19-related infantile epileptic encephalopathy: an unusual X-linked inheritance disorder.
Volume: 33
Issue: 4
Pages: 627-34
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Publication
22504056 | -
First Author: Camacho A
Year: 2012
Journal: Epilepsy Behav
Title: Cognitive and behavioral profile in females with epilepsy with PDCH19 mutation: two novel mutations and review of the literature.
Volume: 24
Issue: 1
Pages: 134-7
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Publication
25204757 | -
First Author: Duszyc K
Year: 2015
Journal: J Appl Genet
Title: Epilepsy and mental retardation restricted to females: X-linked epileptic infantile encephalopathy of unusual inheritance.
Volume: 56
Issue: 1
Pages: 49-56
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Publication
24940003 | J:244761
First Author: Pepermans E
Year: 2014
Journal: EMBO Mol Med
Title: The CD2 isoform of protocadherin-15 is an essential component of the tip-link complex in mature auditory hair cells.
Volume: 6
Issue: 7
Pages: 984-92
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Publication
15537665 | J:95655
First Author: Zheng QY
Year: 2005
Journal: Hum Mol Genet
Title: Digenic inheritance of deafness caused by mutations in genes encoding cadherin 23 and protocadherin 15 in mice and humans.
Volume: 14
Issue: 1
Pages: 103-11
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Publication
15811708 | J:97048
First Author: Washington JL 3rd
Year: 2005
Journal: Hear Res
Title: Characterization of a new allele of Ames waltzer generated by ENU mutagenesis.
Volume: 202
Issue: 1-2
Pages: 161-9
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Protein Domain
IPR030718 | Protocadherin-15
Type: Family
Description: Protocadherin-15 (Pcdh15) belongs to the epsilon subfamily of nonclustered protocadherins. It is a component of the tip-links, the extracellular filaments that connect the tips of stereocilia and gate hair cell mechano-electrical transduction channels in the inner ear []. Pcdh15 interacts with transmembrane channel-like proteins TMC1 and TMC2, which have been implicated in mechanotransduction in mammalian hair cells []. Mutations in genes coding for Pcdh15 cause deafness in both mice and humans [, ]. Pcdh15 plays an important role in hair-bundle morphogenesis [].The cadherin family consists of a large group of cell adhesion proteins. It can be classified into three subfamilies: classical cadherins, desmosomal cadherins and protocadherins (PCDHs). Based on the genomic structure, the PCDH family can be divided into two groups, clustered PCDHs and non-clustered PCDHs. Non-clustered PCDHs can be further classified into three subgroups: delta1 (PCDH1, PCDH7, PCDH9, PCDH11 and PCDH20), delta2 (PCDH8, PCDH10, PCDH12, PCDH17, PCDH18 and PCDH19) and epsilon (PCDH15, PCDH16, PCDH21 and MUCDHL). Non-clustered PCDHs are expressed predominantly in the nervous system and have spatiotemporally diverse expression patterns [].
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Protein Domain
IPR030716 | Protocadherin-19
Type: Family
Description: Protocadherin-19 (Pcdh19) belongs to the delta-2 subfamily of nonclustered protocadherins. The non-clustered PCDHs appear to have homophilic/heterophilc cell-cell adhesion properties [], and the delta-2 subfamily (comprising protocadherin-8, -10, -17, -18, and -19) is widely expressed in the nervous system [, ]. Pcdh19 is highly expressed during brain development, and could play significant roles in neuronal migration or establishment of synaptic connections. Pcdh19 mutations cause an unusual X-linked inheritance disorder resulting in epilepsy and mental retardation [, , ].The cadherin family consists of a large group of cell adhesion proteins. It can be classified into three subfamilies: classical cadherins, desmosomal cadherins and protocadherins (PCDHs). Based on the genomic structure, the PCDH family can be divided into two groups, clustered PCDHs and non-clustered PCDHs. Non-clustered PCDHs can be further classified into three subgroups: delta1 (PCDH1, PCDH7, PCDH9, PCDH11 and PCDH20), delta2 (PCDH8, PCDH10, PCDH12, PCDH17, PCDH18 and PCDH19) and epsilon (PCDH15, PCDH16, PCDH21 and MUCDHL). Non-clustered PCDHs are expressed predominantly in the nervous system and have spatiotemporally diverse expression patterns [].
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Protein Domain
IPR030709 | Protocadherin-17
Type: Family
Description: Protocadherin-17 (Pcdh17) belongs to the delta-2 subfamily of nonclustered protocadherins. The non-clustered PCDHs appear to have homophilic/heterophilc cell-cell adhesion properties [], and the delta-2 subfamily (comprising protocadherin-8, -10, -17, -18, and -19) is widely expressed in the nervous system [, ]. Pcdh17 mediates collective axon extension in amygdala neurons [], regulates presynaptic assembly in corticobasal ganglia circuits [], and is involved in brain vascular development []. In addition, it has been shown to have a role in the formation of the zebrafish retina []and to act as a tumour suppressor [, ].The cadherin family consists of a large group of cell adhesion proteins. It can be classified into three subfamilies: classical cadherins, desmosomal cadherins and protocadherins (PCDHs). Based on the genomic structure, the PCDH family can be divided into two groups, clustered PCDHs and non-clustered PCDHs. Non-clustered PCDHs can be further classified into three subgroups: delta1 (PCDH1, PCDH7, PCDH9, PCDH11 and PCDH20), delta2 (PCDH8, PCDH10, PCDH12, PCDH17, PCDH18 and PCDH19) and epsilon (PCDH15, PCDH16, PCDH21 and MUCDHL). Non-clustered PCDHs are expressed predominantly in the nervous system and have spatiotemporally diverse expression patterns [].
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Protein
A0A0A6YXT8
Organism: Mus musculus/domesticus
Length: 455  
Fragment?: true
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Protein
Q8VHR0
Organism: Mus musculus/domesticus
Length: 1134  
Fragment?: false
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Protein
A0A0A6YXH7
Organism: Mus musculus/domesticus
Length: 917  
Fragment?: false
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Protein
Q8CA99
Organism: Mus musculus/domesticus
Length: 440  
Fragment?: true
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Protein
Q99PJ1
Organism: Mus musculus/domesticus
Length: 1943  
Fragment?: false
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Protein
A0A0A6YY17
Organism: Mus musculus/domesticus
Length: 1783  
Fragment?: false
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Protein
Q3TZ28
Organism: Mus musculus/domesticus
Length: 683  
Fragment?: true
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Protein
E9Q159
Organism: Mus musculus/domesticus
Length: 1865  
Fragment?: false
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Protein
A0A0A6YWL3
Organism: Mus musculus/domesticus
Length: 1333  
Fragment?: true
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Protein
Q147Z9
Organism: Mus musculus/domesticus
Length: 992  
Fragment?: false
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Protein
A0A0A6YXB5
Organism: Mus musculus/domesticus
Length: 1714  
Fragment?: false
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Protein
A2AGW4
Organism: Mus musculus/domesticus
Length: 641  
Fragment?: true
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Protein
A0A140T8S2
Organism: Mus musculus/domesticus
Length: 1675  
Fragment?: false
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Protein
O55134
Organism: Mus musculus/domesticus
Length: 1180  
Fragment?: false
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Protein
Q80TF3
Organism: Mus musculus/domesticus
Length: 1145  
Fragment?: false
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Protein
Q7TSK3
Organism: Mus musculus/domesticus
Length: 1070  
Fragment?: false
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Protein
E9PXF0
Organism: Mus musculus/domesticus
Length: 1157  
Fragment?: false
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Protein
E9PXQ7
Organism: Mus musculus/domesticus
Length: 1057  
Fragment?: false
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Protein
E9PX28
Organism: Mus musculus/domesticus
Length: 1047  
Fragment?: false
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Protein
Q9Z1B1
Organism: Mus musculus/domesticus
Length: 896  
Fragment?: false
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Protein
Q5HZI5
Organism: Mus musculus/domesticus
Length: 1157  
Fragment?: false
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Protein
Q80TE2
Organism: Mus musculus/domesticus
Length: 1098  
Fragment?: true
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Protein
Q3UTP0
Organism: Mus musculus/domesticus
Length: 755  
Fragment?: true
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Protein
E9Q5E1
Organism: Mus musculus/domesticus
Length: 1097  
Fragment?: false
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Protein
Q8C883
Organism: Mus musculus/domesticus
Length: 998  
Fragment?: false
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Protein
Q6P0A6
Organism: Mus musculus/domesticus
Length: 896  
Fragment?: false
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Protein
Q925I8
Organism: Mus musculus/domesticus
Length: 1040  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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