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Search results 201 to 300 out of 395 for Pias1

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0.219s

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Type Details Score
Publication
17159996 | J:159146
First Author: Dadke S
Year: 2007
Journal: Nat Cell Biol
Title: Regulation of protein tyrosine phosphatase 1B by sumoylation.
Volume: 9
Issue: 1
Pages: 80-5
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Publication
16816390 | J:172990
First Author: Albor A
Year: 2006
Journal: J Biol Chem
Title: The interaction of Piasy with Trim32, an E3-ubiquitin ligase mutated in limb-girdle muscular dystrophy type 2H, promotes Piasy degradation and regulates UVB-induced keratinocyte apoptosis through NFkappaB.
Volume: 281
Issue: 35
Pages: 25850-66
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Publication
21931855 | J:177922
First Author: Costa MW
Year: 2011
Journal: PLoS One
Title: Complex SUMO-1 regulation of cardiac transcription factor Nkx2-5.
Volume: 6
Issue: 9
Pages: e24812
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Publication
16127449 | J:101497
First Author: Pascual G
Year: 2005
Journal: Nature
Title: A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma.
Volume: 437
Issue: 7059
Pages: 759-63
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Publication
27009683 | J:320313
First Author: Usui N
Year: 2017
Journal: Biol Psychiatry
Title: Sumoylation of FOXP2 Regulates Motor Function and Vocal Communication Through Purkinje Cell Development.
Volume: 81
Issue: 3
Pages: 220-230
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Publication
34267330 | J:309380
First Author: Mei L
Year: 2021
Journal: Oncogene
Title: SUMOylation activates large tumour suppressor 1 to maintain the tissue homeostasis during Hippo signalling.
Volume: 40
Issue: 35
Pages: 5357-5366
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Publication
29138280 | J:260447
First Author: Usui N
Year: 2017
Journal: Genes Dev
Title: Foxp1 regulation of neonatal vocalizations via cortical development.
Volume: 31
Issue: 20
Pages: 2039-2055
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Publication
22549777 | J:186503
First Author: Han L
Year: 2012
Journal: J Biol Chem
Title: Small ubiquitin-like Modifier (SUMO) modification inhibits GLI2 protein transcriptional activity in vitro and in vivo.
Volume: 287
Issue: 24
Pages: 20483-9
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Publication
- | J:29505
     
First Author: Copeland NG
Year: 1999
Journal: Database Release
Title: Copeland-Jenkins (Frederick) Interspecific Backcross Mapping Data
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:342601
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniPathway vocabulary mapping
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Publication
22988430 | J:190636
 
First Author: Wiese CB
Year: 2012
Journal: Front Neurosci
Title: A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.
Volume: 6
Pages: 130
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Publication
15226823 | J:93300
First Author: Blackshaw S
Year: 2004
Journal: PLoS Biol
Title: Genomic analysis of mouse retinal development.
Volume: 2
Issue: 9
Pages: E247
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Publication
20412781 | J:140465
First Author: Guo G
Year: 2010
Journal: Dev Cell
Title: Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.
Volume: 18
Issue: 4
Pages: 675-85
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Publication
- | J:68100
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: RIKEN Data Curation in Mouse Genome Informatics
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Publication
20059953 | J:156017
First Author: Yokoyama S
Year: 2009
Journal: Dev Cell
Title: A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Volume: 17
Issue: 6
Pages: 836-48
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Publication
17967808 | J:152068
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
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Publication
15618518 | J:91257
First Author: Gray PA
Year: 2004
Journal: Science
Title: Mouse brain organization revealed through direct genome-scale TF expression analysis.
Volume: 306
Issue: 5705
Pages: 2255-7
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:171409
     
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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UniProt Feature
UniProt Feature
Begin: 2
Description: E3 SUMO-protein ligase PIAS1
Type: chain
End: 651
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Protein
A0A1L1SQX9
Organism: Mus musculus/domesticus
Length: 85  
Fragment?: true
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Publication
33468657 | J:301531
 
First Author: Morozko EL
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: PIAS1 modulates striatal transcription, DNA damage repair, and SUMOylation with relevance to Huntington's disease.
Volume: 118
Issue: 4
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Publication
10930443 | J:111647
First Author: Kelley TJ
Year: 2000
Journal: J Clin Invest
Title: In vivo alterations of IFN regulatory factor-1 and PIAS1 protein levels in cystic fibrosis epithelium.
Volume: 106
Issue: 3
Pages: 403-10
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Publication
20421208 | J:230571
First Author: Kang HC
Year: 2010
Journal: Nucleic Acids Res
Title: PIAS1 regulates CP2c localization and active promoter complex formation in erythroid cell-specific alpha-globin expression.
Volume: 38
Issue: 16
Pages: 5456-71
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Allele
Pias1<em1Smoc> | MGI:7291645
Name: protein inhibitor of activated STAT 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Interaction Experiment
Gur I (2014)
Description: Necdin Promotes Ubiquitin-Dependent Degradation of PIAS1 SUMO E3 Ligase.
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Interaction Experiment
Tang Z (2005)
Description: Pias1 interaction and sumoylation of metabotropic glutamate receptor 8.
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Strain
MGI:6476012 | C57BL/6JSmoc-Pias1<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Interaction Experiment
Chanda A (2021)
Description: PIAS1 and TIF1? collaborate to promote SnoN SUMOylation and suppression of epithelial-mesenchymal transition.
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Publication
16144832 | -
First Author: Tang Z
Year: 2005
Journal: J Biol Chem
Title: Pias1 interaction and sumoylation of metabotropic glutamate receptor 8.
Volume: 280
Issue: 46
Pages: 38153-9
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Publication
21338522 | -
 
First Author: Alm-Kristiansen AH
Year: 2011
Journal: Mol Cancer
Title: PIAS1 interacts with FLASH and enhances its co-activation of c-Myb.
Volume: 10
Pages: 21
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GXD Expression
GXD Expression
Probe: MGI:7574627
Assay Type: Immunohistochemistry
Annotation Date: 2024-01-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3273023
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:7574629
Age: embryonic day 15.0
Image: 3A
Note: Expression was detected in the cartilage primordium, and co-localized with Pias1 in dot-like structures within the positive nuclei.
Specimen Label: 3A
Detected: true
Specimen Num: 2
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Publication
32770107 | -
First Author: Chanda A
Year: 2021
Journal: Cell Death Differ
Title: PIAS1 and TIF1γ collaborate to promote SnoN SUMOylation and suppression of epithelial-mesenchymal transition.
Volume: 28
Issue: 1
Pages: 267-282
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Publication
11117529 | -
First Author: Kotaja N
Year: 2000
Journal: Mol Endocrinol
Title: ARIP3 (androgen receptor-interacting protein 3) and other PIAS (protein inhibitor of activated STAT) proteins differ in their ability to modulate steroid receptor-dependent transcriptional activation.
Volume: 14
Issue: 12
Pages: 1986-2000
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Publication
12855578 | -
First Author: Ungureanu D
Year: 2003
Journal: Blood
Title: PIAS proteins promote SUMO-1 conjugation to STAT1.
Volume: 102
Issue: 9
Pages: 3311-3
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Publication
12077349 | -
First Author: Kotaja N
Year: 2002
Journal: Mol Cell Biol
Title: PIAS proteins modulate transcription factors by functioning as SUMO-1 ligases.
Volume: 22
Issue: 14
Pages: 5222-34
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Publication
26842955 | J:236279
 
First Author: Tai DJ
Year: 2016
Journal: Nat Commun
Title: MeCP2 SUMOylation rescues Mecp2-mutant-induced behavioural deficits in a mouse model of Rett syndrome.
Volume: 7
Pages: 10552
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Publication
38489266 | J:348601
First Author: Pitter MR
Year: 2024
Journal: Cell Rep
Title: PAD4 controls tumor immunity via restraining the MHC class II machinery in macrophages.
Volume: 43
Issue: 3
Pages: 113942
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Publication
17991485 | J:166346
First Author: Tolkunova E
Year: 2007
Journal: J Mol Biol
Title: PIAS proteins as repressors of Oct4 function.
Volume: 374
Issue: 5
Pages: 1200-12
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Publication
14752048 | J:150923
First Author: Ling Y
Year: 2004
Journal: Nucleic Acids Res
Title: Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription.
Volume: 32
Issue: 2
Pages: 598-610
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Publication
15988015 | J:99354
First Author: Kang HC
Year: 2005
Journal: Mol Cell Biol
Title: Erythroid cell-specific alpha-globin gene regulation by the CP2 transcription factor family.
Volume: 25
Issue: 14
Pages: 6005-20
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Publication
28186506 | J:348412
First Author: Tao CC
Year: 2017
Journal: Cell Death Differ
Title: Epigenetic regulation of HDAC1 SUMOylation as an endogenous neuroprotection against Aβ toxicity in a mouse model of Alzheimer's disease.
Volume: 24
Issue: 4
Pages: 597-614
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Publication
30849179 | J:295876
First Author: Liu SY
Year: 2019
Journal: Br J Pharmacol
Title: Protein inhibitor of activated STAT1 Ser503 phosphorylation-mediated Elk-1 SUMOylation promotes neuronal survival in APP/PS1 mice.
Volume: 176
Issue: 11
Pages: 1793-1810
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Publication
32950104 | J:352668
First Author: Liu YC
Year: 2021
Journal: Mol Ther
Title: Melatonin Induction of APP Intracellular Domain 50 SUMOylation Alleviates AD through Enhanced Transcriptional Activation and Aβ Degradation.
Volume: 29
Issue: 1
Pages: 376-395
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Publication
19766626 | J:155495
First Author: Yu B
Year: 2009
Journal: Exp Cell Res
Title: BS69 undergoes SUMO modification and plays an inhibitory role in muscle and neuronal differentiation.
Volume: 315
Issue: 20
Pages: 3543-53
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Publication
18656483 | J:168869
First Author: Karvonen U
Year: 2008
Journal: J Mol Biol
Title: ZNF451 is a novel PML body- and SUMO-associated transcriptional coregulator.
Volume: 382
Issue: 3
Pages: 585-600
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Publication
32141127 | J:305214
First Author: Watanabe Y
Year: 2020
Journal: FASEB J
Title: Protein S-glutathionylation stimulate adipogenesis by stabilizing C/EBPβ in 3T3L1 cells.
Volume: 34
Issue: 4
Pages: 5827-5837
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Publication
39068217 | J:353579
First Author: Jin Z
Year: 2024
Journal: Oncogene
Title: GATA2 promotes castration-resistant prostate cancer development by suppressing IFN-β axis-mediated antitumor immunity.
Volume: 43
Issue: 34
Pages: 2595-2610
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Publication
33769609 | J:309250
First Author: Zhang Z
Year: 2021
Journal: FASEB J
Title: CDKN2A deregulation in fatty liver disease and its accelerative role in the process of lipogenesis.
Volume: 35
Issue: 4
Pages: e21230
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Publication
18467627 | J:149013
First Author: Shishido T
Year: 2008
Journal: Circ Res
Title: Effects of MEK5/ERK5 association on small ubiquitin-related modification of ERK5: implications for diabetic ventricular dysfunction after myocardial infarction.
Volume: 102
Issue: 11
Pages: 1416-25
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Publication
28798155 | J:255666
First Author: Zhao Q
Year: 2017
Journal: FASEB J
Title: IFN-γ aggravates neointimal hyperplasia by inducing endoplasmic reticulum stress and apoptosis in macrophages by promoting ubiquitin-dependent liver X receptor-α degradation.
Volume: 31
Issue: 12
Pages: 5321-5331
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Protein
Q0ZCJ7
Organism: Mus musculus/domesticus
Length: 421  
Fragment?: false
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Protein
Q9D1J3
Organism: Mus musculus/domesticus
Length: 210  
Fragment?: false
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Protein
B2RXM7
Organism: Mus musculus/domesticus
Length: 210  
Fragment?: false
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Protein
A0A1W2P6N2
Organism: Mus musculus/domesticus
Length: 147  
Fragment?: false
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Protein
A0A1B0GSW4
Organism: Mus musculus/domesticus
Length: 50  
Fragment?: true
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Protein
Q3UZ28
Organism: Mus musculus/domesticus
Length: 158  
Fragment?: false
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Protein
Q8BIQ7
Organism: Mus musculus/domesticus
Length: 204  
Fragment?: false
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Protein
B7ZWI2
Organism: Mus musculus/domesticus
Length: 209  
Fragment?: false
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Protein
Q8CBF9
Organism: Mus musculus/domesticus
Length: 194  
Fragment?: false
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Publication
10694879 | -
First Author: Aravind L
Year: 2000
Journal: Trends Biochem Sci
Title: SAP - a putative DNA-binding motif involved in chromosomal organization.
Volume: 25
Issue: 3
Pages: 112-4
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Publication
10212141 | -
 
First Author: Weighardt F
Year: 1999
Journal: J Cell Sci
Title: A novel hnRNP protein (HAP/SAF-B) enters a subset of hnRNP complexes and relocates in nuclear granules in response to heat shock.
Volume: 112 ( Pt 10)
Pages: 1465-76
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Publication
9671816 | -
First Author: Nayler O
Year: 1998
Journal: Nucleic Acids Res
Title: SAF-B protein couples transcription and pre-mRNA splicing to SAR/MAR elements.
Volume: 26
Issue: 15
Pages: 3542-9
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Publication
10671544 | -
First Author: Kipp M
Year: 2000
Journal: J Biol Chem
Title: Apoptotic cleavage of scaffold attachment factor A (SAF-A) by caspase-3 occurs at a noncanonical cleavage site.
Volume: 275
Issue: 7
Pages: 5031-6
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Publication
10805787 | -
First Author: Liao J
Year: 2000
Journal: Proc Natl Acad Sci U S A
Title: Distinct roles of the NH2- and COOH-terminal domains of the protein inhibitor of activated signal transducer and activator of transcription (STAT) 1 (PIAS1) in cytokine-induced PIAS1-Stat1 interaction.
Volume: 97
Issue: 10
Pages: 5267-72
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Publication
9862413 | -
First Author: Amor Y
Year: 1998
Journal: FEBS Lett
Title: The involvement of poly(ADP-ribose) polymerase in the oxidative stress responses in plants.
Volume: 440
Issue: 1-2
Pages: 1-7
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Protein
Q9CS24
Organism: Mus musculus/domesticus
Length: 301  
Fragment?: true
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Protein
A0A494B9S9
Organism: Mus musculus/domesticus
Length: 308  
Fragment?: true
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Protein Domain
IPR036361 | SAP_dom_sf
Type: Homologous_superfamily
Description: The SAP motif is a 35-residue motif, which has been named after SAF-A/B,Acinus and PIAS, three proteins known to contain it. The SAP motif is found ina variety of nuclear proteins involved in transcription, DNA repair, RNAprocessing or apoptotic chromatin degradation. As the sap motif of SAF-A hasbeen shown to be essential for specific DNA binding activity, it has beenproposed that it could be a DNA-binding motif [].A multiple alignment of the SAP motif reveals a bipartite distribution ofstrongly conserved hydrophobic, polar and bulky amino acids separated by aregion that contains a glycine. Secondary structure predictions suggest thatthe SAP motif could form two alpha helices separated by a turn [].Some proteins known to contain a SAP motif are listed below:Vertebrate scaffold attachment factors A and B (SAF-A/B). These twoproteins are heterogeneous nuclear ribonucleoproteins (hnRNPs) that bind toAT-rich chromosomal region. It has been proposed that they couple RNAmetabolism to nuclear organisation [, ]. The SAF-A protein is cleaved bycaspase-3 during apoptosis [].Mammalian Acinus, a protein which induces apoptotic chromatin condensationafter cleavage by caspase-3 []. Acinus also contains a RNA-recognitionmotif.Eukaryotic proteins of the PIAS (protein inhibitor of activated STAT)family. These proteins interact with phosphorylated STAT dimers and inhibitSTAT mediated gene activation. Deletion of the first 50 amino acid residuescontaining the SAP domain allows the interaction of PIAS1 with STAT1monomer [].Plant poly(ADP-ribose) polymerase (PARP). PARP is a nuclear protein thatcatalyzes the poly(ADP-ribosyl)ation of proteins. It is involved inresponses to mild and severe oxidative stresses, by mediating DNA repairand programmed cell death processes, respectively []. PARP is tightlybound to chromatin or nuclear matrix.Arabidopsis thaliana Arp, an apurinic endonuclease-redox protein.Yeast THO1 protein. It could be involved in the regulation oftranscriptional elongation by RNA polymerase II [].Animal Ku70. Together with Ku86, it forms a DNA ends binding complex thatis involved in repairing DNA double-strand breaks.Yeast RAD18, a protein involved in DNA repair.Neurospora crassa UVS-2, the homologue of RAD18.
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Protein Domain
IPR003034 | SAP_dom
Type: Domain
Description: The SAP motif is a 35-residue motif, which has been named after SAF-A/B,Acinus and PIAS, three proteins known to contain it. The SAP motif is found ina variety of nuclear proteins involved in transcription, DNA repair, RNAprocessing or apoptotic chromatin degradation. As the sap motif of SAF-A hasbeen shown to be essential for specific DNA binding activity, it has beenproposed that it could be a DNA-binding motif [].A multiple alignment of the SAP motif reveals a bipartite distribution ofstrongly conserved hydrophobic, polar and bulky amino acids separated by aregion that contains a glycine. Secondary structure predictions suggest thatthe SAP motif could form two alpha helices separated by a turn [].Some proteins known to contain a SAP motif are listed below:Vertebrate scaffold attachment factors A and B (SAF-A/B). These twoproteins are heterogeneous nuclear ribonucleoproteins (hnRNPs) that bind toAT-rich chromosomal region. It has been proposed that they couple RNAmetabolism to nuclear organisation [, ]. The SAF-A protein is cleaved bycaspase-3 during apoptosis [].Mammalian Acinus, a protein which induces apoptotic chromatin condensationafter cleavage by caspase-3 []. Acinus also contains a RNA-recognitionmotif.Eukaryotic proteins of the PIAS (protein inhibitor of activated STAT)family. These proteins interact with phosphorylated STAT dimers and inhibitSTAT mediated gene activation. Deletion of the first 50 amino acid residuescontaining the SAP domain allows the interaction of PIAS1 with STAT1monomer [].Plant poly(ADP-ribose) polymerase (PARP). PARP is a nuclear protein thatcatalyzes the poly(ADP-ribosyl)ation of proteins. It is involved inresponses to mild and severe oxidative stresses, by mediating DNA repairand programmed cell death processes, respectively []. PARP is tightlybound to chromatin or nuclear matrix.Arabidopsis thaliana Arp, an apurinic endonuclease-redox protein.Yeast THO1 protein. It could be involved in the regulation oftranscriptional elongation by RNA polymerase II [].Animal Ku70. Together with Ku86, it forms a DNA ends binding complex thatis involved in repairing DNA double-strand breaks.Yeast RAD18, a protein involved in DNA repair.Neurospora crassa UVS-2, the homologue of RAD18.
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