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Search results 201 to 300 out of 321 for Pklr

0.029s
Type Details Score
GXD Expression  
Probe: MGI:3724788
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1757722
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421441
Age: embryonic day 14.5
Image: MH1218; Specimen C1596
Specimen Label: MH1218; Specimen C1596
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3724788
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1757522
Stage: TS22
Assay Id: MGI:5421441
Age: embryonic day 14.5
Specimen Label: MH1218; Specimen C1596
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:3724788
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1738322
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421441
Age: embryonic day 14.5
Image: MH1218; Specimen C1596
Specimen Label: MH1218; Specimen C1596
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3724788
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1802422
Stage: TS22
Assay Id: MGI:5421441
Age: embryonic day 14.5
Specimen Label: MH1218; Specimen C1596
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3724788
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1768022
Stage: TS22
Assay Id: MGI:5421441
Age: embryonic day 14.5
Note: Expression was not detected in the skull (base and vault).
Specimen Label: MH1218; Specimen C1596
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:4423782
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1791823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827232
Age: embryonic day 14.5
Image: euxassay_009487_08
Specimen Label: euxassay_009487_08
Detected: true
Specimen Num: 8
GXD Expression  
Probe: MGI:4423782
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1791823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827232
Age: embryonic day 14.5
Image: euxassay_009487_11
Specimen Label: euxassay_009487_11
Detected: true
Specimen Num: 11
GXD Expression  
Probe: MGI:4423782
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1791823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827232
Age: embryonic day 14.5
Image: euxassay_009487_12
Specimen Label: euxassay_009487_12
Detected: true
Specimen Num: 12
GXD Expression
Probe: MGI:3724788
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:2672022
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421441
Age: embryonic day 14.5
Image: MH1218; Specimen C1596
Note: Expression was weak in whisker follicle.
Specimen Label: MH1218; Specimen C1596
Detected: true
Specimen Num: 1
Publication  
First Author: Bulfield G
Year: 1978
Journal: Mouse News Lett
Title: [Pk-1].
Volume: 59
Pages: 29
Publication  
First Author: Rong R
Year: 2023
Journal: EBioMedicine
Title: Image-based quantification of histological features as a function of spatial location using the Tissue Positioning System.
Volume: 94
Pages: 104698
Publication  
First Author: Wei Y
Year: 2021
Journal: Science
Title: Liver homeostasis is maintained by midlobular zone 2 hepatocytes.
Volume: 371
Issue: 6532
Publication
First Author: Cheng J
Year: 2012
Journal: Genes Cells
Title: AMPD3-deficient mice exhibit increased erythrocyte ATP levels but anemia not improved due to PK deficiency.
Volume: 17
Issue: 11
Pages: 913-22
Publication
First Author: Charles DJ
Year: 1984
Journal: Biochem Genet
Title: A new pyruvate kinase mutation with hyperactivity in the mouse.
Volume: 22
Issue: 11-12
Pages: 1103-17
Publication
First Author: Hunter RW
Year: 2018
Journal: Nat Med
Title: Metformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase.
Volume: 24
Issue: 9
Pages: 1395-1406
Publication
First Author: Adler ID
Year: 1991
Journal: Mouse Genome
Title: Changes in holdings
Volume: 89
Issue: 4
Pages: 845
Publication
First Author: Min-Oo G
Year: 2007
Journal: J Exp Med
Title: Complex genetic control of susceptibility to malaria: positional cloning of the Char9 locus.
Volume: 204
Issue: 3
Pages: 511-24
Publication
First Author: Beatty SC
Year: 2016
Journal: Genes Immun
Title: Survival analysis and microarray profiling identify Cd40 as a candidate for the Salmonella susceptibility locus, Ity5.
Volume: 17
Issue: 1
Pages: 19-29
Publication
First Author: Zha H
Year: 1993
Journal: Cytogenet Cell Genet
Title: Linkage map of 10 polymorphic markers on rat chromosome 2.
Volume: 63
Issue: 2
Pages: 117-23
Publication
First Author: Peters J
Year: 1981
Journal: Biochem Genet
Title: Polymorphism of kidney pyruvate kinase in the mouse is determined by a gene, Pk-3, on chromosome 9.
Volume: 19
Issue: 7-8
Pages: 757-69
Publication
First Author: Campanella ME
Year: 2008
Journal: Blood
Title: Characterization of glycolytic enzyme interactions with murine erythrocyte membranes in wild-type and membrane protein knockout mice.
Volume: 112
Issue: 9
Pages: 3900-6
Publication
First Author: Pretsch W
Year: 2000
Journal: Mamm Genome
Title: Enzyme-activity mutants in Mus musculus. I. Phenotypic description and genetic characterization of ethylnitrosourea-induced mutations.
Volume: 11
Issue: 7
Pages: 537-42
Publication
First Author: Sola B
Year: 1988
Journal: J Virol
Title: Fim-1, Fim-2/c-fms, and Fim-3, three common integration sites of Friend murine leukemia virus in myeloblastic leukemias, map to mouse chromosomes 13, 18, and 3, respectively.
Volume: 62
Issue: 11
Pages: 3973-8
Publication
First Author: Gisselbrecht S
Year: 1989
Journal: Blood
Title: The murine M-CSF gene is localized on chromosome 3.
Volume: 73
Issue: 6
Pages: 1742-5
Publication
First Author: Desbois C
Year: 1994
Journal: Mamm Genome
Title: Localization of the osteocalcin gene cluster on mouse chromosome 3.
Volume: 5
Issue: 5
Pages: 321-2
Publication
First Author: Guevara-Fujita ML
Year: 1996
Journal: Mamm Genome
Title: Chromosomal assignment of seven genes on canine chromosomes by fluorescence in situ hybridization.
Volume: 7
Issue: 4
Pages: 268-70
Publication
First Author: Oelkrug R
Year: 2023
Journal: Nat Commun
Title: Maternal thyroid hormone receptor β activation in mice sparks brown fat thermogenesis in the offspring.
Volume: 14
Issue: 1
Pages: 6742
Publication
First Author: White RA
Year: 2004
Journal: Blood
Title: Chromosomal localization, hematologic characterization, and iron metabolism of the hereditary erythroblastic anemia (hea) mutant mouse.
Volume: 104
Issue: 5
Pages: 1511-8
Publication
First Author: Valdimarsson G
Year: 1993
Journal: Mol Reprod Dev
Title: Coexpression of gap junction proteins in the cumulus-oocyte complex.
Volume: 36
Issue: 1
Pages: 7-15
Publication
First Author: Klinga-Levan K
Year: 1993
Journal: Hereditas
Title: Mapping of glutathione transferase (GST) genes in the rat.
Volume: 119
Issue: 3
Pages: 285-96
Publication
First Author: Kingsmore SF
Year: 1995
Journal: Mamm Genome
Title: Genetic mapping of the tumor-associated mucin 1 gene on mouse chromosome 3.
Volume: 6
Issue: 5
Pages: 378-9
Publication
First Author: Wolfrum C
Year: 2004
Journal: Nature
Title: Foxa2 regulates lipid metabolism and ketogenesis in the liver during fasting and in diabetes.
Volume: 432
Issue: 7020
Pages: 1027-32
Publication
First Author: Bessis A
Year: 1990
Journal: FEBS Lett
Title: Chromosomal localization of the mouse genes coding for alpha 2, alpha 3, alpha 4 and beta 2 subunits of neuronal nicotinic acetylcholine receptor.
Volume: 264
Issue: 1
Pages: 48-52
Publication
First Author: Oakey RJ
Year: 1992
Journal: Immunogenetics
Title: Chromosomal mapping of the high affinity Fc gamma receptor gene.
Volume: 35
Issue: 4
Pages: 279-82
Publication
First Author: Dower NA
Year: 1992
Journal: Mamm Genome
Title: Organization and chromosomal locations of Rap1a/Krev sequences in the mouse.
Volume: 3
Issue: 3
Pages: 162-7
Publication
First Author: Shao H
Year: 1995
Journal: J Biol Chem
Title: Characterization of B61, the ligand for the Eck receptor protein-tyrosine kinase.
Volume: 270
Issue: 10
Pages: 5636-41
Publication
First Author: Karim SA
Year: 2004
Journal: Genomics
Title: A physical map of the genomic region on mouse chromosome 3 containing the hindshaker (hsh) mutation.
Volume: 83
Issue: 2
Pages: 225-30
Publication
First Author: Pang CJ
Year: 2012
Journal: Mol Cell Biol
Title: Kruppel-like factor 1 (KLF1), KLF2, and Myc control a regulatory network essential for embryonic erythropoiesis.
Volume: 32
Issue: 13
Pages: 2628-44
Publication
First Author: Dayton TL
Year: 2016
Journal: Genes Dev
Title: Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma.
Volume: 30
Issue: 9
Pages: 1020-33
Publication
First Author: Kaestner KH
Year: 1999
Journal: Genes Dev
Title: Inactivation of the winged helix transcription factor HNF3alpha affects glucose homeostasis and islet glucagon gene expression in vivo.
Volume: 13
Issue: 4
Pages: 495-504
Publication  
First Author: Monica Shih MC
Year: 2021
Journal: Endocrinology
Title: Embryonic Steroids Control Developmental Programming of Energy Balance.
Volume: 162
Issue: 12
Publication
First Author: Eddleston J
Year: 1999
Journal: Genomics
Title: Physical and transcriptional map of a 3-Mb region of mouse chromosome 1 containing the gene for the neural tube defect mutant loop-tail (Lp).
Volume: 56
Issue: 2
Pages: 149-59
Publication
First Author: Briançon N
Year: 2006
Journal: EMBO J
Title: In vivo role of the HNF4alpha AF-1 activation domain revealed by exon swapping.
Volume: 25
Issue: 6
Pages: 1253-62
Publication  
First Author: Cankaya M
Year: 2007
Journal: BMC Genomics
Title: An analysis of expression patterns of genes encoding proteins with catalytic activities.
Volume: 8
Pages: 232
Publication
First Author: Bowman CE
Year: 2016
Journal: Mol Cell Biol
Title: Requirement for the Mitochondrial Pyruvate Carrier in Mammalian Development Revealed by a Hypomorphic Allelic Series.
Volume: 36
Issue: 15
Pages: 2089-104
Publication
First Author: Bulusu V
Year: 2017
Journal: Dev Cell
Title: Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development.
Volume: 40
Issue: 4
Pages: 331-341.e4
UniProt Feature
Begin: 1
Description: Pyruvate kinase PKLR
Type: chain
End: 574
Publication        
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniPathway vocabulary mapping
Publication        
First Author: Birgit Meldal and Sandra Orchard (1). (1) European Bioinformatics Institute (EBI), Hinxton, Cambridgeshire, United Kingdom
Year: 2023
Title: Manual transfer of experimentally-verified manual GO annotation data to homologous complexes by curator judgment of sequence, composition and function similarity
Publication        
First Author: International Committee on Standardized Genetic Nomenclature for Mice
Year: 1993
Title: Nomenclature rule change to delete hyphens and parentheses from mouse locus symbols
Publication
First Author: Visel A
Year: 2004
Journal: Nucleic Acids Res
Title: GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Volume: 32
Issue: Database issue
Pages: D552-6
Publication      
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
Publication        
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
Publication        
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
Publication
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication        
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Publication        
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Protein
Organism: Mus musculus/domesticus
Length: 574  
Fragment?: false
Allele
Name: pyruvate kinase liver and red blood cell; endonuclease-mediated mutation 1, Applied StemCell
Allele Type: Endonuclease-mediated
Attribute String: Modified isoform(s), Null/knockout
Allele  
Name: pyruvate kinase liver and red blood cell; pyruvate kinase deficiency
Allele Type: Spontaneous
Genotype
Symbol: Pklr/Pklr
Background: CBA/NSlc-Pklr
Zygosity: hm
Has Mutant Allele: true
DO Term
Allele  
Name: pyruvate kinase liver and red blood cell; char4
Allele Type: Spontaneous
Allele
Name: transgene insertion, Axel Kahn
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Allele
Name: transgene insertion B, Axel Kahn
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Allele
Name: pyruvate kinase liver and red blood cell; endonuclease-mediated mutation 1, Hao Zhu
Allele Type: Endonuclease-mediated
Attribute String: Inducible, Recombinase
Genotype
Symbol: Pklr/Pklr
Background: involves: A/J * C57BL/6
Zygosity: hm
Has Mutant Allele: true
Publication
First Author: Mitchell C
Year: 2009
Journal: Am J Pathol
Title: Protection against hepatocyte mitochondrial dysfunction delays fibrosis progression in mice.
Volume: 175
Issue: 5
Pages: 1929-37
Strain
Attribute String: transgenic, mutant strain, congenic
Publication
First Author: Mignon A
Year: 1998
Journal: Nat Med
Title: Selective repopulation of normal mouse liver by Fas/CD95-resistant hepatocytes.
Volume: 4
Issue: 10
Pages: 1185-8
Publication
First Author: Peralta C
Year: 2002
Journal: Am J Pathol
Title: The combination of ischemic preconditioning and liver Bcl-2 overexpression is a suitable strategy to prevent liver and lung damage after hepatic ischemia-reperfusion.
Volume: 160
Issue: 6
Pages: 2111-22
Publication
First Author: Mitchell C
Year: 2011
Journal: Lab Invest
Title: Overexpression of Bcl-2 in hepatocytes protects against injury but does not attenuate fibrosis in a mouse model of chronic cholestatic liver disease.
Volume: 91
Issue: 2
Pages: 273-82
Publication
First Author: Mallet VO
Year: 2002
Journal: Hepatology
Title: Bone marrow transplantation in mice leads to a minor population of hepatocytes that can be selectively amplified in vivo.
Volume: 35
Issue: 4
Pages: 799-804
Allele
Name: transgene insertion 1, Axel Kahn
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Allele
Name: transgene insertion 23, Axel Kahn
Allele Type: Transgenic
Attribute String: Constitutively active, Inserted expressed sequence
Allele
Name: transgene insertion 21, Axel Kahn
Allele Type: Transgenic
Attribute String: Constitutively active, Inserted expressed sequence
Allele
Name: transgene insertion 73, Axel Kahn
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Genotype
Symbol: Tg(Pklr-SV40)1Ak/?
Background: involves: C57BL/6 * DBA
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Tg(Pklr-SV40)1Ak/Tg(Pklr-SV40)1Ak
Background: involves: C57BL/6 * DBA
Zygosity: hm
Has Mutant Allele: true
Publication
First Author: Zhou X
Year: 2021
Journal: Hum Mol Genet
Title: Coordinated pyruvate kinase activity is crucial for metabolic adaptation and cell survival during mitochondrial dysfunction.
Volume: 30
Issue: 21
Pages: 2012-2026
Publication
First Author: Chella Krishnan K
Year: 2018
Journal: Cell Syst
Title: Integration of Multi-omics Data from Mouse Diversity Panel Highlights Mitochondrial Dysfunction in Non-alcoholic Fatty Liver Disease.
Volume: 6
Issue: 1
Pages: 103-115.e7
Publication
First Author: Mizushima T
Year: 2013
Journal: Am J Pathol
Title: Inhibition of epithelial cell death by Bcl-2 improved chronic colitis in IL-10 KO mice.
Volume: 183
Issue: 6
Pages: 1936-44