Type |
Details |
Score |
Publication |
First Author: |
Hori A |
Year: |
2016 |
Journal: |
EMBO Rep |
Title: |
A non-canonical function of Plk4 in centriolar satellite integrity and ciliogenesis through PCM1 phosphorylation. |
Volume: |
17 |
Issue: |
3 |
Pages: |
326-37 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nigg EA |
Year: |
2007 |
Journal: |
Trends Cell Biol |
Title: |
Centrosome duplication: of rules and licenses. |
Volume: |
17 |
Issue: |
5 |
Pages: |
215-21 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bonni S |
Year: |
2008 |
Journal: |
Cell Cycle |
Title: |
Human Plk4 phosphorylates Cdc25C. |
Volume: |
7 |
Issue: |
4 |
Pages: |
545-7 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Polo-like kinases (Plks) belong to the serine/threonine kinase subfamily, and are characterized by the presence of the signature motif called Polo-box domain. Plks are key regulators of cell cycle and cell division in eukaryotes [, ]. Unicellular organisms contain one Plk whereas higher eukaryotes have as many as four Plks: Plk1, Plk2, Plk3 andPlk4.Plk4 (also called Sak) is the most structurally divergent member of the Plks. It plays a pivotal role in centriole duplication [, , , , ]and is required for centriolar satellite function and ciliogenesis []. Substrates identified for Plk4 include Cdc25C and Chk2 [, ]. |
|
•
•
•
•
•
|
Publication |
First Author: |
Andrysik Z |
Year: |
2010 |
Journal: |
Nucleic Acids Res |
Title: |
The novel mouse Polo-like kinase 5 responds to DNA damage and localizes in the nucleolus. |
Volume: |
38 |
Issue: |
9 |
Pages: |
2931-43 |
|
•
•
•
•
•
|
HT Experiment |
Series Id: |
GSE12748 |
Experiment Type: |
transcription profiling by array |
Study Type: |
WT vs. Mutant |
Source: |
ArrayExpress |
|
•
•
•
•
•
|
Publication |
First Author: |
Anger M |
Year: |
2003 |
Journal: |
Mol Reprod Dev |
Title: |
Cell cycle dependent expression of Plk1 in synchronized porcine fetal fibroblasts. |
Volume: |
65 |
Issue: |
3 |
Pages: |
245-53 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang L |
Year: |
2016 |
Journal: |
J Biol Chem |
Title: |
Effect of Hypoxia-regulated Polo-like Kinase 3 (Plk3) on Human Limbal Stem Cell Differentiation. |
Volume: |
291 |
Issue: |
32 |
Pages: |
16519-29 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kleylein-Sohn J |
Year: |
2007 |
Journal: |
Dev Cell |
Title: |
Plk4-induced centriole biogenesis in human cells. |
Volume: |
13 |
Issue: |
2 |
Pages: |
190-202 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
157
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
146
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
115
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
461
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
925
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
922
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY) |
Year: |
2005 |
Journal: |
Database Download |
Title: |
MGI download of GENSAT transgene data |
|
|
|
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•
•
•
•
•
|