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Search results 201 to 300 out of 342 for Plk4

0.034s
Type Details Score
GXD Expression  
Probe: MGI:1765085
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1768023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827275
Age: embryonic day 14.5
Image: euxassay_003979_02
Specimen Label: euxassay_003979_02
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:1765085
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1768023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827275
Age: embryonic day 14.5
Image: euxassay_003979_03
Specimen Label: euxassay_003979_03
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:1765085
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1768023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827275
Age: embryonic day 14.5
Image: euxassay_003979_04
Specimen Label: euxassay_003979_04
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:1765085
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1768023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827275
Age: embryonic day 14.5
Image: euxassay_003979_05
Specimen Label: euxassay_003979_05
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:1765085
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1768023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827275
Age: embryonic day 14.5
Image: euxassay_003979_06
Specimen Label: euxassay_003979_06
Detected: true
Specimen Num: 6
GXD Expression  
Probe: MGI:1765085
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1768023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827275
Age: embryonic day 14.5
Image: euxassay_003979_23
Specimen Label: euxassay_003979_23
Detected: true
Specimen Num: 18
Publication
First Author: Sladky VC
Year: 2022
Journal: Genes Dev
Title: Centriole signaling restricts hepatocyte ploidy to maintain liver integrity.
Volume: 36
Issue: 13-14
Pages: 843-56
Publication
First Author: Marthiens V
Year: 2013
Journal: Nat Cell Biol
Title: Centrosome amplification causes microcephaly.
Volume: 15
Issue: 7
Pages: 731-40
Publication
First Author: Vulprecht J
Year: 2012
Journal: J Cell Sci
Title: STIL is required for centriole duplication in human cells.
Volume: 125
Issue: Pt 5
Pages: 1353-62
Publication
First Author: Zhu F
Year: 2008
Journal: Curr Biol
Title: The mammalian SPD-2 ortholog Cep192 regulates centrosome biogenesis.
Volume: 18
Issue: 2
Pages: 136-41
Publication
First Author: Mahjoub MR
Year: 2012
Journal: Curr Biol
Title: Supernumerary centrosomes nucleate extra cilia and compromise primary cilium signaling.
Volume: 22
Issue: 17
Pages: 1628-34
Publication
First Author: Weiss J
Year: 2012
Journal: Mamm Genome
Title: ENU mutagenesis in mice identifies candidate genes for hypogonadism.
Volume: 23
Issue: 5-6
Pages: 346-55
Publication
First Author: Jordan PW
Year: 2012
Journal: J Cell Sci
Title: Polo-like kinase is required for synaptonemal complex disassembly and phosphorylation in mouse spermatocytes.
Volume: 125
Issue: Pt 21
Pages: 5061-72
Publication
First Author: Hudson JW
Year: 2000
Journal: Gene
Title: Sak kinase gene structure and transcriptional regulation.
Volume: 241
Issue: 1
Pages: 65-73
Publication  
First Author: Marjanović M
Year: 2015
Journal: Nat Commun
Title: CEP63 deficiency promotes p53-dependent microcephaly and reveals a role for the centrosome in meiotic recombination.
Volume: 6
Pages: 7676
Publication
First Author: Goetz JJ
Year: 2016
Journal: PLoS One
Title: Polo-Like Kinase 3 Appears Dispensable for Normal Retinal Development Despite Robust Embryonic Expression.
Volume: 11
Issue: 3
Pages: e0150878
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication      
First Author: Freeman TC
Year: 1998
Journal: MGI Direct Data Submission
Title: Expression Mapping of Mouse Genes
Publication        
First Author: Birgit Meldal and Sandra Orchard (1). (1) European Bioinformatics Institute (EBI), Hinxton, Cambridgeshire, United Kingdom
Year: 2023
Title: Manual transfer of experimentally-verified manual GO annotation data to homologous complexes by curator judgment of sequence, composition and function similarity
Publication        
First Author: GO Central curators, GOA curators, Rhea curators
Year: 2020
Title: Automatic Gene Ontology annotation based on Rhea mapping
Publication
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
Publication  
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
Publication      
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
Publication        
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication        
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication        
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Publication        
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Publication        
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
UniProt Feature
Begin: 372
Description: Phosphoserine; by PLK4
Type: modified residue
End: 372
UniProt Feature
Begin: 1
Description: Serine/threonine-protein kinase PLK4
Type: chain
End: 925
UniProt Feature
Begin: 107
Description: Phosphothreonine; by PLK4
Type: modified residue
End: 107
UniProt Feature
Begin: 109
Description: Phosphoserine; by PLK4
Type: modified residue
End: 109
UniProt Feature
Begin: 151
Description: Phosphoserine; by PLK4
Type: modified residue
End: 151
Publication      
First Author: LoMastro GM
Year: 2022
Journal: bioRxiv
Title: PLK4 drives centriole amplification and apical surface area expansion in multiciliated cells
Publication
First Author: Yang XD
Year: 2020
Journal: EMBO J
Title: PLK4 deubiquitination by Spata2-CYLD suppresses NEK7-mediated NLRP3 inflammasome activation at the centrosome.
Volume: 39
Issue: 2
Pages: e102201
Protein
Organism: Mus musculus/domesticus
Length: 464  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 898  
Fragment?: false
UniProt Feature
Begin: 78
Description: Phosphoserine; by MAPKAPK2 and PLK4
Type: modified residue
End: 78
Publication
First Author: Cizmecioglu O
Year: 2010
Journal: J Cell Biol
Title: Cep152 acts as a scaffold for recruitment of Plk4 and CPAP to the centrosome.
Volume: 191
Issue: 4
Pages: 731-9
Publication
First Author: Liu Y
Year: 2018
Journal: Nat Commun
Title: Direct binding of CEP85 to STIL ensures robust PLK4 activation and efficient centriole assembly.
Volume: 9
Issue: 1
Pages: 1731
Publication
First Author: Shimanovskaya E
Year: 2014
Journal: Structure
Title: Structure of the C. elegans ZYG-1 cryptic polo box suggests a conserved mechanism for centriolar docking of Plk4 kinases.
Volume: 22
Issue: 8
Pages: 1090-1104
Publication
First Author: Leung GC
Year: 2002
Journal: Nat Struct Biol
Title: The Sak polo-box comprises a structural domain sufficient for mitotic subcellular localization.
Volume: 9
Issue: 10
Pages: 719-24
Publication
First Author: Puklowski A
Year: 2011
Journal: Nat Cell Biol
Title: The SCF-FBXW5 E3-ubiquitin ligase is regulated by PLK4 and targets HsSAS-6 to control centrosome duplication.
Volume: 13
Issue: 8
Pages: 1004-9
Publication
First Author: Bahtz R
Year: 2012
Journal: J Cell Sci
Title: GCP6 is a substrate of Plk4 and required for centriole duplication.
Volume: 125
Issue: Pt 2
Pages: 486-96
DO Term
Allele
Name: transgene insertion 39, Don W Cleveland
Allele Type: Transgenic
Attribute String: Conditional ready, Inserted expressed sequence, Reporter
Allele
Name: collagen, type I, alpha 1; targeted mutation 1, Andrew Holland
Allele Type: Targeted
Attribute String: Inducible, Inserted expressed sequence, Reporter
Strain
Attribute String: coisogenic, mutant strain, transgenic
Publication
First Author: Vitre B
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Chronic centrosome amplification without tumorigenesis.
Volume: 112
Issue: 46
Pages: E6321-30
Protein Domain
Type: Family
Description: Cep85 is a centrosomal protein of 85kDa []. It is a centriole duplication factor that directly interacts with STIL. It is essential for efficient centriolar targeting of STIL, PLK4 activation and faithful daughter centriole assembly [].
Protein Domain
Type: Domain
Description: In metazoans, Plk4 kinases control daughter centriole assembly. Plk4 homologues have an N-terminal kinase domain, a C-terminal polo box, and a central domain termed the 'cryptic polo box' (CPB) that has been shown to dimerize, to be sufficient for centriole localization and to be required for Plk4 to promote centriole assembly. Probable serine/threonine-protein kinase zyg-1 () (ZYG-1) is a Plk4 homlogue found in C. elegans. Crystal structure for the CPB of C. elegans ZYG-1, reveals that it forms a Z-shaped dimer containing an intermolecular β-sheet with an extended basic surface patch. Electrostatic interactions between the basic patch on the ZYG-1 CPB dimer and the SPD-2 acidic region dock ZYG-1 onto centrioles to promote new centriole assembly. ZYG-1 CPB contains two tandem polo boxes (PB1 and PB2), each containing a six-stranded β-sheet with an α-helix packed against one side []. This entry represents PB1.
Protein Domain
Type: Domain
Description: In metazoans, Plk4 kinases control daughter centriole assembly. Plk4 homologs have an N-terminal kinase domain, a C-terminal polo box, and a central domain termed the 'cryptic polo box' (CPB) that has been shown to dimerize, to be sufficient for centriole localization and to be required for Plk4 to promote centriole assembly. Probable serine/threonine-protein kinase zyg-1 () (ZYG-1) is a Plk4 homlog found in C. elegans. Crystal structure for the CPB of C. elegans ZYG-1, reveals that it forms a Z-shaped dimer containing an intermolecular β-sheet with an extended basic surface patch. Electrostatic interactions between the basic patch on the ZYG-1 CPB dimer and the SPD-2 acidic region dock ZYG-1 onto centrioles to promote new centriole assembly. ZYG-1 CPB contains two tandem polo boxes (PB1 and PB2), each containing a six-stranded β-sheet with an α-helix packed against one side []. This entry represents PB2.
Protein
Organism: Mus musculus/domesticus
Length: 1736  
Fragment?: false
Publication
First Author: Dzhindzhev NS
Year: 2010
Journal: Nature
Title: Asterless is a scaffold for the onset of centriole assembly.
Volume: 467
Issue: 7316
Pages: 714-8
Protein Domain
Type: Family
Description: Centrosomal protein of 152kDa (Cep152) acts as a scaffold for recruitment of centriole regulators, Plk4 and CPAP, to the centrosome [, ]. In multiciliated cell (MCCs), the basal bodies of the motile cilia are derived from centroles, which are amplified in a structure known as the deuterostome. Cep152 is required for the centriole biogenesis in deuterostome [].
Protein Domain
Type: Homologous_superfamily
Description: The polo-like Ser/Thr kinases (Plk1, Plk2/Snk, Plk3/Prk/Fnk, Plk4/Sak, and the inactive kinase Plk5) play various roles in cytokinesis and mitosis. At their C terminus, they contain a tandemly repeated polo-box domain (PBD) (in the case of Plk4, a tandem repeat of cryptic PBDs is found in the middle of the protein followed by a C-terminal single repeat), which appears to be involved in autoinhibition and in mediating the subcellular localization. The latter may be controlled via interactions between the polo-box domain and phospho-peptide motifs. The phosphopeptide binding site is formed at the interface between the two tandemly repeated PBDs. The PBDs of Plk4/Sak appear unique in participating in homodimer interactions, though it is not clear whether and how they interact with phosphopeptides [, , , , , ].In metazoans, Plk4 kinases control daughter centriole assembly. Plk4 homologues have an N-terminal kinase domain, a C-terminal polo box, and a central domain termed the 'cryptic polo box' (CPB) that has been shown to dimerize, to be sufficient for centriole localization and to be required for Plk4 to promote centriole assembly. Probable serine/threonine-protein kinase zyg-1 () (ZYG-1) is a Plk4 homologue found in C. elegans. Crystal structure for the CPB of C. elegans ZYG-1, reveals that it forms a Z-shaped dimer containing an intermolecular β-sheet with an extended basic surface patch. Electrostatic interactions between the basic patch on the ZYG-1 CPB dimer and the SPD-2 acidic region dock ZYG-1 onto centrioles to promote new centriole assembly. ZYG-1 CPB contains two tandem polo boxes (PB1 and PB2), each containing a six-stranded β-sheet with an α-helix packed against one side [].This entry represents the first (cryptic) polo-box domain of Plk4 and homologues.
Protein
Organism: Mus musculus/domesticus
Length: 761  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 77  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 759  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 135  
Fragment?: false
Publication
First Author: Holland AJ
Year: 2012
Journal: Genes Dev
Title: The autoregulated instability of Polo-like kinase 4 limits centrosome duplication to once per cell cycle.
Volume: 26
Issue: 24
Pages: 2684-9
Protein Domain
Type: Family
Description: Centriole amplification is controlled by two duplicated genes, Cep63 (centrosomal protein of 63kDa) and Deup1 (Deuterosome assembly protein 1).Cep63 regulates mother-centriole-dependent centriole duplication, whereas Deup1 is involved in large-scale de novo centriole biogenesis. Deup1, previously known as coiled-coil domain-containing protein 67, is a structural component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells. Deup1 binds to Cep152 and then recruits Plk4 to activate centriole biogenesis [].
Protein Domain
Type: Family
Description: This entry includes Cep85 and Cep85L from animals.Cep85 is a centrosomal protein of 85kDa []. It is a centriole duplication factor that directly interacts with STIL. It is essential for efficient centriolar targeting of STIL, PLK4 activation and faithful daughter centriole assembly [].Centrosomal protein of 85kDa-like (CEP85L) may localise to the centrosome []. It is also known as breast cancer antigen NY-BR-15 []. A chromosomal aberration involving CEP85L was found in a patient with T-lymphoblastic lymphoma and associated myeloproliferative neoplasm [].
Strain
Attribute String: congenic, mutant strain, targeted mutation
Protein
Organism: Mus musculus/domesticus
Length: 601  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 397  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 351  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 536  
Fragment?: false
Publication
First Author: Kelleher FC
Year: 2019
Journal: Carcinogenesis
Title: Targeting the centrosome and polo-like kinase 4 in osteosarcoma.
Volume: 40
Issue: 4
Pages: 493-499
Publication    
First Author: Grzonka M
Year: 2024
Journal: Elife
Title: Mouse SAS-6 is required for centriole formation in embryos and integrity in embryonic stem cells.
Volume: 13
Publication
First Author: Levine MS
Year: 2017
Journal: Dev Cell
Title: Centrosome Amplification Is Sufficient to Promote Spontaneous Tumorigenesis in Mammals.
Volume: 40
Issue: 3
Pages: 313-322.e5
Protein
Organism: Mus musculus/domesticus
Length: 806  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 449  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 704  
Fragment?: false
Publication  
First Author: Scanlan MJ
Year: 2001
Journal: Cancer Immun
Title: Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression.
Volume: 1
Pages: 4
Publication
First Author: Braun VZ
Year: 2024
Journal: Sci Adv
Title: Extra centrosomes delay DNA damage-driven tumorigenesis.
Volume: 10
Issue: 13
Pages: eadk0564