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Search results 201 to 284 out of 284 for Pnpla2

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Type Details Score
Publication
18390901 | J:138600
First Author: Gauthier MS
Year: 2008
Journal: J Biol Chem
Title: AMP-activated protein kinase is activated as a consequence of lipolysis in the adipocyte: potential mechanism and physiological relevance.
Volume: 283
Issue: 24
Pages: 16514-24
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Publication
32376415 | J:303164
First Author: Schwerbel K
Year: 2020
Journal: J Hepatol
Title: Immunity-related GTPase induces lipophagy to prevent excess hepatic lipid accumulation.
Volume: 73
Issue: 4
Pages: 771-782
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Publication
36476935 | J:332914
First Author: Gong Z
Year: 2022
Journal: Cell Metab
Title: Lipid-laden lung mesenchymal cells foster breast cancer metastasis via metabolic reprogramming of tumor cells and natural killer cells.
Volume: 34
Issue: 12
Pages: 1960-1976.e9
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Publication
38060450 | J:350331
First Author: Lin TY
Year: 2023
Journal: Cell Rep
Title: Epinephrine inhibits PI3Kα via the Hippo kinases.
Volume: 42
Issue: 12
Pages: 113535
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Publication
28404638 | J:242700
First Author: Scerbo D
Year: 2017
Journal: J Lipid Res
Title: Kidney triglyceride accumulation in the fasted mouse is dependent upon serum free fatty acids.
Volume: 58
Issue: 6
Pages: 1132-1142
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Publication
31353262 | J:283668
First Author: Leiria LO
Year: 2019
Journal: Cell Metab
Title: 12-Lipoxygenase Regulates Cold Adaptation and Glucose Metabolism by Producing the Omega-3 Lipid 12-HEPE from Brown Fat.
Volume: 30
Issue: 4
Pages: 768-783.e7
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Publication
32958928 | J:306037
First Author: Li P
Year: 2020
Journal: Nat Immunol
Title: Lung mesenchymal cells elicit lipid storage in neutrophils that fuel breast cancer lung metastasis.
Volume: 21
Issue: 11
Pages: 1444-1455
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Publication
39674178 | J:361345
First Author: Chen H
Year: 2025
Journal: Cell
Title: Intermittent fasting triggers interorgan communication to suppress hair follicle regeneration.
Volume: 188
Issue: 1
Pages: 157-174.e22
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Publication
39195232 | J:353478
 
First Author: Farley A
Year: 2024
Journal: Cells
Title: Activation of VGLL4 Suppresses Cardiomyocyte Maturational Hypertrophic Growth.
Volume: 13
Issue: 16
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Publication
24196706 | J:207678
First Author: Ohno H
Year: 2013
Journal: Nature
Title: EHMT1 controls brown adipose cell fate and thermogenesis through the PRDM16 complex.
Volume: 504
Issue: 7478
Pages: 163-7
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Publication
25662011 | J:219885
First Author: Perry RJ
Year: 2015
Journal: Cell
Title: Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes.
Volume: 160
Issue: 4
Pages: 745-58
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Publication
31110314 | J:282404
First Author: Baazim H
Year: 2019
Journal: Nat Immunol
Title: CD8+ T cells induce cachexia during chronic viral infection.
Volume: 20
Issue: 6
Pages: 701-710
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Publication
25662615 | J:316550
First Author: Himes KP
Year: 2015
Journal: Placenta
Title: Loss of inherited genomic imprints in mice leads to severe disruption in placental lipid metabolism.
Volume: 36
Issue: 4
Pages: 389-96
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Publication
26263173 | J:242781
First Author: Yu T
Year: 2015
Journal: PLoS One
Title: Deficiency of Lipoprotein Lipase in Neurons Decreases AMPA Receptor Phosphorylation and Leads to Neurobehavioral Abnormalities in Mice.
Volume: 10
Issue: 8
Pages: e0135113
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Publication
38942786 | J:350499
First Author: Madsen S
Year: 2024
Journal: Nat Commun
Title: A fluorescent perilipin 2 knock-in mouse model reveals a high abundance of lipid droplets in the developing and adult brain.
Volume: 15
Issue: 1
Pages: 5489
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Publication
33732701 | J:314181
 
First Author: Holzman MA
Year: 2021
Journal: Front Cell Dev Biol
Title: HOXA5 Participates in Brown Adipose Tissue and Epaxial Skeletal Muscle Patterning and in Brown Adipocyte Differentiation.
Volume: 9
Pages: 632303
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Publication
27974211 | J:241708
First Author: Luo X
Year: 2016
Journal: Cell Rep
Title: Dual Shp2 and Pten Deficiencies Promote Non-alcoholic Steatohepatitis and Genesis of Liver Tumor-Initiating Cells.
Volume: 17
Issue: 11
Pages: 2979-2993
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Publication
27754788 | J:240750
First Author: Bose SK
Year: 2016
Journal: Endocrinology
Title: Hepatic Glucocorticoid Receptor Plays a Greater Role Than Adipose GR in Metabolic Syndrome Despite Renal Compensation.
Volume: 157
Issue: 12
Pages: 4943-4960
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Publication
27185876 | J:236180
First Author: Zhou H
Year: 2016
Journal: Mol Cell Biol
Title: Berardinelli-Seip Congenital Lipodystrophy 2/Seipin Is Not Required for Brown Adipogenesis but Regulates Brown Adipose Tissue Development and Function.
Volume: 36
Issue: 15
Pages: 2027-38
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Publication
28364022 | J:241351
First Author: Lu J
Year: 2017
Journal: EMBO Rep
Title: The phosphorylation status of T522 modulates tissue-specific functions of SIRT1 in energy metabolism in mice.
Volume: 18
Issue: 5
Pages: 841-857
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Publication
24086110 | J:201804
First Author: Breckenridge RA
Year: 2013
Journal: PLoS Biol
Title: Hypoxic regulation of hand1 controls the fetal-neonatal switch in cardiac metabolism.
Volume: 11
Issue: 9
Pages: e1001666
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Publication
35863637 | J:327433
 
First Author: Song Z
Year: 2022
Journal: Mol Metab
Title: The conserved Mediator subunit cyclin C (CCNC) is required for brown adipocyte development and lipid accumulation.
Volume: 64
Pages: 101548
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Publication
26220403 | J:224441
 
First Author: Lim GE
Year: 2015
Journal: Nat Commun
Title: 14-3-3ζ coordinates adipogenesis of visceral fat.
Volume: 6
Pages: 7671
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Publication
33059001 | J:306153
First Author: Zhu M
Year: 2021
Journal: Biochim Biophys Acta Mol Basis Dis
Title: A long non-coding RNA specifically expressed in early embryos programs the metabolic balance in adult mice.
Volume: 1867
Issue: 1
Pages: 165988
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Publication
35733999 | J:326089
 
First Author: Ghnaimawi S
Year: 2022
Journal: Front Physiol
Title: The Effects of Maternal Intake of EPA and DHA Enriched Diet During Pregnancy and Lactation on Offspring's Muscle Development and Energy Homeostasis.
Volume: 13
Pages: 881624
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:342601
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniPathway vocabulary mapping
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Publication
- | J:346132
       
First Author: The Gene Ontology Consortium
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Allele
Pnpla2<em2Smoc> | MGI:7291740
Name: patatin-like phospholipase domain containing 2; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:6771066 | C57BL/6JSmoc-Pnpla2<em2Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Allele
Pnpla2<em1Smoc> | MGI:7291739
Name: patatin-like phospholipase domain containing 2; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Strain
MGI:6476054 | C57BL/6JSmoc-Pnpla2<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Allele
Tg(Ckm-Pnpla2)164Eek | MGI:5554433
Name: transgene insertion 164, Erin E Kershaw
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Strain
MGI:5554372 | FVB-Tg(Ckm-Pnpla2)164Eek/J
Attribute String: coisogenic, mutant strain, transgenic
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Genotype
Genotype
Symbol: Tg(Ckm-Pnpla2)164Eek/?
Background: involves: FVB/N
Zygosity: ot
Has Mutant Allele: true
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Publication
26083785 | -
First Author: Xie M
Year: 2015
Journal: PLoS Genet
Title: The Causative Gene in Chanarian Dorfman Syndrome Regulates Lipid Droplet Homeostasis in C. elegans.
Volume: 11
Issue: 6
Pages: e1005284
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Publication
19052547 | -
First Author: Narbonne P
Year: 2009
Journal: Nature
Title: Caenorhabditis elegans dauers need LKB1/AMPK to ration lipid reserves and ensure long-term survival.
Volume: 457
Issue: 7226
Pages: 210-4
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Publication
20176933 | -
First Author: Zhang SO
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Genetic and dietary regulation of lipid droplet expansion in Caenorhabditis elegans.
Volume: 107
Issue: 10
Pages: 4640-5
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Publication
24120942 | -
First Author: Noble T
Year: 2013
Journal: Cell Metab
Title: An integrated serotonin and octopamine neuronal circuit directs the release of an endocrine signal to control C. elegans body fat.
Volume: 18
Issue: 5
Pages: 672-84
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Publication
25202121 | -
First Author: Lee JH
Year: 2014
Journal: Mol Cell Biol
Title: Lipid droplet protein LID-1 mediates ATGL-1-dependent lipolysis during fasting in Caenorhabditis elegans.
Volume: 34
Issue: 22
Pages: 4165-76
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Publication
26098762 | -
First Author: Xie M
Year: 2015
Journal: PLoS One
Title: AMP-Activated Kinase Regulates Lipid Droplet Localization and Stability of Adipose Triglyceride Lipase in C. elegans Dauer Larvae.
Volume: 10
Issue: 6
Pages: e0130480
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Protein Domain
IPR033562 | PLPL
Type: Family
Description: This entry includes patatin-like phospholipase domain-containing proteins 1-5 (PNPLA1-5) from humans and Atgl-1 from Caenorhabditis elegans. They are a group of lipid hydrolases. Atgl-1 may play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion [, , , , , ]. In humans PNPLA1 has a role in the formation of the epidermal lipid barrier; mutations in this gene are associated with the skin disorder known as ichthyosis []. PNPLA1 acts as an omega-hydroxyceramide transacylase involved in the synthesis of omega-O-acylceramides (esterified omega-hydroxyacyl-sphingosine; EOS), which are extremely hydrophobic lipids involved in skin barrier formation [, ]. It catalyzes the last step of the synthesis of omega-O-acylceramides by transferring linoleic acid from triglycerides to an omega-hydroxyceramid [].Human PNPLA2 catalyses the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets []. PNPLA3 has both triacylglycerol lipase and acylglycerol O-acyltransferase activities [].
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Publication
27559856 | J:332366
First Author: Peng Y
Year: 2016
Journal: Autophagy
Title: ABHD5 interacts with BECN1 to regulate autophagy and tumorigenesis of colon cancer independent of PNPLA2.
Volume: 12
Issue: 11
Pages: 2167-2182
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Publication
24659297 | J:355933
First Author: Heck MV
Year: 2014
Journal: Neurogenetics
Title: Dysregulated expression of lipid storage and membrane dynamics factors in Tia1 knockout mouse nervous tissue.
Volume: 15
Issue: 2
Pages: 135-44
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Publication
27751867 | J:240053
First Author: Grond S
Year: 2017
Journal: J Invest Dermatol
Title: PNPLA1 Deficiency in Mice and Humans Leads to a Defect in the Synthesis of Omega-O-Acylceramides.
Volume: 137
Issue: 2
Pages: 394-402
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Publication
22246504 | -
First Author: Grall A
Year: 2012
Journal: Nat Genet
Title: PNPLA1 mutations cause autosomal recessive congenital ichthyosis in golden retriever dogs and humans.
Volume: 44
Issue: 2
Pages: 140-7
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Publication
28248318 | -
 
First Author: Ohno Y
Year: 2017
Journal: Nat Commun
Title: PNPLA1 is a transacylase essential for the generation of the skin barrier lipid ω-O-acylceramide.
Volume: 8
Pages: 14610
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Protein
Q3V1D5
Organism: Mus musculus/domesticus
Length: 599  
Fragment?: false
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Protein
Q32LZ8
Organism: Mus musculus/domesticus
Length: 432  
Fragment?: false
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Protein
E9PZA4
Organism: Mus musculus/domesticus
Length: 305  
Fragment?: true
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Protein
E9Q323
Organism: Mus musculus/domesticus
Length: 158  
Fragment?: true
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Protein
B2KF06
Organism: Mus musculus/domesticus
Length: 599  
Fragment?: false
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Protein
H3BIT5
Organism: Mus musculus/domesticus
Length: 70  
Fragment?: false
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Protein
Q91WW7
Organism: Mus musculus/domesticus
Length: 413  
Fragment?: false
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Protein
E9QNZ9
Organism: Mus musculus/domesticus
Length: 384  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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