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Search results 201 to 300 out of 304 for Pon1

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Type Details Score
GXD Expression
GXD Expression
     
Probe: MGI:5310482
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3599822
Stage: TS22
Assay Id: MGI:5423805
Age: embryonic day 14.5
Specimen Label: EH955; Specimen C2512
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:5310482
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3280922
Stage: TS22
Assay Id: MGI:5423805
Age: embryonic day 14.5
Specimen Label: EH955; Specimen C2512
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:5310482
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1833322
Stage: TS22
Assay Id: MGI:5423805
Age: embryonic day 14.5
Specimen Label: EH955; Specimen C2512
Detected: false
Specimen Num: 1
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•
GXD Expression
GXD Expression
     
Probe: MGI:5310482
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3287022
Stage: TS22
Assay Id: MGI:5423805
Age: embryonic day 14.5
Specimen Label: EH955; Specimen C2512
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:5310482
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1752522
Stage: TS22
Assay Id: MGI:5423805
Age: embryonic day 14.5
Specimen Label: EH955; Specimen C2512
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:5310482
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1821522
Stage: TS22
Assay Id: MGI:5423805
Age: embryonic day 14.5
Specimen Label: EH955; Specimen C2512
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:5310482
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3557722
Stage: TS22
Assay Id: MGI:5423805
Age: embryonic day 14.5
Specimen Label: EH955; Specimen C2512
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:5310482
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1702122
Stage: TS22
Assay Id: MGI:5423805
Age: embryonic day 14.5
Specimen Label: EH955; Specimen C2512
Detected: false
Specimen Num: 1
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•
GXD Expression
GXD Expression
     
Probe: MGI:5310482
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1756322
Stage: TS22
Assay Id: MGI:5423805
Age: embryonic day 14.5
Specimen Label: EH955; Specimen C2512
Detected: false
Specimen Num: 1
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•
GXD Expression
GXD Expression
     
Probe: MGI:5310482
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1668822
Stage: TS22
Assay Id: MGI:5423805
Age: embryonic day 14.5
Specimen Label: EH955; Specimen C2512
Detected: false
Specimen Num: 1
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•
GXD Expression
GXD Expression
     
Probe: MGI:5310482
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1757722
Stage: TS22
Assay Id: MGI:5423805
Age: embryonic day 14.5
Specimen Label: EH955; Specimen C2512
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:5310482
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1757522
Stage: TS22
Assay Id: MGI:5423805
Age: embryonic day 14.5
Specimen Label: EH955; Specimen C2512
Detected: false
Specimen Num: 1
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•
GXD Expression
GXD Expression
     
Probe: MGI:5310482
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1738322
Stage: TS22
Assay Id: MGI:5423805
Age: embryonic day 14.5
Specimen Label: EH955; Specimen C2512
Detected: false
Specimen Num: 1
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•
GXD Expression
GXD Expression
     
Probe: MGI:5310482
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1802422
Stage: TS22
Assay Id: MGI:5423805
Age: embryonic day 14.5
Specimen Label: EH955; Specimen C2512
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:5310482
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1768022
Stage: TS22
Assay Id: MGI:5423805
Age: embryonic day 14.5
Note: Expression was not detected in the skull (base and vault).
Specimen Label: EH955; Specimen C2512
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:5310482
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:2672022
Stage: TS22
Assay Id: MGI:5423805
Age: embryonic day 14.5
Note: Expression was not detected in whisker follicle.
Specimen Label: EH955; Specimen C2512
Detected: false
Specimen Num: 1
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Publication
23772025 | J:204816
First Author: Yamashita J
Year: 2013
Journal: J Immunol
Title: Paraoxonase-1 suppresses experimental colitis via the inhibition of IFN-γ production from CD4 T cells.
Volume: 191
Issue: 2
Pages: 949-60
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Publication
8811508 | J:33846
First Author: Tong L
Year: 1996
Journal: J Neurosci Res
Title: Effect of nerve growth factor on AP-1, NF-kappa B, and Oct DNA binding activity in apoptotic PC12 cells: extrinsic and intrinsic elements.
Volume: 45
Issue: 1
Pages: 1-12
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Publication
9176667 | J:41135
First Author: Kalyuzhny AE
Year: 1997
Journal: Anat Embryol (Berl)
Title: Immunocytochemical localization of mu-opioid receptors in follicular cells and preimplantation mouse embryos.
Volume: 195
Issue: 5
Pages: 451-5
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Publication
10393212 | J:56071
First Author: Forte TM
Year: 1999
Journal: J Lipid Res
Title: Targeted disruption of the murine lecithin:cholesterol acyltransferase gene is associated with reductions in plasma paraoxonase and platelet-activating factor acetylhydrolase activities but not in apolipoprotein J concentration.
Volume: 40
Issue: 7
Pages: 1276-83
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Publication
11893784 | J:75568
First Author: Forte TM
Year: 2002
Journal: J Lipid Res
Title: Altered activities of anti-atherogenic enzymes LCAT, paraoxonase, and platelet-activating factor acetylhydrolase in atherosclerosis-susceptible mice.
Volume: 43
Issue: 3
Pages: 477-85
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Publication
30905786 | J:275795
First Author: Luciano-Mateo F
Year: 2019
Journal: Biochim Biophys Acta Mol Basis Dis
Title: Chemokine (C-C motif) ligand 2 gene ablation protects low-density lipoprotein and paraoxonase-1 double deficient mice from liver injury, oxidative stress and inflammation.
Volume: 1865
Issue: 6
Pages: 1555-1566
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Publication
9475163 | J:50700
First Author: McNally EM
Year: 1998
Journal: FEBS Lett
Title: Human epsilon-sarcoglycan is highly related to alpha-sarcoglycan (adhalin), the limb girdle muscular dystrophy 2D gene.
Volume: 422
Issue: 1
Pages: 27-32
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Publication
12840045 | J:84436
First Author: Ono R
Year: 2003
Journal: Genome Res
Title: Identification of a large novel imprinted gene cluster on mouse proximal chromosome 6.
Volume: 13
Issue: 7
Pages: 1696-705
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Publication
18356571 | J:185114
First Author: Reynolds SD
Year: 2008
Journal: Stem Cells
Title: Conditional stabilization of beta-catenin expands the pool of lung stem cells.
Volume: 26
Issue: 5
Pages: 1337-46
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Publication
18757308 | J:157431
First Author: Zemke AC
Year: 2009
Journal: Am J Respir Cell Mol Biol
Title: Molecular staging of epithelial maturation using secretory cell-specific genes as markers.
Volume: 40
Issue: 3
Pages: 340-8
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Publication
23405202 | J:198319
First Author: Sayin VI
Year: 2013
Journal: PLoS One
Title: Zfp148 deficiency causes lung maturation defects and lethality in newborn mice that are rescued by deletion of p53 or antioxidant treatment.
Volume: 8
Issue: 2
Pages: e55720
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Publication
9457688 | J:40697
First Author: Briquet-Laugier V
Year: 1998
Journal: Mamm Genome
Title: Mapping of three members of the mouse protein disulfide isomerase family.
Volume: 9
Issue: 2
Pages: 176-7
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Publication
16341224 | J:106134
First Author: Ono R
Year: 2006
Journal: Nat Genet
Title: Deletion of Peg10, an imprinted gene acquired from a retrotransposon, causes early embryonic lethality.
Volume: 38
Issue: 1
Pages: 101-6
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Publication
22916088 | J:190056
First Author: Xu Y
Year: 2012
Journal: PLoS One
Title: Transcriptional programs controlling perinatal lung maturation.
Volume: 7
Issue: 8
Pages: e37046
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Publication
30389914 | J:267889
First Author: Moon S
Year: 2018
Journal: Cell Death Dis
Title: Asxl1 exerts an antiproliferative effect on mouse lung maturation via epigenetic repression of the E2f1-Nmyc axis.
Volume: 9
Issue: 11
Pages: 1118
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Publication
22096492 | J:180979
First Author: Besnard V
Year: 2011
Journal: PLoS One
Title: Maternal synchronization of gestational length and lung maturation.
Volume: 6
Issue: 11
Pages: e26682
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Publication
23620511 | J:197340
First Author: Chung C
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Hippo-Foxa2 signaling pathway plays a role in peripheral lung maturation and surfactant homeostasis.
Volume: 110
Issue: 19
Pages: 7732-7
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Publication
22001906 | J:178114
First Author: Pei L
Year: 2011
Journal: Nat Med
Title: Thyroid hormone receptor repression is linked to type I pneumocyte-associated respiratory distress syndrome.
Volume: 17
Issue: 11
Pages: 1466-72
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Publication
8827514 | J:34178
First Author: Welch CL
Year: 1996
Journal: J Lipid Res
Title: Genetic regulation of cholesterol homeostasis: chromosomal organization of candidate genes.
Volume: 37
Issue: 7
Pages: 1406-21
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Publication
- | J:46439
     
First Author: Freeman TC
Year: 1998
Journal: MGI Direct Data Submission
Title: Expression Mapping of Mouse Genes
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Publication
- | J:342608
       
First Author: GO Central curators, GOA curators, Rhea curators
Year: 2020
Title: Automatic Gene Ontology annotation based on Rhea mapping
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Publication
- | J:72245
       
First Author: GOA curators, MGI curators
Year: 2001
Title: Gene Ontology annotation based on Enzyme Commission mapping
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Publication
14681479 | J:122989
First Author: Visel A
Year: 2004
Journal: Nucleic Acids Res
Title: GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Volume: 32
Issue: Database issue
Pages: D552-6
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
14695884 | J:88273
First Author: Aharoni A
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Directed evolution of mammalian paraoxonases PON1 and PON3 for bacterial expression and catalytic specialization.
Volume: 101
Issue: 2
Pages: 482-7
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Transgene
MGI:3795159 | Tg(PON1)1Lus
Type: transgene
Organism: mouse, laboratory
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Publication
28278274 | J:248493
First Author: Ikhlef S
Year: 2017
Journal: PLoS One
Title: Human paraoxonase 1 overexpression in mice stimulates HDL cholesterol efflux and reverse cholesterol transport.
Volume: 12
Issue: 3
Pages: e0173385
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Publication
23291186 | J:198076
First Author: Lu J
Year: 2013
Journal: Biochem Biophys Res Commun
Title: Role of paraoxonase-1 in bone anabolic effects of parathyroid hormone in hyperlipidemic mice.
Volume: 431
Issue: 1
Pages: 19-24
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Publication
16043712 | J:118732
First Author: Bradshaw G
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Facilitated replacement of Kupffer cells expressing a paraoxonase-1 transgene is essential for ameliorating atherosclerosis in mice.
Volume: 102
Issue: 31
Pages: 11029-34
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Publication
33033318 | J:299066
First Author: Charles-Schoeman C
Year: 2020
Journal: Sci Rep
Title: Suppression of inflammatory arthritis in human serum paraoxonase 1 transgenic mice.
Volume: 10
Issue: 1
Pages: 16848
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Allele
Tg(MSR1-Pon1)1Road | MGI:3699359
Name: transgene insertion 1, Roger A Davis
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Strain
MGI:4887377 | C57BL/6-Tg(MSR1-Pon1)1Road/Mmucd
Attribute String: coisogenic, mutant strain, transgenic
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Publication
7749820 | -
First Author: Hegele RA
Year: 1995
Journal: Arterioscler Thromb Vasc Biol
Title: A polymorphism of the paraoxonase gene associated with variation in plasma lipoproteins in a genetic isolate.
Volume: 15
Issue: 1
Pages: 89-95
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Protein Domain
IPR008363 | Paraoxonase1
Type: Family
Description: The serum paraoxonases/arylesterases are enzymes that catalyse the hydrolysisof the toxic metabolites of a variety of organophosphorus insecticides. Theenzymes hydrolyse a broad spectrum of organophosphate substrates, including paraoxon and a number of aromatic carboxylic acid esters (e.g., phenylacetate), and hence confer resistance to organophosphate toxicity []. Mammals have 3 distinct paraoxonase types, termed PON1-3 [, ]. In mice andhumans, the PON genes are found on the same chromosome in close proximity. PON activity has been found in variety of tissues, with highest levels in liver and serum - the source of serum PON is thought to be the liver. Unlike mammals, fish and avian species lack paraoxonase activity. Human and rabbit PONs appear to have two distinct Ca2+ binding sites, onerequired for stability and one required for catalytic activity. The Ca2+dependency of PONs suggests a mechanism of hydrolysis where Ca2+ acts as theelectrophillic catalyst, like that proposed for phospholipase A2. Theparaoxonase enzymes, PON1 and PON3, are high density lipoprotein (HDL)-associated proteins capable of preventing oxidative modification of lowdensity lipoproteins (LPL) []. Although PON2 has oxidative properties, theenzyme does not associate with HDL.Within a given species, PON1, PON2 and PON3 share ~60% amino acid sequence identity, whereas between mammalian species particular PONs (1,2 or 3) share79-90% identity at the amino acid level. Human PON1 and PON3 share numerous conserved phosphorylation and N-glycosylation sites; however, it is not known whether the PON proteins are modified at these sites, or whether modification at these sites is required for activity in vivo []. Rabbit and human serum PON1 also hydrolyse a variety oflactones and cycliccarbonate esters, including naturally occurring lactones and pharmacologicalagents []. Humans have 2 common PON1 allozymes, determined by the presenceof either arginine or glutamine at position 191. The A-type allozyme (glutamine at position 191) causes low paraoxonase activity []; thispolymorphism is associated with variations in cholesterol and lipoproteinlevels.
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Protein Domain
IPR013658 | SGL
Type: Domain
Description: This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30, ), gluconolactonase () and luciferin-regenerating enzyme (LRE, ). SMP-30 is known to hydrolyse diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 () and LRE.
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Publication
11038162 | -
First Author: Billecke S
Year: 2000
Journal: Drug Metab Dispos
Title: Human serum paraoxonase (PON1) isozymes Q and R hydrolyze lactones and cyclic carbonate esters.
Volume: 28
Issue: 11
Pages: 1335-42
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Protein Domain
IPR008364 | Paraoxonase2
Type: Family
Description: The serum paraoxonases/arylesterases are enzymes that catalyse the hydrolysisof the toxic metabolites of a variety of organophosphorus insecticides. Theenzymes hydrolyse a broad spectrum of organophosphate substrates, including paraoxon and a number of aromatic carboxylic acid esters (e.g., phenylacetate), and hence confer resistance to organophosphate toxicity []. Mammals have 3 distinct paraoxonase types, termed PON1-3 [, ]. In mice andhumans, the PON genes are found on the same chromosome in close proximity. PON activity has been found in variety of tissues, with highest levels in liver and serum - the source of serum PON is thought to be the liver. Unlike mammals, fish and avian species lack paraoxonase activity. Human and rabbit PONs appear to have two distinct Ca2+ binding sites, onerequired for stability and one required for catalytic activity. The Ca2+dependency of PONs suggests a mechanism of hydrolysis where Ca2+ acts as theelectrophillic catalyst, like that proposed for phospholipase A2. Theparaoxonase enzymes, PON1 and PON3, are high density lipoprotein (HDL)-associated proteins capable of preventing oxidative modification of lowdensity lipoproteins (LPL) []. Although PON2 has oxidative properties, theenzyme does not associate with HDL.Within a given species, PON1, PON2 and PON3 share ~60% amino acid sequence identity, whereas between mammalian species particular PONs (1,2 or 3) share79-90% identity at the amino acid level. Human PON1 and PON3 share numerous conserved phosphorylation and N-glycosylation sites; however, it is not known whether the PON proteins are modified at these sites, or whether modification at these sites is required for activity in vivo [].
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Publication
27148853 | J:233832
First Author: Ikhlef S
Year: 2016
Journal: FEBS Lett
Title: Paraoxonase 1-treated oxLDL promotes cholesterol efflux from macrophages by stimulating the PPARγ-LXRα-ABCA1 pathway.
Volume: 590
Issue: 11
Pages: 1614-29
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Publication
9032442 | -
 
First Author: Rodrigo L
Year: 1997
Journal: Biochem J
Title: Purification and characterization of paraoxon hydrolase from rat liver.
Volume: 321 ( Pt 3)
Pages: 595-601
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Protein Domain
IPR002640 | Arylesterase
Type: Family
Description: The serum paraoxonases/arylesterases are enzymes that catalyse the hydrolysisof the toxic metabolites of a variety of organophosphorus insecticides. Theenzymes hydrolyse a broad spectrum of organophosphate substrates, including paraoxon and a number of aromatic carboxylic acid esters (e.g., phenylacetate), and hence confer resistance to organophosphate toxicity []. Mammals have 3 distinct paraoxonase types, termed PON1-3 [, ]. In mice andhumans, the PON genes are found on the same chromosome in close proximity. PON activity has been found in variety of tissues, with highest levels in liver and serum - the source of serum PON is thought to be the liver. Unlike mammals, fish and avian species lack paraoxonase activity. Human and rabbit PONs appear to have two distinct Ca2+ binding sites, onerequired for stability and one required for catalytic activity. The Ca2+dependency of PONs suggests a mechanism of hydrolysis where Ca2+ acts as theelectrophillic catalyst, like that proposed for phospholipase A2. Theparaoxonase enzymes, PON1 and PON3, are high density lipoprotein (HDL)-associated proteins capable of preventing oxidative modification of lowdensity lipoproteins (LPL) []. Although PON2 has oxidative properties, theenzyme does not associate with HDL.Within a given species, PON1, PON2 and PON3 share ~60% amino acid sequence identity, whereas between mammalian species particular PONs (1,2 or 3) share79-90% identity at the amino acid level. Human PON1 and PON3 share numerous conserved phosphorylation and N-glycosylation sites; however, it is not known whether the PON proteins are modified at these sites, or whether modification at these sites is required for activity in vivo []. This family consists of arylesterases (Also known as serum paraoxonase) . These enzymes hydrolyse organophosphorus esters such as paraoxon and are found in the liver and blood. They confer resistance to organophosphate toxicity []. Human arylesterase (PON1) is associated with HDL and may protect against LDL oxidation [].
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Protein
P52430
Organism: Mus musculus/domesticus
Length: 355  
Fragment?: false
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Protein
H3BLB8
Organism: Mus musculus/domesticus
Length: 181  
Fragment?: false
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Protein
H3BK03
Organism: Mus musculus/domesticus
Length: 256  
Fragment?: true
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Protein
Q8VDG8
Organism: Mus musculus/domesticus
Length: 200  
Fragment?: false
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Protein
Q99JS7
Organism: Mus musculus/domesticus
Length: 108  
Fragment?: false
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Protein
H3BL07
Organism: Mus musculus/domesticus
Length: 135  
Fragment?: true
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Protein
Q62086
Organism: Mus musculus/domesticus
Length: 354  
Fragment?: false
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Protein
Q62087
Organism: Mus musculus/domesticus
Length: 354  
Fragment?: false
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Publication
20498409 | J:164463
First Author: Wang W
Year: 2010
Journal: J Lipid Res
Title: Genetic deletion of apolipoprotein A-I increases airway hyperresponsiveness, inflammation, and collagen deposition in the lung.
Volume: 51
Issue: 9
Pages: 2560-70
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Publication
32098873 | J:286831
First Author: Zamanian-Daryoush M
Year: 2020
Journal: J Biol Chem
Title: Site-specific 5-hydroxytryptophan incorporation into apolipoprotein A-I impairs cholesterol efflux activity and high-density lipoprotein biogenesis.
Volume: 295
Issue: 15
Pages: 4836-4848
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Publication
12799373 | J:85105
First Author: Robert K
Year: 2003
Journal: J Biol Chem
Title: Altered gene expression in liver from a murine model of hyperhomocysteinemia.
Volume: 278
Issue: 34
Pages: 31504-11
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Publication
16269825 | J:107566
First Author: Shih DM
Year: 2006
Journal: J Lipid Res
Title: A role for FXR and human FGF-19 in the repression of paraoxonase-1 gene expression by bile acids.
Volume: 47
Issue: 2
Pages: 384-92
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Publication
19359600 | J:164769
First Author: She ZG
Year: 2009
Journal: Circ Res
Title: Human paraoxonase gene cluster transgenic overexpression represses atherogenesis and promotes atherosclerotic plaque stability in ApoE-null mice.
Volume: 104
Issue: 10
Pages: 1160-8
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Publication
21354197 | J:178581
First Author: Giordano G
Year: 2011
Journal: Toxicol Appl Pharmacol
Title: Paraoxonase 2 (PON2) in the mouse central nervous system: a neuroprotective role?
Volume: 256
Issue: 3
Pages: 369-78
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Publication
16891303 | J:116935
First Author: Ng CJ
Year: 2006
Journal: J Biol Chem
Title: Paraoxonase-2 deficiency aggravates atherosclerosis in mice despite lower apolipoprotein-B-containing lipoproteins: anti-atherogenic role for paraoxonase-2.
Volume: 281
Issue: 40
Pages: 29491-500
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Publication
30241945 | J:273334
First Author: Teiber JF
Year: 2018
Journal: Biochem Biophys Res Commun
Title: Identification of biologically active δ-lactone eicosanoids as paraoxonase substrates.
Volume: 505
Issue: 1
Pages: 87-92
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Publication
22401958 | J:185056
First Author: Belinskaya T
Year: 2012
Journal: Biochim Biophys Acta
Title: Differences in amino acid residues in the binding pockets dictate substrate specificities of mouse senescence marker protein-30, human paraoxonase1, and squid diisopropylfluorophosphatase.
Volume: 1824
Issue: 5
Pages: 701-10
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Publication
22155455 | J:195965
First Author: Khateeb J
Year: 2012
Journal: Arterioscler Thromb Vasc Biol
Title: Urokinase-type plasminogen activator downregulates paraoxonase 1 expression in hepatocytes by stimulating peroxisome proliferator-activated receptor-γ nuclear export.
Volume: 32
Issue: 2
Pages: 449-58
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Publication
24200861 | J:206672
 
First Author: DeGroot DE
Year: 2014
Journal: Arch Biochem Biophys
Title: Lack of ligand-selective binding of the aryl hydrocarbon receptor to putative DNA binding sites regulating expression of Bax and paraoxonase 1 genes.
Volume: 541
Pages: 13-20
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