| Type |
Details |
Score |
| Publication |
| First Author: |
Kelly DP |
| Year: |
2010 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Direct Submission for Tg(tetO-Ppargc1b) 7Dpk |
|
|
|
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Tg(tetO-Ppargc1b)7Dpk/? |
| Background: |
FVB-Tg(tetO-Ppargc1b)7Dpk |
| Zygosity: |
ot |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion T37, Bruce M Spiegelman |
| Allele Type: |
Transgenic |
| Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, mutant strain, transgenic |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, transgenic |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Tg(Ckm-Ppargc1b)T37Brsp/? |
| Background: |
FVB-Tg(Ckm-Ppargc1b)T37Brsp |
| Zygosity: |
ot |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Meirhaeghe A |
| Year: |
2003 |
| Journal: |
Biochem J |
| Title: |
Characterization of the human, mouse and rat PGC1 beta (peroxisome-proliferator-activated receptor-gamma co-activator 1 beta) gene in vitro and in vivo. |
| Volume: |
373 |
| Issue: |
Pt 1 |
| Pages: |
155-65 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kressler D |
| Year: |
2007 |
| Journal: |
J Biol Chem |
| Title: |
Coactivators PGC-1beta and SRC-1 interact functionally to promote the agonist activity of the selective estrogen receptor modulator tamoxifen. |
| Volume: |
282 |
| Issue: |
37 |
| Pages: |
26897-907 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bourdoncle A |
| Year: |
2005 |
| Journal: |
J Mol Biol |
| Title: |
The nuclear receptor coactivator PGC-1alpha exhibits modes of interaction with the estrogen receptor distinct from those of SRC-1. |
| Volume: |
347 |
| Issue: |
5 |
| Pages: |
921-34 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Heery DM |
| Year: |
1997 |
| Journal: |
Nature |
| Title: |
A signature motif in transcriptional co-activators mediates binding to nuclear receptors. |
| Volume: |
387 |
| Issue: |
6634 |
| Pages: |
733-6 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
This entry represents the RNA recognition motif (RRM) of PPARGC1B (also known as PGC-1beta or PERC), which is one of the members of the PGC-1 transcriptional coactivators family, including PGC-1alpha and PGC-1-related coactivator (PRC). PGC-1beta is a tissue-specifically expressed coactivator of selective nuclear receptors and plays a nonredundant role in controlling mitochondrial oxidative energy metabolism and affects both insulin sensitivity and mitochondrial biogenesis, and functions in a number of oxidative tissues [, , ]. PGC-1beta is a multi-domain protein containing an N-terminal activation domain, an LXXLL coactivator signature [], a tetrapeptide motif (DHDY) responsible for HCF binding, two glutamic/aspartic acid-rich acidic domains, and an RNA recognition motif (RRM). In contrast to PGC-1alpha, PGC-1beta lacks most of the arginine/serine (SR)-rich domain that is responsible for the regulation of RNA processing []. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hallenborg P |
| Year: |
2016 |
| Journal: |
Am J Physiol Endocrinol Metab |
| Title: |
p53 regulates expression of uncoupling protein 1 through binding and repression of PPARγ coactivator-1α. |
| Volume: |
310 |
| Issue: |
2 |
| Pages: |
E116-28 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Su Z |
| Year: |
2008 |
| Journal: |
J Lipid Res |
| Title: |
Candidate genes for plasma triglyceride, FFA, and glucose revealed from an intercross between inbred mouse strains NZB/B1NJ and NZW/LacJ. |
| Volume: |
49 |
| Issue: |
7 |
| Pages: |
1500-10 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Filiano AN |
| Year: |
2013 |
| Journal: |
PLoS One |
| Title: |
Chronic ethanol consumption disrupts the core molecular clock and diurnal rhythms of metabolic genes in the liver without affecting the suprachiasmatic nucleus. |
| Volume: |
8 |
| Issue: |
8 |
| Pages: |
e71684 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1014
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1014
 |
| Fragment?: |
false |
|
•
•
•
•
•
|