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Search results 201 to 300 out of 388 for Psen2

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Type Details Score
Publication
25429133 | J:218189
First Author: Watanabe H
Year: 2014
Journal: J Neurosci
Title: Partial loss of presenilin impairs age-dependent neuronal survival in the cerebral cortex.
Volume: 34
Issue: 48
Pages: 15912-22
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24699228 | J:210440
 
First Author: Dong Z
Year: 2014
Journal: Neuroscience
Title: Ibuprofen partially attenuates neurodegenerative symptoms in presenilin conditional double-knockout mice.
Volume: 270
Pages: 58-68
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Publication
28619096 | J:344699
First Author: Lee SH
Year: 2017
Journal: Mol Neurodegener
Title: Presenilins regulate synaptic plasticity and mitochondrial calcium homeostasis in the hippocampal mossy fiber pathway.
Volume: 12
Issue: 1
Pages: 48
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Publication
29229705 | J:258239
First Author: Servián-Morilla E
Year: 2018
Journal: J Neurosci
Title: Proteolytic Processing of Neurexins by Presenilins Sustains Synaptic Vesicle Release.
Volume: 38
Issue: 4
Pages: 901-917
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Publication
24018889 | J:202691
First Author: Su J
Year: 2013
Journal: Int J Mol Sci
Title: Ibuprofen rescues abnormalities in periodontal tissues in conditional presenilin 1 and presenilin 2 double knockout mice.
Volume: 14
Issue: 9
Pages: 18457-69
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Publication
34593029 | J:311553
First Author: Soto-Faguás CM
Year: 2021
Journal: Acta Neuropathol Commun
Title: Loss of presenilin function enhances tau phosphorylation and aggregation in mice.
Volume: 9
Issue: 1
Pages: 162
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Publication
37465679 | J:346978
 
First Author: Yang G
Year: 2023
Journal: Front Immunol
Title: Guizhi Fuling capsule relieves memory deficits by inhibition of microglial neuroinflammation through blocking JAK2/STAT3 pathway in presenilin1/2 conditional double knockout mice.
Volume: 14
Pages: 1185570
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Publication
20854432 | J:166955
First Author: Zhang D
Year: 2010
Journal: J Neurochem
Title: Inactivation of presenilins causes pre-synaptic impairment prior to post-synaptic dysfunction.
Volume: 115
Issue: 5
Pages: 1215-21
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Publication
36710361 | J:344570
First Author: Lee SH
Year: 2023
Journal: Mol Brain
Title: Presenilins regulate synaptic plasticity in the perforant pathways of the hippocampus.
Volume: 16
Issue: 1
Pages: 17
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Publication
22496554 | J:184454
First Author: Watanabe H
Year: 2012
Journal: J Neurosci
Title: Familial frontotemporal dementia-associated presenilin-1 c.548G>T mutation causes decreased mRNA expression and reduced presenilin function in knock-in mice.
Volume: 32
Issue: 15
Pages: 5085-96
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Publication
19376115 | J:148014
First Author: Suzuki Y
Year: 2009
Journal: FEBS Lett
Title: An alternative spliced mouse presenilin-2 mRNA encodes a novel gamma-secretase inhibitor.
Volume: 583
Issue: 9
Pages: 1403-8
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Publication
21206757 | J:168322
First Author: Jayadev S
Year: 2010
Journal: PLoS One
Title: Presenilin 2 is the predominant γ-secretase in microglia and modulates cytokine release.
Volume: 5
Issue: 12
Pages: e15743
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Publication
15280425 | J:92071
First Author: Gowrishankar K
Year: 2004
Journal: J Cell Sci
Title: Release of a membrane-bound death domain by gamma-secretase processing of the p75NTR homolog NRADD.
Volume: 117
Issue: Pt 18
Pages: 4099-111
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Publication
9535056 | J:46769
First Author: Apert C
Year: 1998
Journal: J Neuroendocrinol
Title: Profiles of amyloid precursor and presenilin 2-like proteins are correlated during development of the mouse hypothalamus.
Volume: 10
Issue: 2
Pages: 101-9
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Publication
11719200 | J:73169
First Author: Annaert WG
Year: 2001
Journal: Neuron
Title: Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins.
Volume: 32
Issue: 4
Pages: 579-89
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Publication
10662508 | J:60346
First Author: Nowotny P
Year: 2000
Journal: Mol Cell Neurosci
Title: Posttranslational modification and plasma membrane localization of the Drosophila melanogaster presenilin.
Volume: 15
Issue: 1
Pages: 88-98
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9246482 | J:46334
 
First Author: Sr George-Hyslop PH
Year: 1996
Journal: Cold Spring Harb Symp Quant Biol
Title: Two homologous genes causing early-onset familial Alzheimer's disease.
Volume: 61
Pages: 559-64
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18367332 | J:136646
First Author: Dehvari N
Year: 2008
Journal: Neurosci Lett
Title: Presenilin regulates extracellular regulated kinase (Erk) activity by a protein kinase C alpha dependent mechanism.
Volume: 436
Issue: 1
Pages: 77-80
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Publication
21285369 | J:169222
First Author: Zampese E
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Presenilin 2 modulates endoplasmic reticulum (ER)-mitochondria interactions and Ca2+ cross-talk.
Volume: 108
Issue: 7
Pages: 2777-82
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Publication
22002539 | J:180062
First Author: Ohki Y
Year: 2011
Journal: EMBO J
Title: Phenylpiperidine-type γ-secretase modulators target the transmembrane domain 1 of presenilin 1.
Volume: 30
Issue: 23
Pages: 4815-24
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Publication
22505025 | J:184696
First Author: Chávez-Gutiérrez L
Year: 2012
Journal: EMBO J
Title: The mechanism of γ-Secretase dysfunction in familial Alzheimer disease.
Volume: 31
Issue: 10
Pages: 2261-74
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Publication
22796216 | J:188047
First Author: Kumar A
Year: 2012
Journal: Neurochem Int
Title: Presenilin 1 and 2 are expressed differentially in the cerebral cortex of mice during development.
Volume: 61
Issue: 5
Pages: 778-82
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Publication
28879407 | J:315890
First Author: Ham S
Year: 2018
Journal: Mol Neurobiol
Title: MicroRNA Profiling in Aging Brain of PSEN1/PSEN2 Double Knockout Mice.
Volume: 55
Issue: 6
Pages: 5232-5242
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Publication
22715045 | J:244939
First Author: Lee D
Year: 2012
Journal: Synapse
Title: Presenilin conditional double knockout mice exhibit decreases in drebrin a at hippocampal CA1 synapses.
Volume: 66
Issue: 10
Pages: 870-9
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15951428 | J:99874
First Author: Mastrangelo P
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases.
Volume: 102
Issue: 25
Pages: 8972-7
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Publication
19494151 | J:149506
First Author: Tabuchi K
Year: 2009
Journal: J Neurosci
Title: Conditional forebrain inactivation of nicastrin causes progressive memory impairment and age-related neurodegeneration.
Volume: 29
Issue: 22
Pages: 7290-301
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Publication
15345711 | J:94484
First Author: Beglopoulos V
Year: 2004
Journal: J Biol Chem
Title: Reduced beta-amyloid production and increased inflammatory responses in presenilin conditional knock-out mice.
Volume: 279
Issue: 45
Pages: 46907-14
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Publication
17626841 | J:142929
First Author: Maraver A
Year: 2007
Journal: Blood
Title: Effect of presenilins in the apoptosis of thymocytes and homeostasis of CD8+ T cells.
Volume: 110
Issue: 9
Pages: 3218-25
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Publication
23083742 | J:326644
First Author: Suzuki K
Year: 2012
Journal: Neuron
Title: Activity-dependent proteolytic cleavage of neuroligin-1.
Volume: 76
Issue: 2
Pages: 410-22
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Publication
12388777 | J:79991
First Author: Rozmahel R
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Alleles at the Nicastrin locus modify presenilin 1- deficiency phenotype.
Volume: 99
Issue: 22
Pages: 14452-7
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Publication
25574842 | J:220391
First Author: Maraver A
Year: 2015
Journal: J Clin Invest
Title: NOTCH pathway inactivation promotes bladder cancer progression.
Volume: 125
Issue: 2
Pages: 824-30
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Publication
8922407 | J:36884
First Author: Lee MK
Year: 1996
Journal: J Neurosci
Title: Expression of presenilin 1 and 2 (PS1 and PS2) in human and murine tissues.
Volume: 16
Issue: 23
Pages: 7513-25
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Publication
10537029 | J:59692
First Author: Guénette SY
Year: 1999
Journal: Neurobiol Aging
Title: Progress toward valid transgenic mouse models for Alzheimer's disease.
Volume: 20
Issue: 2
Pages: 201-11
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Publication
8990127 | J:38430
First Author: Berezovska O
Year: 1997
Journal: J Neuropathol Exp Neurol
Title: Developmental regulation of presenilin mRNA expression parallels notch expression.
Volume: 56
Issue: 1
Pages: 40-4
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Publication
10356989 | J:57211
First Author: Sturchler-Pierrat C
Year: 1999
Journal: Rev Neurosci
Title: Transgenic animals in Alzheimer's disease research.
Volume: 10
Issue: 1
Pages: 15-24
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Publication
11756438 | J:75093
First Author: Berechid BE
Year: 2002
Journal: J Biol Chem
Title: Identification and characterization of presenilin-independent Notch signaling.
Volume: 277
Issue: 10
Pages: 8154-65
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Publication
15613480 | J:97070
First Author: Wood DR
Year: 2005
Journal: J Biol Chem
Title: Intracellular retention of caveolin 1 in presenilin-deficient cells.
Volume: 280
Issue: 8
Pages: 6663-8
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Publication
23103503 | J:206556
 
First Author: Neely Kayala KM
Year: 2012
Journal: Brain Res
Title: Presenilin-null cells have altered two-pore calcium channel expression and lysosomal calcium: implications for lysosomal function.
Volume: 1489
Pages: 8-16
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Publication
10854253 | J:79164
First Author: Kashiwa A
Year: 2000
Journal: J Neurochem
Title: Isolation and characterization of novel presenilin binding protein.
Volume: 75
Issue: 1
Pages: 109-16
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Publication
9950750 | J:53093
First Author: Haks MC
Year: 1999
Journal: Semin Immunol
Title: Cell-fate decisions in early T cell development: regulation by cytokine receptors and the pre-TCR.
Volume: 11
Issue: 1
Pages: 23-37
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Publication
19573812 | J:150340
First Author: Demehri S
Year: 2009
Journal: Cancer Cell
Title: Epidermal Notch1 loss promotes skin tumorigenesis by impacting the stromal microenvironment.
Volume: 16
Issue: 1
Pages: 55-66
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Publication
20208556 | J:168265
First Author: Rocher-Ros V
Year: 2010
Journal: Oncogene
Title: Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7.
Volume: 29
Issue: 20
Pages: 2950-61
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Publication
23918386 | J:200916
First Author: Wu B
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Presenilins regulate calcium homeostasis and presynaptic function via ryanodine receptors in hippocampal neurons.
Volume: 110
Issue: 37
Pages: 15091-6
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Publication
12646573 | J:83641
First Author: Chen F
Year: 2003
Journal: J Biol Chem
Title: Presenilin 1 and presenilin 2 have differential effects on the stability and maturation of nicastrin in Mammalian brain.
Volume: 278
Issue: 22
Pages: 19974-9
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Publication
22897852 | J:191822
First Author: Maraver A
Year: 2012
Journal: Cancer Cell
Title: Therapeutic effect of γ-secretase inhibition in KrasG12V-driven non-small cell lung carcinoma by derepression of DUSP1 and inhibition of ERK.
Volume: 22
Issue: 2
Pages: 222-34
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Publication
15066262 | J:89760
First Author: Saura CA
Year: 2004
Journal: Neuron
Title: Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration.
Volume: 42
Issue: 1
Pages: 23-36
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Publication
11943765 | J:76858
First Author: Leem JY
Year: 2002
Journal: J Biol Chem
Title: Presenilin 1 is required for maturation and cell surface accumulation of nicastrin.
Volume: 277
Issue: 21
Pages: 19236-40
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Publication
21597003 | J:177000
First Author: Barthet G
Year: 2011
Journal: FASEB J
Title: Inhibitors of γ-secretase stabilize the complex and differentially affect processing of amyloid precursor protein and other substrates.
Volume: 25
Issue: 9
Pages: 2937-46
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Publication
16641999 | J:108398
First Author: Chen F
Year: 2006
Journal: Nature
Title: TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity.
Volume: 440
Issue: 7088
Pages: 1208-12
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Publication
19457123 | J:150744
First Author: Sevalle J
Year: 2009
Journal: J Neurochem
Title: Pharmacological evidences for DFK167-sensitive presenilin-independent gamma-secretase-like activity.
Volume: 110
Issue: 1
Pages: 275-83
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Publication
11104755 | J:67950
First Author: Kirschenbaum F
Year: 2001
Journal: J Biol Chem
Title: Substitution of a glycogen synthase kinase-3beta phosphorylation site in presenilin 1 separates presenilin function from beta-catenin signaling.
Volume: 276
Issue: 10
Pages: 7366-75
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Publication
15274632 | J:320147
First Author: Fraering PC
Year: 2004
Journal: Biochemistry
Title: Purification and characterization of the human gamma-secretase complex.
Volume: 43
Issue: 30
Pages: 9774-89
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8533168 | J:42424
First Author: Pericak-Vance MA
Year: 1995
Journal: Trends Genet
Title: Genetic susceptibility to Alzheimer disease.
Volume: 11
Issue: 12
Pages: 504-8
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9928488 | J:52884
 
First Author: Price DL
Year: 1998
Journal: Annu Rev Genet
Title: Alzheimer's disease: genetic studies and transgenic models.
Volume: 32
Pages: 461-93
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14717705 | J:97674
First Author: Culvenor JG
Year: 2004
Journal: Eur J Biochem
Title: Characterization of presenilin complexes from mouse and human brain using Blue Native gel electrophoresis reveals high expression in embryonic brain and minimal change in complex mobility with pathogenic presenilin mutations.
Volume: 271
Issue: 2
Pages: 375-85
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18591429 | J:138593
First Author: Green KN
Year: 2008
Journal: J Cell Biol
Title: SERCA pump activity is physiologically regulated by presenilin and regulates amyloid beta production.
Volume: 181
Issue: 7
Pages: 1107-16
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19111578 | J:153382
First Author: Bojarski L
Year: 2009
Journal: Biochim Biophys Acta
Title: Presenilin-dependent expression of STIM proteins and dysregulation of capacitative Ca2+ entry in familial Alzheimer's disease.
Volume: 1793
Issue: 6
Pages: 1050-7
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10206645 | J:54336
First Author: De Strooper B
Year: 1999
Journal: Nature
Title: A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain.
Volume: 398
Issue: 6727
Pages: 518-22
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Publication
18507503 | J:139386
First Author: Demehri S
Year: 2008
Journal: PLoS Biol
Title: Notch-deficient skin induces a lethal systemic B-lymphoproliferative disorder by secreting TSLP, a sentinel for epidermal integrity.
Volume: 6
Issue: 5
Pages: e123
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Publication
16169548 | J:103603
First Author: Pan Y
Year: 2005
Journal: Dev Biol
Title: Notch1 and 2 cooperate in limb ectoderm to receive an early Jagged2 signal regulating interdigital apoptosis.
Volume: 286
Issue: 2
Pages: 472-82
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Publication
11567612 | J:71606
First Author: Yu H
Year: 2001
Journal: Neuron
Title: APP processing and synaptic plasticity in presenilin-1 conditional knockout mice.
Volume: 31
Issue: 5
Pages: 713-26
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27354375 | J:236794
First Author: Ezratty EJ
Year: 2016
Journal: J Cell Biol
Title: A Presenilin-2-ARF4 trafficking axis modulates Notch signaling during epidermal differentiation.
Volume: 214
Issue: 1
Pages: 89-101
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Publication
24145027 | J:209333
First Author: Almenar-Queralt A
Year: 2013
Journal: J Biol Chem
Title: Presenilins regulate neurotrypsin gene expression and neurotrypsin-dependent agrin cleavage via cyclic AMP response element-binding protein (CREB) modulation.
Volume: 288
Issue: 49
Pages: 35222-36
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Publication
- | J:24000
     
First Author: Mouse Chromosome Committee
Year: 1995
Journal: Personal Communication
Title: Personal Communication to Mouse Chromosome Committee
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23924630 | J:204466
First Author: Tadeu AM
Year: 2013
Journal: Development
Title: Notch signaling represses p63 expression in the developing surface ectoderm.
Volume: 140
Issue: 18
Pages: 3777-86
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31577226 | J:290203
   
First Author: Javier-Torrent M
Year: 2019
Journal: Elife
Title: Presenilin/γ-secretase-dependent EphA3 processing mediates axon elongation through non-muscle myosin IIA.
Volume: 8
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Publication
15525534 | J:94517
First Author: Pan Y
Year: 2004
Journal: Dev Cell
Title: gamma-secretase functions through Notch signaling to maintain skin appendages but is not required for their patterning or initial morphogenesis.
Volume: 7
Issue: 5
Pages: 731-43
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24353058 | J:206586
First Author: Boyle SC
Year: 2014
Journal: Development
Title: Notch signaling is required for the formation of mesangial cells from a stromal mesenchyme precursor during kidney development.
Volume: 141
Issue: 2
Pages: 346-54
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Publication
25741723 | J:219929
First Author: Xia D
Year: 2015
Journal: Neuron
Title: Presenilin-1 knockin mice reveal loss-of-function mechanism for familial Alzheimer's disease.
Volume: 85
Issue: 5
Pages: 967-81
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Publication
34990407 | J:321806
 
First Author: Dave JM
Year: 2022
Journal: J Clin Invest
Title: JAGGED1/NOTCH3 activation promotes aortic hypermuscularization and stenosis in elastin deficiency.
Volume: 132
Issue: 5
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28215940 | J:241013
First Author: Grassmeyer J
Year: 2017
Journal: Dev Biol
Title: Elf5 is a principal cell lineage specific transcription factor in the kidney that contributes to Aqp2 and Avpr2 gene expression.
Volume: 424
Issue: 1
Pages: 77-89
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9090377 | J:49041
First Author: Bassett DE Jr
Year: 1997
Journal: Nat Genet
Title: Genome cross-referencing and XREFdb: implications for the identification and analysis of genes mutated in human disease.
Volume: 15
Issue: 4
Pages: 339-44
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21703454 | J:173367
First Author: Ezratty EJ
Year: 2011
Journal: Cell
Title: A role for the primary cilium in Notch signaling and epidermal differentiation during skin development.
Volume: 145
Issue: 7
Pages: 1129-41
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19369394 | J:148019
First Author: Huang J
Year: 2009
Journal: Development
Title: FGF-regulated BMP signaling is required for eyelid closure and to specify conjunctival epithelial cell fate.
Volume: 136
Issue: 10
Pages: 1741-50
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22935613 | J:205544
First Author: Dai D
Year: 2013
Journal: Cell Death Differ
Title: Planar cell polarity effector gene Intu regulates cell fate-specific differentiation of keratinocytes through the primary cilia.
Volume: 20
Issue: 1
Pages: 130-8
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16000382 | J:101173
First Author: Koo BK
Year: 2005
Journal: Development
Title: Mind bomb 1 is essential for generating functional Notch ligands to activate Notch.
Volume: 132
Issue: 15
Pages: 3459-70
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11172053 | J:67552
First Author: Jiang CH
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: The effects of aging on gene expression in the hypothalamus and cortex of mice.
Volume: 98
Issue: 4
Pages: 1930-4
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23341629 | J:193822
First Author: Lumayag S
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration.
Volume: 110
Issue: 6
Pages: E507-16
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- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:104881
     
First Author: The RIKEN BioResource Center
Year: 2006
Journal: Unpublished
Title: Information obtained from The RIKEN BioResource Center
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
- | J:346132
       
First Author: The Gene Ontology Consortium
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
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Publication
24952961 | J:215487
First Author: Thompson CL
Year: 2014
Journal: Neuron
Title: A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Volume: 83
Issue: 2
Pages: 309-323
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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- | J:171409
     
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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