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Search results 201 to 300 out of 366 for Rab27a

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Type Details Score
Publication
First Author: Araki K
Year: 1999
Journal: Cell Mol Biol (Noisy-le-grand)
Title: Exchangeable gene trap using the Cre/mutated lox system.
Volume: 45
Issue: 5
Pages: 737-50
Publication
First Author: Taniwaki T
Year: 2005
Journal: Dev Growth Differ
Title: Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.
Volume: 47
Issue: 3
Pages: 163-72
Publication
First Author: Tang F
Year: 2011
Journal: PLoS One
Title: Deterministic and stochastic allele specific gene expression in single mouse blastomeres.
Volume: 6
Issue: 6
Pages: e21208
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: RIKEN Data Curation in Mouse Genome Informatics
Publication        
First Author: GOA curators, MGI curators
Year: 2001
Title: Gene Ontology annotation based on Enzyme Commission mapping
Publication      
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
Publication      
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
Publication      
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
Publication      
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication        
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
Publication        
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Publication
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication        
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
Publication        
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Publication        
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication
First Author: Johnson JL
Year: 2012
Journal: Mol Biol Cell
Title: Vesicular trafficking through cortical actin during exocytosis is regulated by the Rab27a effector JFC1/Slp1 and the RhoA-GTPase-activating protein Gem-interacting protein.
Volume: 23
Issue: 10
Pages: 1902-16
Publication
First Author: Zhang M
Year: 2016
Journal: J Immunol
Title: A Heterozygous RAB27A Mutation Associated with Delayed Cytolytic Granule Polarization and Hemophagocytic Lymphohistiocytosis.
Volume: 196
Issue: 6
Pages: 2492-503
Publication
First Author: Wang H
Year: 2013
Journal: Mol Biol Cell
Title: The Rab27a effector exophilin7 promotes fusion of secretory granules that have not been docked to the plasma membrane.
Volume: 24
Issue: 3
Pages: 319-30
Publication
First Author: Jiang S
Year: 2016
Journal: J Pathol
Title: GGPPS-mediated Rab27A geranylgeranylation regulates β cell dysfunction during type 2 diabetes development by affecting insulin granule docked pool formation.
Volume: 238
Issue: 1
Pages: 109-19
Interaction Experiment
Description: Rab27a regulates the peripheral distribution of melanosomes in melanocytes.
Interaction Experiment
Description: Synaptotagmin-like protein 5: a novel Rab27A effector with C-terminal tandem C2 domains.
Publication
First Author: Nagashima K
Year: 2002
Journal: FEBS Lett
Title: Melanophilin directly links Rab27a and myosin Va through its distinct coiled-coil regions.
Volume: 517
Issue: 1-3
Pages: 233-8
Publication
First Author: Ménasché G
Year: 2008
Journal: Blood
Title: A newly identified isoform of Slp2a associates with Rab27a in cytotoxic T cells and participates to cytotoxic granule secretion.
Volume: 112
Issue: 13
Pages: 5052-62
Genotype
Symbol: a/a Rab27a/Rab27a
Background: involves: C3H/HeSnJ * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
Allele
Name: RAB27A, member RAS oncogene family; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Publication
First Author: Strom M
Year: 2002
Journal: J Biol Chem
Title: A family of Rab27-binding proteins. Melanophilin links Rab27a and myosin Va function in melanosome transport.
Volume: 277
Issue: 28
Pages: 25423-30
Strain
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
DO Term
Allele
Name: RAB27A, member RAS oncogene family; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
Publication
First Author: Johnson JL
Year: 2005
Journal: Biochem J
Title: The Rab27a-binding protein, JFC1, regulates androgen-dependent secretion of prostate-specific antigen and prostatic-specific acid phosphatase.
Volume: 391
Issue: Pt 3
Pages: 699-710
Publication
First Author: Aizawa T
Year: 2005
Journal: J Clin Invest
Title: Rab27a: a new face in beta cell metabolism-secretion coupling.
Volume: 115
Issue: 2
Pages: 227-30
Publication
First Author: Fukuda M
Year: 2005
Journal: J Biochem
Title: Versatile role of Rab27 in membrane trafficking: focus on the Rab27 effector families.
Volume: 137
Issue: 1
Pages: 9-16
Protein Domain
Type: Family
Description: This entry includes Rab27a and its highly homologous isoform, Rab27b. Unlike most Rab proteins whose functions remain poorly defined, Rab27a has many known functions. Rab27a has multiple effector proteins, and depending on which effector it binds, Rab27a has different functions as well as tissue distribution and/or cellular localization. Putative functions have been assigned to Rab27a when associated with the effector proteins Slp1, Slp2, Slp3, Slp4, Slp5, DmSlp, rabphilin, Dm/Ce-rabphilin, Slac2-a, Slac2-b, Slac2-c, Noc2, JFC1, and Munc13-4 [, ]. Rab27a has been associated with several human diseases, including hemophagocytic syndrome (Griscelli syndrome or GS), Hermansky-Pudlak syndrome, and choroidermia. In the case of GS, a rare, autosomal recessive disease, a Rab27a mutation is directly responsible for the disorder[]. When Rab27a is localized to the secretory granules of pancreatic beta cells, it is believed to mediate glucose-stimulated insulin secretion, making it a potential target for diabetes therapy [, ]. When bound to JFC1 in prostate cells, Rab27a is believed to regulate the exocytosis of prostate- specific markers [].Rabs are regulated by GTPase activating proteins (GAPs), which interact with GTP-bound Rab and accelerate the hydrolysis of GTP to GDP. Guanine nucleotide exchange factors (GEFs) interact with GDP-bound Rabs to promote the formation of the GTP-bound state. Rabs are further regulated by guanine nucleotide dissociation inhibitors (GDIs), which facilitate Rab recycling by masking C-terminal lipid binding and promoting cytosolic localization. Most Rab GTPases contain a lipid modification site at the C terminus, with sequence motifs CC, CXC, or CCX. Lipid binding is essential for membrane attachment, a key feature of most Rab proteins [, ].
Publication
First Author: Yu M
Year: 2007
Journal: Mol Biol Cell
Title: Exophilin4/Slp2-a targets glucagon granules to the plasma membrane through unique Ca2+-inhibitory phospholipid-binding activity of the C2A domain.
Volume: 18
Issue: 2
Pages: 688-96
Allele  
Name: RAB27A, member RAS oncogene family; ashen
Allele Type: Spontaneous
Allele
Name: transgene insertion 84, Miguel C Seabra
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Allele  
Name: RAB27A, member RAS oncogene family; concrete
Allele Type: Chemically induced (ENU)
Publication
First Author: Matsumoto M
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Noc2 is essential in normal regulation of exocytosis in endocrine and exocrine cells.
Volume: 101
Issue: 22
Pages: 8313-8
Publication
First Author: Fukuda M
Year: 2002
Journal: Biochem J
Title: The C2A domain of synaptotagmin-like protein 3 (Slp3) is an atypical calcium-dependent phospholipid-binding machine: comparison with the C2A domain of synaptotagmin I.
Volume: 366
Issue: Pt 2
Pages: 681-7
Publication
First Author: Kurowska M
Year: 2012
Journal: Blood
Title: Terminal transport of lytic granules to the immune synapse is mediated by the kinesin-1/Slp3/Rab27a complex.
Volume: 119
Issue: 17
Pages: 3879-89
Publication
First Author: Kotake K
Year: 1997
Journal: J Biol Chem
Title: Noc2, a putative zinc finger protein involved in exocytosis in endocrine cells.
Volume: 272
Issue: 47
Pages: 29407-10
Publication
First Author: Shanmugam C
Year: 2009
Journal: Biotech Histochem
Title: Immunohistochemical expression of rabphilin-3A-like (Noc2) in normal and tumor tissues of human endocrine pancreas.
Volume: 84
Issue: 2
Pages: 39-45
Protein Domain
Type: Family
Description: Noc2, also known as Rabphilin-3A-like protein, is a potential effector of Ras-associated binding proteins Rab3A and Rab27A [, ]that is involved in the regulation of exocytosis in endocrine and exocrine cells [, , ]. Noc2 may regulate insulin secretion from pancreatic beta-cells and amylase secretion from pancreatic acini [].
Protein Domain
Type: Family
Description: Synaptotagmin-like protein 5 (SYTL5, also known as Slp5) belongs to the synaptotagmin-like protein family, which contains a N-terminal RabBD (Rab-binding) domain and two C-terminal C2 domains. Slp5 interacts with the GTP-bound form of Rab27A both in vitro and in intact cells. It is highly expressed in human placenta and liver. It may be involved in Rab27A-dependent membrane trafficking in specific tissues [].
Protein Domain
Type: Family
Description: Synaptotagmin-like protein 3 (SYTL3, also known as Slp3) belongs to the synaptotagmin-like protein family, which contains a N-terminal RabBD (Rab-binding) domain and two C-terminal C2 domains. Slp3 binds phospholipids in the presence of calcium ions []. In mouse cytotoxic T lymphocytes, Slp3 is an effector of Rab27a and interacts with kinesin-1 through the tetratricopeptide repeat of the kinesin-1 light chain [].
Strain
Attribute String: spontaneous mutation, congenic, mutant strain
Strain
Attribute String: spontaneous mutation, mutant strain, coisogenic
Strain
Attribute String: coisogenic, spontaneous mutation
Strain
Attribute String: F1 hybrid, mutant stock
Strain
Attribute String: mutant strain, congenic, transgenic
Strain
Attribute String: mutant strain, coisogenic, chemically induced mutation
Strain
Attribute String: coisogenic, chemically induced mutation, mutant strain
Genotype
Symbol: Rab27a/Rab27a
Background: involves: C3H/HeDiSn
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Rab27a/Rab27a
Background: C57BL/6-Rab27a
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Rab27a/Rab27a
Background: C3H/HeSn-Rab27a/JRos
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Rab27a/Rab27a
Background: B6.C3Sn-Rab27a
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Rab27a/Rab27a
Background: C3H/HeSn-Rab27a/J
Zygosity: hm
Has Mutant Allele: true
Publication
First Author: Hokanson DE
Year: 2012
Journal: Mol Biol Cell
Title: EPI64 interacts with Slp1/JFC1 to coordinate Rab8a and Arf6 membrane trafficking.
Volume: 23
Issue: 4
Pages: 701-15
Publication
First Author: McAdara Berkowitz JK
Year: 2001
Journal: J Biol Chem
Title: JFC1, a novel tandem C2 domain-containing protein associated with the leukocyte NADPH oxidase.
Volume: 276
Issue: 22
Pages: 18855-62
Protein Domain
Type: Family
Description: Synaptotagmin-like protein 1 (Slp1/Jfc1) acts as a Rab27a effector and plays a role in vesicle trafficking [, ]. Through its interaction with Rab27a, Slp1 also contributes to secretory lysosome exocytosis from cytotoxic T lymphocytes. Slp1 (and Slp2) may form part of a docking complex, capturing secretory lysosomes at the immunological synapse [].Slp1 possesses two C2 domains in tandem, domain C2A showing homology with the C2B domain of synaptotagmins [].
Strain
Attribute String: mutant strain, targeted mutation, spontaneous mutation, congenic
Genotype
Symbol: Rab27a/Rab27a Rab27b/Rab27b
Background: involves: 129X1/SvJ * C3H/HeSn * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Rab27a/Rab27a Rab27b/Rab27b
Background: involves: 129P2/OlaHsd * C3H/He * C3H/HeSn
Zygosity: cx
Has Mutant Allele: true
Publication
First Author: Kuroda TS
Year: 2004
Journal: Nat Cell Biol
Title: Rab27A-binding protein Slp2-a is required for peripheral melanosome distribution and elongated cell shape in melanocytes.
Volume: 6
Issue: 12
Pages: 1195-203
Publication
First Author: Clark CS
Year: 1984
Journal: J Occup Med
Title: Enteric parasites in workers occupationally exposed to sewage.
Volume: 26
Issue: 4
Pages: 273-5
Protein Domain
Type: Family
Description: Synaptotagmin-like protein 2 (SYTL2) belongs to the synaptotagmin-like protein family, which contains a N-terminal RabBD (Rab-binding) domain and two C-terminal C2 domains. RabBD domain mediates interaction with RAB27A and recruitment on to vesicular structures in cytotoxic T-lymphocytes (CTL) [, ]. The C2 domain mediates binding to phosphatidylserine (PS) and phosphatidylinositol 4,5-bisphosphate (PIP2) and localisation to the cell membrane [, ]. SYTL2 has several isoforms produced by alternative splicing, and different isoforms may have different functions.In humans, SYTL2 isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells. Its binding to PS is inhibited by Ca2+ while binding to PIP2 is Ca2+ insensitive [, , ]. In mice, SYTL2 isoform 1 may play a role in melanosome transport and vesicle trafficking. It controls melanosome distribution in the cell periphery and regulates melanocyte morphology [, ]. Isoform 1 also acts as a positive mediator of mucus secretion by the surface mucus cells of the stomach. It mediates basal mucus secretion by gastric surface cells by promoting the proper granule biognesis and docking of mucus granules with the apical plasma membrane []. Isoform 11 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 1 may play a role in melanosome transport and vesicle trafficking. It controls melanosome distribution in the cell periphery and regulates melanocyte morphology.
Protein
Organism: Mus musculus/domesticus
Length: 221  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 218  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 218  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 218  
Fragment?: false
Genotype
Symbol: Mreg/Mreg Rab27a/Rab27a
Background: involves: C3H/HeSn
Zygosity: cx
Has Mutant Allele: true
Publication
First Author: Izumi T
Year: 2003
Journal: Cell Struct Funct
Title: The roles of Rab27 and its effectors in the regulated secretory pathways.
Volume: 28
Issue: 5
Pages: 465-74
Protein
Organism: Mus musculus/domesticus
Length: 529  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 534  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 211  
Fragment?: true