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Search results 201 to 300 out of 308 for Rab7

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Type Details Score
Publication
20100911 | -
First Author: Pankiv S
Year: 2010
Journal: J Cell Biol
Title: FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end-directed vesicle transport.
Volume: 188
Issue: 2
Pages: 253-69
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Strain
MGI:6448097 | B6(Cg)-Gt(ROSA)26Sor<tm1.1(CMV-Rab7)Zmx>/J
Attribute String: mutant strain, targeted mutation
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Protein
F6X2I0
Organism: Mus musculus/domesticus
Length: 141  
Fragment?: true
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Protein
F6RDF1
Organism: Mus musculus/domesticus
Length: 134  
Fragment?: true
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Protein Domain
IPR021563 | RILP_dimer
Type: Domain
Description: Rab interacting lysosomal protein (RILP) contains a domain which contains two coiled-coil regions and is found mainly in the cytosol. RILP is recruited onto late endosomal and lysosomal membranes by Rab7 and acts as a downstream effector of Rab7 []. This recruitment process is important for phagosome maturation and fusion with late endosomes and lysosomes.
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Protein Domain
IPR040371 | RMC1
Type: Family
Description: RMC1 is a componement of the the CCZ1-MON1 complex, which functions as a guanine exchange factor (GEF) for RAB7 during endocytic and autophagic flux to the lysosome. It positively regulates CCZ1-MON1 function that is necessary for endosomal/autophagic flux and efficient RAB7 localization on CD63-positive vesicle membranes [].
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Publication
25498145 | J:219629
First Author: McEwan DG
Year: 2015
Journal: Mol Cell
Title: PLEKHM1 regulates autophagosome-lysosome fusion through HOPS complex and LC3/GABARAP proteins.
Volume: 57
Issue: 1
Pages: 39-54
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Protein
A0A3Q4EGY8
Organism: Mus musculus/domesticus
Length: 121  
Fragment?: true
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Protein
A0A3Q4EBT5
Organism: Mus musculus/domesticus
Length: 131  
Fragment?: true
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Publication
29038162 | -
     
First Author: Pontano Vaites L
Year: 2017
Journal: Mol Cell Biol
Title: Systematic analysis of human cells lacking ATG8 proteins uncovers roles for GABARAPs and the CCZ1/MON1 regulator C18orf8/RMC1 in macro and selective autophagic flux.
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Publication
11856727 | J:83919
First Author: Fukuda M
Year: 2002
Journal: J Biol Chem
Title: Slac2-a/melanophilin, the missing link between Rab27 and myosin Va: implications of a tripartite protein complex for melanosome transport.
Volume: 277
Issue: 14
Pages: 12432-6
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Publication
10025966 | J:52578
First Author: Cottage A
Year: 1999
Journal: FEBS Lett
Title: Three receptor genes for plasminogen related growth factors in the genome of the puffer fish Fugu rubripes.
Volume: 443
Issue: 3
Pages: 370-4
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Publication
15647795 | -
First Author: Cottage A
Year: 2004
Journal: Cell Mol Biol Lett
Title: Molecular characterisation of the SAND protein family: a study based on comparative genomics, structural bioinformatics and phylogeny.
Volume: 9
Issue: 4A
Pages: 739-53
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Publication
24623720 | -
First Author: Lawrence G
Year: 2014
Journal: Mol Biol Cell
Title: Dynamic association of the PI3P-interacting Mon1-Ccz1 GEF with vacuoles is controlled through its phosphorylation by the type 1 casein kinase Yck3.
Volume: 25
Issue: 10
Pages: 1608-19
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Protein Domain
IPR004353 | Mon1
Type: Family
Description: Members of this family have been called SAND proteins []although these proteins do not contain a SAND domain. In Saccharomyces cerevisiae, Mon1 is part of the Mon1-Ccz1 complex that acts as the guanine nucleotide exchange factor (GEF) of the yeast Rab7 GTPase Ypt7 [, ]. The Mon1/Ccz1 complex is conserved in eukaryotic evolution and members of this family (previously known as DUF254) are distant homologues to domains of known structure that assemble into cargo vesicle adapter (AP) complexes [, ].
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Publication
16923123 | J:123368
First Author: Itoh T
Year: 2006
Journal: Genes Cells
Title: Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16) domain-containing proteins based on their Rab-binding activity.
Volume: 11
Issue: 9
Pages: 1023-37
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Publication
11773082 | J:75312
First Author: Kuroda TS
Year: 2002
Journal: J Biol Chem
Title: The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain.
Volume: 277
Issue: 11
Pages: 9212-8
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Protein
A0A0G2JFP1
Organism: Mus musculus/domesticus
Length: 193  
Fragment?: true
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Protein
A0A0G2JES6
Organism: Mus musculus/domesticus
Length: 196  
Fragment?: true
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Publication
15933719 | -
First Author: Wu M
Year: 2005
Journal: EMBO J
Title: Structural basis for recruitment of RILP by small GTPase Rab7.
Volume: 24
Issue: 8
Pages: 1491-501
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Publication
19995552 | -
First Author: Lin WJ
Year: 2010
Journal: Biochem Biophys Res Commun
Title: Phafin2 modulates the structure and function of endosomes by a Rab5-dependent mechanism.
Volume: 391
Issue: 1
Pages: 1043-8
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Publication
22816767 | -
First Author: Pedersen NM
Year: 2012
Journal: Traffic
Title: The PtdIns3P-binding protein Phafin 2 mediates epidermal growth factor receptor degradation by promoting endosome fusion.
Volume: 13
Issue: 11
Pages: 1547-63
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Protein Domain
IPR037871 | PH_Phafin
Type: Domain
Description: Phafin1 (also known as PLEKHF1 or LAPF) recruits phosphorylated p53 to lysosomes and triggers caspase-independent apoptosis. It is also is involved in lysosomal sorting and induction of autophagosome formation via Rab7 signaling []. Phafin2 (also called EAPF, FLJ13187, ZFYVE18 or PLEKHF2) is differentially expressed in the liver cancer cell and regulates the structure and function of the endosomes through Rab5-dependent processes []. Phafin2 modulates the cell's response to extracellular stimulation by modulating the receptor density on the cell surface [].Phafin1 and Phafin2 are composed of both PH and FYVE domains. Phafin1 has an additional C-terminal tail domain. Phafin1, but not phafin2, exhibits significant binding to PI(4)P and PI(5)P []. This entry represents the PH domain of phafin 1 and 2.
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Publication
12578829 | J:83108
First Author: Fukuda M
Year: 2003
Journal: J Biol Chem
Title: Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2.
Volume: 278
Issue: 17
Pages: 15373-80
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Publication
33157038 | J:302472
First Author: Ghosh S
Year: 2020
Journal: Cell
Title: β-Coronaviruses Use Lysosomes for Egress Instead of the Biosynthetic Secretory Pathway.
Volume: 183
Issue: 6
Pages: 1520-1535.e14
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Publication
32363189 | J:291069
 
First Author: Zhang X
Year: 2020
Journal: Front Cell Dev Biol
Title: CD38 Causes Autophagic Flux Inhibition and Cardiac Dysfunction Through a Transcriptional Inhibition Pathway Under Hypoxia/Ischemia Conditions.
Volume: 8
Pages: 191
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Publication
36190447 | J:353316
 
First Author: Liu N
Year: 2022
Journal: J Cell Biol
Title: WDR91 specifies the endosomal retrieval subdomain for retromer-dependent recycling.
Volume: 221
Issue: 12
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Publication
36465123 | J:332007
First Author: Morita K
Year: 2022
Journal: iScience
Title: PDZD8-deficient mice accumulate cholesteryl esters in the brain as a result of impaired lipophagy.
Volume: 25
Issue: 12
Pages: 105612
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Publication
18375996 | J:138460
First Author: Ahras M
Year: 2008
Journal: J Lipid Res
Title: Scavenger receptor class B type I localizes to a late endosomal compartment.
Volume: 49
Issue: 7
Pages: 1569-76
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Publication
20805499 | J:164362
First Author: Tu C
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Endosomal-sorting complexes required for transport (ESCRT) pathway-dependent endosomal traffic regulates the localization of active Src at focal adhesions.
Volume: 107
Issue: 37
Pages: 16107-12
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Publication
21925142 | J:177516
First Author: Tower-Gilchrist C
Year: 2011
Journal: Biochem Biophys Res Commun
Title: Endosomal trafficking of the G protein-coupled receptor somatostatin receptor 3.
Volume: 413
Issue: 4
Pages: 555-60
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Protein
Q5ND29
Organism: Mus musculus/domesticus
Length: 369  
Fragment?: false
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Protein
Q8VC42
Organism: Mus musculus/domesticus
Length: 657  
Fragment?: false
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Protein
Q9JJC6
Organism: Mus musculus/domesticus
Length: 406  
Fragment?: false
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Protein
Q99LE1
Organism: Mus musculus/domesticus
Length: 197  
Fragment?: false
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Protein
Q3TWH4
Organism: Mus musculus/domesticus
Length: 657  
Fragment?: false
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Protein
Q3UMX3
Organism: Mus musculus/domesticus
Length: 657  
Fragment?: false
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Protein
A0A3Q4EG84
Organism: Mus musculus/domesticus
Length: 305  
Fragment?: false
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Protein
Q3U4H5
Organism: Mus musculus/domesticus
Length: 657  
Fragment?: false
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Protein
Q14AQ2
Organism: Mus musculus/domesticus
Length: 369  
Fragment?: false
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Publication
30704899 | J:272052
First Author: Cheng X
Year: 2019
Journal: Mol Cell
Title: Pacer Is a Mediator of mTORC1 and GSK3-TIP60 Signaling in Regulation of Autophagosome Maturation and Lipid Metabolism.
Volume: 73
Issue: 4
Pages: 788-802.e7
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Protein
Q3TD16
Organism: Mus musculus/domesticus
Length: 648  
Fragment?: false
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Protein
F8WGX2
Organism: Mus musculus/domesticus
Length: 675  
Fragment?: false
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Protein
A0A0B6VSG3
Organism: Mus musculus/domesticus
Length: 66  
Fragment?: true
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Protein
Q3U2M6
Organism: Mus musculus/domesticus
Length: 675  
Fragment?: false
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Protein
A0A0B6VQN9
Organism: Mus musculus/domesticus
Length: 67  
Fragment?: true
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Protein
Q7TPZ3
Organism: Mus musculus/domesticus
Length: 675  
Fragment?: false
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Protein
D5MR38
Organism: Mus musculus/domesticus
Length: 70  
Fragment?: true
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Publication
20943950 | -
First Author: Tabata K
Year: 2010
Journal: Mol Biol Cell
Title: Rubicon and PLEKHM1 negatively regulate the endocytic/autophagic pathway via a novel Rab7-binding domain.
Volume: 21
Issue: 23
Pages: 4162-72
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Publication
32632011 | -
First Author: Bhargava HK
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Structural basis for autophagy inhibition by the human Rubicon-Rab7 complex.
Volume: 117
Issue: 29
Pages: 17003-17010
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Publication
33854187 | -
First Author: Nah J
Year: 2021
Journal: Exp Mol Med
Title: The roles of the inhibitory autophagy regulator Rubicon in the heart: A new therapeutic target to prevent cardiac cell death.
Volume: 53
Issue: 4
Pages: 528-536
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Publication
30581147 | -
First Author: Chang C
Year: 2019
Journal: Mol Cell
Title: Bidirectional Control of Autophagy by BECN1 BARA Domain Dynamics.
Volume: 73
Issue: 2
Pages: 339-353.e6
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Publication
27291868 | -
First Author: Bo T
Year: 2016
Journal: J Bone Miner Res
Title: Characterization of a Relatively Malignant Form of Osteopetrosis Caused by a Novel Mutation in the PLEKHM1 Gene.
Volume: 31
Issue: 11
Pages: 1979-1987
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Publication
28306502 | -
First Author: Cheng X
Year: 2017
Journal: Mol Cell
Title: Pacer Mediates the Function of Class III PI3K and HOPS Complexes in Autophagosome Maturation by Engaging Stx17.
Volume: 65
Issue: 6
Pages: 1029-1043.e5
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Publication
30917850 | J:357800
First Author: Beltran S
Year: 2019
Journal: Mol Neurodegener
Title: Network approach identifies Pacer as an autophagy protein involved in ALS pathogenesis.
Volume: 14
Issue: 1
Pages: 14
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Protein Domain
IPR025258 | RH_dom
Type: Domain
Description: This is the Rubicon homology domain (RH) characterised at the C-terminal of Rubicon, PLEKHM1 and Pacer, proteins that modulate late steps in autophagy [, ]. Rubicon (RUBCN) negatively regulates autophagy and endolysosomal trafficking by inhibiting PI3K complex II (PI3KC3-C2), which impairs autophagosome maturation process. Decrease in autophagy is associated to aging, then suppression of this process by Rubicon has been linked to decreased clearance of alpha-synuclein aggregates in neural tissues, impairment of liver cell homeostasis, and interstitial fibrosis in the kidney. PLEKHM1 is an adapter protein that regulates Rab7-dependent and HOPS complex-dependent fusion events in the endolysosomal system and couples autophagic and the endocytic trafficking pathways [, ], being involved in the suppression of endocytic transport rather than autophagosome maturation. Mutations in PLEKHM1 causes osteopetrosis []. On the other hand, Pacer (Protein associated with UVRAG as autophagy enhancer or Rubicon-like) positively regulates autophagy, promoting autophagosome maturation by facilitating the biogenesis of phosphatidylinositol 3-phosphate (PtdIns3P) in late steps of autophagy [, ]. It antagonizes RUBCN, thereby stimulating phosphatidylinositol 3-kinase activity of the PI3K/PI3KC3 complex []. Pacer is involved in neuronal autophagy, whose deficiency leads to impaired autophagy and accumulation of protein aggregates in ALS which correlates with cell death and vulnerability of motoneurons during ALS pathogenesis [].This domain contains nine conserved cysteines and one conserved histidine, which have been predicted to bind divalent zinc cations, being required for Rubicon and PLEKHM1 to interact with Rab7 [, ].
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Publication
22841712 | J:188709
First Author: Ninkovic M
Year: 2012
Journal: FEBS Lett
Title: Physical and functional interaction of KV10.1 with Rabaptin-5 impacts ion channel trafficking.
Volume: 586
Issue: 19
Pages: 3077-84
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Publication
33193444 | J:313494
 
First Author: Yin C
Year: 2020
Journal: Front Immunol
Title: Efferocytic Defects in Early Atherosclerosis Are Driven by GATA2 Overexpression in Macrophages.
Volume: 11
Pages: 594136
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Publication
35198070 | J:327457
First Author: Cai CZ
Year: 2022
Journal: Theranostics
Title: Enhancing autophagy maturation with CCZ1-MON1A complex alleviates neuropathology and memory defects in Alzheimer disease models.
Volume: 12
Issue: 4
Pages: 1738-1755
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Publication
37300531 | J:339181
First Author: Feng L
Year: 2023
Journal: Glia
Title: Microglial LRRK2-mediated NFATc1 attenuates α-synuclein immunotoxicity in association with CX3CR1-induced migration and the lysosome-initiated degradation.
Volume: 71
Issue: 9
Pages: 2266-2284
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Publication
28067668 | J:239830
First Author: Hirai M
Year: 2017
Journal: J Clin Invest
Title: Adaptor proteins NUMB and NUMBL promote cell cycle withdrawal by targeting ERBB2 for degradation.
Volume: 127
Issue: 2
Pages: 569-582
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Publication
24683188 | J:209973
First Author: Shen KY
Year: 2014
Journal: J Immunol
Title: Molecular mechanisms of TLR2-mediated antigen cross-presentation in dendritic cells.
Volume: 192
Issue: 9
Pages: 4233-41
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Publication
17245426 | J:141672
First Author: Huynh KK
Year: 2007
Journal: EMBO J
Title: LAMP proteins are required for fusion of lysosomes with phagosomes.
Volume: 26
Issue: 2
Pages: 313-24
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Publication
22619176 | J:188865
First Author: Zhao T
Year: 2012
Journal: J Biol Chem
Title: Central role of mitofusin 2 in autophagosome-lysosome fusion in cardiomyocytes.
Volume: 287
Issue: 28
Pages: 23615-25
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Publication
21986281 | J:189459
First Author: Su H
Year: 2011
Journal: Circulation
Title: COP9 signalosome regulates autophagosome maturation.
Volume: 124
Issue: 19
Pages: 2117-28
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Publication
35962060 | J:332139
First Author: Shimozono K
Year: 2022
Journal: J Hum Genet
Title: Ubap1 knock-in mice reproduced the phenotype of SPG80.
Volume: 67
Issue: 12
Pages: 679-686
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Publication
23197834 | J:193112
First Author: Kasmapour B
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Size-dependent mechanism of cargo sorting during lysosome-phagosome fusion is controlled by Rab34.
Volume: 109
Issue: 50
Pages: 20485-90
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Publication
31682603 | J:281946
First Author: Leng C
Year: 2019
Journal: PLoS Biol
Title: Loss of MYO5B expression deregulates late endosome size which hinders mitotic spindle orientation.
Volume: 17
Issue: 11
Pages: e3000531
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Publication
33159835 | J:324481
First Author: Zhang H
Year: 2020
Journal: IUBMB Life
Title: Atg16l1 in dendritic cells is required for antibacterial defense and autophagy in murine colitis.
Volume: 72
Issue: 12
Pages: 2686-2695
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Publication
35589873 | J:336042
First Author: Matsumoto N
Year: 2022
Journal: Sci Rep
Title: The lysosomal V-ATPase a3 subunit is involved in localization of Mon1-Ccz1, the GEF for Rab7, to secretory lysosomes in osteoclasts.
Volume: 12
Issue: 1
Pages: 8455
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Publication
35499056 | J:351294
 
First Author: Liu Y
Year: 2022
Journal: J Adv Res
Title: Leucine-rich repeat kinase-2 deficiency protected against cardiac remodelling in mice via regulating autophagy formation and degradation.
Volume: 37
Pages: 107-117
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Publication
12559036 | J:230359
First Author: Cormont M
Year: 2003
Journal: Traffic
Title: CD2AP/CMS regulates endosome morphology and traffic to the degradative pathway through its interaction with Rab4 and c-Cbl.
Volume: 4
Issue: 2
Pages: 97-112
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Publication
20947830 | J:178511
First Author: Hariharan N
Year: 2010
Journal: Circ Res
Title: Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes.
Volume: 107
Issue: 12
Pages: 1470-82
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Publication
22718342 | J:198881
First Author: Lei N
Year: 2012
Journal: J Cell Sci
Title: Flightless, secreted through a late endosome/lysosome pathway, binds LPS and dampens cytokine secretion.
Volume: 125
Issue: Pt 18
Pages: 4288-96
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Publication
25180605 | J:217637
First Author: Okon IS
Year: 2014
Journal: J Clin Invest
Title: Protein kinase LKB1 promotes RAB7-mediated neuropilin-1 degradation to inhibit angiogenesis.
Volume: 124
Issue: 10
Pages: 4590-602
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Publication
27453211 | J:237216
First Author: Oetjen S
Year: 2016
Journal: J Neurochem
Title: Revisiting the neuronal localization and trafficking of CLN3 in juvenile neuronal ceroid lipofuscinosis.
Volume: 139
Issue: 3
Pages: 456-470
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Publication
26741505 | J:311027
First Author: Wu B
Year: 2016
Journal: Oncotarget
Title: Aldehyde dehydrogenase 2 activation in aged heart improves the autophagy by reducing the carbonyl modification on SIRT1.
Volume: 7
Issue: 3
Pages: 2175-88
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Publication
19407341 | J:151193
First Author: Hoshino T
Year: 2009
Journal: J Biol Chem
Title: Prostaglandin E2 stimulates the production of amyloid-beta peptides through internalization of the EP4 receptor.
Volume: 284
Issue: 27
Pages: 18493-502
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Publication
35153674 | J:325884
 
First Author: Xie D
Year: 2021
Journal: Front Cell Neurosci
Title: Autophagy Contributes to the Rapamycin-Induced Improvement of Otitis Media.
Volume: 15
Pages: 753369
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Publication
28182007 | J:258713
First Author: Girault V
Year: 2017
Journal: Cell Death Dis
Title: Prenatal alcohol exposure impairs autophagy in neonatal brain cortical microvessels.
Volume: 8
Issue: 2
Pages: e2610
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Publication
30354215 | J:285072
First Author: Lo RW
Year: 2018
Journal: Arterioscler Thromb Vasc Biol
Title: NBEAL2 (Neurobeachin-Like 2) Is Required for Retention of Cargo Proteins by α-Granules During Their Production by Megakaryocytes.
Volume: 38
Issue: 10
Pages: 2435-2447
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Publication
10491170 | J:354374
First Author: Alexandrov K
Year: 1999
Journal: Eur J Biochem
Title: Characterization of the ternary complex between Rab7, REP-1 and Rab geranylgeranyl transferase.
Volume: 265
Issue: 1
Pages: 160-70
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Publication
32553594 | J:293688
 
First Author: Qi L
Year: 2020
Journal: J Mol Cell Cardiol
Title: CYLD exaggerates pressure overload-induced cardiomyopathy via suppressing autolysosome efflux in cardiomyocytes.
Volume: 145
Pages: 59-73
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Protein
Q99J78
Organism: Mus musculus/domesticus
Length: 448  
Fragment?: false
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Protein
Q80U62
Organism: Mus musculus/domesticus
Length: 956  
Fragment?: false
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Protein
A0A0R4J2D4
Organism: Mus musculus/domesticus
Length: 461  
Fragment?: false
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Protein
A0A0R4IZW6
Organism: Mus musculus/domesticus
Length: 460  
Fragment?: false
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Protein
D3Z7B1
Organism: Mus musculus/domesticus
Length: 880  
Fragment?: false
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Protein
G3X9U5
Organism: Mus musculus/domesticus
Length: 472  
Fragment?: false
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Publication
36967828 | J:345221
 
First Author: Gao T
Year: 2023
Journal: Front Aging Neurosci
Title: Protective effects of intrathecal injection of AAV9-RabGGTB-GFP(+) in SOD1(G93A) mice.
Volume: 15
Pages: 1092607
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Publication
32518187 | J:303379
 
First Author: Wang J
Year: 2020
Journal: mBio
Title: Integrin α5β1, as a Receptor of Fibronectin, Binds the FbaA Protein of Group A Streptococcus To Initiate Autophagy during Infection.
Volume: 11
Issue: 3
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Publication
30892128 | J:319592
First Author: Fedeli C
Year: 2019
Journal: Autophagy
Title: PSEN2 (presenilin 2) mutants linked to familial Alzheimer disease impair autophagy by altering Ca2+ homeostasis.
Volume: 15
Issue: 12
Pages: 2044-2062
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Protein
Q6PDG8
Organism: Mus musculus/domesticus
Length: 556  
Fragment?: false
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Protein
Q8BMQ8
Organism: Mus musculus/domesticus
Length: 553  
Fragment?: false
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Protein
A0A0R4J0D5
Organism: Mus musculus/domesticus
Length: 556  
Fragment?: false
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Publication
32160108 | J:324480
First Author: Wu MY
Year: 2021
Journal: Autophagy
Title: PI3KC3 complex subunit NRBF2 is required for apoptotic cell clearance to restrict intestinal inflammation.
Volume: 17
Issue: 5
Pages: 1096-1111
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Protein
Q8BM47
Organism: Mus musculus/domesticus
Length: 761  
Fragment?: false
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Publication
17075139 | -
First Author: Kinch LN
Year: 2006
Journal: Protein Sci
Title: Longin-like folds identified in CHiPS and DUF254 proteins: vesicle trafficking complexes conserved in eukaryotic evolution.
Volume: 15
Issue: 11
Pages: 2669-74
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Protein
Q7TSI1
Organism: Mus musculus/domesticus
Length: 1074  
Fragment?: false
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Protein
Q3TB82
Organism: Mus musculus/domesticus
Length: 279  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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