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Search results 201 to 300 out of 2424 for Ran

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Type Details Score
GXD Expression
GXD Expression
 
Probe: MGI:3029296
Assay Type: RNA in situ
Annotation Date: 2004-03-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1611511
Pattern: Not Specified
Stage: TS11
Assay Id: MGI:3029300
Age: embryonic day 7.5
Image: 1D
Specimen Label: 1D
Detected: true
Specimen Num: 4
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•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:3029296
Assay Type: RNA in situ
Annotation Date: 2004-03-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1725519
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:3029300
Age: embryonic day 11.5
Image: 3G
Note: Expression is in the dorsal and ventral mesenchyme.
Specimen Label: 3G
Detected: true
Specimen Num: 21
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3029296
Assay Type: RNA in situ
Annotation Date: 2004-03-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3273713
Pattern: Not Specified
Stage: TS13
Assay Id: MGI:3029300
Age: embryonic day 8.5
Image: 2A
Specimen Label: 2A
Detected: true
Specimen Num: 7
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:3029296
Assay Type: RNA in situ
Annotation Date: 2004-03-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1725219
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:3029300
Age: embryonic day 11.5
Image: 3G
Note: Expression is in the dorsal and ventral mesenchyme.
Specimen Label: 3G
Detected: true
Specimen Num: 21
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:3029296
Assay Type: RNA in situ
Annotation Date: 2004-03-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1715219
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:3029300
Age: embryonic day 11.5
Image: 3H
Note: Expression is in the germ layer within the encephalic vesicle walls.
Specimen Label: 3H
Detected: true
Specimen Num: 22
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•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3029296
Assay Type: RNA in situ
Annotation Date: 2004-03-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1632213
Pattern: Not Specified
Stage: TS13
Assay Id: MGI:3029300
Age: embryonic day 8.5
Image: 2A1
Specimen Label: 2A1
Detected: true
Specimen Num: 8
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:1468472
Assay Type: RNA in situ
Annotation Date: 2010-08-18
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3580628
Stage: TS28
Assay Id: MGI:4819567
Age: postnatal adult
Image: 2Ba
Specimen Label: 2Ba
Detected: false
Specimen Num: 8
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:3029296
Assay Type: RNA in situ
Annotation Date: 2004-03-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267919
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:3029300
Age: embryonic day 11.5
Image: 3A
Note: Expression is in the germ layer within the encephalic vesicle walls.
Specimen Label: 3A
Detected: true
Specimen Num: 15
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3029296
Assay Type: RNA in situ
Annotation Date: 2004-03-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757721
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:3029300
Age: embryonic day 13.5
Image: 4A
Specimen Label: 4A
Detected: true
Specimen Num: 24
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1468472
Assay Type: RNA in situ
Annotation Date: 2010-08-18
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1757726
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:4819567
Age: embryonic day 19.0
Image: 1G
Specimen Label: 1G
Detected: true
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3029296
Assay Type: RNA in situ
Annotation Date: 2004-03-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1652314
Pattern: Not Specified
Stage: TS14
Assay Id: MGI:3029300
Age: embryonic day 9.0
Image: 2C
Specimen Label: 2C
Detected: true
Specimen Num: 12
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3029296
Assay Type: RNA in situ
Annotation Date: 2004-03-03
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1618412
Pattern: Not Specified
Stage: TS12
Assay Id: MGI:3029300
Age: embryonic day 8.0
Image: 1G
Specimen Label: 1G
Detected: true
Specimen Num: 6
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3029296
Assay Type: RNA in situ
Annotation Date: 2004-03-03
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1618413
Pattern: Not Specified
Stage: TS13
Assay Id: MGI:3029300
Age: embryonic day 8.5
Image: 2A2
Specimen Label: 2A2
Detected: true
Specimen Num: 9
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3029296
Assay Type: RNA in situ
Annotation Date: 2004-03-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1654014
Pattern: Not Specified
Stage: TS14
Assay Id: MGI:3029300
Age: embryonic day 9.0
Image: 2C
Specimen Label: 2C
Detected: true
Specimen Num: 12
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3029296
Assay Type: RNA in situ
Annotation Date: 2004-03-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1654015
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:3029300
Age: embryonic day 9.5
Image: 2D1
Specimen Label: 2D1
Detected: true
Specimen Num: 14
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3029296
Assay Type: RNA in situ
Annotation Date: 2004-03-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1680516
Pattern: Not Specified
Stage: TS16
Assay Id: MGI:3029300
Age: embryonic day 10.0
Image: 2B
Specimen Label: 2B
Detected: true
Specimen Num: 11
•
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•
•
GXD Expression
GXD Expression
 
Probe: MGI:1468472
Assay Type: RNA in situ
Annotation Date: 2010-08-18
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:4819567
Age: embryonic day 19.0
Image: 1G
Specimen Label: 1G
Detected: true
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1468472
Assay Type: RNA in situ
Annotation Date: 2010-08-18
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3586328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:4819567
Age: postnatal adult
Image: 2Aa
Specimen Label: 2Aa
Detected: true
Specimen Num: 7
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3029296
Assay Type: RNA in situ
Annotation Date: 2004-03-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1638816
Pattern: Not Specified
Stage: TS16
Assay Id: MGI:3029300
Age: embryonic day 10.0
Image: 2B
Specimen Label: 2B
Detected: true
Specimen Num: 11
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3029296
Assay Type: RNA in situ
Annotation Date: 2004-03-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1638814
Pattern: Not Specified
Stage: TS14
Assay Id: MGI:3029300
Age: embryonic day 9.0
Image: 2C
Specimen Label: 2C
Detected: true
Specimen Num: 12
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3029296
Assay Type: RNA in situ
Annotation Date: 2004-03-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1638815
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:3029300
Age: embryonic day 9.5
Image: 2D1
Specimen Label: 2D1
Detected: true
Specimen Num: 14
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:1468472
Assay Type: RNA in situ
Annotation Date: 2010-08-18
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1881225
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:4819567
Age: embryonic day 17.0
Image: 1F
Note: Authors report expression in the submaxillary gland.
Specimen Label: 1F
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:1468472
Assay Type: RNA in situ
Annotation Date: 2010-08-18
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1881228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:4819567
Age: postnatal day 10
Image: 1H
Note: Authors report expression in the submaxillary gland.
Specimen Label: 1H
Detected: true
Specimen Num: 6
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:3029296
Assay Type: RNA in situ
Annotation Date: 2004-03-03
Strength: Present
Sex: Male
Emaps: EMAPS:1657719
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:3029300
Age: embryonic day 11.5
Image: 3I
Note: Expression is in the mesonephric duct.
Specimen Label: 3I
Detected: true
Specimen Num: 23
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Publication
11424209 | J:69886
First Author: Mangos S
Year: 2001
Journal: Mol Reprod Dev
Title: Ran binding protein RanBP1 in zebrafish embryonic development.
Volume: 59
Issue: 3
Pages: 235-48
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Publication
21874009 | J:176957
First Author: Yi K
Year: 2011
Journal: Nat Cell Biol
Title: Dynamic maintenance of asymmetric meiotic spindle position through Arp2/3-complex-driven cytoplasmic streaming in mouse oocytes.
Volume: 13
Issue: 10
Pages: 1252-8
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Publication
8314081 | J:16895
First Author: DeGregori J
Year: 1994
Journal: Genes Dev
Title: A murine homolog of the yeast RNA1 gene is required for postimplantation development.
Volume: 8
Issue: 3
Pages: 265-76
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Publication
9851930 | J:51522
First Author: Poltorak A
Year: 1998
Journal: Science
Title: Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene.
Volume: 282
Issue: 5396
Pages: 2085-8
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Publication
11809816 | J:74290
First Author: Plafker SM
Year: 2002
Journal: Mol Cell Biol
Title: Ribosomal protein L12 uses a distinct nuclear import pathway mediated by importin 11.
Volume: 22
Issue: 4
Pages: 1266-75
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Publication
8299717 | J:16595
First Author: Dietrich JM
Year: 1994
Journal: Exp Cell Res
Title: Analysis of the factors involved in the retinoic acid-induced differentiation of a retinoid-hypersensitive embryonal carcinoma cell mutant.
Volume: 210
Issue: 2
Pages: 201-8
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Publication
22504302 | J:183927
First Author: Cho S
Year: 2012
Journal: Gene Expr Patterns
Title: Dynamics of Setdb1 expression in early mouse development.
Volume: 12
Issue: 5-6
Pages: 213-8
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Publication
15689618 | J:98705
First Author: Sakakida Y
Year: 2005
Journal: J Biol Chem
Title: Importin alpha/beta mediates nuclear transport of a mammalian circadian clock component, mCRY2, together with mPER2, through a bipartite nuclear localization signal.
Volume: 280
Issue: 14
Pages: 13272-8
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Publication
17397913 | J:211548
First Author: Zhao Y
Year: 2007
Journal: Cell
Title: Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2.
Volume: 129
Issue: 2
Pages: 303-17
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Publication
16420439 | J:105375
First Author: Ajioka I
Year: 2006
Journal: Eur J Neurosci
Title: Identification of ventricular-side-enriched molecules regulated in a stage-dependent manner during cerebral cortical development.
Volume: 23
Issue: 2
Pages: 296-308
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Publication
16919471 | J:116586
First Author: Li H
Year: 2006
Journal: Mol Cell Neurosci
Title: Potential target genes of EMX2 include Odz/Ten-M and other gene families with implications for cortical patterning.
Volume: 33
Issue: 2
Pages: 136-49
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Publication
14651920 | J:86843
First Author: Easterday MC
Year: 2003
Journal: Dev Biol
Title: Neural progenitor genes. Germinal zone expression and analysis of genetic overlap in stem cell populations.
Volume: 264
Issue: 2
Pages: 309-22
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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•
Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
34321999 | J:313619
 
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
22560297 | J:184521
First Author: Koss M
Year: 2012
Journal: Dev Cell
Title: Congenital asplenia in mice and humans with mutations in a Pbx/Nkx2-5/p15 module.
Volume: 22
Issue: 5
Pages: 913-26
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Publication
19521500 | J:149737
First Author: Sansom SN
Year: 2009
Journal: PLoS Genet
Title: The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis.
Volume: 5
Issue: 6
Pages: e1000511
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:157064
     
First Author: University of California, Davis
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the University of California, Davis
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Publication
- | J:81858
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: Data Curation Using Mouse Genome Assembly
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Protein
Q14AA6
Organism: Mus musculus/domesticus
Length: 216  
Fragment?: false
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Protein
Q3ULW0
Organism: Mus musculus/domesticus
Length: 216  
Fragment?: false
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Protein
A6H622
Organism: Mus musculus/domesticus
Length: 216  
Fragment?: false
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Pseudogene
MGI:5645821 | Ranbp2-ps11
Type: pseudogene
Organism: mouse, laboratory
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Pseudogene
MGI:5645822 | Ranbp2-ps12
Type: pseudogene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2683212 | Ranbp6
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
10078529 | -
First Author: Vetter IR
Year: 1999
Journal: Nature
Title: Structure of a Ran-binding domain complexed with Ran bound to a GTP analogue: implications for nuclear transport.
Volume: 398
Issue: 6722
Pages: 39-46
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Publication
10471364 | J:57496
First Author: Nishimoto T
Year: 1999
Journal: Biochem Biophys Res Commun
Title: A new role of ran GTPase.
Volume: 262
Issue: 3
Pages: 571-4
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UniProt Feature
UniProt Feature
Begin: 2
Description: Ran GTPase-activating protein 1
Type: chain
End: 589
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UniProt Feature
UniProt Feature
Begin: 2
Description: GTP-binding nuclear protein Ran
Type: chain
End: 216
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Publication
14648869 | J:87812
First Author: Shibata N
Year: 2004
Journal: Mol Reprod Dev
Title: Mouse RanBPM is a partner gene to a germline specific RNA helicase, mouse vasa homolog protein.
Volume: 67
Issue: 1
Pages: 1-7
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Protein
A9UGK3
Organism: Mus musculus/domesticus
Length: 620  
Fragment?: false
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Publication
32346083 | J:289790
First Author: Soliman SHA
Year: 2020
Journal: Sci Rep
Title: Tagging enhances histochemical and biochemical detection of Ran Binding Protein 9 in vivo and reveals its interaction with Nucleolin.
Volume: 10
Issue: 1
Pages: 7138
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Publication
10404224 | -
First Author: Fedorov AA
Year: 1999
Journal: Nat Struct Biol
Title: Structure of EVH1, a novel proline-rich ligand-binding module involved in cytoskeletal dynamics and neural function.
Volume: 6
Issue: 7
Pages: 661-5
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Protein Domain
IPR000156 | Ran_bind_dom
Type: Domain
Description: Ran is an evolutionary conserved member of the Ras superfamily that regulates all receptor-mediated transport between the nucleus and the cytoplasm. Ran Binding Protein 1 (RanBP1) has guanine nucleotide dissociation inhibitory activity, specific for the GTP form of Ran and also functions to stimulate Ran GTPase activating protein(GAP)-mediated GTP hydrolysis by Ran. RanBP1 contributes to maintaining the gradient of RanGTP across the nuclear envelope high (GDI activity) or the cytoplasmic levels of RanGTP low (GAP cofactor) [].All RanBP1 proteins contain an approx 150 amino acid residue Ran binding domain. Ran BP1 binds directly to RanGTP with high affinity.There are four sites of contact between Ran and the Ran binding domain. One of these involves binding of the C-terminal segment of Ran to a groove on the Ran binding domain that is analogous to the surface utilised in the EVH1-peptide interaction []. Nup358 contains four Ran binding domains. The structure of the first of these is known [].
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Publication
10698256 | -
First Author: Yoneda Y
Year: 1999
Journal: Cell Struct Funct
Title: Nucleocytoplasmic protein transport and recycling of Ran.
Volume: 24
Issue: 6
Pages: 425-33
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Protein Domain
IPR002041 | Ran_GTPase
Type: Family
Description: Small GTPases form an independent superfamily within the larger class ofregulatory GTP hydrolases. This superfamily contains proteins that control avast number of important processes and possess a common, structurallypreserved GTP-binding domain [, ]. Sequence comparisons of small G proteinsfrom various species have revealed that they are conserved in primarystructures at the level of 30-55% similarity [].Crystallographic analysis of various small G proteins revealed the presence of a 20kDa catalytic domain that is unique for the whole superfamily [, ]. The domain is built of five alpha helices (A1-A5), sixβ-strands (B1-B6) and five polypeptide loops (G1-G5). A structuralcomparison of the GTP- and GDP-bound form, allows one to distinguish twofunctional loop regions: switch I and switch II that surround thegamma-phosphate group of the nucleotide. The G1 loop (also called the P-loop)that connects the B1 strand and the A1 helix is responsible for the binding ofthe phosphate groups. The G3 loop provides residues for Mg(2+) and phosphatebinding and is located at the N terminus of the A2 helix. The G1 and G3 loopsare sequentially similar to Walker A and Walker B boxes that are found inother nucleotide binding motifs. The G2 loop connects the A1 helix and the B2strand and contains a conserved Thr residue responsible for Mg(2+) binding.The guanine base is recognised by the G4 and G5 loops. The consensus sequenceNKXD of the G4 loop contains Lys and Asp residues directly interacting withthe nucleotide. Part of the G5 loop located between B6 and A5 acts as arecognition site for the guanine base [].The small GTPase superfamily can be divided in 8 different families:Arf small GTPases. GTP-binding proteins involved in protein trafficking bymodulating vesicle budding and un-coating within the Golgi apparatusRan small GTPases. GTP-binding proteins involved in nucleocytoplasmictransport. Required for the import of proteins into the nucleus and alsofor RNA exportRab small GTPases. GTP-binding proteins involved in vesicular traffic.Rho small GTPases. GTP-binding proteins that control cytoskeletonreorganisationRas small GTPases. GTP-binding proteins involved in signaling pathwaysSar1 small GTPases. Small GTPase component of the coat protein complex II(COPII) which promotes the formation of transport vesicles from theendoplasmic reticulum (ER)Mitochondrial Rho (Miro). Small GTPase domain found in mitochondrialproteins involved in mitochondrial traffickingRoc small GTPases domain. Small GTPase domain always found associated withthe COR domain.Ran (or TC4), is an evolutionary conserved member of the Ras superfamily of small GTPases that regulates all receptor-mediated transport between the nucleus and the cytoplasm. Ran has been implicated in a large number of processes, including nucleocytoplasmic transport, RNA synthesis, processing and export and cell cycle checkpoint control [, ]. Ran plays a crucial role in both import/export pathways and determines the directionality of nuclear transport. Import receptors (importins) bind their cargos in the cytoplasm where the concentration of RanGTP is low (due to action of RanGAP), and release their cargos in the nucleus where the concentration of RanGTP is high (due to action of RanGEF) [, ]. Export receptors (exportins) respond to RanGTP in the opposite manner. Furthermore, it has been shown that nuclear transport factor 2 (NTF2, ) stimulates efficient nuclear import of a cargo protein. NTF2 binds specifically to RanGDP and to the FXFG repeat containing nucleoporins []. Ran is generally included in the RAS 'superfamily' of small GTP-binding proteins [], but it is only slightly related to the other RAS proteins. It also differs from RAS proteins in that it lacks cysteine residues at its C-terminal and is therefore not subject to prenylation. Instead, Ran has an acidic C terminus. It is, however, similar to RAS family members in requiring a specific guanine nucleotide exchange factor (GEF) and a specific GTPase activating protein (GAP) as stimulators of overall GTPase activity.Ran consists of a core domain that is structurally similar to the GTP-binding domains of other small GTPases but, in addition, Ran has a C-terminal extension consisting of an unstructured linker and a 16 residue α-helix that is located opposite the "Switch I"region in the RanGDP structure []. Three regions of Ran change conformation depending on the nucleotide bound, the Switch I and II regions, which interact with the bound nucleotide, as well as the C-terminal extension. In RanGDP, the C-terminal extension contacts the core of the protein, while in RanGTP, the extension is extending away from the core, most likely due to a steric clash between the switch I region and the linker part of the C-terminal extension. This suggests that the C-terminal extension in RanGDP is crucial for shielding residues in the core domain and preventing the switch regions from adopting a GTP-like form. This prevents binding of transport factors to RanGDP that would otherwise lead to uncoordinated interaction between importin beta-like proteins and cellular factors.
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Protein Coding Gene
MGI:1928741 | Ranbp9
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
7799964 | J:35455
First Author: Hattori M
Year: 1995
Journal: Mol Cell Biol
Title: Molecular cloning of a novel mitogen-inducible nuclear protein with a Ran GTPase-activating domain that affects cell cycle progression.
Volume: 15
Issue: 1
Pages: 552-60
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Gene
361396 | Ranbp10
Type: gene
Organism: rat
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Gene
360739 | Ranbp1
Type: gene
Organism: rat
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Gene
294789 | Ranbp3l
Type: gene
Organism: rat
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Gene
294429 | Ranbp2
Type: gene
Organism: rat
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Gene
303029 | Ranbp17
Type: gene
Organism: rat
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Gene
309326 | Ranbp6
Type: gene
Organism: rat
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Gene
501281 | Ranbp3
Type: gene
Organism: rat
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Gene
474539 | RANBP2
Type: gene
Organism: dog, domestic
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Gene
477563 | RANBP1
Type: gene
Organism: dog, domestic
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