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Search results 201 to 269 out of 269 for Rfx5

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Type Details Score
Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
- | J:171409
     
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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UniProt Feature
UniProt Feature
Begin: 2
Description: DNA-binding protein Rfx5
Type: chain
End: 658
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Protein
D6RDE5
Organism: Mus musculus/domesticus
Length: 41  
Fragment?: false
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Publication
20732328 | -
First Author: Laird KM
Year: 2010
Journal: J Mol Biol
Title: Solution structure of the heterotrimeric complex between the interaction domains of RFX5 and RFXAP from the RFX gene regulatory complex.
Volume: 403
Issue: 1
Pages: 40-51
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Allele
Rfx5<em2Smoc> | MGI:7292030
Name: regulatory factor X, 5 (influences HLA class II expression); endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:6476167 | C57BL/6JSmoc-Rfx5<em2Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Allele
Rfx5<em1Smoc> | MGI:7292029
Name: regulatory factor X, 5 (influences HLA class II expression); endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Protein Domain
IPR038308 | RFXAP_C_sf
Type: Homologous_superfamily
Description: This superfamily represents the C-terminal domain ofRFXAP (regulatory factor X-associated protein) that binds to RFXANK [, ], the ankyrin-repeat regulatory factor X protein. RFXAP is part of the RFX complex, mutants of either RFXAP or RFXANK protein fail to bind to each other. RFX5 binds only to the RFXANK-RFXAP scaffold and not to either protein alone, and neither the scaffold nor RFX5 alone can bind DNA. The binding of the RFXANK-RFXAP scaffold to RFX5 leads to a conformational change in the latter that exposes the DNA-binding domain of RFX5. The DNA-binding domain of RFX5 anchors the RFX complex to MHC class II X and S promoter boxes [].
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Protein Domain
IPR029316 | RFXAP_RFXANK-bd
Type: Domain
Description: This C-terminal domain of Regulatory factor X-associated protein (RFXAP) binds to RFXANK [, ], the ankyrin-repeat regulatory factor X protein. RFXAP is part of the RFX complex, mutants of either RFXAP or RFXANK protein fail to bind to each other. RFX5 binds only to the RFXANK-RFXAP scaffold and not to either protein alone, and neither the scaffold nor RFX5 alone can bind DNA. The binding of the RFXANK-RFXAP scaffold to RFX5 leads to a conformational change in the latter that exposes the DNA-binding domain of RFX5. The DNA-binding domain of RFX5 anchors the RFX complex to MHC class II X and S promoter boxes [].
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Protein
Q8VCG9
Organism: Mus musculus/domesticus
Length: 231  
Fragment?: false
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Protein
Q3UMW9
Organism: Mus musculus/domesticus
Length: 204  
Fragment?: false
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Protein
F7DBT7
Organism: Mus musculus/domesticus
Length: 231  
Fragment?: false
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Publication
9118943 | -
First Author: Durand B
Year: 1997
Journal: EMBO J
Title: RFXAP, a novel subunit of the RFX DNA binding complex is mutated in MHC class II deficiency.
Volume: 16
Issue: 5
Pages: 1045-55
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Publication
10072068 | -
First Author: Nagarajan UM
Year: 1999
Journal: Immunity
Title: RFX-B is the gene responsible for the most common cause of the bare lymphocyte syndrome, an MHC class II immunodeficiency.
Volume: 10
Issue: 2
Pages: 153-62
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Protein Domain
IPR040889 | RFX5_N
Type: Domain
Description: This entry represents the N-terminal domain of regulatory factor X (RFX)-5, which is part of the human RFX complex. The RFX complex (consists of RFX5, RFXAP and RFXB) is involved in the regulation of the expression of the major histocompatibility complex class II (MHCII) gene products essential for the initiation and regulation of the mammalian immune response. The N-terminal domain of RFX5 is responsible for homodimerization of RFX5 which promotes folding of the C-terminal domain of RFXAP. The folding of RFXAP results in the formation of a potential binding site for RFXB to bind to the MHCII promoter [].
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Protein
Q3V383
Organism: Mus musculus/domesticus
Length: 245  
Fragment?: false
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Protein
A0A1W2P7F2
Organism: Mus musculus/domesticus
Length: 270  
Fragment?: true
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Protein
Q3TSB6
Organism: Mus musculus/domesticus
Length: 364  
Fragment?: true
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Protein
Q8CB07
Organism: Mus musculus/domesticus
Length: 481  
Fragment?: true
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Publication
10556033 | -
First Author: Katan-Khaykovich Y
Year: 1999
Journal: J Mol Biol
Title: The dimerization/repression domain of RFX1 is related to a conserved region of its yeast homologues Crt1 and Sak1: a new function for an ancient motif.
Volume: 294
Issue: 1
Pages: 121-37
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Publication
18673564 | -
 
First Author: Aftab S
Year: 2008
Journal: BMC Evol Biol
Title: Identification and characterization of novel human tissue-specific RFX transcription factors.
Volume: 8
Pages: 226
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Publication
25497100 | -
First Author: Chandra V
Year: 2014
Journal: Cell Rep
Title: RFX6 regulates insulin secretion by modulating Ca2+ homeostasis in human β cells.
Volume: 9
Issue: 6
Pages: 2206-18
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Protein Domain
IPR029298 | RFX5_C
Type: Domain
Description: Transcription of all the members of MHCII family of genes is controlled by a set of conserved transcription factors and promoter elements. One of these class II transactivators is the DNA-binding RFX complex, which consists of subunits RFX5 and its accessory proteins RFXAP and RFXANK [].This entry represents the C-terminal domain of RFX5. The C-terminal domain mediates cooperative binding between the RFX complex and NF-Y, a transcription factor binding to the Y box sequence of MHC-II promoters [].
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Protein Domain
IPR039779 | RFX-like
Type: Family
Description: This entry includes Rfx1 from budding yeasts, Sak1 from fission yeasts and RFX1-8 from humans []. They are transcription factors that contain a RFX DNA binding domain and a conserved C-terminal region [].Mutations in the RFX5 gene cause Bare lymphocyte syndrome 2 (BLS2), a severe combined immunodeficiency disease with early onset []. Mutations in the RFX6 gene cause Mitchell-Riley syndrome (MTCHRS), a disorder characterized by neonatal diabetes, hypoplastic or annular pancreas, duodenal and jejunal atresia, and absent gallbladder [, ].
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Publication
15121860 | J:89880
First Author: Bonnafe E
Year: 2004
Journal: Mol Cell Biol
Title: The transcription factor RFX3 directs nodal cilium development and left-right asymmetry specification.
Volume: 24
Issue: 10
Pages: 4417-27
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Publication
31549732 | J:285217
First Author: Li P
Year: 2020
Journal: J Neurochem
Title: Neuronal NLRC5 regulates MHC class I expression in Neuro-2a cells and also during hippocampal development.
Volume: 152
Issue: 2
Pages: 182-194
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Protein
Q8C1T6
Organism: Mus musculus/domesticus
Length: 309  
Fragment?: true
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Protein
F8VPJ6
Organism: Mus musculus/domesticus
Length: 1459  
Fragment?: false
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Protein
Q3TDE2
Organism: Mus musculus/domesticus
Length: 291  
Fragment?: false
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Protein
P48379
Organism: Mus musculus/domesticus
Length: 717  
Fragment?: false
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Protein
Q7TNK1
Organism: Mus musculus/domesticus
Length: 735  
Fragment?: false
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Protein
P48381
Organism: Mus musculus/domesticus
Length: 749  
Fragment?: false
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Protein
Q8C7R7
Organism: Mus musculus/domesticus
Length: 927  
Fragment?: false
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Protein
P48377
Organism: Mus musculus/domesticus
Length: 963  
Fragment?: false
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Protein
D3YU81
Organism: Mus musculus/domesticus
Length: 596  
Fragment?: false
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Protein
Q8BYY2
Organism: Mus musculus/domesticus
Length: 695  
Fragment?: true
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Protein
G3UWP0
Organism: Mus musculus/domesticus
Length: 458  
Fragment?: false
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Protein
G5E890
Organism: Mus musculus/domesticus
Length: 724  
Fragment?: false
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Protein
Q3V1T0
Organism: Mus musculus/domesticus
Length: 614  
Fragment?: true
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Protein
A0A3B2WBJ0
Organism: Mus musculus/domesticus
Length: 226  
Fragment?: true
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Protein
Q8BJK3
Organism: Mus musculus/domesticus
Length: 963  
Fragment?: false
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Protein
A0A1B0GRV3
Organism: Mus musculus/domesticus
Length: 910  
Fragment?: false
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Protein
D5FLC2
Organism: Mus musculus/domesticus
Length: 893  
Fragment?: false
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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Publication
19468303 | -
First Author: Church DM
Year: 2009
Journal: PLoS Biol
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume: 7
Issue: 5
Pages: e1000112
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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