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Search results 201 to 218 out of 218 for Rgs3

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0.02s

Type

Details

Score

Publication

10749886 | -

First Author:	Dulin NO
Year:	2000
Journal:	J Biol Chem
Title:	Regulator of G protein signaling RGS3T is localized to the nucleus and induces apoptosis.
Volume:	275
Issue:	28
Pages:	21317-23

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Publication

15488174 | -

First Author:	Lu Q
Year:	2004
Journal:	Methods Enzymol
Title:	Analysis of PDZ-RGS3 function in ephrin-B reverse signaling.
Volume:	390

Pages:	120-8

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Publication

15458844 | -

First Author:	Meyer G
Year:	2004
Journal:	Neuropharmacology
Title:	The complexity of PDZ domain-mediated interactions at glutamatergic synapses: a case study on neuroligin.
Volume:	47
Issue:	5
Pages:	724-33

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Publication

11595167 | -

First Author:	Ikeda M
Year:	2001
Journal:	Gene
Title:	Molecular cloning and characterization of a steroid receptor-binding regulator of G-protein signaling protein cDNA.
Volume:	273
Issue:	2
Pages:	207-14

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Protein Domain

IPR034951 | RGS_RGS3

Type:

Domain

Description:

RGS3 is a member of R4 subfamily of RGS family, a diverse group of multifunctional proteins that regulate cellular signalling events downstream of G-protein coupled receptors (GPCRs) []. Signalling is initiated when GPCRs bind to their ligands, triggering the replacement of GDP bound to the G-alpha subunits of heterotrimeric G proteins with GTP. RGSs inhibit signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. This activity defines them as GTPase activating proteins (GAPs).Regulator of G protein signaling 3 (RGS3) contains a membrane-targeting C2 domain, one PDZ domain, and an RGS (Regulator of G-protein Signalling) domain. RGS3 has been identified to inhibit Galpha-q and Galpha-i-mediated signaling by acting as a GTPase-activating protein []. RGS3 exits as several splice isoforms []. A short form, RGS3S, induced apoptosis when overexpressed [], whereas PDZ-RGS3 has been linked to cell migration through interaction with Ephrin receptors []. RGS3 interacts with neuroligin, estrogen receptor-alpha, and 14-3-3 outside of the GPCR pathways [, , ].This entry represents the RGS domain of RGS3.

•

HT Experiment

GSE108624 | KIF20A/MKLP2 regulates the division modes of neural progenitor cells during cortical development


Experiment Type:	RNA-Seq
Study Type:	WT vs. Mutant
Source:	GEO

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Allele

Rgs3<tm1.1Qlu> | MGI:6762184

Name:	regulator of G-protein signaling 3; targeted mutation 1.1, Qiang Lu
Allele Type:	Targeted
Attribute String:	Null/knockout

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Genotype

Symbol:	Gpr63/Gpr63 Ttc21b/Ttc21b
Background:	involves: A/J * C57BL/6 * FVB
Zygosity:	cx
Has Mutant Allele:	true

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Publication

30006548 | J:266250

First Author:	Geng A
Year:	2018
Journal:	Nat Commun
Title:	KIF20A/MKLP2 regulates the division modes of neural progenitor cells during cortical development.
Volume:	9
Issue:	1
Pages:	2707

•

Genotype

Symbol:	Gpr63/Gpr63 Ttc21b/Ttc21b
Background:	involves: A/J * C57BL/6 * FVB
Zygosity:	cx
Has Mutant Allele:	true

•

Publication

15100254 | J:89680

First Author:	Shi GX
Year:	2004
Journal:	J Immunol
Title:	Toll-like receptor signaling alters the expression of regulator of G protein signaling proteins in dendritic cells: implications for G protein-coupled receptor signaling.
Volume:	172
Issue:	9
Pages:	5175-84

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Publication

19333232 | J:148794

First Author:	Nishiura H
Year:	2009
Journal:	Lab Invest
Title:	Pro- and anti-apoptotic dual functions of the C5a receptor: involvement of regulator of G protein signaling 3 and extracellular signal-regulated kinase.
Volume:	89
Issue:	6
Pages:	676-94

•

Publication

31730647 | J:282171

First Author:	Snedeker J
Year:	2019
Journal:	PLoS Genet
Title:	Gpr63 is a modifier of microcephaly in Ttc21b mouse mutants.
Volume:	15
Issue:	11
Pages:	e1008467

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Protein

F6X4A2

Organism:	Mus musculus/domesticus
Length:	126
Fragment?:	true

•

Protein

Q3TAS0

Organism:	Mus musculus/domesticus
Length:	168
Fragment?:	false

•

Protein

Q542M0

Organism:	Mus musculus/domesticus
Length:	192
Fragment?:	false

•

Publication

16226429 | -

First Author:	Abramow-Newerly M
Year:	2006
Journal:	Cell Signal
Title:	RGS proteins have a signalling complex: interactions between RGS proteins and GPCRs, effectors, and auxiliary proteins.
Volume:	18
Issue:	5
Pages:	579-91

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Publication

- | J:100256

First Author:	The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY)
Year:	2005
Journal:	Database Download
Title:	MGI download of GENSAT transgene data

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