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Search results 201 to 300 out of 313 for Rheb

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Type Details Score
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
Publication        
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
Publication        
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Publication        
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
Publication
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication        
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Publication        
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Publication        
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
UniProt Feature
Begin: 1
Description: GTP-binding protein Rheb
Type: chain
End: 181
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: frog, African clawed
Gene
Type: gene
Organism: frog, African clawed
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
Publication
First Author: Cho JH
Year: 2017
Journal: Nat Commun
Title: Notch transactivates Rheb to maintain the multipotency of TSC-null cells.
Volume: 8
Issue: 1
Pages: 1848
Publication
First Author: Fawal MA
Year: 2015
Journal: Dev Cell
Title: MCRS1 binds and couples Rheb to amino acid-dependent mTORC1 activation.
Volume: 33
Issue: 1
Pages: 67-81
Interaction Experiment
Description: Rheb inhibits C-raf activity and B-raf/C-raf heterodimerization.
Publication
First Author: Sato T
Year: 2009
Journal: J Biol Chem
Title: Specific activation of mTORC1 by Rheb G-protein in vitro involves enhanced recruitment of its substrate protein.
Volume: 284
Issue: 19
Pages: 12783-91
Publication
First Author: Yao Y
Year: 2020
Journal: Mol Cell
Title: Amino Acids Enhance Polyubiquitination of Rheb and Its Binding to mTORC1 by Blocking Lysosomal ATXN3 Deubiquitinase Activity.
Volume: 80
Issue: 3
Pages: 437-451.e6
Interaction Experiment
Description: Ubiquitination of Rheb governs growth factor-induced mTORC1 activation.
Publication
First Author: Scheidenhelm DK
Year: 2005
Journal: Mol Cell Biol
Title: Akt-dependent cell size regulation by the adhesion molecule on glia occurs independently of phosphatidylinositol 3-kinase and Rheb signaling.
Volume: 25
Issue: 8
Pages: 3151-62
Publication
First Author: Karbowniczek M
Year: 2006
Journal: J Biol Chem
Title: Rheb inhibits C-raf activity and B-raf/C-raf heterodimerization.
Volume: 281
Issue: 35
Pages: 25447-56
Interaction Experiment
Description: Localization of Rheb to the endomembrane is critical for its signaling function.
Publication
First Author: Li Y
Year: 2004
Journal: Mol Cell Biol
Title: Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity.
Volume: 24
Issue: 18
Pages: 7965-75
Allele
Name: Ras homolog enriched in brain; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
Publication
First Author: Yang W
Year: 2001
Journal: Mol Microbiol
Title: Failure to farnesylate Rheb protein contributes to the enrichment of G0/G1 phase cells in the Schizosaccharomyces pombe farnesyltransferase mutant.
Volume: 41
Issue: 6
Pages: 1339-47
Allele
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, David H Gutmann
Allele Type: Targeted
Attribute String: Conditional ready, Inserted expressed sequence, Reporter, Transactivator
Allele
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Paul Worley
Allele Type: Targeted
Attribute String: Conditional ready, Inserted expressed sequence
Strain
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: Not Specified
Zygosity: ht
Has Mutant Allele: true
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: Not Specified
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(GFAP-cre)#Gtm/?
Background: involves: C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
GO Term
HT Experiment  
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: GEO
Publication
First Author: Alejandro EU
Year: 2014
Journal: J Clin Invest
Title: Maternal diet-induced microRNAs and mTOR underlie β cell dysfunction in offspring.
Volume: 124
Issue: 10
Pages: 4395-410
Publication
First Author: Wennerberg K
Year: 2005
Journal: J Cell Sci
Title: The Ras superfamily at a glance.
Volume: 118
Issue: Pt 5
Pages: 843-6
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Rheb/Rheb Tg(Nes-cre)1Kln/?
Background: involves: C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor Tg(Nes-cre)1Kln/?
Background: involves: C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
Publication
First Author: Yang H
Year: 2013
Journal: Cell Mol Life Sci
Title: Control of cell growth: Rag GTPases in activation of TORC1.
Volume: 70
Issue: 16
Pages: 2873-85
Publication  
First Author: Hirose E
Year: 1998
Journal: J Cell Sci
Title: RagA is a functional homologue of S. cerevisiae Gtr1p involved in the Ran/Gsp1-GTPase pathway.
Volume: 111 ( Pt 1)
Pages: 11-21
Protein Domain
Type: Family
Description: RagA and RagB are closely related Rag GTPases (ras-related GTP-binding protein A and B) that constitute a unique subgroup of the Ras superfamily [], and are functional homologues of Saccharomyces cerevisiaeGtr1 []. They function by forming heterodimers with RagC or RagD, and similarly, Gtr1 dimerizes with Gtr2, through the carboxy-terminal segments. They play an essential role in regulating amino acid-induced target of rapamycin complex 1 (TORC1) kinase signaling [], exocytic cargo sorting at endosomes, and epigenetic control of gene expression. In response to amino acids, the Rag GTPases guide the TORC1 complex to activate the platform containing Rheb proto-oncogene by driving the relocalization of mTORC1 from discrete locations in the cytoplasm to a late endosomal and/or lysosomal compartment that is Rheb-enriched and contains Rab-7 [].
Protein Domain
Type: Family
Description: RagC and RagD are closely related Rag GTPases (ras-related GTP-binding protein C and D) that constitute a unique subgroup of the Ras superfamily [], and are functional homologues of Saccharomyces cerevisiaeGtr2. They form heterodimers with RagA or RagB [], and similarly, Gtr2 dimerizes with Gtr1 in order to function. They play an essential role in regulating amino acid-induced target of rapamycin complex 1 (TORC1) kinase signaling [], exocytic cargo sorting at endosomes, and epigenetic control of gene expression. In response to amino acids, the Rag GTPases guide the TORC1 complex to activate the platform containing Rheb proto-oncogene by driving the relocalization of mTORC1 from discrete locations in the cytoplasm to a late endosomal and/or lysosomal compartment that is Rheb-enriched and contains Rab-7 [].
Publication
First Author: Nardella C
Year: 2008
Journal: Genes Dev
Title: Aberrant Rheb-mediated mTORC1 activation and Pten haploinsufficiency are cooperative oncogenic events.
Volume: 22
Issue: 16
Pages: 2172-7
Publication
First Author: Arakawa-Takeuchi S
Year: 2010
Journal: FEBS Lett
Title: Mammalian target of rapamycin complex 1 signaling opposes the effects of anchorage loss, leading to activation of Cdk4 and Cdc6 stabilization.
Volume: 584
Issue: 13
Pages: 2779-85
Publication  
First Author: Uno K
Year: 2015
Journal: Nat Commun
Title: A hepatic amino acid/mTOR/S6K-dependent signalling pathway modulates systemic lipid metabolism via neuronal signals.
Volume: 6
Pages: 7940
Publication
First Author: Perkey E
Year: 2013
Journal: J Immunol
Title: Increased mammalian target of rapamycin complex 2 signaling promotes age-related decline in CD4 T cell signaling and function.
Volume: 191
Issue: 9
Pages: 4648-55
Publication
First Author: Saci A
Year: 2011
Journal: Mol Cell
Title: Rac1 regulates the activity of mTORC1 and mTORC2 and controls cellular size.
Volume: 42
Issue: 1
Pages: 50-61
Publication
First Author: Nie D
Year: 2010
Journal: Nat Neurosci
Title: Tsc2-Rheb signaling regulates EphA-mediated axon guidance.
Volume: 13
Issue: 2
Pages: 163-72
Publication
First Author: Joe Y
Year: 2020
Journal: Cell Rep
Title: Cross-talk between CD38 and TTP Is Essential for Resolution of Inflammation during Microbial Sepsis.
Volume: 30
Issue: 4
Pages: 1063-1076.e5
Publication
First Author: Moon UY
Year: 2015
Journal: Cell Rep
Title: Impaired Reelin-Dab1 Signaling Contributes to Neuronal Migration Deficits of Tuberous Sclerosis Complex.
Volume: 12
Issue: 6
Pages: 965-78
Publication
First Author: Hu JK
Year: 2017
Journal: Cell Stem Cell
Title: An FAK-YAP-mTOR Signaling Axis Regulates Stem Cell-Based Tissue Renewal in Mice.
Volume: 21
Issue: 1
Pages: 91-106.e6
Publication
First Author: Uhlmann EJ
Year: 2004
Journal: Glia
Title: Loss of tuberous sclerosis complex 1 (Tsc1) expression results in increased Rheb/S6K pathway signaling important for astrocyte cell size regulation.
Volume: 47
Issue: 2
Pages: 180-8
Publication
First Author: Alesi N
Year: 2024
Journal: Nat Commun
Title: TFEB drives mTORC1 hyperactivation and kidney disease in Tuberous Sclerosis Complex.
Volume: 15
Issue: 1
Pages: 406
Publication
First Author: Child DD
Year: 2018
Journal: Cell Rep
Title: Cardiac mTORC1 Dysregulation Impacts Stress Adaptation and Survival in Huntington's Disease.
Volume: 23
Issue: 4
Pages: 1020-1033
Publication
First Author: Shimada R
Year: 2021
Journal: iScience
Title: NANOS2 suppresses the cell cycle by repressing mTORC1 activators in embryonic male germ cells.
Volume: 24
Issue: 8
Pages: 102890
Publication
First Author: Tan B
Year: 2024
Journal: Science
Title: Drugs of abuse hijack a mesolimbic pathway that processes homeostatic need.
Volume: 384
Issue: 6693
Pages: eadk6742
Publication
First Author: Menon S
Year: 2014
Journal: Cell
Title: Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome.
Volume: 156
Issue: 4
Pages: 771-85
Publication
First Author: Zhang J
Year: 2013
Journal: Nat Cell Biol
Title: A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS.
Volume: 15
Issue: 10
Pages: 1186-96
Publication    
First Author: Gnanapradeepan K
Year: 2020
Journal: Elife
Title: Increased mTOR activity and metabolic efficiency in mouse and human cells containing the African-centric tumor-predisposing p53 variant Pro47Ser.
Volume: 9
Publication
First Author: Sekiguchi T
Year: 2001
Journal: J Biol Chem
Title: Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B.
Volume: 276
Issue: 10
Pages: 7246-57
Publication
First Author: Sofer A
Year: 2005
Journal: Mol Cell Biol
Title: Regulation of mTOR and cell growth in response to energy stress by REDD1.
Volume: 25
Issue: 14
Pages: 5834-45
Publication
First Author: Bernardi R
Year: 2006
Journal: Nature
Title: PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR.
Volume: 442
Issue: 7104
Pages: 779-85
Publication
First Author: Gridley S
Year: 2005
Journal: Cell Signal
Title: Novel insulin-elicited phosphoproteins in adipocytes.
Volume: 17
Issue: 1
Pages: 59-66
Publication
First Author: Ohtani M
Year: 2008
Journal: Blood
Title: Mammalian target of rapamycin and glycogen synthase kinase 3 differentially regulate lipopolysaccharide-induced interleukin-12 production in dendritic cells.
Volume: 112
Issue: 3
Pages: 635-43
Publication
First Author: Zhu C
Year: 2018
Journal: Sci Rep
Title: mTOR complexes differentially orchestrates eosinophil development in allergy.
Volume: 8
Issue: 1
Pages: 6883
Publication
First Author: Yang Y
Year: 2014
Journal: J Clin Invest
Title: ZEB1 sensitizes lung adenocarcinoma to metastasis suppression by PI3K antagonism.
Volume: 124
Issue: 6
Pages: 2696-708
Publication  
First Author: Cho CS
Year: 2019
Journal: Cell Discov
Title: Concurrent activation of growth factor and nutrient arms of mTORC1 induces oxidative liver injury.
Volume: 5
Pages: 60
Publication
First Author: Wang X
Year: 2021
Journal: J Pathol
Title: Cardiac-specific deletion of FDPS induces cardiac remodeling and dysfunction by enhancing the activity of small GTP-binding proteins.
Volume: 255
Issue: 4
Pages: 438-450
Publication
First Author: Asrani K
Year: 2019
Journal: J Clin Invest
Title: mTORC1 feedback to AKT modulates lysosomal biogenesis through MiT/TFE regulation.
Volume: 129
Issue: 12
Pages: 5584-5599
Publication
First Author: Yao Y
Year: 2016
Journal: J Am Soc Nephrol
Title: Role of Ragulator in the Regulation of Mechanistic Target of Rapamycin Signaling in Podocytes and Glomerular Function.
Volume: 27
Issue: 12
Pages: 3653-3665
Publication  
First Author: Park J
Year: 2023
Journal: Metabolism
Title: Metformin-induced TTP mediates communication between Kupffer cells and hepatocytes to alleviate hepatic steatosis by regulating lipophagy and necroptosis.
Volume: 141
Pages: 155516
Publication
First Author: Jiang L
Year: 2013
Journal: J Am Soc Nephrol
Title: Rheb/mTORC1 signaling promotes kidney fibroblast activation and fibrosis.
Volume: 24
Issue: 7
Pages: 1114-26
Publication
First Author: Pryor WM
Year: 2014
Journal: Sci Signal
Title: Huntingtin promotes mTORC1 signaling in the pathogenesis of Huntington's disease.
Volume: 7
Issue: 349
Pages: ra103
Publication
First Author: Napolitano G
Year: 2020
Journal: Nature
Title: A substrate-specific mTORC1 pathway underlies Birt-Hogg-Dubé syndrome.
Volume: 585
Issue: 7826
Pages: 597-602
Publication
First Author: Shao X
Year: 2024
Journal: FASEB J
Title: Deficiency of geranylgeranyl biphosphate synthase in kidney tubules causes cystic kidney disease.
Volume: 38
Issue: 17
Pages: e23875
Publication
First Author: Chakrabarti P
Year: 2010
Journal: Diabetes
Title: Mammalian target of rapamycin complex 1 suppresses lipolysis, stimulates lipogenesis, and promotes fat storage.
Volume: 59
Issue: 4
Pages: 775-81
Publication
First Author: Buller CL
Year: 2011
Journal: Am J Physiol Renal Physiol
Title: GLUT1 enhances mTOR activity independently of TSC2 and AMPK.
Volume: 301
Issue: 3
Pages: F588-96
Publication
First Author: Kang YJ
Year: 2011
Journal: Cell Death Differ
Title: The TSC1 and TSC2 tumor suppressors are required for proper ER stress response and protect cells from ER stress-induced apoptosis.
Volume: 18
Issue: 1
Pages: 133-44
Publication
First Author: Ching JK
Year: 2013
Journal: Hum Mol Genet
Title: mTOR dysfunction contributes to vacuolar pathology and weakness in valosin-containing protein associated inclusion body myopathy.
Volume: 22
Issue: 6
Pages: 1167-79
Publication
First Author: Ode T
Year: 2017
Journal: Exp Cell Res
Title: PDMP, a ceramide analogue, acts as an inhibitor of mTORC1 by inducing its translocation from lysosome to endoplasmic reticulum.
Volume: 350
Issue: 1
Pages: 103-114
Publication
First Author: Frias MA
Year: 2020
Journal: J Biol Chem
Title: Phosphatidic acid drives mTORC1 lysosomal translocation in the absence of amino acids.
Volume: 295
Issue: 1
Pages: 263-274
Publication
First Author: Gui Y
Year: 2019
Journal: Cell Death Differ
Title: Fibroblast mTOR/PPARγ/HGF axis protects against tubular cell death and acute kidney injury.
Volume: 26
Issue: 12
Pages: 2774-2789
Publication
First Author: Arwood ML
Year: 2023
Journal: Immunohorizons
Title: Serendipitous Discovery of T Cell-Produced KLK1b22 as a Regulator of Systemic Metabolism.
Volume: 7
Issue: 6
Pages: 493-507