| Type |
Details |
Score |
| GXD Expression |
| Probe: |
MGI:1101911 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2006-11-24 |
| Strength: |
Strong |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1689417 |
| Pattern: |
Regionally restricted |
| Stage: |
TS17 |
| Assay Id: |
MGI:3688558 |
| Age: |
embryonic day 10.5 |
| Image: |
3A |
| Note: |
Expression is in all neuroepithelia lining the ventricle. |
| Specimen Label: |
3A |
| Detected: |
true |
| Specimen Num: |
6 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3506606 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2014-02-07 |
| Strength: |
Ambiguous |
| Sex: |
Female |
| Emaps: |
EMAPS:2864323 |
| Pattern: |
Not Specified |
| Stage: |
TS23 |
| Assay Id: |
MGI:5539590 |
| Age: |
embryonic day 15.5 |
| Image: |
GUDMAP:13827 |
|
| Specimen Label: |
GUDMAP:13827 |
|
| Specimen Num: |
4 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3506606 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2014-02-07 |
| Strength: |
Present |
| Sex: |
Female |
| Emaps: |
EMAPS:1796223 |
| Pattern: |
Not Specified |
| Stage: |
TS23 |
| Assay Id: |
MGI:5539590 |
| Age: |
embryonic day 15.5 |
| Image: |
GUDMAP:5942 |
|
| Specimen Label: |
GUDMAP:5942 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3506606 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2014-02-07 |
| Strength: |
Present |
| Sex: |
Female |
| Emaps: |
EMAPS:1796223 |
| Pattern: |
Not Specified |
| Stage: |
TS23 |
| Assay Id: |
MGI:5539590 |
| Age: |
embryonic day 15.5 |
| Image: |
GUDMAP:12684 |
|
| Specimen Label: |
GUDMAP:12684 |
| Detected: |
true |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Caron KM |
| Year: |
1997 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Targeted disruption of the mouse gene encoding steroidogenic acute regulatory protein provides insights into congenital lipoid adrenal hyperplasia. |
| Volume: |
94 |
| Issue: |
21 |
| Pages: |
11540-5 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
The Gene Ontology Consortium |
| Year: |
2010 |
|
| Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
228
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sun X |
| Year: |
2020 |
| Journal: |
Br J Pharmacol |
| Title: |
Hydrogen sulfide regulates muscle RING finger-1 protein S-sulfhydration at Cys(44) to prevent cardiac structural damage in diabetic cardiomyopathy. |
| Volume: |
177 |
| Issue: |
4 |
| Pages: |
836-856 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Meng S |
| Year: |
2016 |
| Journal: |
Circ Res |
| Title: |
Transdifferentiation Requires iNOS Activation: Role of RING1A S-Nitrosylation. |
| Volume: |
119 |
| Issue: |
9 |
| Pages: |
e129-e138 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
del Mar Lorente M |
| Year: |
2000 |
| Journal: |
Development |
| Title: |
Loss- and gain-of-function mutations show a polycomb group function for Ring1A in mice. |
| Volume: |
127 |
| Issue: |
23 |
| Pages: |
5093-100 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Maezawa S |
| Year: |
2017 |
| Journal: |
Genes Dev |
| Title: |
Polycomb directs timely activation of germline genes in spermatogenesis. |
| Volume: |
31 |
| Issue: |
16 |
| Pages: |
1693-1703 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Blackledge NP |
| Year: |
2014 |
| Journal: |
Cell |
| Title: |
Variant PRC1 complex-dependent H2A ubiquitylation drives PRC2 recruitment and polycomb domain formation. |
| Volume: |
157 |
| Issue: |
6 |
| Pages: |
1445-1459 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cohen I |
| Year: |
2021 |
| Journal: |
Genes Dev |
| Title: |
Polycomb complexes redundantly maintain epidermal stem cell identity during development. |
| Volume: |
35 |
| Issue: |
5-6 |
| Pages: |
354-366 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Endoh M |
| Year: |
2008 |
| Journal: |
Development |
| Title: |
Polycomb group proteins Ring1A/B are functionally linked to the core transcriptional regulatory circuitry to maintain ES cell identity. |
| Volume: |
135 |
| Issue: |
8 |
| Pages: |
1513-24 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ikawa T |
| Year: |
2016 |
| Journal: |
Genes Dev |
| Title: |
Conversion of T cells to B cells by inactivation of polycomb-mediated epigenetic suppression of the B-lineage program. |
| Volume: |
30 |
| Issue: |
22 |
| Pages: |
2475-2485 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Schoenfelder S |
| Year: |
2015 |
| Journal: |
Nat Genet |
| Title: |
Polycomb repressive complex PRC1 spatially constrains the mouse embryonic stem cell genome. |
| Volume: |
47 |
| Issue: |
10 |
| Pages: |
1179-1186 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kondo T |
| Year: |
2014 |
| Journal: |
Dev Cell |
| Title: |
Polycomb potentiates meis2 activation in midbrain by mediating interaction of the promoter with a tissue-specific enhancer. |
| Volume: |
28 |
| Issue: |
1 |
| Pages: |
94-101 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fielitz J |
| Year: |
2007 |
| Journal: |
J Clin Invest |
| Title: |
Myosin accumulation and striated muscle myopathy result from the loss of muscle RING finger 1 and 3. |
| Volume: |
117 |
| Issue: |
9 |
| Pages: |
2486-95 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Piunti A |
| Year: |
2014 |
| Journal: |
Nat Commun |
| Title: |
Polycomb proteins control proliferation and transformation independently of cell cycle checkpoints by regulating DNA replication. |
| Volume: |
5 |
|
| Pages: |
3649 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shima H |
| Year: |
2018 |
| Journal: |
Blood |
| Title: |
Ring1A and Ring1B inhibit expression of Glis2 to maintain murine MOZ-TIF2 AML stem cells. |
| Volume: |
131 |
| Issue: |
16 |
| Pages: |
1833-1845 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Rossi A |
| Year: |
2016 |
| Journal: |
Sci Adv |
| Title: |
Maintenance of leukemic cell identity by the activity of the Polycomb complex PRC1 in mice. |
| Volume: |
2 |
| Issue: |
10 |
| Pages: |
e1600972 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tsuboi M |
| Year: |
2018 |
| Journal: |
Dev Cell |
| Title: |
Ubiquitination-Independent Repression of PRC1 Targets during Neuronal Fate Restriction in the Developing Mouse Neocortex. |
| Volume: |
47 |
| Issue: |
6 |
| Pages: |
758-772.e5 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Li MY |
| Year: |
2021 |
| Journal: |
Dev Cell |
| Title: |
UV-induced reduction in Polycomb repression promotes epidermal pigmentation. |
| Volume: |
56 |
| Issue: |
18 |
| Pages: |
2547-2561.e8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
An Z |
| Year: |
2018 |
| Journal: |
Cell Rep |
| Title: |
Regulation of Mesenchymal Stem to Transit-Amplifying Cell Transition in the Continuously Growing Mouse Incisor. |
| Volume: |
23 |
| Issue: |
10 |
| Pages: |
3102-3111 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Jansz N |
| Year: |
2018 |
| Journal: |
Cell Rep |
| Title: |
Smchd1 Targeting to the Inactive X Is Dependent on the Xist-HnrnpK-PRC1 Pathway. |
| Volume: |
25 |
| Issue: |
7 |
| Pages: |
1912-1923.e9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Du Z |
| Year: |
2020 |
| Journal: |
Mol Cell |
| Title: |
Polycomb Group Proteins Regulate Chromatin Architecture in Mouse Oocytes and Early Embryos. |
| Volume: |
77 |
| Issue: |
4 |
| Pages: |
825-839.e7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Takano J |
| Year: |
2022 |
| Journal: |
Nat Commun |
| Title: |
PCGF1-PRC1 links chromatin repression with DNA replication during hematopoietic cell lineage commitment. |
| Volume: |
13 |
| Issue: |
1 |
| Pages: |
7159 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ning B |
| Year: |
2017 |
| Journal: |
Nat Commun |
| Title: |
USP26 functions as a negative regulator of cellular reprogramming by stabilising PRC1 complex components. |
| Volume: |
8 |
| Issue: |
1 |
| Pages: |
349 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fursova NA |
| Year: |
2019 |
| Journal: |
Mol Cell |
| Title: |
Synergy between Variant PRC1 Complexes Defines Polycomb-Mediated Gene Repression. |
| Volume: |
74 |
| Issue: |
5 |
| Pages: |
1020-1036.e8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bruggeman SW |
| Year: |
2005 |
| Journal: |
Genes Dev |
| Title: |
Ink4a and Arf differentially affect cell proliferation and neural stem cell self-renewal in Bmi1-deficient mice. |
| Volume: |
19 |
| Issue: |
12 |
| Pages: |
1438-43 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ren X |
| Year: |
2011 |
| Journal: |
Mol Cell Biol |
| Title: |
REST interacts with Cbx proteins and regulates polycomb repressive complex 1 occupancy at RE1 elements. |
| Volume: |
31 |
| Issue: |
10 |
| Pages: |
2100-10 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chiacchiera F |
| Year: |
2016 |
| Journal: |
Cell Stem Cell |
| Title: |
Polycomb Complex PRC1 Preserves Intestinal Stem Cell Identity by Sustaining Wnt/β-Catenin Transcriptional Activity. |
| Volume: |
18 |
| Issue: |
1 |
| Pages: |
91-103 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Vogel T |
| Year: |
2006 |
| Journal: |
Dev Dyn |
| Title: |
Differential expression of polycomb repression complex 1 (PRC1) members in the developing mouse brain reveals multiple complexes. |
| Volume: |
235 |
| Issue: |
9 |
| Pages: |
2574-85 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Liang Q |
| Year: |
2022 |
| Journal: |
Dev Cell |
| Title: |
Essential role of MESP1-RING1A complex in cardiac differentiation. |
| Volume: |
57 |
| Issue: |
22 |
| Pages: |
2533-2549.e7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Riising EM |
| Year: |
2014 |
| Journal: |
Mol Cell |
| Title: |
Gene silencing triggers polycomb repressive complex 2 recruitment to CpG islands genome wide. |
| Volume: |
55 |
| Issue: |
3 |
| Pages: |
347-60 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Suzuki M |
| Year: |
2002 |
| Journal: |
Development |
| Title: |
Involvement of the Polycomb-group gene Ring1B in the specification of the anterior-posterior axis in mice. |
| Volume: |
129 |
| Issue: |
18 |
| Pages: |
4171-83 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yakushiji-Kaminatsui N |
| Year: |
2018 |
| Journal: |
Development |
| Title: |
Variant PRC1 competes with retinoic acid-related signals to repress Meis2 in the mouse distal forelimb bud. |
| Volume: |
145 |
| Issue: |
19 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Masui O |
| Year: |
2023 |
| Journal: |
Nat Cell Biol |
| Title: |
Polycomb repressive complexes 1 and 2 are each essential for maintenance of X inactivation in extra-embryonic lineages. |
| Volume: |
25 |
| Issue: |
1 |
| Pages: |
134-144 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Maezawa S |
| Year: |
2023 |
| Journal: |
Cell Death Dis |
| Title: |
PRC1 suppresses a female gene regulatory network to ensure testicular differentiation. |
| Volume: |
14 |
| Issue: |
8 |
| Pages: |
501 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fujimura Y |
| Year: |
2006 |
| Journal: |
Development |
| Title: |
Distinct roles of Polycomb group gene products in transcriptionally repressed and active domains of Hoxb8. |
| Volume: |
133 |
| Issue: |
12 |
| Pages: |
2371-81 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sánchez C |
| Year: |
2007 |
| Journal: |
Mol Cell Proteomics |
| Title: |
Proteomics analysis of Ring1B/Rnf2 interactors identifies a novel complex with the Fbxl10/Jhdm1B histone demethylase and the Bcl6 interacting corepressor. |
| Volume: |
6 |
| Issue: |
5 |
| Pages: |
820-34 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
183
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
377
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cohen I |
| Year: |
2018 |
| Journal: |
Cell Stem Cell |
| Title: |
PRC1 Fine-tunes Gene Repression and Activation to Safeguard Skin Development and Stem Cell Specification. |
| Volume: |
22 |
| Issue: |
5 |
| Pages: |
726-739.e7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bar C |
| Year: |
2019 |
| Journal: |
Cell Rep |
| Title: |
Polycomb Repressive Complex 1 Controls Maintenance of Fungiform Papillae by Repressing Sonic Hedgehog Expression. |
| Volume: |
28 |
| Issue: |
1 |
| Pages: |
257-266.e5 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cohen I |
| Year: |
2019 |
| Journal: |
Genes Dev |
| Title: |
PRC1 preserves epidermal tissue integrity independently of PRC2. |
| Volume: |
33 |
| Issue: |
1-2 |
| Pages: |
55-60 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Puschendorf M |
| Year: |
2008 |
| Journal: |
Nat Genet |
| Title: |
PRC1 and Suv39h specify parental asymmetry at constitutive heterochromatin in early mouse embryos. |
| Volume: |
40 |
| Issue: |
4 |
| Pages: |
411-20 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Abe K |
| Year: |
2004 |
| Journal: |
Mamm Genome |
| Title: |
Gene content of the 750-kb critical region for mouse embryonic ectoderm lethal tcl-w5. |
| Volume: |
15 |
| Issue: |
4 |
| Pages: |
265-76 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cho KW |
| Year: |
2023 |
| Journal: |
Circulation |
| Title: |
Polycomb Group Protein CBX7 Represses Cardiomyocyte Proliferation Through Modulation of the TARDBP/RBM38 Axis. |
| Volume: |
147 |
| Issue: |
24 |
| Pages: |
1823-1842 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yokoyama S |
| Year: |
2009 |
| Journal: |
Dev Cell |
| Title: |
A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. |
| Volume: |
17 |
| Issue: |
6 |
| Pages: |
836-48 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Burton A |
| Year: |
2013 |
| Journal: |
Cell Rep |
| Title: |
Single-cell profiling of epigenetic modifiers identifies PRDM14 as an inducer of cell fate in the mammalian embryo. |
| Volume: |
5 |
| Issue: |
3 |
| Pages: |
687-701 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Allcock RJ |
| Year: |
2000 |
| Journal: |
Immunol Today |
| Title: |
The mouse as a model for the effects of MHC genes on human disease. |
| Volume: |
21 |
| Issue: |
7 |
| Pages: |
328-32 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gray PA |
| Year: |
2004 |
| Journal: |
Science |
| Title: |
Mouse brain organization revealed through direct genome-scale TF expression analysis. |
| Volume: |
306 |
| Issue: |
5705 |
| Pages: |
2255-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
| Year: |
2000 |
| Journal: |
Database Release |
| Title: |
Entrez Gene Load |
|
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•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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•
•
•
•
•
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| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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•
•
•
•
•
|
| Publication |
| First Author: |
GUDMAP Consortium |
| Year: |
2004 |
| Journal: |
www.gudmap.org |
| Title: |
GUDMAP: the GenitoUrinary Development Molecular Anatomy Project |
|
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•
•
•
•
•
|
| Publication |
| First Author: |
UniProt-GOA |
| Year: |
2012 |
|
| Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
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•
•
•
•
•
|
| Publication |
| First Author: |
Carninci P |
| Year: |
2005 |
| Journal: |
Science |
| Title: |
The transcriptional landscape of the mammalian genome. |
| Volume: |
309 |
| Issue: |
5740 |
| Pages: |
1559-63 |
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•
•
•
•
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| Publication |
| First Author: |
UniProt-GOA |
| Year: |
2012 |
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| Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
|
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•
•
•
•
•
|
| Publication |
| First Author: |
GOA curators |
| Year: |
2016 |
|
| Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
|
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•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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•
•
•
•
•
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| Publication |
| First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
| Year: |
2010 |
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| Title: |
Annotation inferences using phylogenetic trees |
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•
•
•
•
•
|
| Publication |
| First Author: |
Allen Institute for Brain Science |
| Year: |
2004 |
| Journal: |
Allen Institute |
| Title: |
Allen Brain Atlas: mouse riboprobes |
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•
•
•
•
•
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| Publication |
| First Author: |
Mouse Genome Informatics |
| Year: |
2010 |
| Journal: |
Database Release |
| Title: |
Protein Ontology Association Load. |
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•
•
•
•
•
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| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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| Publication |
| First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Consensus CDS project |
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| Publication |
| First Author: |
Mouse Genome Informatics Group |
| Year: |
2003 |
| Journal: |
Database Procedure |
| Title: |
Automatic Encodes (AutoE) Reference |
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| Publication |
| First Author: |
Bairoch A |
| Year: |
1999 |
| Journal: |
Database Release |
| Title: |
SWISS-PROT Annotated protein sequence database |
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| Publication |
| First Author: |
UniProt-GOA |
| Year: |
2012 |
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| Title: |
Gene Ontology annotation based on UniPathway vocabulary mapping |
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| Publication |
| First Author: |
Wiese CB |
| Year: |
2012 |
| Journal: |
Front Neurosci |
| Title: |
A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. |
| Volume: |
6 |
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| Pages: |
130 |
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| Publication |
| First Author: |
University of California, Davis |
| Year: |
2010 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Alleles produced for the KOMP project by the University of California, Davis |
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| Publication |
| First Author: |
Cyagen Biosciences Inc. |
| Year: |
2022 |
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| Title: |
Cyagen Biosciences Website. |
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| Publication |
| First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
| Year: |
2004 |
| Journal: |
Database Release |
| Title: |
Mouse T31 Radiation Hybrid Data Load |
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| Publication |
| First Author: |
MGI Genome Annotation Group and UniGene Staff |
| Year: |
2015 |
| Journal: |
Database Download |
| Title: |
MGI-UniGene Interconnection Effort |
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| Gene |
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| Gene |
| Type: |
gene |
| Organism: |
dog, domestic |
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| Gene |
| Type: |
gene |
| Organism: |
chimpanzee |
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| Gene |
| Type: |
gene |
| Organism: |
cattle |
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| Gene |
| Type: |
gene |
| Organism: |
chicken |
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| Gene |
| Type: |
gene |
| Organism: |
macaque, rhesus |
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| Gene |
| Type: |
gene |
| Organism: |
frog, western clawed |
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| UniProt Feature |
| Begin: |
1 |
| Description: |
RING1 and YY1-binding protein |
| Type: |
chain |
| End: |
228 |
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| UniProt Feature |
| Begin: |
1 |
| Description: |
E3 ubiquitin-protein ligase RING1 |
| Type: |
chain |
| End: |
406 |
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| Pseudogene |
| Type: |
pseudogene |
| Organism: |
mouse, laboratory |
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| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
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| Gene |
| Type: |
gene |
| Organism: |
zebrafish |
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| Gene |
| Type: |
gene |
| Organism: |
zebrafish |
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| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
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| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
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| Publication |
| First Author: |
McGinty RK |
| Year: |
2014 |
| Journal: |
Nature |
| Title: |
Crystal structure of the PRC1 ubiquitylation module bound to the nucleosome. |
| Volume: |
514 |
| Issue: |
7524 |
| Pages: |
591-6 |
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| Protein Domain |
| Type: |
Domain |
| Description: |
RING1 is a transcriptional repressor associated with the Polycomb group (PcG) protein complex involved in stable repression of gene activity. It is a core component of polycomb repressive complex 1 (PRC1) that functions as an E3-ubuiquitin ligase that transferring the mono-ubuiquitin mark to the C-terminal tail of Histone H2A at K118/K119 []. PRC1 is also capable of chromatin compaction, a function not requiring histone tails, and this activity appears important in gene silencing []. RING1 interacts with multiple PcG proteins and displays tumorigenic activity[]. It also shows zinc-dependent DNA binding activity. Moreover, RING1 inhibits transactivation of the DNA-binding protein recombination signal binding protein-Jkappa (RBP-J) by Notch through interaction with the LIM domains of KyoT2 []. RING1 contains a C3HC4-type RING-HC finger []. |
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| Publication |
| First Author: |
Danen-van Oorschot AA |
| Year: |
2004 |
| Journal: |
Cell Death Differ |
| Title: |
Human death effector domain-associated factor interacts with the viral apoptosis agonist Apoptin and exerts tumor-preferential cell killing. |
| Volume: |
11 |
| Issue: |
5 |
| Pages: |
564-73 |
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| Publication |
| First Author: |
He Z |
| Year: |
2020 |
| Journal: |
Genes (Basel) |
| Title: |
Ring 1 and YY1 Binding Protein Expressed in Murine Spermatocytes but Dispensable for Spermatogenesis. |
| Volume: |
11 |
| Issue: |
1 |
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| Publication |
| First Author: |
Lin SS |
| Year: |
2008 |
| Journal: |
Plant J |
| Title: |
RING1 E3 ligase localizes to plasma membrane lipid rafts to trigger FB1-induced programmed cell death in Arabidopsis. |
| Volume: |
56 |
| Issue: |
4 |
| Pages: |
550-61 |
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| Protein Domain |
| Type: |
Family |
| Description: |
Proteins included in this entry have an N-terminal RanBP2-type zinc finger and a Yaf2/RYBP C-terminal binding motif. Proteins with these regions include Yaf2 and RYBP proteins, which are homologous parts of the PRC1 complex [].RYBP is a zinc finger protein with an essential role during embryonic development, which binds transcriptional factors, Polycomb products, and mediators of apoptosisis []. RYBP also binds ubiquitin and Cbx proteins via the C-terminal docking module [, ]. RYBP is natively unstructured until it binds to the C-terminal region of the Polycomb protein Ring1B or to DNA []. Yaf2 binds to MYC and inhibits MYC-mediated transactivation []. |
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| Pseudogene |
| Type: |
pseudogene |
| Organism: |
Mus caroli |
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•
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| Pseudogene |
| Type: |
pseudogene |
| Organism: |
mouse, laboratory |
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| Pseudogene |
| Type: |
pseudogene |
| Organism: |
mouse, laboratory |
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