Type |
Details |
Score |
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
1 |
Description: |
E3 ubiquitin-protein ligase Rnf220 |
Type: |
chain |
End: |
566 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
353
 |
Fragment?: |
false |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7608290 |
Assay Type: |
RNA in situ |
Annotation Date: |
2024-03-04 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1756320 |
Pattern: |
Regionally restricted |
Stage: |
TS20 |
Assay Id: |
MGI:7608298 |
Age: |
embryonic day 12.5 |
Image: |
3B Dbh |
Note: |
Expression overlapping with Rnf220 expression. |
Specimen Label: |
3B Dbh |
Detected: |
true |
Specimen Num: |
14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ma P |
Year: |
2014 |
Journal: |
Mol Cell Biol |
Title: |
The ubiquitin ligase RNF220 enhances canonical Wnt signaling through USP7-mediated deubiquitination of β-catenin. |
Volume: |
34 |
Issue: |
23 |
Pages: |
4355-66 |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
RNF220 mediates K63-linked polyubiquitination of STAT1 and promotes host defense. |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7608065 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2024-03-04 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1707919 |
Pattern: |
Regionally restricted |
Stage: |
TS19 |
Assay Id: |
MGI:7608331 |
Age: |
embryonic day 11.5 |
Image: |
S1D Rnf220/Zc4h2 |
Note: |
Expression colocalized with Rnf220 expression in locus coeruleus noradrenergic neurons. |
Specimen Label: |
S1D Rnf220/Zc4h2 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7608290 |
Assay Type: |
RNA in situ |
Annotation Date: |
2024-03-04 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1629017 |
Pattern: |
Regionally restricted |
Stage: |
TS17 |
Assay Id: |
MGI:7608298 |
Age: |
embryonic day 10.5 |
Image: |
3A Dbh |
Note: |
Expression in dorsal rhombomere 1 overlapping with Rnf220 expression. |
Specimen Label: |
3A Dbh |
Detected: |
true |
Specimen Num: |
13 |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
RNF220 is an E3 ubiquitin ligase for AMPA receptors to regulate synaptic transmission. |
|
•
•
•
•
•
|
Publication |
First Author: |
Inaki M |
Year: |
2010 |
Journal: |
Development |
Title: |
Drosophila Tey represses transcription of the repulsive cue Toll and generates neuromuscular target specificity. |
Volume: |
137 |
Issue: |
13 |
Pages: |
2139-46 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This entry represents the central region of the E3 ubiquitin-protein ligase RNF220 []. RNF220 also interacts with beta-catenin independently of its E3 ligase activity; instead of ubiquitinating and destabilising it, RNF220 promotes beta-catenin stabilisation and canonical Wnt signaling []. Proteins containing this domain also include Drosophila Tey protein and some uncharacterised fungal proteins. Tey (Teyrha-Meyhra) is a transcription factor that suppresses Toll expression []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Kelsall IR |
Year: |
2013 |
Journal: |
EMBO J |
Title: |
TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexes. |
Volume: |
32 |
Issue: |
21 |
Pages: |
2848-60 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
RNF220 is an E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of Sin3B, a scaffold protein of the Sin3/HDAC (histone deacetylase) corepressor complex. It can also bind E2 and mediate auto-ubiquitination of itself. Moreover, RNF220 specifically interacts with beta-catenin, and enhances canonical Wnt signaling through ubiquitin-specific protease 7 (USP7)-mediated deubiquitination and stabilization of beta-catenin, which is independent of its E3 ligase activity. RNF220 contains a characteristic C3HC4-type RING-HC finger at its C terminus [, ]. |
|
•
•
•
•
•
|
DO Term |
|
•
•
•
•
•
|
Publication |
First Author: |
Scoville DK |
Year: |
2017 |
Journal: |
FASEB J |
Title: |
Genetic determinants of susceptibility to silver nanoparticle-induced acute lung inflammation in mice. |
Volume: |
31 |
Issue: |
10 |
Pages: |
4600-4611 |
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2000 |
Journal: |
Genome Res |
Title: |
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. |
Volume: |
10 |
Issue: |
10 |
Pages: |
1617-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
1999 |
Journal: |
Methods Enzymol |
Title: |
High-efficiency full-length cDNA cloning. |
Volume: |
303 |
|
Pages: |
19-44 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shibata K |
Year: |
2000 |
Journal: |
Genome Res |
Title: |
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. |
Volume: |
10 |
Issue: |
11 |
Pages: |
1757-71 |
|
•
•
•
•
•
|
Publication |
First Author: |
Katayama S |
Year: |
2005 |
Journal: |
Science |
Title: |
Antisense transcription in the mammalian transcriptome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1564-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gerhard DS |
Year: |
2004 |
Journal: |
Genome Res |
Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
Volume: |
14 |
Issue: |
10B |
Pages: |
2121-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Huttlin EL |
Year: |
2010 |
Journal: |
Cell |
Title: |
A tissue-specific atlas of mouse protein phosphorylation and expression. |
Volume: |
143 |
Issue: |
7 |
Pages: |
1174-89 |
|
•
•
•
•
•
|
Publication |
First Author: |
Church DM |
Year: |
2009 |
Journal: |
PLoS Biol |
Title: |
Lineage-specific biology revealed by a finished genome assembly of the mouse. |
Volume: |
7 |
Issue: |
5 |
Pages: |
e1000112 |
|
•
•
•
•
•
|