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Search results 201 to 256 out of 256 for Rnf31

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Type Details Score
Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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UniProt Feature
UniProt Feature
Begin: 1
Description: E3 ubiquitin-protein ligase RNF31
Type: chain
End: 1066
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Publication
35688159 | J:350318
First Author: Zhang Z
Year: 2022
Journal: Cell Rep Med
Title: RNF31 inhibition sensitizes tumors to bystander killing by innate and adaptive immune cells.
Volume: 3
Issue: 6
Pages: 100655
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Protein
A0A2I3BRY4
Organism: Mus musculus/domesticus
Length: 103  
Fragment?: true
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Publication
23708998 | J:197674
First Author: Rivkin E
Year: 2013
Journal: Nature
Title: The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis.
Volume: 498
Issue: 7454
Pages: 318-24
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Allele
Rnf31<tm1Smoc> | MGI:7292089
Name: ring finger protein 31; targeted mutation 1, Shanghai Model Organisms Center
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Publication
29950720 | J:264084
First Author: Heger K
Year: 2018
Journal: Nature
Title: OTULIN limits cell death and inflammation by deubiquitinating LUBAC.
Volume: 559
Issue: 7712
Pages: 120-124
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Publication
28701375 | J:244164
First Author: Wei R
Year: 2017
Journal: Genes Dev
Title: SPATA2 regulates the activation of RIPK1 by modulating linear ubiquitination.
Volume: 31
Issue: 11
Pages: 1162-1176
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Publication
22430200 | -
First Author: Yagi H
Year: 2012
Journal: EMBO Rep
Title: A non-canonical UBA-UBL interaction forms the linear-ubiquitin-chain assembly complex.
Volume: 13
Issue: 5
Pages: 462-8
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Protein Domain
IPR032065 | RNF31-UBA
Type: Domain
Description: This entry represents a binding domain found in E3 ubiquitin-protein ligase RNF31 like proteins. RNF31 is also known as HOIL-1L binding partner (HOIP). The interaction of HOIL-1L and HOIP is via the UBL-UBA interaction. This interaction is important in E3 complex formation and the subsequent activation of NF-kappaB [].
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GO Term
GO:0071797 | LUBAC complex
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Publication
20956555 | J:187563
First Author: Landgraf K
Year: 2010
Journal: Mol Cell Biol
Title: Sipl1 and Rbck1 are novel Eya1-binding proteins with a role in craniofacial development.
Volume: 30
Issue: 24
Pages: 5764-75
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Publication
30026495 | -
First Author: Aalto AL
Year: 2019
Journal: Cell Death Differ
Title: M1-linked ubiquitination by LUBEL is required for inflammatory responses to oral infection in Drosophila.
Volume: 26
Issue: 5
Pages: 860-876
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Publication
27702987 | -
First Author: Asaoka T
Year: 2016
Journal: EMBO Rep
Title: Linear ubiquitination by LUBEL has a role in Drosophila heat stress response.
Volume: 17
Issue: 11
Pages: 1624-1640
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Protein Domain
IPR026254 | RNF31-like
Type: Family
Description: RNF31 is a component of the linear ubiquitin chain assembly complex (LUBAC) [, , ]. RNF31 is also known as HOIL-1L interacting protein (HOIP). It has been shown that RNF31 interacts with the muscle-specific kinase (MuSK) in mice [].LUBAC catalyses the formation of linear ubiquitin chains and regulates immune and apoptopic signaling pathways [, , ]. LUBAC consists of SHARPIN, HOIL-1 (also known as RBCK1) and HOIP [, ].This family also includes the fly E3 ubiquitin-protein ligase lubel, which conjugates linear 'Met-1'- and 'Lys-63'-linked polyubiquitin chains to substrates. Ithas been shown to play a role in heat-stress response [], as well as being involved in the NF-kappa-B intestinal inflammatory response to oral infection in Drosophila [].
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Protein
Q9ER92
Organism: Mus musculus/domesticus
Length: 183  
Fragment?: true
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Protein
A0A2I3BQB7
Organism: Mus musculus/domesticus
Length: 58  
Fragment?: false
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Publication
23746843 | -
First Author: Keusekotten K
Year: 2013
Journal: Cell
Title: OTULIN antagonizes LUBAC signaling by specifically hydrolyzing Met1-linked polyubiquitin.
Volume: 153
Issue: 6
Pages: 1312-26
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Publication
17006537 | -
First Author: Kirisako T
Year: 2006
Journal: EMBO J
Title: A ubiquitin ligase complex assembles linear polyubiquitin chains.
Volume: 25
Issue: 20
Pages: 4877-87
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Publication
24141947 | -
First Author: Stieglitz B
Year: 2013
Journal: Nature
Title: Structural basis for ligase-specific conjugation of linear ubiquitin chains by HOIP.
Volume: 503
Issue: 7476
Pages: 422-426
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Protein Domain
IPR041031 | RNF31_C
Type: Domain
Description: This is the C-terminal domain of RNF31 (also known as HOIP) from humans. HOIP is a component of the linear ubiquitin chain assembly complex (LUBAC), which synthesizes the linear ubiquitin chains that help control innate immunity and inflammation [, , ]. This region has an RBR domain which catalyzes the transfer of ubiquitin onto a substrate [].
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Protein Domain
IPR023237 | Otulin
Type: Family
Description: Otulin (also known as FAM105B) belongs to the ovarian tumour (OTU) deubiquitinases (DUBs) family []. It specifically removes linear ('Met-1'-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response []. It associates with the LUBAC complex via direct interaction with RNF31 and counteracts its action by cleaving linear polyubiquitin chains to substrates [].
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Publication
21455173 | J:170810
First Author: Gerlach B
Year: 2011
Journal: Nature
Title: Linear ubiquitination prevents inflammation and regulates immune signalling.
Volume: 471
Issue: 7340
Pages: 591-6
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Publication
21829440 | J:176256
First Author: Liang Y
Year: 2011
Journal: PLoS One
Title: SHARPIN negatively associates with TRAF2-mediated NFκB activation.
Volume: 6
Issue: 7
Pages: e21696
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Publication
27460922 | -
 
First Author: Zhu J
Year: 2016
Journal: BMC Cancer
Title: Atypical ubiquitin ligase RNF31: the nuclear factor modulator in breast cancer progression.
Volume: 16
Pages: 538
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Publication
24726327 | -
First Author: Schaeffer V
Year: 2014
Journal: Mol Cell
Title: Binding of OTULIN to the PUB domain of HOIP controls NF-κB signaling.
Volume: 54
Issue: 3
Pages: 349-61
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Publication
24726323 | -
First Author: Elliott PR
Year: 2014
Journal: Mol Cell
Title: Molecular basis and regulation of OTULIN-LUBAC interaction.
Volume: 54
Issue: 3
Pages: 335-48
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Protein Domain
IPR040641 | RNF31_PUB
Type: Domain
Description: This is a PUB domain (PNGase/UBA- or UBX-containing domain), found in E3 ubiquitin-protein ligase RNF31, also known as Ring finger protein 31 and HOIL-1-interacting protein (HOIP) []. RNF31/HOIP has been shown to contribute to inborn human immunity disorders, in which RNF31/HOIP missense mutation at PUB domain gives rise to the de-stabilized LUBAC complex (linear ubiquitin chain assembly complex) and subsequently causes the auto-inflammation and immunodeficiency. In addition, RNF31 is reported to modify ERK and JNK pathways leading to cisplatin resistance []. Functional studies indicate that HOIP and OTULIN interact and act as a bimolecular editing pair for linear ubiquitin signals where the HOIP-PUB domain binds to the PUB interacting motif (PIM) of OTULIN and the chaperone VCP/p9. This interaction plays an important role where the HOIP binding to OTULIN is required for the recruitment of OTULIN to the TNF receptor complex and to counteract HOIP-dependent activation of the NF-KB pathway [, ].
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Protein
Q3UCV8
Organism: Mus musculus/domesticus
Length: 352  
Fragment?: false
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Protein Coding Gene
MGI:3577015 | Otulin
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q6KAP7
Organism: Mus musculus/domesticus
Length: 590  
Fragment?: true
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Protein
Q6WIZ9
Organism: Mus musculus/domesticus
Length: 1067  
Fragment?: false
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Protein Coding Gene
MGI:1344372 | Rbck1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
F6XVP7
Organism: Mus musculus/domesticus
Length: 912  
Fragment?: true
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Publication
23827681 | -
First Author: Mevissen TE
Year: 2013
Journal: Cell
Title: OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis.
Volume: 154
Issue: 1
Pages: 169-84
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Protein Coding Gene
MGI:1913331 | Sharpin
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
24576094 | -
First Author: Spratt DE
Year: 2014
Journal: Biochem J
Title: RBR E3 ubiquitin ligases: new structures, new insights, new questions.
Volume: 458
Issue: 3
Pages: 421-37
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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Publication
21183079 | J:292518
First Author: Huttlin EL
Year: 2010
Journal: Cell
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume: 143
Issue: 7
Pages: 1174-89
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Publication
19468303 | -
First Author: Church DM
Year: 2009
Journal: PLoS Biol
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume: 7
Issue: 5
Pages: e1000112
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