Search our database by keyword

Examples

Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 201 to 223 out of 223 for Rnf4

<< First < Previous | Next > Last >>

0.018s

Type

Details

Score

UniProt Feature

Begin:	1
Description:	E3 ubiquitin-protein ligase RNF4
Type:	chain
End:	194

•

Interaction Experiment

Aguilar-Martinez E (2017)

Description:

RNF4 interacts with multiSUMOylated ETV4.

•

Protein

S4R2C9

Organism:	Mus musculus/domesticus
Length:	115
Fragment?:	true

•

Publication

26299341 | -

First Author:	Tan B
Year:	2015
Journal:	FEBS Lett
Title:	RNF4 negatively regulates NF-κB signaling by down-regulating TAB2.
Volume:	589
Issue:	19 Pt B
Pages:	2850-8

•

Publication

28612051 | -

First Author:	Aguilar-Martinez E
Year:	2016
Journal:	Wellcome Open Res
Title:	RNF4 interacts with multiSUMOylated ETV4.
Volume:	1

Pages:	3

•

Publication

10713105 | J:69260

First Author:	Fedele M
Year:	2000
Journal:	J Biol Chem
Title:	A novel member of the BTB/POZ family, PATZ, associates with the RNF4 RING finger protein and acts as a transcriptional repressor.
Volume:	275
Issue:	11
Pages:	7894-901

•

Publication

18408734 | -

First Author:	Tatham MH
Year:	2008
Journal:	Nat Cell Biol
Title:	RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation.
Volume:	10
Issue:	5
Pages:	538-46

•

Interaction Experiment

Liew CW (2010)

Description:

RING domain dimerization is essential for RNF4 function.

•

Publication

12874792 | -

First Author:	Pero R
Year:	2003
Journal:	Mol Reprod Dev
Title:	Translational regulation of a novel testis-specific RNF4 transcript.
Volume:	66
Issue:	1
Pages:	1-7

•

Interaction Experiment

Liu Y (2017)

Description:

Manipulating PML SUMOylation via Silencing UBC9 and RNF4 Regulates Cardiac Fibrosis.

•

Publication

28143738 | -

First Author:	Liu Y
Year:	2017
Journal:	Mol Ther
Title:	Manipulating PML SUMOylation via Silencing UBC9 and RNF4 Regulates Cardiac Fibrosis.
Volume:	25
Issue:	3
Pages:	666-678

•

GO Term

GO:0033768 | SUMO-targeted ubiquitin ligase complex

•

Publication

22842904 | -

First Author:	Plechanovová A
Year:	2012
Journal:	Nature
Title:	Structure of a RING E3 ligase and ubiquitin-loaded E2 primed for catalysis.
Volume:	489
Issue:	7414
Pages:	115-20

•

Publication

26450775 | -

First Author:	Her J
Year:	2015
Journal:	FEBS Lett
Title:	PIAS1-mediated sumoylation promotes STUbL-dependent proteasomal degradation of the human telomeric protein TRF2.
Volume:	589
Issue:	21
Pages:	3277-86

•

Publication

25969536 | -

First Author:	Hendriks IA
Year:	2015
Journal:	J Biol Chem
Title:	Ubiquitin-specific Protease 11 (USP11) Deubiquitinates Hybrid Small Ubiquitin-like Modifier (SUMO)-Ubiquitin Chains to Counteract RING Finger Protein 4 (RNF4).
Volume:	290
Issue:	25
Pages:	15526-37

•

Publication

26148049 | -

First Author:	Branigan E
Year:	2015
Journal:	Nat Struct Mol Biol
Title:	Structural basis for the RING-catalyzed synthesis of K63-linked ubiquitin chains.
Volume:	22
Issue:	8
Pages:	597-602

•

Protein Domain

IPR043295 | RING-HC_RNF4

Type:

Domain

Description:

RNF4 is a SUMO-targeted E3 ubiquitin-protein ligase with a pivotal function in the DNA damage response (DDR) through interacting with the deubiquitinating enzyme ubiquitin-specific protease 11 (USP11), a known DDR-component, and further facilitating DNA repair []. It plays a novel role in preventing the loss of intact chromosomes and ensures the maintenance of chromosome integrity. Moreover, RNF4 is responsible for the UbcH5A-catalyzed formation of K48 chains that target SUMO-modified promyelocytic leukemia (PML) protein for proteasomal degradation in response to arsenic treatment []. It also interacts with telomeric repeat binding factor 2 (TRF2) in a small ubiquitin-like modifiers (SUMO)-dependent manner and preferentially targets SUMO-conjugated TRF2 for ubiquitination through SUMO-interacting motifs (SIMs) []. Furthermore, RNF4 can form a complex with a Ubc13-ubiquitin conjugate and Ube2V2. It catalyzes K63-linked polyubiquitination by the Ube2V2-Ubc13 (ubiquitin-loaded) complex []. Meanwhile, RNF4 negatively regulates nuclear factor kappa B (NF-kappaB) signaling by down-regulating transforming growth factor beta (TGF-beta)-activated kinase 1 (TAK1)-TAK1-binding protein2 (TAB2) []. RNF4 contains four SIMs followed by a C3HC4-type RING-HC finger at the C-terminal [].This entry represents the C3HC4-type RING-HC finger.

•

Protein

Q3TXE6

Organism:	Mus musculus/domesticus
Length:	194
Fragment?:	false

•

Protein

Q3ULB8

Organism:	Mus musculus/domesticus
Length:	202
Fragment?:	false

•

Publication

17242355 | -

First Author:	Villén J
Year:	2007
Journal:	Proc Natl Acad Sci U S A
Title:	Large-scale phosphorylation analysis of mouse liver.
Volume:	104
Issue:	5
Pages:	1488-93

•

Publication

15489334 | -

First Author:	Gerhard DS
Year:	2004
Journal:	Genome Res
Title:	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume:	14
Issue:	10B
Pages:	2121-7

•

Publication

21183079 | J:292518

First Author:	Huttlin EL
Year:	2010
Journal:	Cell
Title:	A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume:	143
Issue:	7
Pages:	1174-89

•

Publication

19468303 | -

First Author:	Church DM
Year:	2009
Journal:	PLoS Biol
Title:	Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume:	7
Issue:	5
Pages:	e1000112

•

Questions? Comments? Click here!

MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Your name:
Your email address:
Subject:
Message:	---- Current page: ---- /mousemine/keywordSearchResults.do?searchOffset=200&searchTerm=Rnf4

MouseMine

Search our database by keyword

Examples

Search results 201 to 223 out of 223 for Rnf4

Categories

Hits by Pathway

Hits by Category

Hits by Strain