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Search results 201 to 216 out of 216 for Rnf43

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0.017s

Type

Details

Score

Publication

29405118 | J:259879

First Author:	Lebensohn AM
Year:	2018
Journal:	Elife
Title:	R-spondins can potentiate WNT signaling without LGRs.
Volume:	7

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Protein Domain

IPR045903 | ZNRF3_Znf_RING

Type:

Domain

Description:

This entry represents the RING-type zinc finger domain of E3 ubiquitin-protein ligase ZNRF3 (Zinc/RING finger protein 3), a transmembrane enzyme () homologue of Ring finger protein 43 (RNF43). It is predominantly found in vertebrates.In humans, ZNRF3 acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6 [, , ]. ZNRF3 also functions as a tumour suppressor in the intestinal stem cell zone by restricting the size of the intestinal stem cell zone []. In frogs (Xenopus), ZNRF3 and RNF43 were seen to play a key role in limb specification, constituting a master switch along with RSPO2, which may have implications for regenerative medicine []. Zinc finger (Znf) domains are relatively small protein motifs which contain multiple finger-like protrusions that make tandem contacts with their target molecule. Some of these domains bind zinc, but many do not; instead binding other metals such as iron, or no metal at all. For example, some family members form salt bridges to stabilise the finger-like folds. They were first identified as a DNA-binding motif in transcription factor TFIIIA from Xenopus laevis (African clawed frog), however they are now recognised to bind DNA, RNA, protein and/or lipid substrates [, , , , ]. Their binding properties depend on the amino acid sequence of the finger domains and of the linker between fingers, as well as on the higher-order structures and the number of fingers. Znf domains are often found in clusters, where fingers can have different binding specificities. There are many superfamilies of Znf motifs, varying in both sequence and structure. They display considerable versatility in binding modes, even between members of the same class (e.g. some bind DNA, others protein), suggesting that Znf motifs are stable scaffolds that have evolved specialised functions. For example, Znf-containing proteins function in gene transcription, translation, mRNA trafficking, cytoskeleton organisation, epithelial development, cell adhesion, protein folding, chromatin remodelling and zinc sensing, to name but a few []. Zinc-binding motifs are stable structures, and they rarely undergo conformational changes upon binding their target.

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Publication

23756652 | -

First Author:	Wang D
Year:	2013
Journal:	Genes Dev
Title:	Structural basis for R-spondin recognition by LGR4/5/6 receptors.
Volume:	27
Issue:	12
Pages:	1339-44

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Protein

Q8BJ73

Organism:	Mus musculus/domesticus
Length:	228
Fragment?:	false

•

Protein

A0AUN1

Organism:	Mus musculus/domesticus
Length:	221
Fragment?:	true

•

Protein

Q0P5Y9

Organism:	Mus musculus/domesticus
Length:	228
Fragment?:	false

•

Protein

Q8BFU0

Organism:	Mus musculus/domesticus
Length:	243
Fragment?:	false

•

Protein

Q5SSZ7

Organism:	Mus musculus/domesticus
Length:	913
Fragment?:	false

•

Publication

12665246 | -

First Author:	Matthews JM
Year:	2002
Journal:	IUBMB Life
Title:	Zinc fingers--folds for many occasions.
Volume:	54
Issue:	6
Pages:	351-5

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Publication

17210253 | -

First Author:	Gamsjaeger R
Year:	2007
Journal:	Trends Biochem Sci
Title:	Sticky fingers: zinc-fingers as protein-recognition motifs.
Volume:	32
Issue:	2
Pages:	63-70

•

Publication

15963892 | -

First Author:	Hall TM
Year:	2005
Journal:	Curr Opin Struct Biol
Title:	Multiple modes of RNA recognition by zinc finger proteins.
Volume:	15
Issue:	3
Pages:	367-73

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Publication

15718139 | -

First Author:	Brown RS
Year:	2005
Journal:	Curr Opin Struct Biol
Title:	Zinc finger proteins: getting a grip on RNA.
Volume:	15
Issue:	1
Pages:	94-8

•

Publication

10529348 | -

First Author:	Klug A
Year:	1999
Journal:	J Mol Biol
Title:	Zinc finger peptides for the regulation of gene expression.
Volume:	293
Issue:	2
Pages:	215-8

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Publication

11179890 | -

First Author:	Laity JH
Year:	2001
Journal:	Curr Opin Struct Biol
Title:	Zinc finger proteins: new insights into structural and functional diversity.
Volume:	11
Issue:	1
Pages:	39-46

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Publication

15489334 | -

First Author:	Gerhard DS
Year:	2004
Journal:	Genome Res
Title:	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume:	14
Issue:	10B
Pages:	2121-7

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Publication

19468303 | -

First Author:	Church DM
Year:	2009
Journal:	PLoS Biol
Title:	Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume:	7
Issue:	5
Pages:	e1000112

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