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Search results 201 to 300 out of 1033 for Rpe

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Type Details Score
Publication
30098172 | J:264290
First Author: Ghosh S
Year: 2018
Journal: Invest Ophthalmol Vis Sci
Title: A Role for βA3/A1-Crystallin in Type 2 EMT of RPE Cells Occurring in Dry Age-Related Macular Degeneration.
Volume: 59
Issue: 4
Pages: AMD104-AMD113
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Publication
24791136 | J:212319
 
First Author: Kolko M
Year: 2014
Journal: Mol Vis
Title: Calcium-independent phospholipase A₂, group VIA, is critical for RPE cell survival.
Volume: 20
Pages: 511-21
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Publication
19799898 | J:158327
First Author: Elliot SJ
Year: 2010
Journal: Exp Eye Res
Title: Estrogen receptor beta protects against in vivo injury in RPE cells.
Volume: 90
Issue: 1
Pages: 10-6
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Publication
39223298 | J:353569
First Author: Ma X
Year: 2024
Journal: Commun Biol
Title: Deficient RPE mitochondrial energetics leads to subretinal fibrosis in age-related neovascular macular degeneration.
Volume: 7
Issue: 1
Pages: 1075
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Publication
37585292 | J:339640
First Author: Tworak A
Year: 2023
Journal: Cell Rep
Title: Rapid RGR-dependent visual pigment recycling is mediated by the RPE and specialized Müller glia.
Volume: 42
Issue: 8
Pages: 112982
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Publication
31101737 | J:280338
 
First Author: Rosales MAB
Year: 2019
Journal: Life Sci Alliance
Title: Loss of PGC-1α in RPE induces mesenchymal transition and promotes retinal degeneration.
Volume: 2
Issue: 3
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Publication
29721994 | J:324348
 
First Author: Dhingra A
Year: 2018
Journal: Adv Exp Med Biol
Title: Microtubule-Associated Protein 1 Light Chain 3 (LC3) Isoforms in RPE and Retina.
Volume: 1074
Pages: 609-616
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Publication
30254279 | J:280318
First Author: Sluch VM
Year: 2018
Journal: Sci Rep
Title: ADIPOR1 is essential for vision and its RPE expression is lost in the Mfrprd6 mouse.
Volume: 8
Issue: 1
Pages: 14339
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Publication
32234210 | J:305466
   
First Author: Yang X
Year: 2020
Journal: Elife
Title: CSF1R blockade induces macrophage ablation and results in mouse choroidal vascular atrophy and RPE disorganization.
Volume: 9
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HT Experiment
GSE180641 | Zfp503/Nlz2 is Required for RPE Differentiation and Optic Fissure Closure
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Sample
GSM8048364
Organism Name: mouse, laboratory
Sex: Not Specified
Age: postnatal month 3
Stage: 28
Structure . Name: pigmented retinal epithelium
Notes: bulk RNA-seq of cells from inferior RPE
Curation Status: Curated
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HT Sample
GSM8048365
Organism Name: mouse, laboratory
Sex: Not Specified
Age: postnatal month 3
Stage: 28
Structure . Name: pigmented retinal epithelium
Notes: bulk RNA-seq of cells from inferior RPE
Curation Status: Curated
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HT Sample
GSM8048366
Organism Name: mouse, laboratory
Sex: Not Specified
Age: postnatal month 3
Stage: 28
Structure . Name: pigmented retinal epithelium
Notes: bulk RNA-seq of cells from inferior RPE
Curation Status: Curated
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HT Sample
GSM8048367
Organism Name: mouse, laboratory
Sex: Not Specified
Age: postnatal month 3
Stage: 28
Structure . Name: pigmented retinal epithelium
Notes: bulk RNA-seq of cells from inferior RPE
Curation Status: Curated
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HT Sample
GSM8048368
Organism Name: mouse, laboratory
Sex: Not Specified
Age: postnatal month 4
Stage: 28
Structure . Name: pigmented retinal epithelium
Notes: bulk RNA-seq of cells from inferior RPE
Curation Status: Curated
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HT Sample
GSM8048369
Organism Name: mouse, laboratory
Sex: Not Specified
Age: postnatal month 5
Stage: 28
Structure . Name: pigmented retinal epithelium
Notes: bulk RNA-seq of cells from superior RPE
Curation Status: Curated
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HT Sample
GSM8048370
Organism Name: mouse, laboratory
Sex: Not Specified
Age: postnatal month 6
Stage: 28
Structure . Name: pigmented retinal epithelium
Notes: bulk RNA-seq of cells from superior RPE
Curation Status: Curated
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HT Sample
GSM8048371
Organism Name: mouse, laboratory
Sex: Not Specified
Age: postnatal month 7
Stage: 28
Structure . Name: pigmented retinal epithelium
Notes: bulk RNA-seq of cells from superior RPE
Curation Status: Curated
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HT Sample
GSM8048372
Organism Name: mouse, laboratory
Sex: Not Specified
Age: postnatal month 8
Stage: 28
Structure . Name: pigmented retinal epithelium
Notes: bulk RNA-seq of cells from superior RPE
Curation Status: Curated
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HT Sample
GSM8048373
Organism Name: mouse, laboratory
Sex: Not Specified
Age: postnatal month 9
Stage: 28
Structure . Name: pigmented retinal epithelium
Notes: bulk RNA-seq of cells from superior RPE
Curation Status: Curated
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Publication
30576241 | J:274397
First Author: Shao Y
Year: 2019
Journal: Am J Physiol Endocrinol Metab
Title: miRNA-451a regulates RPE function through promoting mitochondrial function in proliferative diabetic retinopathy.
Volume: 316
Issue: 3
Pages: E443-E452
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Publication
22572847 | J:191152
First Author: Liu J
Year: 2012
Journal: Am J Physiol Cell Physiol
Title: Cystic fibrosis transmembrane conductance regulator contributes to reacidification of alkalinized lysosomes in RPE cells.
Volume: 303
Issue: 2
Pages: C160-9
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Publication
28395299 | J:258464
First Author: Zhao J
Year: 2017
Journal: Invest Ophthalmol Vis Sci
Title: Multimodal Fundus Imaging of Sodium Iodate-Treated Mice Informs RPE Susceptibility and Origins of Increased Fundus Autofluorescence.
Volume: 58
Issue: 4
Pages: 2152-2159
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Publication
21810984 | J:181596
First Author: Fogerty J
Year: 2011
Journal: Invest Ophthalmol Vis Sci
Title: 174delG mutation in mouse MFRP causes photoreceptor degeneration and RPE atrophy.
Volume: 52
Issue: 10
Pages: 7256-66
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Publication
20811045 | J:171563
First Author: Wang H
Year: 2011
Journal: Invest Ophthalmol Vis Sci
Title: The role of RPE cell-associated VEGF₁₈₉ in choroidal endothelial cell transmigration across the RPE.
Volume: 52
Issue: 1
Pages: 570-8
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Publication
37934161 | J:342424
First Author: Swinkels D
Year: 2023
Journal: Invest Ophthalmol Vis Sci
Title: DHA Shortage Causes the Early Degeneration of Photoreceptors and RPE in Mice With Peroxisomal β-Oxidation Deficiency.
Volume: 64
Issue: 14
Pages: 10
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Publication
36539414 | J:333696
First Author: Zhou T
Year: 2022
Journal: Cell Death Dis
Title: IL-4 induces reparative phenotype of RPE cells and protects against retinal neurodegeneration via Nrf2 activation.
Volume: 13
Issue: 12
Pages: 1056
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Publication
24065812 | J:214491
First Author: Sugita S
Year: 2013
Journal: Invest Ophthalmol Vis Sci
Title: Suppression of IL-22-producing T helper 22 cells by RPE cells via PD-L1/PD-1 interactions.
Volume: 54
Issue: 10
Pages: 6926-33
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Publication
20657788 | J:279792
First Author: Béby F
Year: 2010
Journal: PLoS One
Title: Otx2 gene deletion in adult mouse retina induces rapid RPE dystrophy and slow photoreceptor degeneration.
Volume: 5
Issue: 7
Pages: e11673
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Publication
33784255 | J:310003
 
First Author: Choi EH
Year: 2021
Journal: JCI Insight
Title: An inducible Cre mouse for studying roles of the RPE in retinal physiology and disease.
Volume: 6
Issue: 9
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Publication
38048369 | J:343556
First Author: Kretschmer V
Year: 2023
Journal: PLoS Biol
Title: Deletion of IFT20 exclusively in the RPE ablates primary cilia and leads to retinal degeneration.
Volume: 21
Issue: 12
Pages: e3002402
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Publication
29735674 | J:262491
First Author: Esteve-Rudd J
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Defective phagosome motility and degradation in cell nonautonomous RPE pathogenesis of a dominant macular degeneration.
Volume: 115
Issue: 21
Pages: 5468-5473
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Publication
17684062 | J:128356
First Author: Chang Y
Year: 2007
Journal: J Cell Sci
Title: Tetraspanin CD81 is required for the alpha v beta5-integrin-dependent particle-binding step of RPE phagocytosis.
Volume: 120
Issue: Pt 17
Pages: 3053-63
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Publication
24216314 | J:210385
 
First Author: Sachdeva MM
Year: 2014
Journal: Exp Eye Res
Title: Nrf2 signaling is impaired in the aging RPE given an oxidative insult.
Volume: 119
Pages: 111-4
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Publication
26392743 | J:227074
 
First Author: Camelo S
Year: 2015
Journal: Mol Vis
Title: Thinning of the RPE and choroid associated with T lymphocyte recruitment in aged and light-challenged mice.
Volume: 21
Pages: 1051-9
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Publication
23982842 | J:214499
First Author: Ramos de Carvalho JE
Year: 2013
Journal: Invest Ophthalmol Vis Sci
Title: Complement factor C3a alters proteasome function in human RPE cells and in an animal model of age-related RPE degeneration.
Volume: 54
Issue: 10
Pages: 6489-501
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Publication
15572405 | J:94444
First Author: Gibbs D
Year: 2004
Journal: J Cell Sci
Title: Role of myosin VIIa and Rab27a in the motility and localization of RPE melanosomes.
Volume: 117
Issue: Pt 26
Pages: 6473-83
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Publication
22627278 | J:185536
First Author: Lange CA
Year: 2012
Journal: Development
Title: Von Hippel-Lindau protein in the RPE is essential for normal ocular growth and vascular development.
Volume: 139
Issue: 13
Pages: 2340-50
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Publication
22183388 | J:328030
 
First Author: Chrenek MA
Year: 2012
Journal: Adv Exp Med Biol
Title: Analysis of the RPE sheet in the rd10 retinal degeneration model.
Volume: 723
Pages: 641-7
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Publication
20811066 | J:171561
First Author: Graziotto JJ
Year: 2011
Journal: Invest Ophthalmol Vis Sci
Title: Three gene-targeted mouse models of RNA splicing factor RP show late-onset RPE and retinal degeneration.
Volume: 52
Issue: 1
Pages: 190-8
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Publication
24039860 | J:206397
First Author: Wittchen ES
Year: 2013
Journal: PLoS One
Title: Rap1 GTPase activation and barrier enhancement in rpe inhibits choroidal neovascularization in vivo.
Volume: 8
Issue: 9
Pages: e73070
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Publication
24880143 | J:230003
 
First Author: Chen S
Year: 2014
Journal: Exp Eye Res
Title: CD73 expression in RPE cells is associated with the suppression of conventional CD4 cell proliferation.
Volume: 127
Pages: 26-36
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GXD Expression
GXD Expression
Probe: MGI:7797423
Assay Type: RNA in situ
Annotation Date: 2025-01-02
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1717220
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:7797456
Age: embryonic day 12.5
Image: 5M
Note: Strong expression in RPE at E12.5.
Specimen Label: 5M
Detected: true
Specimen Num: 1
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Publication
18235027 | J:132587
First Author: Liu J
Year: 2008
Journal: Invest Ophthalmol Vis Sci
Title: Restoration of lysosomal pH in RPE cells from cultured human and ABCA4(-/-) mice: pharmacologic approaches and functional recovery.
Volume: 49
Issue: 2
Pages: 772-80
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Publication
25159211 | J:230209
First Author: Kim SY
Year: 2014
Journal: Invest Ophthalmol Vis Sci
Title: Deletion of aryl hydrocarbon receptor AHR in mice leads to subretinal accumulation of microglia and RPE atrophy.
Volume: 55
Issue: 9
Pages: 6031-40
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Publication
33674251 | J:330290
 
First Author: Mazzoni F
Year: 2021
Journal: Redox Biol
Title: Lack of the antioxidant enzyme methionine sulfoxide reductase A in mice impairs RPE phagocytosis and causes photoreceptor cone dysfunction.
Volume: 42
Pages: 101918
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Publication
32245241 | J:287362
 
First Author: DeRamus ML
Year: 2020
Journal: Cells
Title: Selective Ablation of Dehydrodolichyl Diphosphate Synthase in Murine Retinal Pigment Epithelium (RPE) Causes RPE Atrophy and Retinal Degeneration.
Volume: 9
Issue: 3
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Publication
22442691 | J:224208
First Author: Sreekumar PG
Year: 2012
Journal: PLoS One
Title: Mechanism of RPE cell death in α-crystallin deficient mice: a novel and critical role for MRP1-mediated GSH efflux.
Volume: 7
Issue: 3
Pages: e33420
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Publication
19450445 | J:151253
First Author: Fujihara M
Year: 2009
Journal: Exp Eye Res
Title: A human apoB100 transgenic mouse expresses human apoB100 in the RPE and develops features of early AMD.
Volume: 88
Issue: 6
Pages: 1115-23
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Publication
20071672 | J:160207
First Author: Edwards MM
Year: 2010
Journal: Invest Ophthalmol Vis Sci
Title: Photoreceptor degeneration, azoospermia, leukoencephalopathy, and abnormal RPE cell function in mice expressing an early stop mutation in CLCN2.
Volume: 51
Issue: 6
Pages: 3264-72
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Publication
31039480 | J:280468
 
First Author: Brown EE
Year: 2019
Journal: Redox Biol
Title: Mitochondrial oxidative stress in the retinal pigment epithelium (RPE) led to metabolic dysfunction in both the RPE and retinal photoreceptors.
Volume: 24
Pages: 101201
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Publication
34064901 | J:314533
 
First Author: Rohrer B
Year: 2021
Journal: Int J Mol Sci
Title: Conditional Loss of the Exocyst Component Exoc5 in Retinal Pigment Epithelium (RPE) Results in RPE Dysfunction, Photoreceptor Cell Degeneration, and Decreased Visual Function.
Volume: 22
Issue: 10
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Publication
20361964 | J:164130
First Author: Cao X
Year: 2010
Journal: Exp Eye Res
Title: The effects of quercetin in cultured human RPE cells under oxidative stress and in Ccl2/Cx3cr1 double deficient mice.
Volume: 91
Issue: 1
Pages: 15-25
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Publication
28465655 | J:245130
 
First Author: Zhang Y
Year: 2017
Journal: Mol Vis
Title: Early AMD-like defects in the RPE and retinal degeneration in aged mice with RPE-specific deletion of Atg5 or Atg7.
Volume: 23
Pages: 228-241
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Publication
9620764 | J:48237
First Author: Liu X
Year: 1998
Journal: Nat Genet
Title: Mutant myosin VIIa causes defective melanosome distribution in the RPE of shaker-1 mice.
Volume: 19
Issue: 2
Pages: 117-8
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HT Experiment
GSE221952 | Impaired RPE Mitochondrial Energetics Leads Subretinal Fibrosis in Neovascular Age-related Macular Degeneration
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE210414 | The transcriptional networks governing the spatial regulation of RPE differentiation are regulated by the SWI/SNF complexes
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
26529045 | J:231059
First Author: Kuny S
Year: 2015
Journal: Invest Ophthalmol Vis Sci
Title: Early Onset Ultrastructural and Functional Defects in RPE and Photoreceptors of a Stargardt-Like Macular Dystrophy (STGD3) Transgenic Mouse Model.
Volume: 56
Issue: 12
Pages: 7109-21
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Publication
19643958 | J:160432
First Author: Gibbs D
Year: 2010
Journal: Invest Ophthalmol Vis Sci
Title: Function of MYO7A in the human RPE and the validity of shaker1 mice as a model for Usher syndrome 1B.
Volume: 51
Issue: 2
Pages: 1130-5
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Publication
25316721 | J:230317
First Author: Fujihara M
Year: 2014
Journal: Invest Ophthalmol Vis Sci
Title: Mice that produce ApoB100 lipoproteins in the RPE do not develop drusen yet are still a valuable experimental system.
Volume: 55
Issue: 11
Pages: 7285-95
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Publication
33622781 | J:316346
First Author: Holoman NC
Year: 2021
Journal: J Neurosci
Title: Reduction of Glut1 in the Neural Retina But Not the RPE Alleviates Polyol Accumulation and Normalizes Early Characteristics of Diabetic Retinopathy.
Volume: 41
Issue: 14
Pages: 3275-3299
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Publication
27616714 | J:237224
First Author: Kim JY
Year: 2016
Journal: Dev Biol
Title: Yap is essential for retinal progenitor cell cycle progression and RPE cell fate acquisition in the developing mouse eye.
Volume: 419
Issue: 2
Pages: 336-347
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GXD Expression
GXD Expression
Probe: MGI:6323014
Assay Type: RNA in situ
Annotation Date: 2019-07-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1717219
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:6323046
Age: embryonic day 11.5
Image: 5E
Note: Expression in both dorsal and ventral RPE in control eye.
Specimen Label: 5E
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
Probe: MGI:7738410
Assay Type: Immunohistochemistry
Annotation Date: 2024-10-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1717221
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:7738438
Age: embryonic day 13.5
Image: 4b
Note: Most of expression localized in RPE and choroid.
Specimen Label: 4b
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:7738410
Assay Type: Immunohistochemistry
Annotation Date: 2024-10-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1907721
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:7738438
Age: embryonic day 13.5
Image: 4b
Note: Most of expression localized in RPE and choroid.
Specimen Label: 4b
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:6323012
Assay Type: RNA in situ
Annotation Date: 2019-07-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1654015
Pattern: Regionally restricted
Stage: TS15
Assay Id: MGI:6323042
Age: embryonic day 9.5
Image: 1F
Note: Expression in dorsal optic vesicle (future RPE domain).
Specimen Label: 1F
Detected: true
Specimen Num: 1
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Publication
17122142 | J:123097
First Author: Mandal MN
Year: 2006
Journal: Invest Ophthalmol Vis Sci
Title: CTRP5 is a membrane-associated and secretory protein in the RPE and ciliary body and the S163R mutation of CTRP5 impairs its secretion.
Volume: 47
Issue: 12
Pages: 5505-13
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Publication
29338041 | J:257796
First Author: Yang X
Year: 2018
Journal: PLoS One
Title: Cadherins in the retinal pigment epithelium (RPE) revisited: P-cadherin is the highly dominant cadherin expressed in human and mouse RPE in vivo.
Volume: 13
Issue: 1
Pages: e0191279
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Publication
23548623 | J:215296
First Author: Sparrow JR
Year: 2013
Journal: Invest Ophthalmol Vis Sci
Title: Quantitative fundus autofluorescence in mice: correlation with HPLC quantitation of RPE lipofuscin and measurement of retina outer nuclear layer thickness.
Volume: 54
Issue: 4
Pages: 2812-20
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Publication
18515570 | J:141801
First Author: Radu RA
Year: 2008
Journal: Invest Ophthalmol Vis Sci
Title: Accelerated accumulation of lipofuscin pigments in the RPE of a mouse model for ABCA4-mediated retinal dystrophies following Vitamin A supplementation.
Volume: 49
Issue: 9
Pages: 3821-9
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MP Term
MP:0005201 | abnormal retina pigment epithelium morphology
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Publication
30038866 | J:280303
 
First Author: Taubitz T
Year: 2018
Journal: PeerJ
Title: Ultrastructural alterations in the retinal pigment epithelium and photoreceptors of a Stargardt patient and three Stargardt mouse models: indication for the central role of RPE melanin in oxidative stress.
Volume: 6
Pages: e5215
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GXD Expression
GXD Expression
Probe: MGI:6323012
Assay Type: RNA in situ
Annotation Date: 2019-07-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3659420
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:6323042
Age: embryonic day 12.5
Image: 1H
Note: Expression in presumptive ciliary body, RPE and mesenchyme surrouding the eye.
Specimen Label: 1H
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:4830472
Assay Type: Immunohistochemistry
Annotation Date: 2001-08-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1717225
Pattern: Regionally restricted
Stage: TS25
Assay Id: MGI:2137655
Age: embryonic day 17.5
Image: 8B,C
Note: Expression in the RPE indicates that this tissue is patterned incorrectly and has taken on the identity of neural retina.
Specimen Label: 8B,C
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:4830472
Assay Type: Immunohistochemistry
Annotation Date: 2001-08-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1859025
Pattern: Regionally restricted
Stage: TS25
Assay Id: MGI:2137655
Age: embryonic day 17.5
Image: 8B,C
Note: Expression in the RPE indicates that this tissue is patterned incorrectly and has taken on the identity of neural retina.
Specimen Label: 8B,C
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:6323013
Assay Type: RNA in situ
Annotation Date: 2019-07-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1667717
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:6323045
Age: embryonic day 10.5
Image: 5C'
Note: Normal levels of expression in dorsal RPE region. Expression downregulated in ventral RPE region of mutant eye.
Specimen Label: 5C'
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
Probe: MGI:6323014
Assay Type: RNA in situ
Annotation Date: 2019-07-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1667717
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:6323046
Age: embryonic day 10.5
Image: 5D'
Note: Normal levels of expression in dorsal RPE region; reduced expression in ventral RPE region of mutant eye.
Specimen Label: 5D'
Detected: true
Specimen Num: 4
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Publication
18055825 | -
First Author: Li R
Year: 2007
Journal: Invest Ophthalmol Vis Sci
Title: PDGF-C and -D induced proliferation/migration of human RPE is abolished by inflammatory cytokines.
Volume: 48
Issue: 12
Pages: 5722-32
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GXD Expression
GXD Expression
Probe: MGI:3525824
Assay Type: RNA in situ
Annotation Date: 2005-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1717222
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:3525849
Age: embryonic day 14.5
Image: E14.5 heterozygote
Note: Expression is present throughout the retinal pigmented epithelium (RPE) and at higher levels in the peripheral RPE in zones 2 and 3 as well.
Specimen Label: E14.5 heterozygote
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:2149792
Assay Type: Immunohistochemistry
Annotation Date: 2024-05-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1717222
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:7643163
Age: embryonic day 14.5
Note: Expression in ectopic retinal ganglion cell (RGC) axon bundle extending from subretinal space into retinal pigment epithelium (RPE), inserting bewteen pigmented RPE cells.
Specimen Label: 5i
Detected: true
Specimen Num: 5
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HT Experiment
GSE263427 | Deciphering age-related transcriptomic changes in mouse retinal pigment epithelium
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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HT Experiment
GSE191077 | Retinal pigment epithelium-specific CLIC4 mutant is a mouse model of dry age-related macular degeneration
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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GXD Expression
GXD Expression
Probe: MGI:3525824
Assay Type: RNA in situ
Annotation Date: 2005-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1717225
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:3525849
Age: embryonic day 17.5
Image: E17.5 heterozygote
Note: Expression is present throughout the retinal pigmented epithelium (RPE) and at higher levels in the peripheral RPE in zones 2, 3, and 4. There is also expression in migrating melanoblasts.
Specimen Label: E17.5 heterozygote
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:6323014
Assay Type: RNA in situ
Annotation Date: 2019-07-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1717219
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:6323046
Age: embryonic day 11.5
Image: 5E'
Note: Normal levels of expression in dorsal RPE region; reduced expression in ventral RPE region. Authors report subdomains in ventral RPE: domain 2 is closer to midline and has less expression than domain 1 which is further away from midline.
Specimen Label: 5E'
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
 
Probe: MGI:7619944
Assay Type: Immunohistochemistry
Annotation Date: 2024-04-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1717221
Pattern: Regionally restricted
Stage: TS21
Assay Id: MGI:7619953
Age: embryonic day 13.5-14.5
Note: In the mutant, expression was not found in the dorsal expanded region of the retinal pigmented epithelium (RPE), but was observed in only in regions where the RPE remained a monolayer.
Specimen Label: 1D
Detected: true
Specimen Num: 2
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HT Experiment
GSE203138 | Single-cell RNA sequencing reveals molecular features of postnatal maturation in the murine retinal pigment epithelium
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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HT Experiment
GSE121467 | Expression data from retinal pigment epithelium in pigmented and albino mouse embryos
 
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE214005 | INFLAMMATION OF THE RETINAL PIGMENT EPITHELIUM DRIVES EARLY-ONSET PHOTORECEPTOR DEGENERATION IN MERTK-ASSOCIATED RETINITIS PIGMENTOSA
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE254669 | RNA-Seq data of mouse retina, retinal pigment epithelium and cones
 
Experiment Type: RNA-Seq
Study Type: Baseline and WT vs. Mutant
Source: GEO
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Publication
9275222 | J:42814
First Author: Sun H
Year: 1997
Journal: Proc Natl Acad Sci U S A
Title: Peropsin, a novel visual pigment-like protein located in the apical microvilli of the retinal pigment epithelium.
Volume: 94
Issue: 18
Pages: 9893-8
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HT Experiment
GSE209908 | DARPP32, a target of hyperactive mTORC1 in the retinal pigment epithelium
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE225344 | Transcriptome changes in the retinal pigment epithelial cells of Microtubule-Associated Protein 1 Light Chain 3B gene knockout mouse (LC3b-/-)
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
35042858 | J:357303
First Author: Chuang JZ
Year: 2022
Journal: Nat Commun
Title: Retinal pigment epithelium-specific CLIC4 mutant is a mouse model of dry age-related macular degeneration.
Volume: 13
Issue: 1
Pages: 374
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Protein Domain
IPR002962 | Peropsin
Type: Family
Description: Peropsin is a visual pigment-like protein found in ocular tissues.The protein has been localised to the apical face of the retinal pigmentepithelium (RPE), most prominently to the microvilli that surround thephotoreceptor outer segments. It is believed that peropsin may play arole in RPE physiology, either by detecting light directly, or by monitoringthe concentration of retinoids or other photoreceptor-derived compounds [].
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Protein Domain
IPR013611 | Transp-assoc_OB_typ2
Type: Domain
Description: The TOBE domain [](Transport-associated OB) always occurs as a dimer as the C-terminal strand of each domain is supplied by the partner. Probably involved in the recognition of small ligands such as molybdenum (e.g. ) and sulphate (). Found in ABC transporters immediately after the ATPase domain. A strong RPE motif is found at the presumed N terminus of the domain.
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Publication
38085785 | J:349805
First Author: Chen Y
Year: 2023
Journal: Proc Natl Acad Sci U S A
Title: Interleukin-17-mediated protective cytokine signaling against degeneration of the retinal pigment epithelium.
Volume: 120
Issue: 51
Pages: e2311647120
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Publication
24854863 | J:211651
First Author: He L
Year: 2014
Journal: Am J Pathol
Title: Age- and gene-dosage-dependent cre-induced abnormalities in the retinal pigment epithelium.
Volume: 184
Issue: 6
Pages: 1660-7
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Publication
30864945 | J:275133
   
First Author: Storti F
Year: 2019
Journal: Elife
Title: Impaired ABCA1/ABCG1-mediated lipid efflux in the mouse retinal pigment epithelium (RPE) leads to retinal degeneration.
Volume: 8
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Publication
21135502 | J:171850
First Author: Zhao C
Year: 2011
Journal: J Clin Invest
Title: mTOR-mediated dedifferentiation of the retinal pigment epithelium initiates photoreceptor degeneration in mice.
Volume: 121
Issue: 1
Pages: 369-83
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Publication
38445789 | J:360749
First Author: Grubaugh CR
Year: 2024
Journal: FASEB J
Title: Microsomal triglyceride transfer protein is necessary to maintain lipid homeostasis and retinal function.
Volume: 38
Issue: 5
Pages: e23522
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