Type |
Details |
Score |
Publication |
First Author: |
Vidal VP |
Year: |
2005 |
Journal: |
Curr Biol |
Title: |
Sox9 is essential for outer root sheath differentiation and the formation of the hair stem cell compartment. |
Volume: |
15 |
Issue: |
15 |
Pages: |
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•
•
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Publication |
First Author: |
Oleari R |
Year: |
2019 |
Journal: |
Development |
Title: |
PLXNA1 and PLXNA3 cooperate to pattern the nasal axons that guide gonadotropin-releasing hormone neurons. |
Volume: |
146 |
Issue: |
21 |
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Publication |
First Author: |
Oakey RJ |
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1992 |
Journal: |
Immunogenetics |
Title: |
Chromosomal mapping of the high affinity Fc gamma receptor gene. |
Volume: |
35 |
Issue: |
4 |
Pages: |
279-82 |
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Publication |
First Author: |
Dower NA |
Year: |
1992 |
Journal: |
Mamm Genome |
Title: |
Organization and chromosomal locations of Rap1a/Krev sequences in the mouse. |
Volume: |
3 |
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3 |
Pages: |
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Shao H |
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Journal: |
J Biol Chem |
Title: |
Characterization of B61, the ligand for the Eck receptor protein-tyrosine kinase. |
Volume: |
270 |
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Publication |
First Author: |
Marenholz I |
Year: |
2006 |
Journal: |
Biochim Biophys Acta |
Title: |
An update of the S100 nomenclature. |
Volume: |
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Issue: |
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Pages: |
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Publication |
First Author: |
Coccia E |
Year: |
2020 |
Journal: |
Cell Death Dis |
Title: |
SIVA-1 regulates apoptosis and synaptic function by modulating XIAP interaction with the death receptor antagonist FAIM-L. |
Volume: |
11 |
Issue: |
2 |
Pages: |
82 |
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First Author: |
Rhee H |
Year: |
2006 |
Journal: |
Science |
Title: |
Lhx2 maintains stem cell character in hair follicles. |
Volume: |
312 |
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5782 |
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Derk J |
Year: |
2023 |
Journal: |
Dev Cell |
Title: |
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Volume: |
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Issue: |
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First Author: |
Romano RA |
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2010 |
Journal: |
Development |
Title: |
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Volume: |
137 |
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9 |
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First Author: |
Park YK |
Year: |
2005 |
Journal: |
Genesis |
Title: |
Gene expression profile analysis of mouse colon embryonic development. |
Volume: |
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Issue: |
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First Author: |
Kurek D |
Year: |
2007 |
Journal: |
Development |
Title: |
Transcriptome and phenotypic analysis reveals Gata3-dependent signalling pathways in murine hair follicles. |
Volume: |
134 |
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DeSisto J |
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2020 |
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Dev Cell |
Title: |
Single-Cell Transcriptomic Analyses of the Developing Meninges Reveal Meningeal Fibroblast Diversity and Function. |
Volume: |
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Publication |
First Author: |
Moseley WS |
Year: |
1989 |
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Genomics |
Title: |
Definition of mouse chromosome 1 and 3 gene linkage groups that are conserved on human chromosome 1: evidence that a conserved linkage group spans the centromere of human chromosome 1. |
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Publication |
First Author: |
Higashi AY |
Year: |
2021 |
Journal: |
Sci Rep |
Title: |
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First Author: |
Velecela V |
Year: |
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Journal: |
Development |
Title: |
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20 |
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First Author: |
Butts JC |
Year: |
2024 |
Journal: |
Dev Cell |
Title: |
A single-cell transcriptomic map of the developing Atoh1 lineage identifies neural fate decisions and neuronal diversity in the hindbrain. |
Volume: |
59 |
Issue: |
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Publication |
First Author: |
Thut CJ |
Year: |
2001 |
Journal: |
Dev Biol |
Title: |
A large-scale in situ screen provides molecular evidence for the induction of eye anterior segment structures by the developing lens. |
Volume: |
231 |
Issue: |
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Pages: |
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Publication |
First Author: |
Hu B |
Year: |
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Journal: |
Cell |
Title: |
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Volume: |
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Publication |
First Author: |
Lumayag S |
Year: |
2013 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. |
Volume: |
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Publication |
First Author: |
Naba A |
Year: |
2017 |
Journal: |
Sci Rep |
Title: |
Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression. |
Volume: |
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Pages: |
40495 |
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Publication |
First Author: |
Shanghai Model Organisms Center |
Year: |
2017 |
Journal: |
MGI Direct Data Submission |
Title: |
Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
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Publication |
First Author: |
Dickinson ME |
Year: |
2016 |
Journal: |
Nature |
Title: |
High-throughput discovery of novel developmental phenotypes. |
Volume: |
537 |
Issue: |
7621 |
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508-514 |
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Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2016 |
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Title: |
Automatic assignment of GO terms using logical inference, based on on inter-ontology links |
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Publication |
First Author: |
Koscielny G |
Year: |
2014 |
Journal: |
Nucleic Acids Res |
Title: |
The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. |
Volume: |
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Pages: |
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First Author: |
Bedogni F |
Year: |
2021 |
Journal: |
Front Mol Neurosci |
Title: |
Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. |
Volume: |
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Pages: |
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Publication |
First Author: |
International Knockout Mouse Consortium |
Year: |
2014 |
Journal: |
Database Download |
Title: |
MGI download of modified allele data from IKMC and creation of new knockout alleles |
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Publication |
First Author: |
Lennon G |
Year: |
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Journal: |
Database Download |
Title: |
WashU-HHMI Mouse EST Project |
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First Author: |
International Mouse Strain Resource |
Year: |
2014 |
Journal: |
Database Download |
Title: |
MGI download of germline transmission data for alleles from IMSR strain data |
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Publication |
First Author: |
Wellcome Trust Sanger Institute |
Year: |
2009 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute |
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First Author: |
GUDMAP Consortium |
Year: |
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Title: |
GUDMAP: the GenitoUrinary Development Molecular Anatomy Project |
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First Author: |
Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
Year: |
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Journal: |
Database Release |
Title: |
Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
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First Author: |
The Gene Ontology Consortium |
Year: |
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Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
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First Author: |
UniProt-GOA |
Year: |
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Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
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First Author: |
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Year: |
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PLoS Biol |
Title: |
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. |
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The transcriptional landscape of the mammalian genome. |
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Nature |
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MGD Nomenclature Committee |
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Nature |
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A conditional knockout resource for the genome-wide study of mouse gene function. |
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Year: |
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Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
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Mouse T31 Radiation Hybrid Data Load |
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Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
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Mouse Genome Informatics Scientific Curators |
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Mouse Genome Informatics Computational Sequence to Gene Associations |
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Mouse Genome Informatics Scientific Curators |
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MGI Genome Annotation Group and UniGene Staff |
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Database Download |
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Mouse Genome Database and National Center for Biotechnology Information |
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Allen Institute for Brain Science |
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Allen Institute |
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Allen Brain Atlas: mouse riboprobes |
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Mouse Genome Informatics Scientific Curators |
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Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
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Journal: |
Database Download |
Title: |
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First Author: |
Mouse Genome Informatics Group |
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Database Procedure |
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First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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Publication |
First Author: |
Tamai H |
Year: |
2017 |
Journal: |
Cancer Res |
Title: |
Amlexanox Downregulates S100A6 to Sensitize KMT2A/AFF1-Positive Acute Lymphoblastic Leukemia to TNFα Treatment. |
Volume: |
77 |
Issue: |
16 |
Pages: |
4426-4433 |
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•
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Allele |
Name: |
S100 calcium binding protein A6 (calcyclin); endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
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Publication |
First Author: |
Schneider G |
Year: |
2011 |
Journal: |
Amino Acids |
Title: |
S100A6 binding protein and Siah-1 interacting protein (CacyBP/SIP): spotlight on properties and cellular function. |
Volume: |
41 |
Issue: |
4 |
Pages: |
773-80 |
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•
•
•
•
|
Interaction Experiment |
Description: |
Interactions of S100A2 and S100A6 with the tetratricopeptide repeat proteins, Hsp90/Hsp70-organizing protein and kinesin light chain. |
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Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
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•
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Publication |
First Author: |
Nowotny M |
Year: |
2003 |
Journal: |
J Biol Chem |
Title: |
Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and other S100 proteins. |
Volume: |
278 |
Issue: |
29 |
Pages: |
26923-8 |
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•
•
•
•
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Publication |
First Author: |
Shimamoto S |
Year: |
2008 |
Journal: |
J Biol Chem |
Title: |
Interactions of S100A2 and S100A6 with the tetratricopeptide repeat proteins, Hsp90/Hsp70-organizing protein and kinesin light chain. |
Volume: |
283 |
Issue: |
42 |
Pages: |
28246-58 |
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•
•
•
•
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Publication |
First Author: |
Lee YT |
Year: |
2008 |
Journal: |
Biochemistry |
Title: |
Structure of the S100A6 complex with a fragment from the C-terminal domain of Siah-1 interacting protein: a novel mode for S100 protein target recognition. |
Volume: |
47 |
Issue: |
41 |
Pages: |
10921-32 |
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•
•
|
Protein Domain |
Type: |
Family |
Description: |
S100A6 is a member of the S100 domain family within the EF-hand Ca2+-binding proteins superfamily. Note that the S-100 hierarchy, to which this S-100A6 group belongs, contains only S-100 EF-hand domains, other EF-hands have been modeled separately []. S100 proteins exhibit unique patterns of tissue- and cell type-specific expression and have been implicated in the Ca2+-dependent regulation of diverse physiological processes, including cell cycle regulation, differentiation, growth, and metabolic control [, , , ]. S100A6 is normally expressed in the G1 phase of the cell cycle in neuronal cells. The function of S100A6 remains unclear, but evidence suggests that it is involved in cell cycle regulation and exocytosis. S100A6 may also be involved in tumorigenesis; the protein is overexpressed in several tumours. Ca2+binding to S100A6 leads to a conformational change in the protein, which exposes a hydrophobic surface for interaction with target proteins. Several such proteins have been identified: glyceraldehyde-3-phosphate dehydrogenase, annexins 2, 6 and 11 and Calcyclin-Binding Protein (CacyBP) [, ]. |
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•
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•
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Publication |
First Author: |
Schneider G |
Year: |
2007 |
Journal: |
Biochim Biophys Acta |
Title: |
CacyBP/SIP interacts with tubulin in neuroblastoma NB2a cells and induces formation of globular tubulin assemblies. |
Volume: |
1773 |
Issue: |
11 |
Pages: |
1628-36 |
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•
•
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•
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Publication |
First Author: |
Sastry M |
Year: |
1998 |
Journal: |
Structure |
Title: |
The three-dimensional structure of Ca(2+)-bound calcyclin: implications for Ca(2+)-signal transduction by S100 proteins. |
Volume: |
6 |
Issue: |
2 |
Pages: |
223-31 |
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•
•
•
•
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Publication |
First Author: |
Donato R |
Year: |
2001 |
Journal: |
Int J Biochem Cell Biol |
Title: |
S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles. |
Volume: |
33 |
Issue: |
7 |
Pages: |
637-68 |
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•
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•
•
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Publication |
First Author: |
Santamaria-Kisiel L |
Year: |
2006 |
Journal: |
Biochem J |
Title: |
Calcium-dependent and -independent interactions of the S100 protein family. |
Volume: |
396 |
Issue: |
2 |
Pages: |
201-14 |
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•
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•
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Publication |
First Author: |
Heizmann CW |
Year: |
1998 |
Journal: |
Biometals |
Title: |
New perspectives on S100 proteins: a multi-functional Ca(2+)-, Zn(2+)- and Cu(2+)-binding protein family. |
Volume: |
11 |
Issue: |
4 |
Pages: |
383-97 |
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Publication |
First Author: |
Heizmann CW |
Year: |
2002 |
Journal: |
Methods Mol Biol |
Title: |
The multifunctional S100 protein family. |
Volume: |
172 |
|
Pages: |
69-80 |
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•
•
•
•
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Publication |
First Author: |
Huang YC |
Year: |
2022 |
Journal: |
Cancers (Basel) |
Title: |
Single-Cell Transcriptomic Profiles of Lung Pre-Metastatic Niche Reveal Neutrophil and Lymphatic Endothelial Cell Roles in Breast Cancer. |
Volume: |
15 |
Issue: |
1 |
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•
•
•
•
•
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Publication |
First Author: |
Takata M |
Year: |
2010 |
Journal: |
FEBS Lett |
Title: |
Regulation of nuclear localization signal-importin α interaction by Ca2+/S100A6. |
Volume: |
584 |
Issue: |
22 |
Pages: |
4517-23 |
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•
•
•
•
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Publication |
First Author: |
Kilanczyk E |
Year: |
2009 |
Journal: |
Biochem Biophys Res Commun |
Title: |
CacyBP/SIP binds ERK1/2 and affects transcriptional activity of Elk-1. |
Volume: |
380 |
Issue: |
1 |
Pages: |
54-9 |
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•
•
•
•
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Publication |
First Author: |
Ning X |
Year: |
2007 |
Journal: |
Mol Cancer Res |
Title: |
Calcyclin-binding protein inhibits proliferation, tumorigenicity, and invasion of gastric cancer. |
Volume: |
5 |
Issue: |
12 |
Pages: |
1254-62 |
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Protein Domain |
Type: |
Domain |
Description: |
This CS p23-like domain is found in the CacyBP/SIP protein (S100A6 binding protein and Siah-1 interacting protein) []. CacyBP/SIP interacts with S100A6 (calcyclin), with some other members of the S100 family, with tubulin, and with Siah-1 and Skp-1 []. The latter two are components of the ubiquitin ligase that regulates beta-catenin degradation. The beta-catenin gene is an oncogene participating in tumorigenesis in many different cancers. Overexpression of CacyBP/SIP, in part through its effect on the expression of beta-catenin, inhibits the proliferation, tumorigenicity, and invasion of gastric cancer cells []. CacyBP/SIP is abundant in neurons and neuroblastoma NB2a cells. An extensive re-organization of microtubules accompanies the differentiation of NB2a cells. CacyBP/SIP may contribute to NB2a cell differentiation through binding to and increasing the oligomerization of tubulin. CacyBP/SIP is also implicated in differentiation of erythroid cells, rat neonatal cardiomyocytes, in mouse endometrial events, and in thymocyte development []. |
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•
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Publication |
First Author: |
Harris MA |
Year: |
2008 |
Journal: |
Cancer Res |
Title: |
Cancer stem cells are enriched in the side population cells in a mouse model of glioma. |
Volume: |
68 |
Issue: |
24 |
Pages: |
10051-9 |
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•
•
•
•
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Publication |
First Author: |
Stancill JS |
Year: |
2017 |
Journal: |
Diabetes |
Title: |
Chronic β-Cell Depolarization Impairs β-Cell Identity by Disrupting a Network of Ca2+-Regulated Genes. |
Volume: |
66 |
Issue: |
8 |
Pages: |
2175-2187 |
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•
•
•
•
•
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Publication |
First Author: |
Hoyaux D |
Year: |
2000 |
Journal: |
Biochim Biophys Acta |
Title: |
S100A6, a calcium- and zinc-binding protein, is overexpressed in SOD1 mutant mice, a model for amyotrophic lateral sclerosis. |
Volume: |
1498 |
Issue: |
2-3 |
Pages: |
264-72 |
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•
•
•
•
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Publication |
First Author: |
Schneider G |
Year: |
2010 |
Journal: |
Biochim Biophys Acta |
Title: |
Tubulin binding protein, CacyBP/SIP, induces actin polymerization and may link actin and tubulin cytoskeletons. |
Volume: |
1803 |
Issue: |
11 |
Pages: |
1308-17 |
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•
•
•
•
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Publication |
First Author: |
Tamai H |
Year: |
2012 |
Journal: |
Blood |
Title: |
AAV8 vector expressing IL24 efficiently suppresses tumor growth mediated by specific mechanisms in MLL/AF4-positive ALL model mice. |
Volume: |
119 |
Issue: |
1 |
Pages: |
64-71 |
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•
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
89
 |
Fragment?: |
false |
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•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
89
 |
Fragment?: |
false |
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•
•
•
•
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Publication |
First Author: |
Bhattacharya S |
Year: |
2005 |
Journal: |
Biochemistry |
Title: |
The modular structure of SIP facilitates its role in stabilizing multiprotein assemblies. |
Volume: |
44 |
Issue: |
27 |
Pages: |
9462-71 |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
229
 |
Fragment?: |
false |
|
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•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
135
 |
Fragment?: |
true |
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•
•
•
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