|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 201 to 300 out of 403 for Sars

<< First    < Previous  |  Next >    Last >>
0.018s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Protein Coding Gene
MGP_PahariEiJ_G0026319 | -
Type: protein_coding_gene
Organism: Mus pahari
•
•
•
•
•
Protein Coding Gene
MGP_SPRETEiJ_G0025804 | -
Type: protein_coding_gene
Organism: Mus spretus
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5140769
Assay Type: Western blot
Annotation Date: 2011-08-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610515
Stage: TS15
Assay Id: MGI:5141293
Age: embryonic day 9.5
Image: 1
Specimen Label: E9.5
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5140769
Assay Type: Western blot
Annotation Date: 2011-08-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610523
Stage: TS23
Assay Id: MGI:5141293
Age: embryonic day 15.5
Image: 1
Specimen Label: E15.5
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5140769
Assay Type: Western blot
Annotation Date: 2011-08-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610526
Stage: TS26
Assay Id: MGI:5141293
Age: embryonic day 18.5
Image: 1
Specimen Label: E18.5
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5140769
Assay Type: Western blot
Annotation Date: 2011-08-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:5141293
Age: postnatal day 24
Image: 1
Specimen Label: P24
Detected: true
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5140769
Assay Type: Western blot
Annotation Date: 2011-08-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:5141293
Age: postnatal week 6
Image: 1
Specimen Label: 6 Wks
Detected: true
Specimen Num: 6
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5140769
Assay Type: Western blot
Annotation Date: 2011-08-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:5141293
Age: postnatal adult
Image: 1
Specimen Label: Adult
Detected: true
Specimen Num: 7
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5140764
Assay Type: RT-PCR
Annotation Date: 2011-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610523
Stage: TS23
Assay Id: MGI:5141413
Age: embryonic day 15.5
Image: 1
Specimen Label: E15.5
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5140764
Assay Type: RT-PCR
Annotation Date: 2011-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610527
Stage: TS27
Assay Id: MGI:5141413
Age: postnatal day 0
Image: 1
Specimen Label: P0
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5140764
Assay Type: RT-PCR
Annotation Date: 2011-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:5141413
Age: postnatal day 16
Image: 1
Specimen Label: P16
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5140764
Assay Type: RT-PCR
Annotation Date: 2011-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:5141413
Age: postnatal adult
Image: 1
Specimen Label: Adult
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5140769
Assay Type: Western blot
Annotation Date: 2011-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1731528
Stage: TS28
Assay Id: MGI:5141414
Age: postnatal day 9
Image: 1
Specimen Label: LA
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5140769
Assay Type: Western blot
Annotation Date: 2011-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1733728
Stage: TS28
Assay Id: MGI:5141414
Age: postnatal day 9
Image: 1
Specimen Label: LV
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5140769
Assay Type: Western blot
Annotation Date: 2011-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1731528
Stage: TS28
Assay Id: MGI:5141414
Age: postnatal adult
Image: 1
Specimen Label: LA
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5140769
Assay Type: Western blot
Annotation Date: 2011-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1733728
Stage: TS28
Assay Id: MGI:5141414
Age: postnatal adult
Image: 1
Specimen Label: LV
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5141512
Assay Type: RT-PCR
Annotation Date: 2011-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1733728
Stage: TS28
Assay Id: MGI:5141416
Age: postnatal
Image: S1
Specimen Label: LV
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5141513
Assay Type: RT-PCR
Annotation Date: 2011-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1733728
Stage: TS28
Assay Id: MGI:5141417
Age: postnatal
Image: S1
Specimen Label: LV
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5140764
Assay Type: RT-PCR
Annotation Date: 2011-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1733728
Stage: TS28
Assay Id: MGI:5141418
Age: postnatal adult
Image: S1
Specimen Label: None
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5140764
Assay Type: RT-PCR
Annotation Date: 2011-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1733728
Stage: TS28
Assay Id: MGI:5141418
Age: postnatal adult
Image: S1
Specimen Label: None
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5141420
Assay Type: RT-PCR
Annotation Date: 2011-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1733728
Stage: TS28
Assay Id: MGI:5141419
Age: postnatal adult
Image: S1
Specimen Label: None
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5140769
Assay Type: Western blot
Annotation Date: 2011-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:5141421
Age: postnatal adult
Image: S2
Specimen Label: g MuRF2 A
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5141312
Assay Type: Western blot
Annotation Date: 2011-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:5141422
Age: postnatal adult
Image: S2
Specimen Label: r HPC
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5141314
Assay Type: Western blot
Annotation Date: 2011-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:5141423
Age: postnatal adult
Image: S2
Specimen Label: HP60
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5140769
Assay Type: Western blot
Annotation Date: 2011-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610515
Stage: TS15
Assay Id: MGI:5141424
Age: embryonic day 9.5
Image: S2
Specimen Label: E9.5
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5140769
Assay Type: Western blot
Annotation Date: 2011-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610522
Stage: TS22
Assay Id: MGI:5141424
Age: embryonic day 14.5
Image: S2
Specimen Label: E14.5
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5140769
Assay Type: Western blot
Annotation Date: 2011-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610524
Stage: TS24
Assay Id: MGI:5141424
Age: embryonic day 16.5
Image: S2
Specimen Label: E16.5
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5140769
Assay Type: Western blot
Annotation Date: 2011-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610526
Stage: TS26
Assay Id: MGI:5141424
Age: embryonic day 18.5
Image: S2
Specimen Label: E18.5
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5140769
Assay Type: Western blot
Annotation Date: 2011-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610527
Stage: TS27
Assay Id: MGI:5141424
Age: postnatal day 0
Image: S2
Specimen Label: P0
Detected: true
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5140769
Assay Type: Western blot
Annotation Date: 2011-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:5141424
Age: postnatal day 4
Image: S2
Specimen Label: P4
Detected: true
Specimen Num: 6
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5140769
Assay Type: Western blot
Annotation Date: 2011-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:5141424
Age: postnatal day 8
Image: S2
Specimen Label: P8
Detected: true
Specimen Num: 7
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5140769
Assay Type: Western blot
Annotation Date: 2011-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:5141424
Age: postnatal day 16
Image: S2
Specimen Label: P16
Detected: true
Specimen Num: 8
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5140769
Assay Type: Western blot
Annotation Date: 2011-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:5141424
Age: postnatal day 21
Image: S2
Specimen Label: P21
Detected: true
Specimen Num: 9
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5140769
Assay Type: Western blot
Annotation Date: 2011-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:5141424
Age: postnatal adult
Image: S2
Specimen Label: Adult
Detected: true
Specimen Num: 10
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5140769
Assay Type: Western blot
Annotation Date: 2011-08-30
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1610526
Stage: TS26
Assay Id: MGI:5141428
Age: embryonic day 18.5
Image: S2
Specimen Label: E18.5
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5140769
Assay Type: Western blot
Annotation Date: 2011-08-30
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1610527
Stage: TS27
Assay Id: MGI:5141428
Age: postnatal day 0
Image: S2
Specimen Label: P0
Detected: false
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5140769
Assay Type: Western blot
Annotation Date: 2011-08-30
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:5141428
Age: postnatal day 4
Image: S2
Specimen Label: P4
Detected: false
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5140769
Assay Type: Western blot
Annotation Date: 2011-08-30
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:5141428
Age: postnatal day 8
Image: S2
Specimen Label: P8
Detected: false
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5140769
Assay Type: Western blot
Annotation Date: 2011-08-30
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:5141428
Age: postnatal day 16
Image: S2
Specimen Label: P16
Detected: false
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5140769
Assay Type: Western blot
Annotation Date: 2011-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:5141428
Age: postnatal day 21
Image: S2
Specimen Label: P21
Detected: true
Specimen Num: 6
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5140769
Assay Type: Western blot
Annotation Date: 2011-08-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:5141293
Age: postnatal day 9
Image: 1
Specimen Label: P9
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:5140769
Assay Type: Immunohistochemistry
Annotation Date: 2011-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3268813
Pattern: Regionally restricted
Stage: TS13
Assay Id: MGI:5141415
Age: embryonic day 8.5
Image: 2A
Note: Expression is in the ballooning regions of the heart tube.
Specimen Label: 2A
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5140769
Assay Type: Immunohistochemistry
Annotation Date: 2011-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3268813
Pattern: Not Specified
Stage: TS13
Assay Id: MGI:5141415
Age: embryonic day 8.5
Image: 2B
Specimen Label: 2B
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5140769
Assay Type: Immunohistochemistry
Annotation Date: 2011-08-30
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3268815
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:5141415
Age: embryonic day 9.5
Image: 2C
Specimen Label: 2C
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5140769
Assay Type: Immunohistochemistry
Annotation Date: 2011-08-30
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3268815
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:5141415
Age: embryonic day 9.5
Image: 2D
Specimen Label: 2D
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5140769
Assay Type: Immunohistochemistry
Annotation Date: 2011-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3268817
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:5141415
Age: embryonic day 10.5
Image: 2E
Specimen Label: 2E
Detected: true
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5140769
Assay Type: Immunohistochemistry
Annotation Date: 2011-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3268817
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:5141415
Age: embryonic day 10.5
Image: 2F
Specimen Label: 2F
Detected: true
Specimen Num: 6
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:5140769
Assay Type: Immunohistochemistry
Annotation Date: 2011-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3268813
Pattern: Not Specified
Stage: TS13
Assay Id: MGI:5141415
Age: embryonic day 8.5
Image: 3A
Note: Higher magnification was shown in the inset.
Specimen Label: 3A
Detected: true
Specimen Num: 7
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5140769
Assay Type: Immunohistochemistry
Annotation Date: 2011-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3268815
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:5141415
Age: embryonic day 9.5
Image: 3B
Specimen Label: 3B
Detected: true
Specimen Num: 8
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5140769
Assay Type: Immunohistochemistry
Annotation Date: 2011-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3268815
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:5141415
Age: embryonic day 9.5
Image: 3C
Specimen Label: 3C
Detected: true
Specimen Num: 9
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:5140769
Assay Type: Immunohistochemistry
Annotation Date: 2011-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3268815
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:5141415
Age: embryonic day 9.5
Image: 3D
Note: Higher magnification was shown in the inset.
Specimen Label: 3D
Detected: true
Specimen Num: 10
•
•
•
•
•
Gene
28 | ABO
Type: gene
Organism: human
•
•
•
•
•
Gene
6352 | CCL5
Type: gene
Organism: human
•
•
•
•
•
Publication
17037516 | -
 
First Author: Pekosz A
Year: 2006
Journal: Adv Exp Med Biol
Title: Structure, expression, and intracellular localization of the SARS-CoV accessory proteins 7a and 7b.
Volume: 581
Pages: 115-20
•
•
•
•
•
Publication
16682811 | -
First Author: Yuan X
Year: 2006
Journal: Mol Cells
Title: Mitochondrial location of severe acute respiratory syndrome coronavirus 3b protein.
Volume: 21
Issue: 2
Pages: 186-91
•
•
•
•
•
Publication
16107218 | -
 
First Author: Yuan X
Year: 2005
Journal: Virol J
Title: G0/G1 arrest and apoptosis induced by SARS-CoV 3b protein in transfected cells.
Volume: 2
Pages: 66
•
•
•
•
•
Publication
16046244 | -
First Author: Yuan X
Year: 2005
Journal: Virus Res
Title: Nucleolar localization of non-structural protein 3b, a protein specifically encoded by the severe acute respiratory syndrome coronavirus.
Volume: 114
Issue: 1-2
Pages: 70-9
•
•
•
•
•
Publication
22012463 | -
First Author: Zhou P
Year: 2012
Journal: J Gen Virol
Title: Bat severe acute respiratory syndrome-like coronavirus ORF3b homologues display different interferon antagonist activities.
Volume: 93
Issue: Pt 2
Pages: 275-281
•
•
•
•
•
Publication
17108024 | -
First Author: Kopecky-Bromberg SA
Year: 2007
Journal: J Virol
Title: Severe acute respiratory syndrome coronavirus open reading frame (ORF) 3b, ORF 6, and nucleocapsid proteins function as interferon antagonists.
Volume: 81
Issue: 2
Pages: 548-57
•
•
•
•
•
Protein Domain
IPR022117 | SARS_3b
Type: Family
Description: This family contains the SARS coronavirus 3b protein which is predominantly localized in the nucleolus, and induces G0/G1 arrest and apoptosis in transfected cells [, ]. SARS-CoV mRNA 3 encodes the distinct proteins ORF3a and ORF3b proteins, which are translated in different reading frames. SARS-CoV accessory protein ORF3b antagonizes interferon (IFN) function by modulating the activity of IFN regulatory factor 3 (IRF3). The IFN system functions as the first line of defense against viral infection in mammalian cells. Viral infection triggers a series of cellular events that lead to the production of IFN and several downstream antiviral genes, helping to establish an antiviral state. Viruses encode IFN antagonists to counteract the antiviral effects of IFN. SARS-CoV ORF3b, ORF6, and N proteins function as IFN antagonists. ORF3b inhibits both IFN synthesis and signaling [, ]. It localizes to the nucleus in transfected cells [].
•
•
•
•
•
Protein Domain
IPR021532 | NS7B_bCoV
Type: Family
Description: This entry corresponds to ORF7b (also known as accessory protein 7b, NS7B, and 7b) from human SARS coronavirus (SARS-CoV) and SARS-CoV-2, which belong to the betacoronavirus B lineage (Sarbecovirus) [].ORF7b/NS7b from betacoronavirus in the B lineage are not related to NS7b proteins from other betacoronavirus lineages. The SARS-CoV ORF7b protein is a highly hydrophobic 43 amino acid protein which is homologous to an accessory but structural component of SARS-CoV virion. While ORF7b is packaged into virions, it is not required for the virus budding process, as gene 7 deletion viruses replicate efficiently in vitro and in vivo. Moreover, ORF7b possesses a transmembrane helical domain (TMD), between 9-29 amino acid residues, is necessary for its Golgi complex localization, as replacing it with the TMD from the human endoprotease furin results in aberrant localization [, ].
•
•
•
•
•
Protein Domain
IPR037227 | EndoU-like
Type: Homologous_superfamily
Description: This entry represents the EndoU-like endoribonucleases from a variety of organisms that range from viruses to humans. The founding member XendoU is a uridylate-specific, divalent cation-dependent enzyme that produces molecules with 2',3'-cyclic phosphate ends [, ]. The human EndoU, known as PP11, is a endoribonuclease with placental tissue specificity [].In human SARS coronavirus, EndoU (also known as NSP15) is part of the replicase-transcriptase complex that plays important roles in virus replication and transcription. NSP15 is a Uridylate-specific endoribonuclease that cleaves the 5'-polyuridines from negative-sense viral RNA, termed PUN RNA [], either upstream or downstream of uridylates, at GUU or GU to produce molecules with 2',3'-cyclic phosphate ends []. PUN RNA is a CoV MDA5-dependent pathogen-associated molecular pattern (PAMP) [].
•
•
•
•
•
Protein Domain
IPR043177 | PLpro_N_sf_CoV
Type: Homologous_superfamily
Description: All coronaviruses such as the SARS virus and the Middle East Respiratory Syndrome (MERS) virus encode in their genomes at least one papain-like protease (PLpro) enzyme which cleaves the viral replicase polyproteins at three sites releasing non-structural protein NSP1, NSP2 and NSP3. PLpro also possesses deubiquitinating and deISGylating activities. These have been suggested to suppress the host antiviral response by counteracting the post-translational modification of signalling molecules that activate the innate immune response. PLpro is made up of an N-terminal ubiquitin-like domain (found in many ubiquitin-specific proteases or USPs) and a C-terminal catalytic domain containing a right-handed fingers, palm, and thumb domain organisation [, , , ].This superfamily represents the N-terminal ubiquitin-like domain of the papain-like viral protease from alpha and betacoronavirus. It has a β-grasp fold [].
•
•
•
•
•
Protein Domain
IPR043178 | PLpro_thumb_sf_CoV
Type: Homologous_superfamily
Description: All coronaviruses such as the SARS virus and the Middle East Respiratory Syndrome (MERS) virus encode in their genomes at least one papain-like protease (PLpro) enzyme which cleaves the viral replicase polyproteins at three sites releasing non-structural protein NSP1, NSP2 and NSP3. PLpro also possesses deubiquitinating and deISGylating activities. These have been suggested to suppress the host antiviral response by counteracting the post-translational modification of signalling molecules that activate the innate immune response. PLpro is made up of an N-terminal ubiquitin-like domain (found in many ubiquitin-specific proteases or USPs) and a C-terminal catalytic domain containing a right-handed fingers, palm, and thumb domain organisation [, , , ].This entry represents the thumb domain of the papain-like viral protease from coronavirus. It consists of 6 α-helices in MERS-CoV []and 4 α-helices in SARS-CoV [].
•
•
•
•
•
Publication
24854014 | -
First Author: Ratia K
Year: 2014
Journal: PLoS Pathog
Title: Structural Basis for the Ubiquitin-Linkage Specificity and deISGylating activity of SARS-CoV papain-like protease.
Volume: 10
Issue: 5
Pages: e1004113
•
•
•
•
•
Protein Domain
IPR044391 | ORF8_SARS-CoV-2-like
Type: Family
Description: This entry represents the ORF8 immunoglobulin (Ig) domain protein of Severe acute respiratory syndrome (SARS) coronavirus 2 (SARS-CoV-2, also known as a 2019 novel coronavirus, 2019-nCoV) and related Sarbecovirus ORF8 proteins.ORF8 is an accessory protein that is not shared by all members of subgenus sarbecovirus. The presence and location of ORF8 in the SARS-CoV-2 genome has led its classification with SARS-CoV [, ]. ORF8 is a potential pathogenicity factor which evolves rapidly to counter the immune response and facilitate the transmission between hosts []. ORF8 has been suggested to be one of the relevant genes in the study of human adaptation of the virus [, ].The ORF8 protein is a fast-evolving protein in SARS-related CoVs, with a tendency to recombine and undergo deletions. During the early phases of the SARS (SARS-CoV) epidemic in 2002, human isolates were found to possess a unique continuous ORF8 with 366 nucleotides and a predicted protein with 122 amino acids. During the middle and late phases of the SARS epidemic, two functional ORFs (ORF8a and ORF8b) were emerged; they are predicted to encode two small proteins, 8a with 39 amino acids and 8b with 84 amino acids. Interestingly, SARS-CoV-2 ORF8 has not undergone any significantly measurable deletion events, so its function as a full-length protein might be more important to its pathogenicity []. ORF8 plays a role in modulating host immune response []which may act by down-regulating major histocompatibility complex class I (MHC-I) []. It may inhibit expression of some members of the IFN-stimulated gene (ISG) family including hosts IGF2BP1/ZBP1, MX1 and MX2, and DHX58 []. ORF8 also binds to IL17RA receptor, leading to IL17 pathway activation and an increased secretion of pro-inflammatory factors, contributing to cytokine storm during COVID-19 infection [].
•
•
•
•
•
Publication
- | J:308730
     
First Author: Schafer A
Year: 2021
Journal: bioRxiv
Title: Common mechanism of SARS-CoV and SARS-CoV-2 pathogenesis across species.
•
•
•
•
•
Publication
16001071 | J:100334
First Author: Imai Y
Year: 2005
Journal: Nature
Title: Angiotensin-converting enzyme 2 protects from severe acute lung failure.
Volume: 436
Issue: 7047
Pages: 112-6
•
•
•
•
•
Publication
22837003 | J:186775
First Author: Hashimoto T
Year: 2012
Journal: Nature
Title: ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation.
Volume: 487
Issue: 7408
Pages: 477-81
•
•
•
•
•
Publication
20386712 | J:286237
First Author: Frieman MB
Year: 2010
Journal: PLoS Pathog
Title: SARS-CoV pathogenesis is regulated by a STAT1 dependent but a type I, II and III interferon receptor independent mechanism.
Volume: 6
Issue: 4
Pages: e1000849
•
•
•
•
•
Publication
19553337 | J:153918
First Author: Khanolkar A
Year: 2009
Journal: J Virol
Title: Toll-like receptor 4 deficiency increases disease and mortality after mouse hepatitis virus type 1 infection of susceptible C3H mice.
Volume: 83
Issue: 17
Pages: 8946-56
•
•
•
•
•
Publication
27716790 | J:254505
First Author: Xu X
Year: 2016
Journal: PLoS One
Title: Cathepsin L Helps to Defend Mice from Infection with Influenza A.
Volume: 11
Issue: 10
Pages: e0164501
•
•
•
•
•
Publication
12175314 | J:78507
First Author: Utteridge TD
Year: 2002
Journal: Radiat Res
Title: Long-term exposure of E-mu-Pim1 transgenic mice to 898.4 MHz microwaves does not increase lymphoma incidence.
Volume: 158
Issue: 3
Pages: 357-64
•
•
•
•
•
Publication
22732935 | J:188421
First Author: Han B
Year: 2012
Journal: Lab Invest
Title: Protective effects of long pentraxin PTX3 on lung injury in a severe acute respiratory syndrome model in mice.
Volume: 92
Issue: 9
Pages: 1285-96
•
•
•
•
•
Publication
20554960 | J:161935
First Author: Khanolkar A
Year: 2010
Journal: J Immunol
Title: T cell epitope specificity and pathogenesis of mouse hepatitis virus-1-induced disease in susceptible and resistant hosts.
Volume: 185
Issue: 2
Pages: 1132-41
•
•
•
•
•
Publication
32333487 | J:287925
     
First Author: Natoli S
Year: 2020
Journal: Eur J Neurol
Title: Does SARS-Cov-2 invade the brain? Translational lessons from animal models.
•
•
•
•
•
Publication
32887790 | J:295328
 
First Author: Leist SR
Year: 2020
Journal: Dis Model Mech
Title: Cell and animal models of SARS-CoV-2 pathogenesis and immunity.
Volume: 13
Issue: 9
•
•
•
•
•
Publication
17079315 | J:283648
First Author: McCray PB Jr
Year: 2007
Journal: J Virol
Title: Lethal infection of K18-hACE2 mice infected with severe acute respiratory syndrome coronavirus.
Volume: 81
Issue: 2
Pages: 813-21
•
•
•
•
•
Publication
33166988 | J:303220
First Author: Zheng J
Year: 2021
Journal: Nature
Title: COVID-19 treatments and pathogenesis including anosmia in K18-hACE2 mice.
Volume: 589
Issue: 7843
Pages: 603-607
•
•
•
•
•
Publication
38078382 | J:357500
First Author: Guo H
Year: 2023
Journal: Emerg Microbes Infect
Title: An ACE2 decamer viral trap as a durable intervention solution for current and future SARS-CoV.
Volume: 12
Issue: 2
Pages: 2275598
•
•
•
•
•
Publication
- | J:311915
     
First Author: Puhl AC
Year: 2021
Journal: bioRxiv
Title: Pyronaridine protects against SARS-CoV-2 in mouse.
•
•
•
•
•
Publication
17108019 | J:117824
First Author: Tseng CT
Year: 2007
Journal: J Virol
Title: Severe acute respiratory syndrome coronavirus infection of mice transgenic for the human Angiotensin-converting enzyme 2 virus receptor.
Volume: 81
Issue: 3
Pages: 1162-73
•
•
•
•
•
Publication
32511354 | J:297123
     
First Author: Pinto D
Year: 2020
Journal: bioRxiv
Title: Structural and functional analysis of a potent sarbecovirus neutralizing antibody.
•
•
•
•
•
Publication
32817939 | J:293212
     
First Author: Zheng J
Year: 2020
Journal: bioRxiv
Title: K18-hACE2 Mice for Studies of COVID-19 Treatments and Pathogenesis Including Anosmia.
•
•
•
•
•
Publication
8007971 | J:18889
First Author: Thompson EM
Year: 1994
Journal: Mol Cell Biol
Title: Scaffold attachment regions stimulate HSP70.1 expression in mouse preimplantation embryos but not in differentiated tissues.
Volume: 14
Issue: 7
Pages: 4694-703
•
•
•
•
•
Publication
9749833 | J:49608
First Author: Ellsworth KP
Year: 1998
Journal: J Steroid Biochem Mol Biol
Title: Cloning, expression and characterization of rhesus macaque types 1 and 2 5alpha-reductase: evidence for mechanism-based inhibition by finasteride.
Volume: 66
Issue: 5-6
Pages: 271-9
•
•
•
•
•
Publication
9806599 | J:50792
First Author: Frei MR
Year: 1998
Journal: Radiat Res
Title: Chronic, low-level (1.0 W/kg) exposure of mice prone to mammary cancer to 2450 MHz microwaves.
Volume: 150
Issue: 5
Pages: 568-76
•
•
•
•
•
Publication
2118999 | J:176953
First Author: Brun C
Year: 1990
Journal: Mol Cell Biol
Title: Studies of an 800-kilobase DNA stretch of the Drosophila X chromosome: comapping of a subclass of scaffold-attached regions with sequences able to replicate autonomously in Saccharomyces cerevisiae.
Volume: 10
Issue: 10
Pages: 5455-63
•
•
•
•
•
Publication
28373583 | J:291593
First Author: Channappanavar R
Year: 2017
Journal: J Immunol
Title: Sex-Based Differences in Susceptibility to Severe Acute Respiratory Syndrome Coronavirus Infection.
Volume: 198
Issue: 10
Pages: 4046-4053
•
•
•
•
•
Publication
24664247 | J:291636
First Author: Song L
Year: 2014
Journal: PLoS One
Title: Multi-organ lesions in suckling mice infected with SARS-associated mammalian reovirus linked with apoptosis induced by viral proteins μ1 and σ1.
Volume: 9
Issue: 3
Pages: e92678
•
•
•
•
•
Publication
26552008 | J:286371
First Author: Menachery VD
Year: 2015
Journal: Nat Med
Title: A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence.
Volume: 21
Issue: 12
Pages: 1508-13
•
•
•
•
•
Publication
23576515 | J:286952
First Author: Fett C
Year: 2013
Journal: J Virol
Title: Complete protection against severe acute respiratory syndrome coronavirus-mediated lethal respiratory disease in aged mice by immunization with a mouse-adapted virus lacking E protein.
Volume: 87
Issue: 12
Pages: 6551-9
•
•
•
•
•
Publication
20032190 | J:288029
First Author: O'Keefe BR
Year: 2010
Journal: J Virol
Title: Broad-spectrum in vitro activity and in vivo efficacy of the antiviral protein griffithsin against emerging viruses of the family Coronaviridae.
Volume: 84
Issue: 5
Pages: 2511-21
•
•
•
•
•
Publication
21937658 | J:288593
First Author: Bolles M
Year: 2011
Journal: J Virol
Title: A double-inactivated severe acute respiratory syndrome coronavirus vaccine provides incomplete protection in mice and induces increased eosinophilic proinflammatory pulmonary response upon challenge.
Volume: 85
Issue: 23
Pages: 12201-15
•
•
•
•
•
Publication
22072787 | J:288640
First Author: Frieman M
Year: 2012
Journal: J Virol
Title: Molecular determinants of severe acute respiratory syndrome coronavirus pathogenesis and virulence in young and aged mouse models of human disease.
Volume: 86
Issue: 2
Pages: 884-97
•
•
•
•
•
Publication
31692019 | J:291879
First Author: Sekimukai H
Year: 2020
Journal: Microbiol Immunol
Title: Gold nanoparticle-adjuvanted S protein induces a strong antigen-specific IgG response against severe acute respiratory syndrome-related coronavirus infection, but fails to induce protective antibodies and limit eosinophilic infiltration in lungs.
Volume: 64
Issue: 1
Pages: 33-51
•
•
•
•
•
Publication
33275517 | J:303463
First Author: Viveiros A
Year: 2021
Journal: Am J Physiol Heart Circ Physiol
Title: Sex differences in COVID-19: candidate pathways, genetics of ACE2, and sex hormones.
Volume: 320
Issue: 1
Pages: H296-H304
•
•
•
•
•
Publication
33039209 | J:302247
First Author: Chen WH
Year: 2020
Journal: Vaccine
Title: Yeast-expressed SARS-CoV recombinant receptor-binding domain (RBD219-N1) formulated with aluminum hydroxide induces protective immunity and reduces immune enhancement.
Volume: 38
Issue: 47
Pages: 7533-7541
•
•
•
•
•
Publication
26433221 | -
First Author: Wu Z
Year: 2016
Journal: J Infect Dis
Title: ORF8-Related Genetic Evidence for Chinese Horseshoe Bats as the Source of Human Severe Acute Respiratory Syndrome Coronavirus.
Volume: 213
Issue: 4
Pages: 579-83
•
•
•
•
•
Publication
25320088 | -
First Author: Bailey-Elkin BA
Year: 2014
Journal: J Biol Chem
Title: Crystal structure of the Middle East respiratory syndrome coronavirus (MERS-CoV) papain-like protease bound to ubiquitin facilitates targeted disruption of deubiquitinating activity to demonstrate its role in innate immune suppression.
Volume: 289
Issue: 50
Pages: 34667-82
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom