Type |
Details |
Score |
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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•
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•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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Publication |
First Author: |
Zhang N |
Year: |
2020 |
Journal: |
Int J Biol Sci |
Title: |
Septin4 Prevents PDGF-BB-induced HAVSMC Phenotypic Transformation, Proliferation and Migration by Promoting SIRT1-STAT3 Deacetylation and Dephosphorylation. |
Volume: |
16 |
Issue: |
4 |
Pages: |
708-718 |
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•
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Allele |
Name: |
transgene insertion 1, Makoto Kinoshita |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence |
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Strain |
Attribute String: |
mutant strain, coisogenic, transgenic |
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Publication |
First Author: |
Moon IS |
Year: |
2013 |
Journal: |
Cytotechnology |
Title: |
Septin 6 localizes to microtubules in neuronal dendrites. |
Volume: |
65 |
Issue: |
2 |
Pages: |
179-86 |
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•
•
•
•
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Publication |
First Author: |
Sheffield PJ |
Year: |
2003 |
Journal: |
J Biol Chem |
Title: |
Borg/septin interactions and the assembly of mammalian septin heterodimers, trimers, and filaments. |
Volume: |
278 |
Issue: |
5 |
Pages: |
3483-8 |
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•
•
•
•
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Publication |
First Author: |
Cho SJ |
Year: |
2011 |
Journal: |
Mol Cells |
Title: |
Septin 6 regulates the cytoarchitecture of neurons through localization at dendritic branch points and bases of protrusions. |
Volume: |
32 |
Issue: |
1 |
Pages: |
89-98 |
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•
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Publication |
First Author: |
Low C |
Year: |
2006 |
Journal: |
J Biol Chem |
Title: |
Structural analysis of septin 2, 6, and 7 complexes. |
Volume: |
281 |
Issue: |
41 |
Pages: |
30697-706 |
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•
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Publication |
First Author: |
Kuo YC |
Year: |
2015 |
Journal: |
J Cell Sci |
Title: |
SEPT12 orchestrates the formation of mammalian sperm annulus by organizing core octameric complexes with other SEPT proteins. |
Volume: |
128 |
Issue: |
5 |
Pages: |
923-34 |
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Protein Domain |
Type: |
Family |
Description: |
Septin 6 (SEPT6) belongs to the septin family and forms a complex with SEPT2 and SEPT7 (SEPT2/6/7) [, ]. It is required for ciliogenesis in Kupffer's vesicle, the pronephros, and the neural tube during early embryonic development in zebrafish []. Rat SEPT6 localises to microtubules in neuronal dendrite branch points and bases of protrusions [, ]. It may play a role in hepatitis C virus RNAreplication []. It forms a filamentous structure with SEPTIN12, SEPTIN2, SEPTIN7 and SEPTIN4 at the sperm annulus, required structural integrity and motility of the sperm tail during postmeiotic differentiation [].Septins were first discovered in budding yeast as a major component of bud neck filaments during cell septation [, ]. Later, its homologues were identified in nearly all eukaryotes, including humans. They are all GTP-binding proteins that are involved in diverse cellular functions, including cell cycle progression, vesicle trafficking, cytokinesis, cell migration, membrane dynamics, and chromosome segregation [, ]. Similar to cytoskeleton components such as actins and tubulins, they can assemble into filaments and bundles. However, unlike actin filaments and microtubules, septin filaments are not polar, similarly to intermediate filaments []. The number of septin genes per organism is variable: S. cerevisiae has seven and humans have 13 (SEPT1-12 and SEPT14; SEPT13 is a pseudogene now called SEPT7P2) []. All septins can form heteromeric complexes, which associate to form higher-order structures, including filaments, rings and cage-like formations [, ]. |
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Publication |
First Author: |
Kim CS |
Year: |
2007 |
Journal: |
J Virol |
Title: |
An RNA-binding protein, hnRNP A1, and a scaffold protein, septin 6, facilitate hepatitis C virus replication. |
Volume: |
81 |
Issue: |
8 |
Pages: |
3852-65 |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
434
 |
Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
427
 |
Fragment?: |
false |
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•
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Publication |
First Author: |
Byers B |
Year: |
1976 |
Journal: |
J Cell Biol |
Title: |
A highly ordered ring of membrane-associated filaments in budding yeast. |
Volume: |
69 |
Issue: |
3 |
Pages: |
717-21 |
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Publication |
First Author: |
Mostowy S |
Year: |
2012 |
Journal: |
Nat Rev Mol Cell Biol |
Title: |
Septins: the fourth component of the cytoskeleton. |
Volume: |
13 |
Issue: |
3 |
Pages: |
183-94 |
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Publication |
First Author: |
Hall PA |
Year: |
2012 |
Journal: |
J Pathol |
Title: |
Mammalian septins: dynamic heteromers with roles in cellular morphogenesis and compartmentalization. |
Volume: |
226 |
Issue: |
2 |
Pages: |
287-99 |
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Publication |
First Author: |
Zhai G |
Year: |
2014 |
Journal: |
Mol Cell Biol |
Title: |
Sept6 is required for ciliogenesis in Kupffer's vesicle, the pronephros, and the neural tube during early embryonic development. |
Volume: |
34 |
Issue: |
7 |
Pages: |
1310-21 |
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Publication |
First Author: |
Hartwell LH |
Year: |
1971 |
Journal: |
Exp Cell Res |
Title: |
Genetic control of the cell division cycle in yeast. IV. Genes controlling bud emergence and cytokinesis. |
Volume: |
69 |
Issue: |
2 |
Pages: |
265-76 |
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