Type |
Details |
Score |
GXD Expression |
Probe: |
MGI:3724509 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:2672022 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:5421169 |
Age: |
embryonic day 14.5 |
Image: |
MH640; Specimen C1439 |
Note: |
Expression was weak in whisker follicle. |
Specimen Label: |
MH640; Specimen C1439 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
Publication |
First Author: |
Menon MB |
Year: |
2014 |
Journal: |
PLoS Genet |
Title: |
Genetic deletion of SEPT7 reveals a cell type-specific role of septins in microtubule destabilization for the completion of cytokinesis. |
Volume: |
10 |
Issue: |
8 |
Pages: |
e1004558 |
|
•
•
•
•
•
|
Publication |
First Author: |
Füchtbauer A |
Year: |
2011 |
Journal: |
Biol Chem |
Title: |
Septin9 is involved in septin filament formation and cellular stability. |
Volume: |
392 |
Issue: |
8-9 |
Pages: |
769-77 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gilden JK |
Year: |
2012 |
Journal: |
J Cell Biol |
Title: |
The septin cytoskeleton facilitates membrane retraction during motility and blebbing. |
Volume: |
196 |
Issue: |
1 |
Pages: |
103-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dhanya SK |
Year: |
2021 |
Journal: |
Front Cell Dev Biol |
Title: |
Deficits Associated With Loss of STIM1 in Purkinje Neurons Including Motor Coordination Can Be Rescued by Loss of Septin 7. |
Volume: |
9 |
|
Pages: |
794807 |
|
•
•
•
•
•
|
Publication |
First Author: |
Weidemann M |
Year: |
2016 |
Journal: |
Development |
Title: |
CFAP157 is a murine downstream effector of FOXJ1 that is specifically required for flagellum morphogenesis and sperm motility. |
Volume: |
143 |
Issue: |
24 |
Pages: |
4736-4748 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ageta-Ishihara N |
Year: |
2013 |
Journal: |
Nat Commun |
Title: |
Septins promote dendrite and axon development by negatively regulating microtubule stability via HDAC6-mediated deacetylation. |
Volume: |
4 |
|
Pages: |
2532 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rachev E |
Year: |
2020 |
Journal: |
Dev Biol |
Title: |
CFAP43 modulates ciliary beating in mouse and Xenopus. |
Volume: |
459 |
Issue: |
2 |
Pages: |
109-125 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shinoda T |
Year: |
2010 |
Journal: |
Mol Biol Cell |
Title: |
Septin 14 is involved in cortical neuronal migration via interaction with Septin 4. |
Volume: |
21 |
Issue: |
8 |
Pages: |
1324-34 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kinoshita A |
Year: |
2000 |
Journal: |
J Comp Neurol |
Title: |
Differential localization of septins in the mouse brain. |
Volume: |
428 |
Issue: |
2 |
Pages: |
223-39 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wasik AA |
Year: |
2012 |
Journal: |
Mol Biol Cell |
Title: |
Septin 7 forms a complex with CD2AP and nephrin and regulates glucose transporter trafficking. |
Volume: |
23 |
Issue: |
17 |
Pages: |
3370-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tsang CW |
Year: |
2008 |
Journal: |
Mol Cell Biol |
Title: |
Superfluous role of mammalian septins 3 and 5 in neuronal development and synaptic transmission. |
Volume: |
28 |
Issue: |
23 |
Pages: |
7012-29 |
|
•
•
•
•
•
|
Publication |
First Author: |
Thomas JW |
Year: |
2000 |
Journal: |
Genome Res |
Title: |
Comparative genome mapping in the sequence-based era: early experience with human chromosome 7. |
Volume: |
10 |
Issue: |
5 |
Pages: |
624-33 |
|
•
•
•
•
•
|
Publication |
First Author: |
Peng XR |
Year: |
2002 |
Journal: |
Mol Cell Biol |
Title: |
The septin CDCrel-1 is dispensable for normal development and neurotransmitter release. |
Volume: |
22 |
Issue: |
1 |
Pages: |
378-87 |
|
•
•
•
•
•
|
Publication |
First Author: |
Moore KS |
Year: |
2022 |
Journal: |
J Cardiovasc Dev Dis |
Title: |
DCHS1, Lix1L, and the Septin Cytoskeleton: Molecular and Developmental Etiology of Mitral Valve Prolapse. |
Volume: |
9 |
Issue: |
2 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Yoshida A |
Year: |
2012 |
Journal: |
Hear Res |
Title: |
Localization of septin proteins in the mouse cochlea. |
Volume: |
289 |
Issue: |
1-2 |
Pages: |
40-51 |
|
•
•
•
•
•
|
Publication |
First Author: |
Keppner A |
Year: |
2022 |
Journal: |
Elife |
Title: |
Androglobin, a chimeric mammalian globin, is required for male fertility. |
Volume: |
11 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Werner HB |
Year: |
2007 |
Journal: |
J Neurosci |
Title: |
Proteolipid protein is required for transport of sirtuin 2 into CNS myelin. |
Volume: |
27 |
Issue: |
29 |
Pages: |
7717-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cobellis G |
Year: |
2005 |
Journal: |
Nucleic Acids Res |
Title: |
Tagging genes with cassette-exchange sites. |
Volume: |
33 |
Issue: |
4 |
Pages: |
e44 |
|
•
•
•
•
•
|
Publication |
First Author: |
University of California, Davis |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by the University of California, Davis |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Visel A |
Year: |
2004 |
Journal: |
Nucleic Acids Res |
Title: |
GenePaint.org: an atlas of gene expression patterns in the mouse embryo. |
Volume: |
32 |
Issue: |
Database issue |
Pages: |
D552-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stryke D |
Year: |
2003 |
Journal: |
Nucleic Acids Res |
Title: |
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. |
Volume: |
31 |
Issue: |
1 |
Pages: |
278-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bedogni F |
Year: |
2021 |
Journal: |
Front Mol Neurosci |
Title: |
Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. |
Volume: |
14 |
|
Pages: |
686034 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shanghai Model Organisms Center |
Year: |
2017 |
Journal: |
MGI Direct Data Submission |
Title: |
Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
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|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Hansen GM |
Year: |
2008 |
Journal: |
Genome Res |
Title: |
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. |
Volume: |
18 |
Issue: |
10 |
Pages: |
1670-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2014 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
MGD Nomenclature Committee |
Year: |
1995 |
|
Title: |
Nomenclature Committee Use |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Zambrowicz BP |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
Volume: |
100 |
Issue: |
24 |
Pages: |
14109-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
Year: |
2011 |
|
Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
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|
|
|
•
•
•
•
•
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Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
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|
|
•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
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|
|
•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
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|
|
•
•
•
•
•
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Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
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|
|
•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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|
|
•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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|
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
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|
•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
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•
•
•
•
•
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Publication |
First Author: |
Collins KB |
Year: |
2020 |
Journal: |
J Cell Biol |
Title: |
Septin2 mediates podosome maturation and endothelial cell invasion associated with angiogenesis. |
Volume: |
219 |
Issue: |
2 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Martens AK |
Year: |
2022 |
Journal: |
Cytoskeleton (Hoboken) |
Title: |
Targeted inactivation of the Septin2 and Septin9 genes in myelinating Schwann cells of mice. |
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•
•
•
•
•
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Publication |
First Author: |
Moon IS |
Year: |
2013 |
Journal: |
Cytotechnology |
Title: |
Septin 6 localizes to microtubules in neuronal dendrites. |
Volume: |
65 |
Issue: |
2 |
Pages: |
179-86 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sheffield PJ |
Year: |
2003 |
Journal: |
J Biol Chem |
Title: |
Borg/septin interactions and the assembly of mammalian septin heterodimers, trimers, and filaments. |
Volume: |
278 |
Issue: |
5 |
Pages: |
3483-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cho SJ |
Year: |
2011 |
Journal: |
Mol Cells |
Title: |
Septin 6 regulates the cytoarchitecture of neurons through localization at dendritic branch points and bases of protrusions. |
Volume: |
32 |
Issue: |
1 |
Pages: |
89-98 |
|
•
•
•
•
•
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Publication |
First Author: |
Low C |
Year: |
2006 |
Journal: |
J Biol Chem |
Title: |
Structural analysis of septin 2, 6, and 7 complexes. |
Volume: |
281 |
Issue: |
41 |
Pages: |
30697-706 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kuo YC |
Year: |
2015 |
Journal: |
J Cell Sci |
Title: |
SEPT12 orchestrates the formation of mammalian sperm annulus by organizing core octameric complexes with other SEPT proteins. |
Volume: |
128 |
Issue: |
5 |
Pages: |
923-34 |
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•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Septin 6 (SEPT6) belongs to the septin family and forms a complex with SEPT2 and SEPT7 (SEPT2/6/7) [, ]. It is required for ciliogenesis in Kupffer's vesicle, the pronephros, and the neural tube during early embryonic development in zebrafish []. Rat SEPT6 localises to microtubules in neuronal dendrite branch points and bases of protrusions [, ]. It may play a role in hepatitis C virus RNAreplication []. It forms a filamentous structure with SEPTIN12, SEPTIN2, SEPTIN7 and SEPTIN4 at the sperm annulus, required structural integrity and motility of the sperm tail during postmeiotic differentiation [].Septins were first discovered in budding yeast as a major component of bud neck filaments during cell septation [, ]. Later, its homologues were identified in nearly all eukaryotes, including humans. They are all GTP-binding proteins that are involved in diverse cellular functions, including cell cycle progression, vesicle trafficking, cytokinesis, cell migration, membrane dynamics, and chromosome segregation [, ]. Similar to cytoskeleton components such as actins and tubulins, they can assemble into filaments and bundles. However, unlike actin filaments and microtubules, septin filaments are not polar, similarly to intermediate filaments []. The number of septin genes per organism is variable: S. cerevisiae has seven and humans have 13 (SEPT1-12 and SEPT14; SEPT13 is a pseudogene now called SEPT7P2) []. All septins can form heteromeric complexes, which associate to form higher-order structures, including filaments, rings and cage-like formations [, ]. |
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•
•
•
•
•
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Publication |
First Author: |
Kim CS |
Year: |
2007 |
Journal: |
J Virol |
Title: |
An RNA-binding protein, hnRNP A1, and a scaffold protein, septin 6, facilitate hepatitis C virus replication. |
Volume: |
81 |
Issue: |
8 |
Pages: |
3852-65 |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
434
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
427
 |
Fragment?: |
false |
|
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•
•
•
•
|