|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 201 to 300 out of 878 for Sf1

<< First    < Previous  |  Next >    Last >>
0.028s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
•
•
•
•
•
Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
•
•
•
•
•
Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
•
•
•
•
•
Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
•
•
•
•
•
Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
•
•
•
•
•
Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
•
•
•
•
•
Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
•
•
•
•
•
Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
•
•
•
•
•
Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
•
•
•
•
•
Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
•
•
•
•
•
Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
•
•
•
•
•
Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
•
•
•
•
•
Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
•
•
•
•
•
Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
•
•
•
•
•
Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
•
•
•
•
•
Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
•
•
•
•
•
Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
•
•
•
•
•
Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
•
•
•
•
•
Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
•
•
•
•
•
Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
•
•
•
•
•
Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
•
•
•
•
•
Allele
Nr5a1<tm1Jmi> | MGI:1931426
Name: nuclear receptor subfamily 5, group A, member 1; targeted mutation 1, Jeffrey Milbrandt
Allele Type: Targeted
Attribute String: Null/knockout
•
•
•
•
•
Allele
Nr5a1<tm1.1Ics> | MGI:6468246
Name: nuclear receptor subfamily 5, group A, member 1; targeted mutation 1.1, Mouse Clinical Institute
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
•
•
•
•
•
Publication
21907137 | J:176658
First Author: Ramadori G
Year: 2011
Journal: Cell Metab
Title: SIRT1 deacetylase in SF1 neurons protects against metabolic imbalance.
Volume: 14
Issue: 3
Pages: 301-12
•
•
•
•
•
Publication
33722691 | J:309289
 
First Author: Rouabhi M
Year: 2021
Journal: Mol Metab
Title: BBSome ablation in SF1 neurons causes obesity without comorbidities.
Volume: 48
Pages: 101211
•
•
•
•
•
Protein Domain
IPR044336 | SF1_Hel_ZBD_tv
Type: Domain
Description: This entry represents the Cys/His rich zinc-binding domain (ZBD) of SF1 helicase from tornidovirus which includes White bream virus (WBV). This domain has 3 zinc-finger motifs []. This group of viruses belong to Nidovirales order and it shares the same genome organisation. It encodes the large polyprotein pp1a which is then proteolytically processed to produce the enzymes required for the replicative machinery. This is a novel cluster of nidoviruses that significantly diverged from toroviruses and, even more, from coronaviruses, roniviruses, and arteriviruses [].
•
•
•
•
•
Protein Domain
IPR044396 | SF1_Hel_unc_rv-like
Type: Domain
Description: This entry represents an uncharacterised domain located between the Cys/His zinc-binding domain (ZBD) and the first helicase domain found in helicases from Gill-associated virus (GAV) and related viruses from ronidovirus family. It is thought to be a linker domain. They are related to the SF1 family of nidoviral replication helicases, similar to the Severe Acute Respiratory Syndrome coronavirus (SARS) non-structural protein 13 (SARS-NSP13) helicase (not included in this entry), which share a similar domain organisation. The location and orientation of this uncharacterized domain represented in this ronidovirus group resembles that of the 1B domain in SARS-NSP13 helicase [, ].
•
•
•
•
•
Publication
28987511 | J:249768
 
First Author: Ramos-Lobo AM
Year: 2017
Journal: Neuroscience
Title: SOCS3 ablation in SF1 cells causes modest metabolic effects during pregnancy and lactation.
Volume: 365
Pages: 114-124
•
•
•
•
•
Publication
28899903 | J:313233
First Author: Pedroso JAB
Year: 2017
Journal: J Endocrinol
Title: SOCS3 expression in SF1 cells regulates adrenal differentiation and exercise performance.
Volume: 235
Issue: 3
Pages: 207-222
•
•
•
•
•
Publication
10811931 | -
First Author: Cowley JA
Year: 2000
Journal: J Gen Virol
Title: Gill-associated virus of Penaeus monodon prawns: an invertebrate virus with ORF1a and ORF1b genes related to arteri- and coronaviruses.
Volume: 81
Issue: Pt 6
Pages: 1473-84
•
•
•
•
•
Protein Domain
IPR044395 | SF1_Hel-like_ZBD_rv
Type: Domain
Description: This entry represents the Cys/His rich zinc-binding domain (ZBD) of the helicase encoded on ORF1a and belongs to helicase superfamily 1 (SF1) from ronidovirus family including Gill-associated virus (GAV) []. The ZBD has 3 zinc-finger (ZnF1-3) motifs. Proteins containing this domain belong to a family of nindoviral replication helicases similar to SARS-NSP13 helicase, not included in this entry. The SARS-NSP13 ZBD is indispensable for helicase activity and interacts with SARS-Nsp12. SARS-Nsp12 can enhance the helicase activity of SARS-Nsp13 and can interact with SARS-Nsp13 on the third zinc finger motif of the ZBD [].
•
•
•
•
•
Publication
29262334 | J:255693
First Author: Viskaitis P
Year: 2017
Journal: Cell Rep
Title: Modulation of SF1 Neuron Activity Coordinately Regulates Both Feeding Behavior and Associated Emotional States.
Volume: 21
Issue: 12
Pages: 3559-3572
•
•
•
•
•
Protein Domain
IPR044355 | SF1_Hel_unc_tv
Type: Domain
Description: This entry represents an uncharacterised domain found in SF1 helicases from tornidovirus, including Breda virus serotype 1. This group of viruses belong to Nidovirales order and it shares the same genome organisation. It encodes the large polyprotein pp1a which is then proteolytically processed to produce the enzymes required for the replicative machinery. This is a novel cluster of nidoviruses that significantly diverged from toroviruses and, even more, from coronaviruses, roniviruses, and arteriviruses []. This domain connects the zinc-binding domain (ZBD) with the first helicase domain, resembling that of the 1B domain in SARS-Nsp13 helicase [, ].
•
•
•
•
•
Publication
27888191 | J:238424
First Author: Chen M
Year: 2017
Journal: Development
Title: Wt1 directs the lineage specification of sertoli and granulosa cells by repressing Sf1 expression.
Volume: 144
Issue: 1
Pages: 44-53
•
•
•
•
•
Publication
15829514 | J:98517
First Author: Park SY
Year: 2005
Journal: Development
Title: Nuclear receptors Sf1 and Dax1 function cooperatively to mediate somatic cell differentiation during testis development.
Volume: 132
Issue: 10
Pages: 2415-23
•
•
•
•
•
Publication
19757380 | J:158334
First Author: Combes AN
Year: 2010
Journal: Int J Dev Biol
Title: Gonadal defects in Cited2-mutant mice indicate a role for SF1 in both testis and ovary differentiation.
Volume: 54
Issue: 4
Pages: 683-9
•
•
•
•
•
Publication
24451388 | J:212053
First Author: Takasawa K
Year: 2014
Journal: FASEB J
Title: FOXL2 transcriptionally represses Sf1 expression by antagonizing WT1 during ovarian development in mice.
Volume: 28
Issue: 5
Pages: 2020-8
•
•
•
•
•
Publication
18669597 | J:145473
First Author: Zhang R
Year: 2008
Journal: Endocrinology
Title: Selective inactivation of Socs3 in SF1 neurons improves glucose homeostasis without affecting body weight.
Volume: 149
Issue: 11
Pages: 5654-61
•
•
•
•
•
Publication
33571700 | J:317115
 
First Author: Coupé B
Year: 2021
Journal: Mol Metab
Title: Defective autophagy in Sf1 neurons perturbs the metabolic response to fasting and causes mitochondrial dysfunction.
Volume: 47
Pages: 101186
•
•
•
•
•
Publication
26420826 | J:227344
First Author: Crisci A
Year: 2015
Journal: Nucleic Acids Res
Title: Mammalian splicing factor SF1 interacts with SURP domains of U2 snRNP-associated proteins.
Volume: 43
Issue: 21
Pages: 10456-73
•
•
•
•
•
Publication
22128028 | J:181772
First Author: Bernard P
Year: 2012
Journal: Endocrinology
Title: Wnt signaling in ovarian development inhibits Sf1 activation of Sox9 via the Tesco enhancer.
Volume: 153
Issue: 2
Pages: 901-12
•
•
•
•
•
Publication
18454134 | J:136679
First Author: Sekido R
Year: 2008
Journal: Nature
Title: Sex determination involves synergistic action of SRY and SF1 on a specific Sox9 enhancer.
Volume: 453
Issue: 7197
Pages: 930-4
•
•
•
•
•
Publication
23136395 | J:189958
First Author: Buaas FW
Year: 2012
Journal: Development
Title: In vivo evidence for the crucial role of SF1 in steroid-producing cells of the testis, ovary and adrenal gland.
Volume: 139
Issue: 24
Pages: 4561-70
•
•
•
•
•
Publication
28673934 | J:247917
First Author: Coutinho EA
Year: 2017
Journal: Diabetes
Title: Activation of SF1 Neurons in the Ventromedial Hypothalamus by DREADD Technology Increases Insulin Sensitivity in Peripheral Tissues.
Volume: 66
Issue: 9
Pages: 2372-2386
•
•
•
•
•
Publication
12732652 | J:84530
First Author: Schepers G
Year: 2003
Journal: J Biol Chem
Title: SOX8 is expressed during testis differentiation in mice and synergizes with SF1 to activate the Amh promoter in vitro.
Volume: 278
Issue: 30
Pages: 28101-8
•
•
•
•
•
Publication
9573336 | J:47589
First Author: Krämer A
Year: 1998
Journal: Gene
Title: Diverse modes of alternative splicing of human splicing factor SF1 deduced from the exon-intron structure of the gene.
Volume: 211
Issue: 1
Pages: 29-37
•
•
•
•
•
Publication
31314542 | J:279262
First Author: Senn SS
Year: 2019
Journal: Am J Physiol Regul Integr Comp Physiol
Title: Unsilencing of native LepRs in hypothalamic SF1 neurons does not rescue obese phenotype in LepR-deficient mice.
Volume: 317
Issue: 3
Pages: R451-R460
•
•
•
•
•
HT Experiment
GSE129518 | Circadian gene expression in mouse gastrocnemius muscle after deletion of SIRT1 in SF1 neurons
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
•
•
•
•
•
Publication
33846709 | J:335396
 
First Author: Matsumura S
Year: 2021
Journal: Endocrinology
Title: Loss of CREB Coactivator CRTC1 in SF1 Cells Leads to Hyperphagia and Obesity by High-fat Diet But Not Normal Chow Diet.
Volume: 162
Issue: 9
•
•
•
•
•
Publication
16176945 | J:101728
First Author: Gut P
Year: 2005
Journal: Development
Title: Lack of an adrenal cortex in Sf1 mutant mice is compatible with the generation and differentiation of chromaffin cells.
Volume: 132
Issue: 20
Pages: 4611-9
•
•
•
•
•
Publication
16423694 | J:105327
First Author: Dhillon H
Year: 2006
Journal: Neuron
Title: Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis.
Volume: 49
Issue: 2
Pages: 191-203
•
•
•
•
•
Publication
16987966 | -
First Author: Schütze H
Year: 2006
Journal: J Virol
Title: Characterization of White bream virus reveals a novel genetic cluster of nidoviruses.
Volume: 80
Issue: 23
Pages: 11598-609
•
•
•
•
•
Interaction Experiment
Schepers G (2003)
Description: SOX8 is expressed during testis differentiation in mice and synergizes with SF1 to activate the Amh promoter in vitro.
•
•
•
•
•
Publication
23273425 | -
First Author: Wang W
Year: 2013
Journal: Structure
Title: Structure of phosphorylated SF1 bound to U2AF⁶⁵ in an essential splicing factor complex.
Volume: 21
Issue: 2
Pages: 197-208
•
•
•
•
•
Publication
16399799 | J:105445
First Author: Beverdam A
Year: 2006
Journal: Hum Mol Genet
Title: Expression profiling of purified mouse gonadal somatic cells during the critical time window of sex determination reveals novel candidate genes for human sexual dysgenesis syndromes.
Volume: 15
Issue: 3
Pages: 417-31
•
•
•
•
•
Allele
Tg(Sf1-EGFP)1Koop | MGI:4361666
Name: transgene insertion 1, Peter Koopman
Allele Type: Transgenic
Attribute String: Reporter
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:6391003
Assay Type: RNA in situ
Annotation Date: 2020-02-19
Strength: Present
Sex: Male
Emaps: EMAPS:3542125
Pattern: Regionally restricted
Stage: TS25
Assay Id: MGI:6391014
Age: embryonic day 17.5
Image: 7A XY WT
Note: Expression was present in the arcuate nucleus. The labeled cells in XY wild type animals were consistently lighter in color than in either XX wild type or XY Sf1 KO mice.
Specimen Label: 7A XY WT
Detected: true
Specimen Num: 18
•
•
•
•
•
Publication
18162467 | -
First Author: Fukami M
Year: 2008
Journal: J Biol Chem
Title: Mastermind-like domain-containing 1 (MAMLD1 or CXorf6) transactivates the Hes3 promoter, augments testosterone production, and contains the SF1 target sequence.
Volume: 283
Issue: 9
Pages: 5525-32
•
•
•
•
•
Publication
31131400 | -
First Author: Jia Z
Year: 2019
Journal: Nucleic Acids Res
Title: Delicate structural coordination of the Severe Acute Respiratory Syndrome coronavirus Nsp13 upon ATP hydrolysis.
Volume: 47
Issue: 12
Pages: 6538-6550
•
•
•
•
•
Protein Coding Gene
MGI:1346833 | Nr5a1
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Publication
25855264 | J:222626
First Author: McClelland KS
Year: 2015
Journal: Biol Reprod
Title: Purification and Transcriptomic Analysis of Mouse Fetal Leydig Cells Reveals Candidate Genes for Specification of Gonadal Steroidogenic Cells.
Volume: 92
Issue: 6
Pages: 145
•
•
•
•
•
Genotype
Genotype
Symbol: Tg(Sf1-EGFP)1Koop/?
Background: involves: C57BL/6 * CBA
Zygosity: ot
Has Mutant Allele: true
•
•
•
•
•
Publication
10894149 | -
First Author: Zhou D
Year: 2000
Journal: Mol Endocrinol
Title: PNRC: a proline-rich nuclear receptor coregulatory protein that modulates transcriptional activation of multiple nuclear receptors including orphan receptors SF1 (steroidogenic factor 1) and ERRalpha1 (estrogen related receptor alpha-1).
Volume: 14
Issue: 7
Pages: 986-98
•
•
•
•
•
Publication
27712628 | -
 
First Author: Snijder EJ
Year: 2016
Journal: Adv Virus Res
Title: The Nonstructural Proteins Directing Coronavirus RNA Synthesis and Processing.
Volume: 96
Pages: 59-126
•
•
•
•
•
HT Experiment
E-GEOD-27261 | Dmrt1 (doublesex and mab-3 related transcription factor 1) conditional knockout expression analysis of P28 testes
Series Id: GSE27261
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
•
•
•
•
•
Publication
30594505 | J:272515
First Author: Garcia-Moreno SA
Year: 2019
Journal: Dev Biol
Title: Gonadal supporting cells acquire sex-specific chromatin landscapes during mammalian sex determination.
Volume: 446
Issue: 2
Pages: 168-179
•
•
•
•
•
HT Experiment
E-GEOD-45592 | Dicer deficiency reveals microRNAs predicted to control gene expression in developing adrenal cortex [array]
Series Id: GSE45592
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
•
•
•
•
•
Protein Domain
IPR007807 | Helicase_dom
Type: Domain
Description: This domain contains a P-loop (Walker A) motif, suggesting that it has ATPase activity, and a Walker B motif. In tRNA(Met) cytidine acetyltransferase (TmcA) it may function as an RNA helicase motor (driven by ATP hydrolysis) which delivers the wobble base to the active centre of the GCN5-related N-acetyltransferase (GNAT) domain []. It is found in the bacterial exodeoxyribonuclease V alpha chain (RecD), which has 5'-3' helicase activity. It is structurally similar to the motor domain 1A in other SF1 helicases [].
•
•
•
•
•
Publication
36423694 | J:332416
 
First Author: Milbank E
Year: 2023
Journal: Metabolism
Title: Small extracellular vesicle targeting of hypothalamic AMPKα1 promotes weight loss in leptin receptor deficient mice.
Volume: 139
Pages: 155350
•
•
•
•
•
Publication
12130543 | J:77996
First Author: Wilhelm D
Year: 2002
Journal: Genes Dev
Title: The Wilms tumor suppressor WT1 regulates early gonad development by activation of Sf1.
Volume: 16
Issue: 14
Pages: 1839-51
•
•
•
•
•
Publication
10571183 | J:58474
First Author: Arango NA
Year: 1999
Journal: Cell
Title: Targeted mutagenesis of the endogenous mouse Mis gene promoter: in vivo definition of genetic pathways of vertebrate sexual development.
Volume: 99
Issue: 4
Pages: 409-19
•
•
•
•
•
Publication
19207816 | J:152290
First Author: Arnold AP
Year: 2009
Journal: J Neuroendocrinol
Title: Mouse models for evaluating sex chromosome effects that cause sex differences in non-gonadal tissues.
Volume: 21
Issue: 4
Pages: 377-86
•
•
•
•
•
Publication
18599507 | J:138575
First Author: Kim AC
Year: 2008
Journal: Development
Title: Targeted disruption of beta-catenin in Sf1-expressing cells impairs development and maintenance of the adrenal cortex.
Volume: 135
Issue: 15
Pages: 2593-602
•
•
•
•
•
Publication
23376610 | J:198851
First Author: Guasti L
Year: 2013
Journal: Mol Cell Endocrinol
Title: FGF signalling through Fgfr2 isoform IIIb regulates adrenal cortex development.
Volume: 371
Issue: 1-2
Pages: 182-8
•
•
•
•
•
Publication
21982706 | J:177649
First Author: Xu Y
Year: 2011
Journal: Cell Metab
Title: Distinct hypothalamic neurons mediate estrogenic effects on energy homeostasis and reproduction.
Volume: 14
Issue: 4
Pages: 453-65
•
•
•
•
•
Publication
17488640 | J:129860
First Author: Tong Q
Year: 2007
Journal: Cell Metab
Title: Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia.
Volume: 5
Issue: 5
Pages: 383-93
•
•
•
•
•
Publication
27018534 | J:269597
First Author: Vasquez YM
Year: 2016
Journal: Mol Endocrinol
Title: Endometrial Expression of Steroidogenic Factor 1 Promotes Cystic Glandular Morphogenesis.
Volume: 30
Issue: 5
Pages: 518-32
•
•
•
•
•
Publication
37339627 | J:347481
First Author: Rashid M
Year: 2023
Journal: Cell Rep
Title: Inhibition of high-fat diet-induced inflammatory responses in adipose tissue by SF1-expressing neurons of the ventromedial hypothalamus.
Volume: 42
Issue: 6
Pages: 112627
•
•
•
•
•
Publication
29212022 | J:254839
First Author: Felsted JA
Year: 2017
Journal: Cell Rep
Title: Alpha2delta-1 in SF1+ Neurons of the Ventromedial Hypothalamus Is an Essential Regulator of Glucose and Lipid Homeostasis.
Volume: 21
Issue: 10
Pages: 2737-2747
•
•
•
•
•
Publication
30104247 | J:265904
First Author: Seoane-Collazo P
Year: 2018
Journal: Diabetes
Title: SF1-Specific AMPKα1 Deletion Protects Against Diet-Induced Obesity.
Volume: 67
Issue: 11
Pages: 2213-2226
•
•
•
•
•
Publication
33303759 | J:300990
First Author: Zhang J
Year: 2020
Journal: Nat Commun
Title: An excitatory ventromedial hypothalamus to paraventricular thalamus circuit that suppresses food intake.
Volume: 11
Issue: 1
Pages: 6326
•
•
•
•
•
Publication
37020955 | J:350276
First Author: Guo Y
Year: 2023
Journal: iScience
Title: Steroidogenic factor 1 protects mice from obesity-induced glucose intolerance via improving glucose-stimulated insulin secretion by beta cells.
Volume: 26
Issue: 4
Pages: 106451
•
•
•
•
•
Publication
27402603 | J:256905
 
First Author: Laverrière JN
Year: 2016
Journal: Mol Cell Endocrinol
Title: Epigenetic regulation of alternative promoters and enhancers in progenitor, immature, and mature gonadotrope cell lines.
Volume: 434
Pages: 250-65
•
•
•
•
•
Protein
A0A494B9N0
Organism: Mus musculus/domesticus
Length: 283  
Fragment?: true
•
•
•
•
•
Protein
A0A494BAT6
Organism: Mus musculus/domesticus
Length: 61  
Fragment?: true
•
•
•
•
•
Publication
8253085 | -
First Author: Fuller-Pace FV
Year: 1993
Journal: EMBO J
Title: DbpA: a DEAD box protein specifically activated by 23s rRNA.
Volume: 12
Issue: 9
Pages: 3619-26
•
•
•
•
•
Publication
9016593 | -
First Author: Böddeker N
Year: 1997
Journal: Nucleic Acids Res
Title: Characterization of DbpA, an Escherichia coli DEAD box protein with ATP independent RNA unwinding activity.
Volume: 25
Issue: 3
Pages: 537-45
•
•
•
•
•
Publication
19734347 | -
First Author: Sharpe Elles LM
Year: 2009
Journal: Nucleic Acids Res
Title: A dominant negative mutant of the E. coli RNA helicase DbpA blocks assembly of the 50S ribosomal subunit.
Volume: 37
Issue: 19
Pages: 6503-14
•
•
•
•
•
Publication
12787353 | -
First Author: Charollais J
Year: 2003
Journal: Mol Microbiol
Title: The DEAD-box RNA helicase SrmB is involved in the assembly of 50S ribosomal subunits in Escherichia coli.
Volume: 48
Issue: 5
Pages: 1253-65
•
•
•
•
•
Publication
18668125 | -
First Author: Saikrishnan K
Year: 2008
Journal: EMBO J
Title: DNA binding to RecD: role of the 1B domain in SF1B helicase activity.
Volume: 27
Issue: 16
Pages: 2222-9
•
•
•
•
•
Publication
19467629 | -
First Author: Kang CH
Year: 2009
Journal: Arch Biochem Biophys
Title: Arabidopsis thaliana PRP40s are RNA polymerase II C-terminal domain-associating proteins.
Volume: 484
Issue: 1
Pages: 30-8
•
•
•
•
•
Publication
11604498 | -
First Author: Goldstrohm AC
Year: 2001
Journal: Mol Cell Biol
Title: The transcription elongation factor CA150 interacts with RNA polymerase II and the pre-mRNA splicing factor SF1.
Volume: 21
Issue: 22
Pages: 7617-28
•
•
•
•
•
Publication
16782886 | -
First Author: Sánchez-Alvarez M
Year: 2006
Journal: Mol Cell Biol
Title: Human transcription elongation factor CA150 localizes to splicing factor-rich nuclear speckles and assembles transcription and splicing components into complexes through its amino and carboxyl regions.
Volume: 26
Issue: 13
Pages: 4998-5014
•
•
•
•
•
Protein Domain
IPR028619 | DEAD_helicase_DbpA
Type: Family
Description: RNA helicases from the DEAD-box family are found in almost all organisms andhave important roles in RNA metabolism, such as splicing, RNA transport,ribosome biogenesis, translation and RNA decay. They are enzymes that unwinddouble-stranded RNA molecules in an energy dependent fashion through thehydrolysis of NTP. DEAD-box RNA helicases belong to superfamily 2 (SF2) ofhelicases. As other SF1 and SF2 members they contain seven conserved motifswhich are characteristic of these two superfamilies [].DEAD-box is named after the amino acids of motif II or Walker B (Mg2+-bindingaspartic acid). The RNA helicase DbpA has an RNA-dependent ATPase activity, which is specific for 23S rRNA [, ]. It is involved in assembly of the 50S ribosomal subunit [].
•
•
•
•
•
Protein Domain
IPR028621 | DEAD_helicase_SrmB
Type: Family
Description: RNA helicases from the DEAD-box family are found in almost all organisms andhave important roles in RNA metabolism, such as splicing, RNA transport,ribosome biogenesis, translation and RNA decay. They are enzymes that unwinddouble-stranded RNA molecules in an energy dependent fashion through thehydrolysis of NTP. DEAD-box RNA helicases belong to superfamily 2 (SF2) ofhelicases. As other SF1 and SF2 members they contain seven conserved motifswhich are characteristic of these two superfamilies [].DEAD-box is named after the amino acids of motif II or Walker B (Mg2+-bindingaspartic acid). SrmB is a DEAD-box RNA helicase that is involved in ribosome assembly. Deletion of the srmB gene in Escherichia coli causes a slow-growth phenotype at low temperature [].
•
•
•
•
•
Protein Domain
IPR041851 | RecD_N
Type: Homologous_superfamily
Description: RecBCD is a multi-functional enzyme complex that processes DNA ends resulting from a double-strand break. RecBCD is a bipolar helicase that splits the duplex into its component strands and digests them until encountering a recombinational hotspot (Chi site) []. The RecD subunit accounts for the 5'-3' helicase activity of RecBCD. The structure of the RecD subunit resembles SF1 helicase. RecD comprises several domains - N-terminal domain, domains 1A, 1B, 2A (or 3) and 2B (in D. radiodurans RecD2) []. This superfamily entry represents the N-terminal domain of RecD subunit.
•
•
•
•
•
Protein Domain
IPR045148 | TCRG1-like
Type: Family
Description: This entry includes TCRG1/TCRGL from human and related proteins from animals, fungi and plants. TCRG1 (also known as CA150) contains three N-terminal WW domains and six consecutive FF domains. WW and FF domains are versatile modules that mediate protein-protein interactions []. TCRG1 is a transcription elongation factor that interacts with the splicing factor SF1 and with the phosphorylated C-terminal repeat domain (CTD) of RNA polymerase II (RNAPII) through its WW and FF domains, respectively [].This entry also includes Urn1 from budding yeasts and PRP40C from Arabidopsis. They are predicted to be involved in pre-mRNA splicing [].
•
•
•
•
•
Publication
22573863 | -
First Author: Nishikiori M
Year: 2012
Journal: J Virol
Title: Crystal structure of the superfamily 1 helicase from Tomato mosaic virus.
Volume: 86
Issue: 14
Pages: 7565-76
•
•
•
•
•
Publication
11000230 | -
First Author: Seybert A
Year: 2000
Journal: J Virol
Title: Biochemical characterization of the equine arteritis virus helicase suggests a close functional relationship between arterivirus and coronavirus helicases.
Volume: 74
Issue: 20
Pages: 9586-93
•
•
•
•
•
Protein Domain
IPR027351 | (+)RNA_virus_helicase_core_dom
Type: Domain
Description: Helicases have been classified in 6 superfamilies (SF1-SF6) []. All of the proteins bind ATP and, consequently, all of them carry the classical Walker A (phosphate-binding loop or P-loop) and Walker B (Mg2+-binding aspartic acid) motifs. The two largest superfamilies,commonly referred to as SF1 and SF2, share similar patterns of seven conserved sequence motifs, some of which are separated by long poorly conserved spacers. Helicase motifs appear to be organised in a core domain which provides the catalytic function, whereas optional inserts and amino- and carboxy-terminal sequences may comprise distinct domains with diverse accessory roles. The helicase core contains two structural domains, an N-terminal ATP-binding domain and a C-terminal domain. Putative SF1 helicases are extremely widespread among positive-stranded (+)RNA viruses. They have been identified in a variety of plant virus families, as well as alpha- rubi-, arteri-, hepatitis E, and coronaviruses. A number of these viral enzymes have been implicated in diverse aspects of transcription and replication but also in RNA stability and cell-to-cell movement [].The (+) RNA virus helicase core contains two RecA-like α/β domains. The N-terminal ATP-binding domain contains a parallel six-stranded β-sheet surrounded by four helices on one side and two helices on the other. The C-terminal domain contains a parallel four-stranded β-sheetsandwiched between two helices on each of its sides. The (+)RNA virus helicase core is likely to bind NTP in cleft between the N terminus of the ATP-binding domain and the beginning of the C-terminal domain [].This entry represents the (+)RNA virus helicase core domain.
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom