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Search results 201 to 212 out of 212 for Sharpin

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0.024s

Type

Details

Score

Publication

22549881 | -

First Author:	Stieglitz B
Year:	2012
Journal:	J Biol Chem
Title:	Structural analysis of SHARPIN, a subunit of a large multi-protein E3 ubiquitin ligase, reveals a novel dimerization function for the pleckstrin homology superfold.
Volume:	287
Issue:	25
Pages:	20823-9

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Publication

20103625 | -

First Author:	Gustafsson N
Year:	2010
Journal:	Cancer Res
Title:	RBCK1 drives breast cancer cell proliferation by promoting transcription of estrogen receptor alpha and cyclin B1.
Volume:	70
Issue:	3
Pages:	1265-74

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Publication

28978479 | -

First Author:	Liu J
Year:	2017
Journal:	Cell Rep
Title:	Structural Insights into SHARPIN-Mediated Activation of HOIP for the Linear Ubiquitin Chain Assembly.
Volume:	21
Issue:	1
Pages:	27-36

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Protein Domain

IPR026261 | RBCK1/SHARPIN

Type:

Family

Description:

This entry consists of RanBP-type and C3HC4-type zinc finger-containing protein 1 (RBCK1, also known as HOIL-1) and SHARPIN. Both are components of the E3 ligase complex LUBAC (linear ubiquitin chain assembly complex). LUBAC is composed of HOIP, RBCK1/HOIL-1, and SHARPIN. HOIP is the catalytic subunit and its E3 activity can be effectively activated by HOIL-1 or SHARPIN []. The LUBAC complex catalyses the formation of linear ubiquitin chains and regulates immune and apoptopic signaling pathways [, , ].RBCK1/HOIL-1 contains an ubiquitin-like (UBL) domain followed by a Npl4 zinc finger (NZF) domain and a RBR (RING-between-RING) domain in the C-terminal portion of the protein. RBCK1 is a RING-between-RING E3 ligase, and it has also been shown to act as a transcriptional activator []. SHARPIN also contains a UBL domain and a Ub-binding NZF domain, but lacks the RBR domain and has a additional N-terminal pleckstrin homology (PH) domain [, ].

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Publication

27857075 | J:242860

First Author:	Teh CE
Year:	2016
Journal:	Nat Commun
Title:	Linear ubiquitin chain assembly complex coordinates late thymic T-cell differentiation and regulatory T-cell homeostasis.
Volume:	7

Pages:	13353

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Publication

35274759 | J:342869

First Author:	Kelsall IR
Year:	2022
Journal:	EMBO J
Title:	HOIL-1 ubiquitin ligase activity targets unbranched glucosaccharides and is required to prevent polyglucosan accumulation.
Volume:	41
Issue:	8
Pages:	e109700

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Publication

23815148 | J:216562

First Author:	Etemadi N
Year:	2013
Journal:	FEBS J
Title:	Lymphotoxin α induces apoptosis, necroptosis and inflammatory signals with the same potency as tumour necrosis factor.
Volume:	280
Issue:	21
Pages:	5283-97

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Protein

F6VII1

Organism:	Mus musculus/domesticus
Length:	233
Fragment?:	true

•

Protein

Q9WUB0

Organism:	Mus musculus/domesticus
Length:	508
Fragment?:	false

•

Publication

15489334 | -

First Author:	Gerhard DS
Year:	2004
Journal:	Genome Res
Title:	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume:	14
Issue:	10B
Pages:	2121-7

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Publication

21183079 | J:292518

First Author:	Huttlin EL
Year:	2010
Journal:	Cell
Title:	A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume:	143
Issue:	7
Pages:	1174-89

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Publication

19468303 | -

First Author:	Church DM
Year:	2009
Journal:	PLoS Biol
Title:	Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume:	7
Issue:	5
Pages:	e1000112

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