Type |
Details |
Score |
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
83
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
219
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
408
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
176
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
375
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
100
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
137
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
146
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
70
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
242
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
379
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
63
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
167
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
73
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
133
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Yamamoto A |
Year: |
2005 |
Journal: |
Cell |
Title: |
Shisa promotes head formation through the inhibition of receptor protein maturation for the caudalizing factors, Wnt and FGF. |
Volume: |
120 |
Issue: |
2 |
Pages: |
223-35 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hedge TA |
Year: |
2008 |
Journal: |
Int J Dev Biol |
Title: |
Expression of Shisa2, a modulator of both Wnt and Fgf signaling, in the chick embryo. |
Volume: |
52 |
Issue: |
1 |
Pages: |
81-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pei J |
Year: |
2012 |
Journal: |
Cell Signal |
Title: |
Unexpected diversity in Shisa-like proteins suggests the importance of their roles as transmembrane adaptors. |
Volume: |
24 |
Issue: |
3 |
Pages: |
758-69 |
|
•
•
•
•
•
|
Publication |
First Author: |
He X |
Year: |
2005 |
Journal: |
Cell |
Title: |
Antagonizing Wnt and FGF receptors: an enemy from within (the ER). |
Volume: |
120 |
Issue: |
2 |
Pages: |
156-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhu Y |
Year: |
2008 |
Journal: |
Nagoya J Med Sci |
Title: |
Expression and roles of a xenopus head-forming gene homologue in human cancer cell lines. |
Volume: |
70 |
Issue: |
3-4 |
Pages: |
73-82 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Shisa is a transmembrane, transcription factor-type protein that physically interacts with immature forms of the Wnt receptor Frizzled and the FGF receptor within the endoplasmic reticulum to inhibit their post-translational maturation and trafficking to the cell surface [, ].The Shisa family founding member, Xenopus Shisa, promotes head development by antagonising Wnt and FGF signaling []. Several vertebrate homologues have been identified with implicated roles in development, cancer and apoptosis [, , ]. Distantly related Shisa homologues have also been detected that possess an N-terminal domain with six conserved cysteines. These Shisa-like proteins include SHISAL1 (shisa-like-1, also known as KIAA1644), SHISAL2A (FAM159A) and SHISAL2B (FAM159B) from vertebrates []. |
|
•
•
•
•
•
|