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Search results 201 to 300 out of 302 for Slc41a3

0.044s
Type Details Score
GXD Expression  
Probe: MGI:1509564
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1831123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828230
Age: embryonic day 14.5
Image: euxassay_006674_19
Specimen Label: euxassay_006674_19
Detected: true
Specimen Num: 19
GXD Expression  
Probe: MGI:1509564
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1831123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828230
Age: embryonic day 14.5
Image: euxassay_006674_20
Specimen Label: euxassay_006674_20
Detected: true
Specimen Num: 20
GXD Expression  
Probe: MGI:1509564
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1831123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828230
Age: embryonic day 14.5
Image: euxassay_006674_21
Specimen Label: euxassay_006674_21
Detected: true
Specimen Num: 21
GXD Expression  
Probe: MGI:1509564
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1831123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828230
Age: embryonic day 14.5
Image: euxassay_006674_22
Specimen Label: euxassay_006674_22
Detected: true
Specimen Num: 22
GXD Expression  
Probe: MGI:1509564
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1831123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828230
Age: embryonic day 14.5
Image: euxassay_006674_23
Specimen Label: euxassay_006674_23
Detected: true
Specimen Num: 23
GXD Expression      
Probe: MGI:4428062
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1741222
Stage: TS22
Assay Id: MGI:5422508
Age: embryonic day 14.5
Specimen Label: MH2890; Specimen C3975
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309714
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1741222
Stage: TS22
Assay Id: MGI:5423055
Age: embryonic day 14.5
Specimen Label: MH3183; Specimen C4261
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4428062
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1754022
Stage: TS22
Assay Id: MGI:5422508
Age: embryonic day 14.5
Specimen Label: MH2890; Specimen C3975
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309714
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1754022
Stage: TS22
Assay Id: MGI:5423055
Age: embryonic day 14.5
Specimen Label: MH3183; Specimen C4261
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4428062
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3599822
Stage: TS22
Assay Id: MGI:5422508
Age: embryonic day 14.5
Specimen Label: MH2890; Specimen C3975
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309714
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3599822
Stage: TS22
Assay Id: MGI:5423055
Age: embryonic day 14.5
Specimen Label: MH3183; Specimen C4261
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:4428062
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3280922
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5422508
Age: embryonic day 14.5
Image: MH2890; Specimen C3975
Specimen Label: MH2890; Specimen C3975
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:5309714
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3280922
Stage: TS22
Assay Id: MGI:5423055
Age: embryonic day 14.5
Specimen Label: MH3183; Specimen C4261
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4428062
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1833322
Stage: TS22
Assay Id: MGI:5422508
Age: embryonic day 14.5
Specimen Label: MH2890; Specimen C3975
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309714
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1833322
Stage: TS22
Assay Id: MGI:5423055
Age: embryonic day 14.5
Specimen Label: MH3183; Specimen C4261
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:4428062
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3287022
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5422508
Age: embryonic day 14.5
Image: MH2890; Specimen C3975
Specimen Label: MH2890; Specimen C3975
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:5309714
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3287022
Stage: TS22
Assay Id: MGI:5423055
Age: embryonic day 14.5
Specimen Label: MH3183; Specimen C4261
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4428062
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1752522
Stage: TS22
Assay Id: MGI:5422508
Age: embryonic day 14.5
Specimen Label: MH2890; Specimen C3975
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309714
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1752522
Stage: TS22
Assay Id: MGI:5423055
Age: embryonic day 14.5
Specimen Label: MH3183; Specimen C4261
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:4428062
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1821522
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5422508
Age: embryonic day 14.5
Image: MH2890; Specimen C3975
Specimen Label: MH2890; Specimen C3975
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:5309714
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1821522
Stage: TS22
Assay Id: MGI:5423055
Age: embryonic day 14.5
Specimen Label: MH3183; Specimen C4261
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4428062
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3557722
Stage: TS22
Assay Id: MGI:5422508
Age: embryonic day 14.5
Specimen Label: MH2890; Specimen C3975
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309714
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3557722
Stage: TS22
Assay Id: MGI:5423055
Age: embryonic day 14.5
Specimen Label: MH3183; Specimen C4261
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4428062
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1702122
Stage: TS22
Assay Id: MGI:5422508
Age: embryonic day 14.5
Specimen Label: MH2890; Specimen C3975
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309714
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1702122
Stage: TS22
Assay Id: MGI:5423055
Age: embryonic day 14.5
Specimen Label: MH3183; Specimen C4261
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:4428062
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1756322
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5422508
Age: embryonic day 14.5
Image: MH2890; Specimen C3975
Specimen Label: MH2890; Specimen C3975
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:5309714
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1756322
Stage: TS22
Assay Id: MGI:5423055
Age: embryonic day 14.5
Specimen Label: MH3183; Specimen C4261
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4428062
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1668822
Stage: TS22
Assay Id: MGI:5422508
Age: embryonic day 14.5
Specimen Label: MH2890; Specimen C3975
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309714
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1668822
Stage: TS22
Assay Id: MGI:5423055
Age: embryonic day 14.5
Specimen Label: MH3183; Specimen C4261
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:4428062
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1757722
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5422508
Age: embryonic day 14.5
Image: MH2890; Specimen C3975
Specimen Label: MH2890; Specimen C3975
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:5309714
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1757722
Stage: TS22
Assay Id: MGI:5423055
Age: embryonic day 14.5
Specimen Label: MH3183; Specimen C4261
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4428062
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1757522
Stage: TS22
Assay Id: MGI:5422508
Age: embryonic day 14.5
Specimen Label: MH2890; Specimen C3975
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309714
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1757522
Stage: TS22
Assay Id: MGI:5423055
Age: embryonic day 14.5
Specimen Label: MH3183; Specimen C4261
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4428062
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1738322
Stage: TS22
Assay Id: MGI:5422508
Age: embryonic day 14.5
Specimen Label: MH2890; Specimen C3975
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309714
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1738322
Stage: TS22
Assay Id: MGI:5423055
Age: embryonic day 14.5
Specimen Label: MH3183; Specimen C4261
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4428062
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1802422
Stage: TS22
Assay Id: MGI:5422508
Age: embryonic day 14.5
Specimen Label: MH2890; Specimen C3975
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309714
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1802422
Stage: TS22
Assay Id: MGI:5423055
Age: embryonic day 14.5
Specimen Label: MH3183; Specimen C4261
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:4428062
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1768022
Stage: TS22
Assay Id: MGI:5422508
Age: embryonic day 14.5
Note: Expression was not detected in the skull (base and vault).
Specimen Label: MH2890; Specimen C3975
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5309714
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1768022
Stage: TS22
Assay Id: MGI:5423055
Age: embryonic day 14.5
Note: Expression was not detected in the skull (base and vault).
Specimen Label: MH3183; Specimen C4261
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:4428062
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:2672022
Stage: TS22
Assay Id: MGI:5422508
Age: embryonic day 14.5
Note: Expression was not detected in whisker follicle.
Specimen Label: MH2890; Specimen C3975
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5309714
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:2672022
Stage: TS22
Assay Id: MGI:5423055
Age: embryonic day 14.5
Note: Expression was not detected in whisker follicle.
Specimen Label: MH3183; Specimen C4261
Detected: false
Specimen Num: 1
Publication
First Author: Suzuki H
Year: 2001
Journal: Genome Res
Title: Protein-protein interaction panel using mouse full-length cDNAs.
Volume: 11
Issue: 10
Pages: 1758-65
Publication      
First Author: Mouse Genome Informatics and the Wellcome Trust Sanger Institute Mouse Genetics Project (MGP)
Year: 2011
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the Wellcome Trust Sanger Institute (WTSI) Mouse Resources Portal
Publication        
First Author: Mouse Genome Database and National Center for Biotechnology Information Editorial Staff Collaboration
Year: 2001
Title: LocusLink Collaboration
Publication
First Author: Ingham NJ
Year: 2019
Journal: PLoS Biol
Title: Mouse screen reveals multiple new genes underlying mouse and human hearing loss.
Volume: 17
Issue: 4
Pages: e3000194
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
Publication        
First Author: The Gene Ontology Consortium
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Publication
First Author: Visel A
Year: 2004
Journal: Nucleic Acids Res
Title: GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Volume: 32
Issue: Database issue
Pages: D552-6
Publication      
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
Publication      
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication        
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Allele
Name: transgene insertion HQ259, GENSAT Project at Rockefeller University
Allele Type: Transgenic
Attribute String: Reporter
Strain
Attribute String: mutant stock, transgenic
Allele
Name: transgene insertion B36-3, M I Kotlikoff
Allele Type: Transgenic
Attribute String: Reporter
Strain
Attribute String: transgenic, mutant strain, congenic
Publication  
First Author: Mastrototaro L
Year: 2016
Journal: Sci Rep
Title: Solute carrier 41A3 encodes for a mitochondrial Mg(2+) efflux system.
Volume: 6
Pages: 27999
Protein
Organism: Mus musculus/domesticus
Length: 89  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 131  
Fragment?: true
Publication
First Author: Lin CH
Year: 2014
Journal: Parkinsonism Relat Disord
Title: Variant R244H in Na+/Mg2+ exchanger SLC41A1 in Taiwanese Parkinson's disease is associated with loss of Mg2+ efflux function.
Volume: 20
Issue: 6
Pages: 600-3
Publication
First Author: Kolisek M
Year: 2012
Journal: Am J Physiol Cell Physiol
Title: Human gene SLC41A1 encodes for the Na+/Mg²+ exchanger.
Volume: 302
Issue: 1
Pages: C318-26
Publication  
First Author: Schweigel-Röntgen M
Year: 2014
Journal: Curr Top Membr
Title: SLC41 transporters--molecular identification and functional role.
Volume: 73
Pages: 383-410
Publication
First Author: Feeney KA
Year: 2016
Journal: Nature
Title: Daily magnesium fluxes regulate cellular timekeeping and energy balance.
Volume: 532
Issue: 7599
Pages: 375-9
Publication
First Author: Tsao YT
Year: 2017
Journal: Stem Cell Res Ther
Title: Knockdown of SLC41A1 magnesium transporter promotes mineralization and attenuates magnesium inhibition during osteogenesis of mesenchymal stromal cells.
Volume: 8
Issue: 1
Pages: 39
Publication
First Author: Kolisek M
Year: 2013
Journal: Hypertens Pregnancy
Title: SLC41A1 is the only magnesium responsive gene significantly overexpressed in placentas of preeclamptic women.
Volume: 32
Issue: 4
Pages: 378-89
Protein Domain
Type: Family
Description: This entry includes the SLC41A family members mostly from eukaryotes and archaea. Some proteins are from bacteria. The SLC41A family of divalent cation transporters includes SLC41A1, SLC41A2 and SLC41A3 and MgtE [, , , ]. MgtE, the SLC41A1 orthologue found in prokaryotes, consists of a homodimer architecture with five transmembrane domains at the C terminus and the cytosolic domains at the N terminus. Structural and functional analyses showed MgtE conserved acidic side-chains play a key role as part of its selectivity filter [, ]. In humans, SLC41A1 is a Na+/Mg2+ ion exchanger that acts as a predominant Mg2+ efflux system at the plasma membrane. The transporter activity is driven by the inwardly directed electrochemical gradient for Na+ ions, thus directly depends on the extracellular Na+ ion concentration set by the Na+/K+ pump. In this way, it generates circadian cellular Mg2+ fluxes that feed back to regulate clock-controlled gene expression and metabolism and facilitate higher energetic demands during the day. This protein is located in the cell membrane [, ]. Its expression level has been linked to diverse disorders such as preeclampsia in pregnant woman, nephronophthisis, Parkinson's disease and bone mass loss. Hence, it has been suggested this protein might be a great therapeutic target [, , , ]. Mouse SLC41A2 has been shown to transport Mg2+ and a range of other divalent cations: Ba2+, Ni2+, Co2+, Fe2+, or Mn2+, but not Ca2+, Zn2+, or Cu2+ [].
Protein
Organism: Mus musculus/domesticus
Length: 512  
Fragment?: false
Publication
First Author: Goytain A
Year: 2005
Journal: Biochem Biophys Res Commun
Title: Functional characterization of the mouse [corrected] solute carrier, SLC41A2.
Volume: 330
Issue: 3
Pages: 701-5
Protein
Organism: Mus musculus/domesticus
Length: 573  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 488  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 488  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 573  
Fragment?: false
Publication
First Author: Wabakken T
Year: 2003
Journal: Biochem Biophys Res Commun
Title: The human solute carrier SLC41A1 belongs to a novel eukaryotic subfamily with homology to prokaryotic MgtE Mg2+ transporters.
Volume: 306
Issue: 3
Pages: 718-24
Publication
First Author: Jin F
Year: 2021
Journal: PLoS Biol
Title: The structure of MgtE in the absence of magnesium provides new insights into channel gating.
Volume: 19
Issue: 4
Pages: e3001231
Publication
First Author: Payandeh J
Year: 2013
Journal: Biochim Biophys Acta
Title: The structure and regulation of magnesium selective ion channels.
Volume: 1828
Issue: 11
Pages: 2778-92
Publication
First Author: Sahni J
Year: 2013
Journal: Mol Aspects Med
Title: The SLC41 family of MgtE-like magnesium transporters.
Volume: 34
Issue: 2-3
Pages: 620-8
Publication
First Author: Hattori M
Year: 2007
Journal: Nature
Title: Crystal structure of the MgtE Mg2+ transporter.
Volume: 448
Issue: 7157
Pages: 1072-5