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Search results 201 to 215 out of 215 for Snx27

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Type Details Score
Publication
25472716 | -
First Author: Ghai R
Year: 2015
Journal: J Cell Sci
Title: Phosphoinositide binding by the SNX27 FERM domain regulates its localization at the immune synapse of activated T-cells.
Volume: 128
Issue: 3
Pages: 553-65
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Protein Domain
IPR037833 | SNX27_PX
Type: Domain
Description: Sorting nexin-27 (SNX27) belongs to the sorting nexin family, which contains a conserved PX (phox homology) domain that may be responsible for binding to specific phosphoinositides []. SNX27 also possesses an PDZ (DHR) domain, a Ras-associating domain and a FERM-like domain with an atypical tertiary structure [].SNX27 is a core component of the SNX27-retromer, a multiprotein complex composed of SNX27, the WASH complex and the retromer complex. It specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ-binding motif at the C terminus []. Its PDZ domain mediates binding to the retromer complex via direct interaction with VPS26 (VPS26A or VPS26B) [], while its PX domain mediates binding to phosphatidylinositol 3-phosphate (PtdIns(3P)) and localization to early endosome membranes []. This entry represents the PX domain of SNX27. The SNX27 PX domain preferentially binds to phosphatidylinositol-3-phosphate (PI3P) and is important for targeting to the early endosome [].
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Publication
31541095 | J:279367
First Author: Stangl A
Year: 2019
Journal: Nat Commun
Title: Regulation of the endosomal SNX27-retromer by OTULIN.
Volume: 10
Issue: 1
Pages: 4320
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Protein Domain
IPR037835 | SNX27_RA
Type: Domain
Description: Sorting nexin-27 (SNX27) belongs to the sorting nexin family, which contains a conserved PX (phox homology) domain that may be responsible for binding to specific phosphoinositides []. SNX27 also possesses an PDZ (DHR) domain, a Ras-associating domain and a FERM-like domain with an atypical tertiary structure [].SNX27 is a core component of the SNX27-retromer, a multiprotein complex composed of SNX27, the WASH complex and the retromer complex. It specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ-binding motif at the C terminus []. Its PDZ domain mediates binding to the retromer complex via direct interaction with VPS26 (VPS26A or VPS26B) [], while its PX domain mediates binding to phosphatidylinositol 3-phosphate (PtdIns(3P)) and localization to early endosome membranes []. This entry represents the RAS-associated (RA) domain of SNX27.
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Protein Domain
IPR037827 | SNX27_FERM-like_dom
Type: Domain
Description: Sorting nexin-27 (SNX27) belongs to the sorting nexin family, which contains a conserved PX (phox homology) domain that may be responsible for binding to specific phosphoinositides []. SNX27 also possesses an PDZ (DHR) domain, a Ras-associating domain and a FERM-like domain with an atypical tertiary structure [].SNX27 is a core component of the SNX27-retromer, a multiprotein complex composed of SNX27, the WASH complex and the retromer complex. It specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ-binding motif at the C terminus []. Its PDZ domain mediates binding to the retromer complex via direct interaction with VPS26 (VPS26A or VPS26B) [], while its PX domain mediates binding to phosphatidylinositol 3-phosphate (PtdIns(3P)) and localization to early endosome membranes []. This entry represents the FERM-like domain of SNX27. This domain binds PtdInsPs in a manner that is distinct to that of distantly related FERM, pleckstrin homology (PH) and phosphotyrosine-binding (PTB) domains [].
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Publication
26442671 | J:285847
 
First Author: Merkulova M
Year: 2015
Journal: Sci Rep
Title: Mapping the H(+) (V)-ATPase interactome: identification of proteins involved in trafficking, folding, assembly and phosphorylation.
Volume: 5
Pages: 14827
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Publication
24523912 | J:212946
First Author: Bauch C
Year: 2014
Journal: PLoS One
Title: Subcellular sorting of the G-protein coupled mouse somatostatin receptor 5 by a network of PDZ-domain containing proteins.
Volume: 9
Issue: 2
Pages: e88529
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Publication
24914955 | J:220499
First Author: Vieira N
Year: 2014
Journal: PLoS One
Title: SNX31: a novel sorting nexin associated with the uroplakin-degrading multivesicular bodies in terminally differentiated urothelial cells.
Volume: 9
Issue: 6
Pages: e99644
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Publication
24359963 | -
 
First Author: Ghai R
Year: 2014
Journal: Methods Enzymol
Title: Measuring interactions of FERM domain-containing sorting Nexin proteins with endosomal lipids and cargo molecules.
Volume: 534
Pages: 331-49
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Protein Domain
IPR037831 | SNX17/27/31
Type: Family
Description: SNX17/27/31 are known as PX-FERM proteins, a sub-group of the PX superfamily that contain a defining PtdInsP-binding PX domain, and a C-terminal 4.1, ezrin, radixin, moesin (FERM) domain with an atypical tertiary structure []. They are modular peripheralmembrane proteins that act as central scaffolds mediating protein-lipid interactions, cargo binding, and regulatory protein recruitment [].SNX17 is a critical regulator of endosomal recycling of numerous receptors, channels, and other transmembrane proteins. It binds to Asn-Pro-Xaa-Tyr (NPxY) sequences in the cytoplasmic tails of cargo such as LDL receptors and the amyloid precursor protein []. SNX27 is a core component of the SNX27-retromer, a multiprotein complex composed of SNX27, the WASH complex and the retromer complex. It specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ-binding motif at the C terminus []. Its PDZ domain mediates binding to the retromer complex via direct interaction with VPS26 (VPS26A or VPS26B) [], while its PX domain mediates binding to phosphatidylinositol 3-phosphate (PtdIns(3P)) and localization to early endosome membranes []. SNX31 is a sorting nexin that binds to PtdIns3P-enriched lipids via its N-terminal PX-domain. It also binds to uroplakins [].
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Protein
Q6P8Y7
Organism: Mus musculus/domesticus
Length: 439  
Fragment?: false
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Protein
D3Z3J1
Organism: Mus musculus/domesticus
Length: 67  
Fragment?: true
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Protein
D3Z7S9
Organism: Mus musculus/domesticus
Length: 169  
Fragment?: true
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Protein
H3BKG9
Organism: Mus musculus/domesticus
Length: 87  
Fragment?: false
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Protein
Q8BVL3
Organism: Mus musculus/domesticus
Length: 470  
Fragment?: false
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