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Search results 201 to 218 out of 218 for Socs4

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Type Details Score
Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
22423360 | -
First Author: Feng ZP
Year: 2012
Journal: Proteins
Title: The N-terminal domains of SOCS proteins: a conserved region in the disordered N-termini of SOCS4 and 5.
Volume: 80
Issue: 3
Pages: 946-57
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Protein
Q9JLY0
Organism: Mus musculus/domesticus
Length: 533  
Fragment?: false
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Protein Domain
IPR035864 | SOCS4_SH2
Type: Domain
Description: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS4 (Suppressor of cytokine signalling 4) is the substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins []. SOCS4 and SOCS5 regulate epidermal growth factor receptor signaling [].This entry represents the SH3 domain of SOCS4.
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Protein Coding Gene
MGI:1924885 | Socs6
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR028420 | SOCS5
Type: Family
Description: Suppressor of cytokine signalling (SOCS) proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS5 inhibits the IL4 signaling pathway, which promotes the Th (helper T) 2 cell development []. SOCS5 and SOCS4 regulate epidermal growth factor receptor signaling [].
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Publication
12242343 | J:113957
First Author: Seki Y
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation.
Volume: 99
Issue: 20
Pages: 13003-8
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Protein
Q3UXZ1
Organism: Mus musculus/domesticus
Length: 203  
Fragment?: true
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Protein Domain
IPR037342 | SOCS4_SOCS
Type: Domain
Description: This entry represents the SOCS box domain of SOCS4.SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS4 (Suppressor of cytokine signalling 4) is the substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins []. SOCS4 and SOCS5 regulate epidermal growth factor receptor signaling [].The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions [, ].
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Publication
29642001 | J:270948
First Author: Sekine Y
Year: 2018
Journal: Cell Rep
Title: Functional Genome-wide Screen Identifies Pathways Restricting Central Nervous System Axonal Regeneration.
Volume: 23
Issue: 2
Pages: 415-428
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Protein Domain
IPR022252 | SOCS4/SOCS5_dom
Type: Domain
Description: Suppressors of cytokine signaling (SOCS) proteins play important roles in regulating a variety of signal transduction pathways that are involved in immunity, growth and development of organisms. They share a similar domain organisation, with a central SH2 domain and a conserved C-terminal SOCS box. In contrast, the N-terminal domains vary in length and amino acid sequence. In the case of SOCS4-7, the N-terminal domain accounts for a large proportion of the protein [].This entry represents a conserved region in the N-terminal domains of SOCS4 and 5. This domain is approximately 60 amino acids in length. It is found in association with , .
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Protein Domain
IPR037343 | SOCS5_SOCS
Type: Domain
Description: This entry represents the SOCS box domain of SOCS5.Suppressor of cytokine signalling (SOCS) proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS5 inhibits the IL4 signaling pathway, which promotes the Th (helper T) 2 cell development []. SOCS5 and SOCS4 regulate epidermal growth factor receptor signaling [].The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions [, ].
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Publication
9869640 | -
First Author: Kamura T
Year: 1998
Journal: Genes Dev
Title: The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families.
Volume: 12
Issue: 24
Pages: 3872-81
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Protein
O54928
Organism: Mus musculus/domesticus
Length: 536  
Fragment?: false
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Publication
16675548 | -
First Author: Bullock AN
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Crystal structure of the SOCS2-elongin C-elongin B complex defines a prototypical SOCS box ubiquitin ligase.
Volume: 103
Issue: 20
Pages: 7637-42
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Protein
Q6A021
Organism: Mus musculus/domesticus
Length: 198  
Fragment?: true
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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