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Search results 201 to 300 out of 427 for Sos1

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Type Details Score
Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
22827337 | J:192971
First Author: Saha M
Year: 2012
Journal: Biochem J
Title: RSK phosphorylates SOS1 creating 14-3-3-docking sites and negatively regulating MAPK activation.
Volume: 447
Issue: 1
Pages: 159-66
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Allele
Sos1<tm1.2Rak> | MGI:5000290
Name: SOS Ras/Rac guanine nucleotide exchange factor 1; targeted mutation 1.2, Raju Kucherlapati
Allele Type: Targeted
Attribute String: Humanized sequence
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Interaction Experiment
Zarich N (2019)
Description: The CSN3 subunit of the COP9 signalosome interacts with the HD region of Sos1 regulating stability of this GEF protein.
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Genotype
Genotype
Symbol: Sos1/Sos1<+>
Background: involves: 129S/Sv * C57BL/6 * FVB/N * SJL
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Sos1/Sos1
Background: involves: 129S/Sv * C57BL/6 * FVB/N * SJL
Zygosity: hm
Has Mutant Allele: true
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DO Term
DOID:0060582 | Noonan syndrome 4
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Allele
Sos1<tm1Smoc> | MGI:7292532
Name: SOS Ras/Rac guanine nucleotide exchange factor 1; targeted mutation 1, Shanghai Model Organisms Center
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Publication
30631038 | -
First Author: Zarich N
Year: 2019
Journal: Oncogenesis
Title: The CSN3 subunit of the COP9 signalosome interacts with the HD region of Sos1 regulating stability of this GEF protein.
Volume: 8
Issue: 1
Pages: 2
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Strain
MGI:7623498 | C57BL/6JSmoc-Sos1<tm1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Publication
19429099 | J:150447
First Author: Arai JA
Year: 2009
Journal: Neurosci Lett
Title: Sos2 is dispensable for NMDA-induced Erk activation and LTP induction.
Volume: 455
Issue: 1
Pages: 22-5
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Protein
A0A3Q4L2R8
Organism: Mus musculus/domesticus
Length: 22  
Fragment?: true
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Publication
8479541 | -
First Author: Li N
Year: 1993
Journal: Nature
Title: Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling.
Volume: 363
Issue: 6424
Pages: 85-8
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Publication
12628188 | -
First Author: Margarit SM
Year: 2003
Journal: Cell
Title: Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS.
Volume: 112
Issue: 5
Pages: 685-95
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Publication
16452984 | J:245330
First Author: Rehmann H
Year: 2006
Journal: Nature
Title: Structure of the cyclic-AMP-responsive exchange factor Epac2 in its auto-inhibited state.
Volume: 439
Issue: 7076
Pages: 625-8
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Publication
18541156 | -
First Author: Buday L
Year: 2008
Journal: Biochim Biophys Acta
Title: Many faces of Ras activation.
Volume: 1786
Issue: 2
Pages: 178-87
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Publication
18236214 | -
First Author: Bernards A
Year: 2007
Journal: Growth Factors
Title: GEFs in growth factor signaling.
Volume: 25
Issue: 5
Pages: 355-61
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Protein Domain
IPR000651 | Ras-like_Gua-exchang_fac_N
Type: Domain
Description: The N-terminal domain of guanine nucleotide exchange factor (GEF) for Ras-like GTPases is also called REM domain (Ras exchanger motif). REM contacts the GTPase and is assumed to participate in the catalytic activity of the exchange factor. Proteins with the REM domain include Sos1 and Sos2, which relay signals from tyrosine-kinase mediated signalling to Ras, RasGRP1-4, RasGRF1,2, CNrasGEF, and RAP-specific nucleotide exchange factors, to name a few [, , , , , , , ].The crystal structure of the GEF region of human Sos1 complexes with Ras hasbeen solved []. The structure consists of two distinct alpha helical structural domains: the N-terminal domain which seems to have a purely structural role and the C-terminal domain which is sufficient for catalyticactivity and contains all residues that interact with Ras. A main feature ofthe catalytic domain is the protrusion of a helical hairpin important for thenucleotide-exchange mechanism. The N-terminal domain is likely to be importantfor the stability and correct placement of the hairpin structure.This entry represents a domain found in several GEF for Ras-like small GTPases which lies N-terminal to the RasGef (Cdc25-like) domain.
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Publication
11889037 | J:114759
First Author: Rossman KL
Year: 2002
Journal: EMBO J
Title: A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange.
Volume: 21
Issue: 6
Pages: 1315-26
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Publication
23589333 | J:204491
First Author: Jun JE
Year: 2013
Journal: Mol Cell Biol
Title: Activation of extracellular signal-regulated kinase but not of p38 mitogen-activated protein kinase pathways in lymphocytes requires allosteric activation of SOS.
Volume: 33
Issue: 12
Pages: 2470-84
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Publication
22751148 | J:188414
First Author: Kovacevic I
Year: 2012
Journal: EMBO J
Title: The F-BAR protein NOSTRIN participates in FGF signal transduction and vascular development.
Volume: 31
Issue: 15
Pages: 3309-22
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Publication
11369229 | J:69138
First Author: Saxton TM
Year: 2001
Journal: Curr Biol
Title: Gene dosage-dependent functions for phosphotyrosine-Grb2 signaling during mammalian tissue morphogenesis.
Volume: 11
Issue: 9
Pages: 662-70
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Publication
10938118 | J:63931
First Author: Esteban LM
Year: 2000
Journal: Mol Cell Biol
Title: Ras-guanine nucleotide exchange factor sos2 is dispensable for mouse growth and development.
Volume: 20
Issue: 17
Pages: 6410-3
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Publication
26500062 | J:297037
First Author: Heltemes-Harris LM
Year: 2016
Journal: Oncogene
Title: Sleeping Beauty transposon screen identifies signaling modules that cooperate with STAT5 activation to induce B-cell acute lymphoblastic leukemia.
Volume: 35
Issue: 26
Pages: 3454-64
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Publication
11003655 | J:175120
First Author: Fan PD
Year: 2000
Journal: Mol Cell Biol
Title: Abl interactor 1 binds to sos and inhibits epidermal growth factor- and v-Abl-induced activation of extracellular signal-regulated kinases.
Volume: 20
Issue: 20
Pages: 7591-601
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Publication
16520382 | J:107918
First Author: Khanday FA
Year: 2006
Journal: J Cell Biol
Title: Sos-mediated activation of rac1 by p66shc.
Volume: 172
Issue: 6
Pages: 817-22
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Publication
23027861 | J:316433
First Author: Wu Y
Year: 2012
Journal: J Biol Chem
Title: Interplay between menin and K-Ras in regulating lung adenocarcinoma.
Volume: 287
Issue: 47
Pages: 40003-11
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Publication
9690470 | -
First Author: Boriack-Sjodin PA
Year: 1998
Journal: Nature
Title: The structural basis of the activation of Ras by Sos.
Volume: 394
Issue: 6691
Pages: 337-43
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Protein
D3Z0W7
Organism: Mus musculus/domesticus
Length: 314  
Fragment?: false
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Protein
B2RW27
Organism: Mus musculus/domesticus
Length: 314  
Fragment?: false
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Protein
Q9D5E3
Organism: Mus musculus/domesticus
Length: 319  
Fragment?: false
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Protein
Q9D506
Organism: Mus musculus/domesticus
Length: 307  
Fragment?: false
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Protein
J3QNG1
Organism: Mus musculus/domesticus
Length: 320  
Fragment?: false
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Protein
J3QMS8
Organism: Mus musculus/domesticus
Length: 315  
Fragment?: false
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Protein
L7N464
Organism: Mus musculus/domesticus
Length: 315  
Fragment?: false
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Protein
Q9DA78
Organism: Mus musculus/domesticus
Length: 314  
Fragment?: false
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Protein
L7N1Z6
Organism: Mus musculus/domesticus
Length: 307  
Fragment?: false
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Protein
A0A0G2JGB2
Organism: Mus musculus/domesticus
Length: 317  
Fragment?: false
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Protein
K7N5P2
Organism: Mus musculus/domesticus
Length: 326  
Fragment?: false
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Protein
D3YYA7
Organism: Mus musculus/domesticus
Length: 307  
Fragment?: false
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Protein
L7N250
Organism: Mus musculus/domesticus
Length: 311  
Fragment?: false
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Protein
A0A0G2JE67
Organism: Mus musculus/domesticus
Length: 319  
Fragment?: false
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Protein
A0A0G2JG26
Organism: Mus musculus/domesticus
Length: 315  
Fragment?: false
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Protein
L7N481
Organism: Mus musculus/domesticus
Length: 315  
Fragment?: false
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Protein
L7N249
Organism: Mus musculus/domesticus
Length: 307  
Fragment?: false
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Protein
A0A0G2JGX9
Organism: Mus musculus/domesticus
Length: 315  
Fragment?: false
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Protein
Q3V0R1
Organism: Mus musculus/domesticus
Length: 218  
Fragment?: false
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Protein
Q9D991
Organism: Mus musculus/domesticus
Length: 295  
Fragment?: false
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Protein
Q80ZR8
Organism: Mus musculus/domesticus
Length: 219  
Fragment?: false
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Protein
Q3V0H9
Organism: Mus musculus/domesticus
Length: 216  
Fragment?: false
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Protein
Q8BVR5
Organism: Mus musculus/domesticus
Length: 218  
Fragment?: false
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Protein
Q9D420
Organism: Mus musculus/domesticus
Length: 214  
Fragment?: false
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Publication
18722177 | J:138820
First Author: Kim JH
Year: 2008
Journal: Mol Cell
Title: CCAR1, a key regulator of mediator complex recruitment to nuclear receptor transcription complexes.
Volume: 31
Issue: 4
Pages: 510-9
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Protein
A0A1W2P6V0
Organism: Mus musculus/domesticus
Length: 92  
Fragment?: false
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Protein
A0A1W2P7Q7
Organism: Mus musculus/domesticus
Length: 161  
Fragment?: true
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Publication
7786285 | J:25630
First Author: Quilliam LA
Year: 1995
Journal: Bioessays
Title: Guanine nucleotide exchange factors: activators of the Ras superfamily of proteins.
Volume: 17
Issue: 5
Pages: 395-404
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Protein Domain
IPR025224 | CCAR1/CCAR2
Type: Family
Description: Cell division cycle and apoptosis regulator protein 1 (CCAR1) associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery. CCAR1 also functions as a p53 coactivator and regulates expression of key proliferation-inducing genes [].Cell cycle and apoptosis regulator protein 2 (CCAR2, also known as DBC-1) regulates biological processes such as transcription, heterochromatin formation, metabolism, mRNA splicing, apoptosis, and cell proliferation []. It is a core component of the DBIRD complex, which affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions []. It binds to SIRT1 and is a negative regulator of SIRT1 []. DBC-1 has been implicated in tumorigenesis [].This entry also includes protein SHORT ROOT IN SALT MEDIUM 1 (RSA1, also known as EMB1579) from Arabidopsis. It regulates the transcription of several genes involved in the detoxification of reactive oxygen species generated by salt stress and the SOS1 gene that encodes a plasma membrane Na(+)/H(+) antiporter essential for salt tolerance []. RSA1 is localised to the nucleus and the loss of function of RSA1 affects global transcription and mRNA splicing [].
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Publication
8094051 | J:25192
First Author: Albright CF
Year: 1993
Journal: EMBO J
Title: Characterization of a guanine nucleotide dissociation stimulator for a ras-related GTPase.
Volume: 12
Issue: 1
Pages: 339-47
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Protein
Q8BXW6
Organism: Mus musculus/domesticus
Length: 176  
Fragment?: true
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Protein
B0R018
Organism: Mus musculus/domesticus
Length: 127  
Fragment?: true
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Protein
D3YXD6
Organism: Mus musculus/domesticus
Length: 164  
Fragment?: true
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Protein
A0A3Q4EC09
Organism: Mus musculus/domesticus
Length: 56  
Fragment?: true
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Protein
A0A3Q4EG32
Organism: Mus musculus/domesticus
Length: 69  
Fragment?: true
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Protein
D3YZX2
Organism: Mus musculus/domesticus
Length: 95  
Fragment?: true
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Protein
D3Z3N3
Organism: Mus musculus/domesticus
Length: 58  
Fragment?: true
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Protein
D3YZP2
Organism: Mus musculus/domesticus
Length: 97  
Fragment?: true
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Protein
F6QRS4
Organism: Mus musculus/domesticus
Length: 116  
Fragment?: true
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Protein
D6RDD3
Organism: Mus musculus/domesticus
Length: 125  
Fragment?: false
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Publication
9438849 | -
First Author: Nimnual AS
Year: 1998
Journal: Science
Title: Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos.
Volume: 279
Issue: 5350
Pages: 560-3
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Protein
Q0KK55
Organism: Mus musculus/domesticus
Length: 1742  
Fragment?: false
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Protein
A6H650
Organism: Mus musculus/domesticus
Length: 481  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom