Type |
Details |
Score |
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
226
 |
Fragment?: |
false |
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•
•
•
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Publication |
First Author: |
Wei RR |
Year: |
2006 |
Journal: |
Structure |
Title: |
Structure of a central component of the yeast kinetochore: the Spc24p/Spc25p globular domain. |
Volume: |
14 |
Issue: |
6 |
Pages: |
1003-9 |
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•
•
•
•
•
|
Protein Domain |
Type: |
Homologous_superfamily |
Description: |
Spc24 is a component of the evolutionarily conserved kinetochore-associated Ndc80 complex, which is implicated in several essential outer kinetochore functions, including microtubule binding and control the spindle assembly checkpoint [, ].The Ndc80 complex appears to be a long rod with globular 'heads'. Ndc80 and Nuf2 contribute to one head and to the intervening shaft; Spc24 and Spc25 complete the shaft and contribute to the other head. Spc24 and Spc25 fold tightly together. TheC-terminal globular domains of Spc24 and Spc25 form the 'inner' head, which faces the centromere []. |
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Protein Domain |
Type: |
Domain |
Description: |
The Ndc80 complex is a conserved outer kinetochore protein complex consisting of Ndc80 (Hec1), Nuf2, Spc24 and Spc25. The Ndc80 complex is required for chromosome segregation and spindle checkpoint activity [, , ].This entry represents the C-terminal domain of Spc25 []. |
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•
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Publication |
First Author: |
Kalies KU |
Year: |
1996 |
Journal: |
J Biol Chem |
Title: |
Membrane topology of the 12- and the 25-kDa subunits of the mammalian signal peptidase complex. |
Volume: |
271 |
Issue: |
7 |
Pages: |
3925-9 |
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•
•
•
•
•
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Publication |
First Author: |
Kim S |
Year: |
2012 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Structure of human Mad1 C-terminal domain reveals its involvement in kinetochore targeting. |
Volume: |
109 |
Issue: |
17 |
Pages: |
6549-54 |
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•
•
•
•
|
Publication |
First Author: |
Pathania R |
Year: |
2016 |
Journal: |
Cancer Res |
Title: |
Combined Inhibition of DNMT and HDAC Blocks the Tumorigenicity of Cancer Stem-like Cells and Attenuates Mammary Tumor Growth. |
Volume: |
76 |
Issue: |
11 |
Pages: |
3224-35 |
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•
•
•
•
•
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Publication |
First Author: |
Keller MP |
Year: |
2023 |
Journal: |
Diabetes |
Title: |
An Enhancer Within Abcb11 Regulates G6pc2 in C57BL/6 Mouse Pancreatic Islets. |
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•
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•
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Publication |
First Author: |
Gerhard DS |
Year: |
2004 |
Journal: |
Genome Res |
Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
Volume: |
14 |
Issue: |
10B |
Pages: |
2121-7 |
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•
•
•
•
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Publication |
First Author: |
Church DM |
Year: |
2009 |
Journal: |
PLoS Biol |
Title: |
Lineage-specific biology revealed by a finished genome assembly of the mouse. |
Volume: |
7 |
Issue: |
5 |
Pages: |
e1000112 |
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•
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