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Search results 201 to 300 out of 461 for Spo11

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Hits by Strain

Type Details Score
GXD Expression
GXD Expression
 
Probe: MGI:4425198
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1752523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828420
Age: embryonic day 14.5
Image: euxassay_010771_09
Specimen Label: euxassay_010771_09
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
 
Probe: MGI:4425198
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1752523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828420
Age: embryonic day 14.5
Image: euxassay_010771_12
Specimen Label: euxassay_010771_12
Detected: true
Specimen Num: 12
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GXD Expression
GXD Expression
 
Probe: MGI:4425198
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1752523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828420
Age: embryonic day 14.5
Image: euxassay_010771_15
Specimen Label: euxassay_010771_15
Detected: true
Specimen Num: 15
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GXD Expression
GXD Expression
 
Probe: MGI:4425198
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1752523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828420
Age: embryonic day 14.5
Image: euxassay_010771_18
Specimen Label: euxassay_010771_18
Detected: true
Specimen Num: 18
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GXD Expression
GXD Expression
 
Probe: MGI:4425198
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1752523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828420
Age: embryonic day 14.5
Image: euxassay_010771_21
Specimen Label: euxassay_010771_21
Detected: true
Specimen Num: 21
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Publication
24589552 | J:209347
First Author: Ishiguro K
Year: 2014
Journal: Genes Dev
Title: Meiosis-specific cohesin mediates homolog recognition in mouse spermatocytes.
Volume: 28
Issue: 6
Pages: 594-607
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Publication
18694567 | J:140402
First Author: Soper SF
Year: 2008
Journal: Dev Cell
Title: Mouse maelstrom, a component of nuage, is essential for spermatogenesis and transposon repression in meiosis.
Volume: 15
Issue: 2
Pages: 285-97
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Publication
31965061 | J:300349
First Author: Zhang B
Year: 2020
Journal: Cell Death Differ
Title: NBS1 is required for SPO11-linked DNA double-strand break repair in male meiosis.
Volume: 27
Issue: 7
Pages: 2176-2190
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Publication
21147852 | J:166888
First Author: Pellegrini M
Year: 2011
Journal: J Cell Sci
Title: Targeted JAM-C deletion in germ cells by Spo11-controlled Cre recombinase.
Volume: 124
Issue: Pt 1
Pages: 91-9
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Publication
20551173 | J:161203
First Author: Kumar R
Year: 2010
Journal: Genes Dev
Title: Functional conservation of Mei4 for meiotic DNA double-strand break formation from yeasts to mice.
Volume: 24
Issue: 12
Pages: 1266-80
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Publication
22660327 | J:186641
First Author: Brick K
Year: 2012
Journal: Nature
Title: Genetic recombination is directed away from functional genomic elements in mice.
Volume: 485
Issue: 7400
Pages: 642-5
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Publication
26209650 | J:239795
First Author: Fedoriw AM
Year: 2015
Journal: Development
Title: Key mediators of somatic ATR signaling localize to unpaired chromosomes in spermatocytes.
Volume: 142
Issue: 17
Pages: 2972-80
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Publication
29161344 | J:256976
First Author: Hu J
Year: 2018
Journal: Biol Reprod
Title: Nuclear localization of EIF4G3 suggests a role for the XY body in translational regulation during spermatogenesis in mice.
Volume: 98
Issue: 1
Pages: 102-114
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Publication
30853435 | J:280261
First Author: Bhattacharyya T
Year: 2019
Journal: Curr Biol
Title: Prdm9 and Meiotic Cohesin Proteins Cooperatively Promote DNA Double-Strand Break Formation in Mammalian Spermatocytes.
Volume: 29
Issue: 6
Pages: 1002-1018.e7
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Publication
16055729 | J:133053
First Author: Barchi M
Year: 2005
Journal: Mol Cell Biol
Title: Surveillance of different recombination defects in mouse spermatocytes yields distinct responses despite elimination at an identical developmental stage.
Volume: 25
Issue: 16
Pages: 7203-15
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Publication
20577743 | J:163018
First Author: Saferali A
Year: 2010
Journal: Mamm Genome
Title: Defective imprint resetting in carriers of Robertsonian translocation Rb (8.12).
Volume: 21
Issue: 7-8
Pages: 377-87
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Publication
32610038 | J:297178
First Author: Hinch AG
Year: 2020
Journal: Mol Cell
Title: The Configuration of RPA, RAD51, and DMC1 Binding in Meiosis Reveals the Nature of Critical Recombination Intermediates.
Volume: 79
Issue: 4
Pages: 689-701.e10
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Publication
27723721 | J:238496
First Author: Stanzione M
Year: 2016
Journal: Nat Cell Biol
Title: Meiotic DNA break formation requires the unsynapsed chromosome axis-binding protein IHO1 (CCDC36) in mice.
Volume: 18
Issue: 11
Pages: 1208-1220
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Publication
27165042 | J:278848
First Author: Papanikos F
Year: 2017
Journal: Chromosoma
Title: The enigmatic meiotic dense body and its newly discovered component, SCML1, are dispensable for fertility and gametogenesis in mice.
Volume: 126
Issue: 3
Pages: 399-415
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Publication
38696471 | J:348825
First Author: Bai L
Year: 2024
Journal: Proc Natl Acad Sci U S A
Title: BRCA1 safeguards genome integrity by activating chromosome asynapsis checkpoint to eliminate recombination-defective oocytes.
Volume: 121
Issue: 19
Pages: e2401386121
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Publication
20522776 | J:160897
First Author: Lu WJ
Year: 2010
Journal: Science
Title: Meiotic recombination provokes functional activation of the p53 regulatory network.
Volume: 328
Issue: 5983
Pages: 1278-81
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Publication
23318132 | J:194067
First Author: Boateng KA
Year: 2013
Journal: Dev Cell
Title: Homologous pairing preceding SPO11-mediated double-strand breaks in mice.
Volume: 24
Issue: 2
Pages: 196-205
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Publication
29674518 | J:319464
First Author: Thibault-Sennett S
Year: 2018
Journal: Genetics
Title: Interrogating the Functions of PRDM9 Domains in Meiosis.
Volume: 209
Issue: 2
Pages: 475-487
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Publication
24914237 | J:215795
First Author: Broering TJ
Year: 2014
Journal: J Cell Biol
Title: BRCA1 establishes DNA damage signaling and pericentric heterochromatin of the X chromosome in male meiosis.
Volume: 205
Issue: 5
Pages: 663-75
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Publication
38580643 | J:361361
First Author: Dereli I
Year: 2024
Journal: Nat Commun
Title: Seeding the meiotic DNA break machinery and initiating recombination on chromosome axes.
Volume: 15
Issue: 1
Pages: 2941
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Publication
33047671 | J:298562
   
First Author: Imai Y
Year: 2020
Journal: Elife
Title: PRDM9 activity depends on HELLS and promotes local 5-hydroxymethylcytosine enrichment.
Volume: 9
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Publication
32460033 | J:291970
First Author: Takemoto K
Year: 2020
Journal: Cell Rep
Title: Meiosis-Specific C19orf57/4930432K21Rik/BRME1 Modulates Localization of RAD51 and DMC1 to DSBs in Mouse Meiotic Recombination.
Volume: 31
Issue: 8
Pages: 107686
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Publication
23039116 | J:192634
First Author: Kogo H
Year: 2012
Journal: Genes Cells
Title: HORMAD2 is essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity.
Volume: 17
Issue: 11
Pages: 897-912
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Publication
24882376 | J:213575
First Author: Malki S
Year: 2014
Journal: Dev Cell
Title: A role for retrotransposon LINE-1 in fetal oocyte attrition in mice.
Volume: 29
Issue: 5
Pages: 521-533
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Publication
34941868 | J:316797
First Author: Weitzel AJ
Year: 2021
Journal: PLoS Biol
Title: Meiotic Cas9 expression mediates gene conversion in the male and female mouse germline.
Volume: 19
Issue: 12
Pages: e3001478
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Publication
24390283 | J:205585
First Author: Qiao H
Year: 2014
Journal: Nat Genet
Title: Antagonistic roles of ubiquitin ligase HEI10 and SUMO ligase RNF212 regulate meiotic recombination.
Volume: 46
Issue: 2
Pages: 194-9
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Publication
21355037 | J:173800
First Author: Paronetto MP
Year: 2011
Journal: Nucleic Acids Res
Title: Sam68 marks the transcriptionally active stages of spermatogenesis and modulates alternative splicing in male germ cells.
Volume: 39
Issue: 12
Pages: 4961-74
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Publication
28844861 | J:253200
First Author: Rinaldi VD
Year: 2017
Journal: Mol Cell
Title: The DNA Damage Checkpoint Eliminates Mouse Oocytes with Chromosome Synapsis Failure.
Volume: 67
Issue: 6
Pages: 1026-1036.e2
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Publication
25795304 | J:231710
First Author: Kumar R
Year: 2015
Journal: J Cell Sci
Title: MEI4 – a central player in the regulation of meiotic DNA double-strand break formation in the mouse.
Volume: 128
Issue: 9
Pages: 1800-11
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Publication
32451402 | J:292247
First Author: ElInati E
Year: 2020
Journal: Nat Commun
Title: The BCL-2 pathway preserves mammalian genome integrity by eliminating recombination-defective oocytes.
Volume: 11
Issue: 1
Pages: 2598
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Publication
23396135 | J:196206
First Author: Reynolds A
Year: 2013
Journal: Nat Genet
Title: RNF212 is a dosage-sensitive regulator of crossing-over during mammalian meiosis.
Volume: 45
Issue: 3
Pages: 269-78
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Publication
39147779 | J:359005
First Author: Zainu A
Year: 2024
Journal: Nat Commun
Title: FIGNL1-FIRRM is essential for meiotic recombination and prevents DNA damage-independent RAD51 and DMC1 loading.
Volume: 15
Issue: 1
Pages: 7015
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Publication
37891173 | J:342157
First Author: Ito M
Year: 2023
Journal: Nat Commun
Title: FIGNL1 AAA+ ATPase remodels RAD51 and DMC1 filaments in pre-meiotic DNA replication and meiotic recombination.
Volume: 14
Issue: 1
Pages: 6857
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Publication
21807948 | J:177475
First Author: Inagaki A
Year: 2011
Journal: J Cell Sci
Title: Meiotic functions of RAD18.
Volume: 124
Issue: Pt 16
Pages: 2837-50
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Publication
23468651 | J:195191
First Author: Lyndaker AM
Year: 2013
Journal: PLoS Genet
Title: Conditional inactivation of the DNA damage response gene Hus1 in mouse testis reveals separable roles for components of the RAD9-RAD1-HUS1 complex in meiotic chromosome maintenance.
Volume: 9
Issue: 2
Pages: e1003320
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Publication
24532689 | J:209141
First Author: Roset R
Year: 2014
Journal: Genes Dev
Title: The Rad50 hook domain regulates DNA damage signaling and tumorigenesis.
Volume: 28
Issue: 5
Pages: 451-62
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Publication
22530760 | J:213984
First Author: Kogo H
Year: 2012
Journal: Genes Cells
Title: HORMAD1-dependent checkpoint/surveillance mechanism eliminates asynaptic oocytes.
Volume: 17
Issue: 6
Pages: 439-54
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Publication
29976923 | J:266323
First Author: Widger A
Year: 2018
Journal: Nat Commun
Title: ATR is a multifunctional regulator of male mouse meiosis.
Volume: 9
Issue: 1
Pages: 2621
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Publication
22549958 | J:183982
First Author: Wojtasz L
Year: 2012
Journal: Genes Dev
Title: Meiotic DNA double-strand breaks and chromosome asynapsis in mice are monitored by distinct HORMAD2-independent and -dependent mechanisms.
Volume: 26
Issue: 9
Pages: 958-73
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Publication
34571960 | J:333243
 
First Author: de la Fuente R
Year: 2021
Journal: Cells
Title: Epigenetic Dysregulation of Mammalian Male Meiosis Caused by Interference of Recombination and Synapsis.
Volume: 10
Issue: 9
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Publication
30760716 | J:273173
First Author: Zhang J
Year: 2019
Journal: Nat Commun
Title: A meiosis-specific BRCA2 binding protein recruits recombinases to DNA double-strand breaks to ensure homologous recombination.
Volume: 10
Issue: 1
Pages: 722
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Publication
38657614 | J:348407
First Author: Biot M
Year: 2024
Journal: Mol Cell
Title: Principles of chromosome organization for meiotic recombination.
Volume: 84
Issue: 10
Pages: 1826-1841.e5
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Publication
28617799 | J:244520
First Author: Marcet-Ortega M
Year: 2017
Journal: PLoS Genet
Title: p53 and TAp63 participate in the recombination-dependent pachytene arrest in mouse spermatocytes.
Volume: 13
Issue: 6
Pages: e1006845
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Publication
25768017 | J:224234
First Author: Pacheco S
Year: 2015
Journal: PLoS Genet
Title: The ATM signaling cascade promotes recombination-dependent pachytene arrest in mouse spermatocytes.
Volume: 11
Issue: 3
Pages: e1005017
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Publication
18663141 | J:139518
First Author: Mahadevaiah SK
Year: 2008
Journal: J Cell Biol
Title: Extensive meiotic asynapsis in mice antagonises meiotic silencing of unsynapsed chromatin and consequently disrupts meiotic sex chromosome inactivation.
Volume: 182
Issue: 2
Pages: 263-76
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Publication
31358751 | J:279342
First Author: Zhang Q
Year: 2019
Journal: Nat Commun
Title: Meiosis I progression in spermatogenesis requires a type of testis-specific 20S core proteasome.
Volume: 10
Issue: 1
Pages: 3387
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Publication
24413433 | J:205574
First Author: Shibuya H
Year: 2014
Journal: Nat Cell Biol
Title: The TRF1-binding protein TERB1 promotes chromosome movement and telomere rigidity in meiosis.
Volume: 16
Issue: 2
Pages: 145-56
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Publication
32555348 | J:292293
First Author: Bondarieva A
Year: 2020
Journal: Nat Commun
Title: Proline-rich protein PRR19 functions with cyclin-like CNTD1 to promote meiotic crossing over in mouse.
Volume: 11
Issue: 1
Pages: 3101
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Publication
27760146 | J:236226
First Author: Finsterbusch F
Year: 2016
Journal: PLoS Genet
Title: Alignment of Homologous Chromosomes and Effective Repair of Programmed DNA Double-Strand Breaks during Mouse Meiosis Require the Minichromosome Maintenance Domain Containing 2 (MCMDC2) Protein.
Volume: 12
Issue: 10
Pages: e1006393
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Publication
32051414 | J:286736
First Author: Paiano J
Year: 2020
Journal: Nat Commun
Title: ATM and PRDM9 regulate SPO11-bound recombination intermediates during meiosis.
Volume: 11
Issue: 1
Pages: 857
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Publication
24068956 | J:203426
First Author: Souquet B
Year: 2013
Journal: PLoS Genet
Title: MEIOB targets single-strand DNA and is necessary for meiotic recombination.
Volume: 9
Issue: 9
Pages: e1003784
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Publication
35920200 | J:329968
First Author: Kazi S
Year: 2022
Journal: FASEB J
Title: MRNIP interacts with sex body chromatin to support meiotic progression, spermatogenesis, and male fertility in mice.
Volume: 36
Issue: 9
Pages: e22479
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Publication
32345962 | J:292036
First Author: Zhang J
Year: 2020
Journal: Nat Commun
Title: The BRCA2-MEILB2-BRME1 complex governs meiotic recombination and impairs the mitotic BRCA2-RAD51 function in cancer cells.
Volume: 11
Issue: 1
Pages: 2055
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Publication
21536735 | J:171414
First Author: Ichijima Y
Year: 2011
Journal: Genes Dev
Title: MDC1 directs chromosome-wide silencing of the sex chromosomes in male germ cells.
Volume: 25
Issue: 9
Pages: 959-71
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Publication
17696610 | J:123677
First Author: Li XC
Year: 2007
Journal: PLoS Genet
Title: Mouse pachytene checkpoint 2 (trip13) is required for completing meiotic recombination but not synapsis.
Volume: 3
Issue: 8
Pages: e130
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Publication
10559489 | J:58623
First Author: Aruga J
Year: 1999
Journal: Mech Dev
Title: Zic1 regulates the patterning of vertebral arches in cooperation with Gli3.
Volume: 89
Issue: 1-2
Pages: 141-50
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Publication
19851446 | J:161829
First Author: Wojtasz L
Year: 2009
Journal: PLoS Genet
Title: Mouse HORMAD1 and HORMAD2, two conserved meiotic chromosomal proteins, are depleted from synapsed chromosome axes with the help of TRIP13 AAA-ATPase.
Volume: 5
Issue: 10
Pages: e1000702
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Publication
35489071 | J:325094
First Author: Guan Y
Year: 2022
Journal: Nucleic Acids Res
Title: SCF ubiquitin E3 ligase regulates DNA double-strand breaks in early meiotic recombination.
Volume: 50
Issue: 9
Pages: 5129-5144
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Publication
21478856 | J:173089
First Author: Daniel K
Year: 2011
Journal: Nat Cell Biol
Title: Meiotic homologue alignment and its quality surveillance are controlled by mouse HORMAD1.
Volume: 13
Issue: 5
Pages: 599-610
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Protein
Q9WTK8
Organism: Mus musculus/domesticus
Length: 396  
Fragment?: false
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Publication
26742488 | J:231231
 
First Author: Abby E
Year: 2016
Journal: Nat Commun
Title: Implementation of meiosis prophase I programme requires a conserved retinoid-independent stabilizer of meiotic transcripts.
Volume: 7
Pages: 10324
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Publication
32845237 | J:303558
   
First Author: Felipe-Medina N
Year: 2020
Journal: Elife
Title: A missense in HSF2BP causing primary ovarian insufficiency affects meiotic recombination by its novel interactor C19ORF57/BRME1.
Volume: 9
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Publication
27760317 | J:240753
First Author: Alavattam KG
Year: 2016
Journal: Cell Rep
Title: Elucidation of the Fanconi Anemia Protein Network in Meiosis and Its Function in the Regulation of Histone Modifications.
Volume: 17
Issue: 4
Pages: 1141-1157
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Publication
32463460 | J:291221
First Author: Shang Y
Year: 2020
Journal: Nucleic Acids Res
Title: MEIOK21: a new component of meiotic recombination bridges required for spermatogenesis.
Volume: 48
Issue: 12
Pages: 6624-6639
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Publication
17115059 | J:116498
First Author: Baltus AE
Year: 2006
Journal: Nat Genet
Title: In germ cells of mouse embryonic ovaries, the decision to enter meiosis precedes premeiotic DNA replication.
Volume: 38
Issue: 12
Pages: 1430-4
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Publication
17010969 | J:147391
First Author: Liebe B
Year: 2006
Journal: Exp Cell Res
Title: Mutations that affect meiosis in male mice influence the dynamics of the mid-preleptotene and bouquet stages.
Volume: 312
Issue: 19
Pages: 3768-81
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Strain
MGI:3850046 | B.Cg-Spo11<tm1Mjn> H2<aw9>/Orl
Attribute String: targeted mutation, major histocompatibility congenic, congenic
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Publication
20336070 | J:158887
First Author: Zalzman M
Year: 2010
Journal: Nature
Title: Zscan4 regulates telomere elongation and genomic stability in ES cells.
Volume: 464
Issue: 7290
Pages: 858-63
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Publication
19074348 | J:142245
First Author: Lin Y
Year: 2008
Journal: Science
Title: Germ cell-intrinsic and -extrinsic factors govern meiotic initiation in mouse embryos.
Volume: 322
Issue: 5908
Pages: 1685-7
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Protein Domain
IPR004084 | Meiosis_Spo11
Type: Domain
Description: Spo11 is a meiosis-specific protein that is responsible for the initiation of recombination during the early stages of meiosis through the formation of DNA double-strand breaks (DSBs) by a type II DNA topoisomerase-like activity [, ]. These DSBs initiate homologous recombination, which is required for chromosomal segregation and generation of genetic diversity during meiosis. Spo11 acts in conjunction with several other proteins, including Rec102 in yeast, to bring about meiotic recombination []. Mouse and human homologues of Spo11 have been cloned and characterised. The proteins are 82% identical and share ~25% identity with other family members. Mouse Spo11 has been localised to chromosome 2H4, and human SPO11 to chromosome 20q13.2-q13.3, a region amplified in some breast and ovarian tumours [].Similarity between SPO11 and archaebacterial TOP6A proteins points to evolutionary specialisation of a DNA-cleavage function for meiotic recombination []. Note that the yeast SPO11 protein shares far less similarity to other SPO11 proteins than the human and mouse homologues do to each other.
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Protein Domain
IPR013048 | Meiotic_Spo11
Type: Family
Description: Spo11 is a meiosis-specific protein that is responsible for the initiation of recombination during the early stages of meiosis through the formation of DNA double-strand breaks (DSBs) by a type II DNA topoisomerase-like activity [, ]. These DSBs initiate homologous recombination, which is required for chromosomal segregation and generation of genetic diversity during meiosis. Spo11 acts in conjunction with several other proteins, including Rec102 in yeast, to bring about meiotic recombination []. Mouse and human homologues of Spo11 have been cloned and characterised. The proteins are 82% identical and share ~25% identity with other family members. Mouse Spo11 has been localised to chromosome 2H4, and human SPO11 to chromosome 20q13.2-q13.3, a region amplified in some breast and ovarian tumours [].Similarity between SPO11 and archaebacterial TOP6A proteins points to evolutionary specialisation of a DNA-cleavage function for meiotic recombination []. Note that the yeast SPO11 protein shares far less similarity to other SPO11 proteins than the human and mouse homologues do to each other.
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Publication
21123517 | J:180844
First Author: Strauss TJ
Year: 2011
Journal: Reproduction
Title: GATA-like protein-1 (GLP-1) is required for normal germ cell development during embryonic oogenesis.
Volume: 141
Issue: 2
Pages: 173-81
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Publication
29087293 | J:253477
   
First Author: Bailey AS
Year: 2017
Journal: Elife
Title: The conserved RNA helicase YTHDC2 regulates the transition from proliferation to differentiation in the germline.
Volume: 6
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Publication
22071108 | J:178676
First Author: Le Bouffant R
Year: 2011
Journal: Development
Title: Msx1 and Msx2 promote meiosis initiation.
Volume: 138
Issue: 24
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UniProt Feature
UniProt Feature
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Description: Meiotic recombination protein SPO11
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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