|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 201 to 215 out of 215 for Spred3

<< First    < Previous  |  Next >    Last >>
0.017s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
•
•
•
•
•
Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
•
•
•
•
•
Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
•
•
•
•
•
Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
•
•
•
•
•
Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
•
•
•
•
•
Publication
15213456 | -
First Author: Zimmermann J
Year: 2004
Journal: J Biomol NMR
Title: 1H, 13C and 15N resonance assignment of the human Spred2 EVH1 domain.
Volume: 29
Issue: 3
Pages: 435-6
•
•
•
•
•
Protein Domain
IPR041937 | SPRE_EVH1
Type: Domain
Description: The SPRE (also known as SPRED) proteins have the following domains: an N-terminal EVH1 domain, a unique KBD (c-Kit kinase binding) domain which is phosphorylated by the stem cell factor receptor c-Kit, and a C-terminal cysteine-rich SPR (Sprouty-related) domain which is involved in membrane localization. This entry represents the EVH1 domain of SPRE. Proteins containing this domaininclude Spred1 which interacts with both Ras and Raf through its SPR domain; Spred2 which is the most abundant isoform; and Spred3 which has a non-functional KBD and maintains the inhibitory action on Raf. Legius syndrome is caused by heterozygous mutations in Spred1. Both EVH1 and SPR domains are involved in the inhibition of the MAP kinase pathway by SPRE proteins. The specific function of the EVH1 domain is unknown and there are no known interacting proteins to date. EVH1 has a PH-like fold, despite having minimal sequence similarity to PH or PTB domains [, , ].
•
•
•
•
•
Publication
15710406 | -
First Author: Harmer NJ
Year: 2005
Journal: FEBS Lett
Title: 1.15 A crystal structure of the X. tropicalis Spred1 EVH1 domain suggests a fourth distinct peptide-binding mechanism within the EVH1 family.
Volume: 579
Issue: 5
Pages: 1161-6
•
•
•
•
•
Protein
Q924S7
Organism: Mus musculus/domesticus
Length: 410  
Fragment?: false
•
•
•
•
•
Protein
Q6P6N5
Organism: Mus musculus/domesticus
Length: 408  
Fragment?: false
•
•
•
•
•
Protein
Q924S8
Organism: Mus musculus/domesticus
Length: 444  
Fragment?: false
•
•
•
•
•
Protein
Q5SRF9
Organism: Mus musculus/domesticus
Length: 229  
Fragment?: true
•
•
•
•
•
Protein
A0A0R4J0K0
Organism: Mus musculus/domesticus
Length: 408  
Fragment?: false
•
•
•
•
•
Protein
Q5SRF8
Organism: Mus musculus/domesticus
Length: 437  
Fragment?: false
•
•
•
•
•
Publication
9883880 | J:51858
First Author: Callebaut I
Year: 1998
Journal: FEBS Lett
Title: EVH1/WH1 domains of VASP and WASP proteins belong to a large family including Ran-binding domains of the RanBP1 family.
Volume: 441
Issue: 2
Pages: 181-5
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom