Type |
Details |
Score |
Publication |
First Author: |
Talanian RV |
Year: |
1997 |
Journal: |
J Biol Chem |
Title: |
Substrate specificities of caspase family proteases. |
Volume: |
272 |
Issue: |
15 |
Pages: |
9677-82 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang XJ |
Year: |
2010 |
Journal: |
EMBO Rep |
Title: |
Crystal structures of human caspase 6 reveal a new mechanism for intramolecular cleavage self-activation. |
Volume: |
11 |
Issue: |
11 |
Pages: |
841-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Orth K |
Year: |
1996 |
Journal: |
J Biol Chem |
Title: |
The CED-3/ICE-like protease Mch2 is activated during apoptosis and cleaves the death substrate lamin A. |
Volume: |
271 |
Issue: |
28 |
Pages: |
16443-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cowling V |
Year: |
2002 |
Journal: |
Cell Death Differ |
Title: |
Caspase-6 is the direct activator of caspase-8 in the cytochrome c-induced apoptosis pathway: absolute requirement for removal of caspase-6 prodomain. |
Volume: |
9 |
Issue: |
10 |
Pages: |
1046-56 |
|
•
•
•
•
•
|
Publication |
First Author: |
Inoue S |
Year: |
2009 |
Journal: |
Cell Death Differ |
Title: |
Ordering of caspases in cells undergoing apoptosis by the intrinsic pathway. |
Volume: |
16 |
Issue: |
7 |
Pages: |
1053-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bideshi DK |
Year: |
2005 |
Journal: |
Genes Dev |
Title: |
A viral caspase contributes to modified apoptosis for virus transmission. |
Volume: |
19 |
Issue: |
12 |
Pages: |
1416-21 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Caspase-6 (EC 3.4.22.59; MEROPS identifier C14.005) is a cysteine endopeptidase from family C14. It cleaves aspartyl bonds, and has a preference for Val in P4, Glu or Gln in P3, His or Val in P2 and Gly in P1' [, ]similar to the initiator caspases 8 and 9 []. Caspase-6 processes its own precursor to generate a two-chain form [, ]and lamin A []and STAB1 [], which are not cleaved by caspases 3 or 7. Unusually, caspase-6 activity is unaffected by XIAP []. Caspase-6 is an initiator caspase activated by caspases 3 and 7 []and activating caspase-8 [, ]. It also translocates to the nucleus where processing of lamin A occurs.This entry also includes SfAV caspase from Spodoptera frugiperda ascovirus (MEROPS identifier C14.037), which is an executioner caspase that can induce apoptosis in host insect cells []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Nakagomi K |
Year: |
1994 |
Journal: |
Mol Cell Biol |
Title: |
A novel DNA-binding motif in the nuclear matrix attachment DNA-binding protein SATB1. |
Volume: |
14 |
Issue: |
3 |
Pages: |
1852-60 |
|
•
•
•
•
•
|
Publication |
First Author: |
Thornberry NA |
Year: |
1997 |
Journal: |
J Biol Chem |
Title: |
A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis. |
Volume: |
272 |
Issue: |
29 |
Pages: |
17907-11 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stennicke HR |
Year: |
2000 |
Journal: |
Biochem J |
Title: |
Internally quenched fluorescent peptide substrates disclose the subsite preferences of human caspases 1, 3, 6, 7 and 8. |
Volume: |
350 Pt 2 |
|
Pages: |
563-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Deveraux QL |
Year: |
1997 |
Journal: |
Nature |
Title: |
X-linked IAP is a direct inhibitor of cell-death proteases. |
Volume: |
388 |
Issue: |
6639 |
Pages: |
300-4 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
276
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
276
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
276
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
276
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kawai J |
Year: |
2001 |
Journal: |
Nature |
Title: |
Functional annotation of a full-length mouse cDNA collection. |
Volume: |
409 |
Issue: |
6821 |
Pages: |
685-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2000 |
Journal: |
Genome Res |
Title: |
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. |
Volume: |
10 |
Issue: |
10 |
Pages: |
1617-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
1999 |
Journal: |
Methods Enzymol |
Title: |
High-efficiency full-length cDNA cloning. |
Volume: |
303 |
|
Pages: |
19-44 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shibata K |
Year: |
2000 |
Journal: |
Genome Res |
Title: |
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. |
Volume: |
10 |
Issue: |
11 |
Pages: |
1757-71 |
|
•
•
•
•
•
|
Publication |
First Author: |
Katayama S |
Year: |
2005 |
Journal: |
Science |
Title: |
Antisense transcription in the mammalian transcriptome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1564-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gerhard DS |
Year: |
2004 |
Journal: |
Genome Res |
Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
Volume: |
14 |
Issue: |
10B |
Pages: |
2121-7 |
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•
•
•
•
•
|