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Search results 201 to 300 out of 328 for Stat2

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Type Details Score
Publication
15102471 | J:114108
First Author: Papin J
Year: 2004
Journal: Curr Opin Biotechnol
Title: Bioinformatics and cellular signaling.
Volume: 15
Issue: 1
Pages: 78-81
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Publication
- | J:237616
     
First Author: MGI and IMPC
Year: 2017
Journal: MGI Direct Data Submission
Title: MGI Curation of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
20412781 | J:140465
First Author: Guo G
Year: 2010
Journal: Dev Cell
Title: Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.
Volume: 18
Issue: 4
Pages: 675-85
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Publication
- | J:68100
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: RIKEN Data Curation in Mouse Genome Informatics
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Publication
20059953 | J:156017
First Author: Yokoyama S
Year: 2009
Journal: Dev Cell
Title: A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Volume: 17
Issue: 6
Pages: 836-48
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
15618518 | J:91257
First Author: Gray PA
Year: 2004
Journal: Science
Title: Mouse brain organization revealed through direct genome-scale TF expression analysis.
Volume: 306
Issue: 5705
Pages: 2255-7
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Publication
- | J:171409
     
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Allele
Stat2<tm1Jdf> | MGI:3528233
Name: signal transducer and activator of transcription 2; targeted mutation 1, J David Farrar
Allele Type: Targeted
Attribute String: Humanized sequence, Inserted expressed sequence
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Publication
33203860 | J:299767
First Author: Boudewijns R
Year: 2020
Journal: Nat Commun
Title: STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters.
Volume: 11
Issue: 1
Pages: 5838
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Publication
10518610 | -
First Author: Park C
Year: 1999
Journal: Nucleic Acids Res
Title: Murine Stat2 is uncharacteristically divergent.
Volume: 27
Issue: 21
Pages: 4191-9
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Publication
8848048 | -
First Author: Bhattacharya S
Year: 1996
Journal: Nature
Title: Cooperation of Stat2 and p300/CBP in signalling induced by interferon-alpha.
Volume: 383
Issue: 6598
Pages: 344-7
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Publication
9020188 | -
First Author: Bluyssen HA
Year: 1997
Journal: J Biol Chem
Title: Stat2 is a transcriptional activator that requires sequence-specific contacts provided by stat1 and p48 for stable interaction with DNA.
Volume: 272
Issue: 7
Pages: 4600-5
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Publication
31462568 | -
 
First Author: Yang L
Year: 2019
Journal: J Virol
Title: Nonstructural Protein 11 of Porcine Reproductive and Respiratory Syndrome Virus Induces STAT2 Degradation To Inhibit Interferon Signaling.
Volume: 93
Issue: 22
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Publication
29317535 | -
First Author: Rengachari S
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Structural basis of STAT2 recognition by IRF9 reveals molecular insights into ISGF3 function.
Volume: 115
Issue: 4
Pages: E601-E609
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Publication
19214187 | -
First Author: Wojciak JM
Year: 2009
Journal: EMBO J
Title: Structural basis for recruitment of CBP/p300 coactivators by STAT1 and STAT2 transactivation domains.
Volume: 28
Issue: 7
Pages: 948-58
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Publication
23555265 | -
First Author: Morrison J
Year: 2013
Journal: PLoS Pathog
Title: Dengue virus co-opts UBR4 to degrade STAT2 and antagonize type I interferon signaling.
Volume: 9
Issue: 3
Pages: e1003265
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DO Term
DOID:0111975 | immunodeficiency 44
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Publication
22305621 | -
First Author: Pulit-Penaloza JA
Year: 2012
Journal: Virology
Title: Activation of Oas1a gene expression by type I IFN requires both STAT1 and STAT2 while only STAT2 is required for Oas1b activation.
Volume: 425
Issue: 2
Pages: 71-81
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Protein
Q8C5D8
Organism: Mus musculus/domesticus
Length: 621  
Fragment?: false
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Protein
Q8C5D8-2
Organism: Mus musculus/domesticus
Length: 572  
Fragment?: false
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Protein
Q8C5D8-3
Organism: Mus musculus/domesticus
Length: 563  
Fragment?: false
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Protein
Q8C5D8-4
Organism: Mus musculus/domesticus
Length: 580  
Fragment?: false
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Protein
Q8C5D8-5
Organism: Mus musculus/domesticus
Length: 612  
Fragment?: false
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Ontology Term
- | Inhibition of host JAK1 by virus
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GO Term
GO:0007260 | tyrosine phosphorylation of STAT protein
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GO Term
GO:0042509 | regulation of tyrosine phosphorylation of STAT protein
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Protein
Q9CW17
Organism: Mus musculus/domesticus
Length: 92  
Fragment?: false
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Protein Domain
IPR022756 | STAT2_C
Type: Domain
Description: This region is found in the mammalian signal transducer and activation of transcription (STAT) 2 protein, and is approximately 60 amino acids in length. The family is found in association with , , , . There is a conserved DLP sequence motif. STATs are involved in transcriptional regulation and are the only regulators known to be modulated by tyrosine phosphorylation. STAT2 forms a trimeric complex with STAT1 and IRF-9 (Interferon Regulatory Factor 9), on activation of the cell by interferon, which is called ISGF3 (Interferon-stimulated gene factor 3). The C-terminal domain of STAT2 contains a nuclear export signal (NES) which allows export of STAT2 into the cytoplasm along with any complexed molecules.
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Allele
Stat2<p117> | MGI:4830698
Name: signal transducer and activator of transcription 2; pedigree p117
Allele Type: Chemically induced (ENU)
Attribute String: Hypomorph
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Ontology Term
- | Inhibition of host interferon signaling pathway by virus
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Ontology Term
- | Inhibition of host TYK2 by virus
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Strain
MGI:4830988 | C57BL/6J-Stat2<P117>
Attribute String: coisogenic, mutant strain, chemically induced mutation
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Allele
Stat2<tm1.1(STAT2)Diam> | MGI:6156567
Name: signal transducer and activator of transcription 2; targeted mutation 1.1, Michael S Diamond
Allele Type: Targeted
Attribute String: Humanized sequence, Inserted expressed sequence
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Genotype
Genotype
Symbol: Stat2/Stat2
Background: C57BL/6J-Stat2
Zygosity: hm
Has Mutant Allele: true
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Strain
MGI:6192489 | C57BL/6-Stat2<tm1.1(STAT2)Diam>
Attribute String: coisogenic, mutant strain, targeted mutation
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Strain
MGI:6156574 | C57BL/6-Stat2<tm1.1(STAT2)Diam>/AgsaJ
Attribute String: mutant strain, targeted mutation, coisogenic
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Genotype
Genotype
Symbol: Stat2/Stat2
Background: C57BL/6-Stat2
Zygosity: hm
Has Mutant Allele: true
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HT Experiment
GSE227168 | JAK-STAT signaling maintains homeostasis in T cells and macrophages (spatial transcriptomics)
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Protein Domain
IPR035854 | STAT2_SH2
Type: Domain
Description: STAT2 is a member of the STAT protein family. In response to interferon, STAT2 forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly []. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with STAT2, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus []. This entry represents the SH2 domain of STAT2.STAT proteins have a dual function: signal transduction and activation of transcription. When cytokines are bound to cell surface receptors, the associated Janus kinases (JAKs) are activated, leading to tyrosine phosphorylation of the given STAT proteins []. Phosphorylated STATs form dimers, translocate to the nucleus, and bind specific response elements to activate transcription of target genes []. STAT proteins contain an N-terminal domain (NTD), a coiled-coil domain (CCD), a DNA-binding domain (DBD), an α-helical linker domain (LD), an SH2 domain, and a transactivation domain (TAD). The SH2 domain is necessary for receptor association and tyrosine phosphodimer formation. There are seven mammalian STAT family members which have been identified: STAT1, STAT2, STAT3, STAT4, STAT5 (STAT5A and STAT5B), and STAT6 [].
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Protein Domain
IPR044320 | NSP11_Av_N
Type: Domain
Description: This entry represents the N-terminal domain of Nsp11 from arteriviruses.Nidovirus endoribonucleases (NendoUs) are uridylate-specific endoribonucleases, which release a cleavage product containing a 2',3'-cyclic phosphate at the 3' terminal end. They are conserved among this order and a genetic marker of nidoviruses [, , , ]. A feature of these viruses' evolutionary relationship is the organisation and processing of the genome, which is translated in two large precursor polyproteins (pp1a and pp1ab) from the replicase gene, that are proteolytically processed by virus proteases into 13 to 16 nonstructural proteins (NSPs) []. Proteins containing the NendoU domain include NSP15 from coronaviruses and NSP11 from arteriviruses, both of which participate in the viral replication process and in the evasion of the host immune system. Although they are similar and conserved, they only share 27% identical residues and show structural differences []. NSP11 has an N-terminal domain and a C-terminal NendoU catalytic domain. NSP11 functions as a dimer and Mg2 is dispensable for its activity. In Porcine reproductive and respiratory syndrome virus (PRRSV), NSP11 induces STAT2 degradation to inhibit interferon signaling. Mutagenesis studies revealed that the amino acid residue K59 located at the N-terminal domain of NSP11 is indispensable for inducing STAT2 reduction []. This domain is not conserved in those nidovirus branches that replicate in invertebrate hosts (Mesoniviridae, Roniviridae), suggesting specific roles in vertebrate hosts.
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Protein Domain
IPR043609 | NendoU_nidovirus
Type: Domain
Description: Nidovirus endoribonucleases (NendoUs) are uridylate-specific endoribonucleases, which release a cleavage product containing a 2',3'-cyclic phosphate at the 3' terminal end. They are conserved among this order and a genetic marker of nidoviruses [, , , ]. A feature of these viruses' evolutionary relationship is the organisation and processing of the genome, which is translated in two large precursor polyproteins (pp1a and pp1ab) from the replicase gene, that are proteolytically processed by virus proteases into 13 to 16 nonstructural proteins (NSPs) []. Proteins containing the NendoU domain include NSP15 from coronaviruses and NSP11 from arteriviruses, both of which participate in the viral replication process and in the evasion of the host immune system. Although they are similar and conserved, they only share 27% identical residues and show structural differences []. NSP11 has an N-terminal domain and a C-terminal NendoU catalytic domain. NSP11 functions as a dimer and Mg2 is dispensable for its activity. In Porcine reproductive and respiratory syndrome virus (PRRSV), NSP11 induces STAT2 degradation to inhibit interferon signaling. Mutagenesis studies revealed that the amino acid residue K59 located at the N-terminal domain of NSP11 is indispensable for inducing STAT2 reduction []. This domain is not conserved in those nidovirusbranches that replicate in invertebrate hosts (Mesoniviridae, Roniviridae), suggesting specific roles in vertebrate hosts.The NendoU domain packs into two β-sheets which constitute the catalytic-site cleft located at one side of the domain. A group of small α-helices packed at the other side of the domain face the concave surface of the β-sheets. The active site, located in the shallow groove between the two β-sheets, carries the catalytic triad made of two histidines and a lysine [, ].
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Protein Domain
IPR044314 | NSP11_NendoU_Av
Type: Domain
Description: Nidovirus endoribonucleases (NendoUs) are uridylate-specific endoribonucleases, which release a cleavage product containing a 2',3'-cyclic phosphate at the 3' terminal end. They are conserved among this order and a genetic marker of nidoviruses [, , , ]. A feature of these viruses' evolutionary relationship is the organisation and processing of the genome, which is translated in two large precursor polyproteins (pp1a and pp1ab) from the replicase gene, that are proteolytically processed by virus proteases into 13 to 16 nonstructural proteins (NSPs) []. Proteins containing the NendoU domain include NSP15 from coronaviruses and NSP11 from arteriviruses, both of which participate in the viral replication process and in the evasion of the host immune system. Although they are similar and conserved, they only share 27% identical residues and show structural differences []. NSP11 has an N-terminal domain and a C-terminal NendoU catalytic domain. NSP11 functions as a dimer and Mg2 is dispensable for its activity. In Porcine reproductive and respiratory syndrome virus (PRRSV), NSP11 induces STAT2 degradation to inhibit interferon signaling. Mutagenesis studies revealed that the amino acid residue K59 located at the N-terminal domain of NSP11 is indispensable for inducing STAT2 reduction []. This domain is not conserved in those nidovirus branches that replicate in invertebrate hosts (Mesoniviridae, Roniviridae), suggesting specific roles in vertebrate hosts.The NendoU domain packs into two β-sheets which constitute the catalytic-site cleft located at one side of the domain. A group of small α-helices packed at the other side of the domain face the concave surface of the β-sheets. The active site, located in the shallow groove between the two β-sheets, carries the catalytic triad made of two histidines and a lysine [, ].This entry represents the C-terminal NendoU catalytic domain of NSP11 from arteriviruses.
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Publication
35081346 | J:332371
First Author: Yang L
Year: 2022
Journal: Cell Rep
Title: Histone deacetylase 3 contributes to the antiviral innate immunity of macrophages by interacting with FOXK1 to regulate STAT1/2 transcription.
Volume: 38
Issue: 4
Pages: 110302
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Publication
32503978 | J:291910
First Author: Swaminathan S
Year: 2020
Journal: Nat Commun
Title: MYC functions as a switch for natural killer cell-mediated immune surveillance of lymphoid malignancies.
Volume: 11
Issue: 1
Pages: 2860
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Publication
17923090 | J:127194
First Author: Tang X
Year: 2007
Journal: Cell
Title: Acetylation-dependent signal transduction for type I interferon receptor.
Volume: 131
Issue: 1
Pages: 93-105
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Publication
25512607 | J:224299
First Author: Wiesauer I
Year: 2015
Journal: Mol Cell Biol
Title: Promoter occupancy of STAT1 in interferon responses is regulated by processive transcription.
Volume: 35
Issue: 4
Pages: 716-27
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Publication
38452758 | J:346747
     
First Author: Ghosh C
Year: 2024
Journal: Dev Cell
Title: Type I gamma phosphatidylinositol phosphate 5-kinase i5 controls cell sensitivity to interferon.
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GO Term
GO:0042532 | negative regulation of tyrosine phosphorylation of STAT protein
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Publication
30135128 | -
 
First Author: Zhang L
Year: 2018
Journal: J Virol
Title: Structural and Biochemical Characterization of Endoribonuclease Nsp15 Encoded by Middle East Respiratory Syndrome Coronavirus.
Volume: 92
Issue: 22
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Publication
27795409 | -
 
First Author: Zhang M
Year: 2017
Journal: J Virol
Title: Structural Biology of the Arterivirus nsp11 Endoribonucleases.
Volume: 91
Issue: 1
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Protein Domain
IPR044401 | NSP15_NendoU_CoV
Type: Domain
Description: Nidovirus endoribonucleases (NendoUs) are uridylate-specific endoribonucleases, which release a cleavage product containing a 2',3'-cyclic phosphate at the 3' terminal end. They are conserved among this order and a genetic marker of nidoviruses [, , , ]. A feature of these viruses' evolutionary relationship is the organisation and processing of the genome, which is translated in two large precursor polyproteins (pp1a and pp1ab) from the replicase gene, that are proteolytically processed by virus proteases into 13 to 16 nonstructural proteins (NSPs) []. Proteins containing the NendoU domain include NSP15 from coronaviruses and NSP11 from arteriviruses, both of which participate in the viral replication process and in the evasion of the host immune system. Although they are similar and conserved, they only share 27% identical residues and show structural differences []. NSP11 has an N-terminal domain and a C-terminal NendoU catalytic domain. NSP11 functions as a dimer and Mg2 is dispensable for its activity. In Porcine reproductive and respiratory syndrome virus (PRRSV), NSP11 induces STAT2 degradation to inhibit interferon signaling. Mutagenesis studies revealed that the amino acid residue K59 located at the N-terminal domain of NSP11 is indispensable for inducing STAT2 reduction []. This domain is not conserved in those nidovirus branches that replicate in invertebrate hosts (Mesoniviridae, Roniviridae), suggesting specific roles in vertebrate hosts.The NendoU domain packs into two β-sheets which constitute the catalytic-site cleft located at one side of the domain. A group of small α-helices packed at the other side of the domain face the concave surface of the β-sheets. The active site, located in the shallow groove between the two β-sheets, carries the catalytic triad made of two histidines and a lysine [, ].This entry represents the C-terminal NendoU domain of NSP15. NSP15 is encoded by ORF1a/1ab and proteolytically released from the pp1a/1ab polyprotein. This domain exhibits endoribonuclease activity designated EndoU, highly conserved in all known CoVs and is part of the replicase-transcriptase complex that plays important roles in virus replication and transcription [, , ]. NSP15 is a Uridylate-specific endoribonuclease that cleaves the 5'-polyuridines from negative-sense viral RNA, termed PUN RNA either upstream or downstream of uridylates, at GUU or GU to produce molecules with 2',3'-cyclic phosphate ends [, , ]. PUN RNA is a CoV MDA5-dependent pathogen-associated molecular pattern (PAMP) [].
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Publication
8621447 | -
First Author: Li X
Year: 1996
Journal: J Biol Chem
Title: Formation of STAT1-STAT2 heterodimers and their role in the activation of IRF-1 gene transcription by interferon-alpha.
Volume: 271
Issue: 10
Pages: 5790-4
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Publication
11909852 | -
First Author: Wong LH
Year: 2002
Journal: J Biol Chem
Title: Isolation and characterization of a human STAT1 gene regulatory element. Inducibility by interferon (IFN) types I and II and role of IFN regulatory factor-1.
Volume: 277
Issue: 22
Pages: 19408-17
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Protein Domain
IPR035859 | STAT1_SH2
Type: Domain
Description: STAT1 is a member of the STAT family of transcription factors. STAT1 is involved in upregulating genes due to a signal by interferons []. STAT1 forms a heterodimer with STAT2 that can bind Interferon Stimulated Response Element (ISRE) promoter element in response to either IFN-alpha or IFN-beta stimulation [].STAT proteins have a dual function: signal transduction and activation of transcription. When cytokines are bound to cell surface receptors, the associated Janus kinases (JAKs) are activated, leading to tyrosine phosphorylation of the given STAT proteins []. Phosphorylated STATs form dimers, translocate to the nucleus, and bind specific response elements to activate transcription of target genes []. STAT proteins contain an N-terminal domain (NTD), a coiled-coil domain (CCD), a DNA-binding domain (DBD), an α-helical linker domain (LD), an SH2 domain, and a transactivation domain (TAD). The SH2 domain is necessary for receptor association and tyrosine phosphodimer formation. There are seven mammalian STAT family members which have been identified: STAT1, STAT2, STAT3, STAT4, STAT5 (STAT5A and STAT5B), and STAT6 [].
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GO Term
GO:0042531 | positive regulation of tyrosine phosphorylation of STAT protein
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Publication
9724754 | J:55317
First Author: Liu B
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: Inhibition of Stat1-mediated gene activation by PIAS1.
Volume: 95
Issue: 18
Pages: 10626-31
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Publication
16148148 | J:116703
First Author: Strobl B
Year: 2005
Journal: J Immunol
Title: Novel functions of tyrosine kinase 2 in the antiviral defense against murine cytomegalovirus.
Volume: 175
Issue: 6
Pages: 4000-8
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Publication
20089923 | J:157694
First Author: Hofer MJ
Year: 2010
Journal: J Neurosci
Title: The type I interferon-alpha mediates a more severe neurological disease in the absence of the canonical signaling molecule interferon regulatory factor 9.
Volume: 30
Issue: 3
Pages: 1149-57
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Publication
15356135 | J:92745
First Author: Kamiya S
Year: 2004
Journal: J Immunol
Title: An indispensable role for STAT1 in IL-27-induced T-bet expression but not proliferation of naive CD4+ T cells.
Volume: 173
Issue: 6
Pages: 3871-7
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Publication
25669994 | J:343107
 
First Author: Cavanaugh SE
Year: 2015
Journal: J Neuroimmunol
Title: Homeostatic interferon expression in neurons is sufficient for early control of viral infection.
Volume: 279
Pages: 11-9
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Publication
28432122 | J:245633
First Author: Hsu KS
Year: 2017
Journal: J Biol Chem
Title: Dual regulation of Stat1 and Stat3 by the tumor suppressor protein PML contributes to interferon α-mediated inhibition of angiogenesis.
Volume: 292
Issue: 24
Pages: 10048-10060
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Publication
10982828 | J:331651
First Author: Murphy TL
Year: 2000
Journal: Mol Cell Biol
Title: Role of the Stat4 N domain in receptor proximal tyrosine phosphorylation.
Volume: 20
Issue: 19
Pages: 7121-31
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Publication
32161097 | J:287105
First Author: McCormack R
Year: 2020
Journal: J Immunol
Title: An Essential Role for Perforin-2 in Type I IFN Signaling.
Volume: 204
Issue: 8
Pages: 2242-2256
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Publication
10486314 | J:57868
First Author: Davey HW
Year: 1999
Journal: Am J Hum Genet
Title: STAT5 signaling in sexually dimorphic gene expression and growth patterns.
Volume: 65
Issue: 4
Pages: 959-65
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Publication
7537213 | J:29555
First Author: Azam M
Year: 1995
Journal: EMBO J
Title: Interleukin-3 signals through multiple isoforms of Stat5.
Volume: 14
Issue: 7
Pages: 1402-11
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Publication
8918689 | J:35052
First Author: Shi W
Year: 1996
Journal: Int Immunol
Title: The genomic structure and chromosomal localization of the mouse STAT3 gene.
Volume: 8
Issue: 8
Pages: 1205-11
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Publication
12901872 | J:85050
First Author: Uddin S
Year: 2003
Journal: Biochem Biophys Res Commun
Title: Role of Stat5 in type I interferon-signaling and transcriptional regulation.
Volume: 308
Issue: 2
Pages: 325-30
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Publication
14662340 | J:86970
First Author: Aoki K
Year: 2003
Journal: Exp Hematol
Title: Limitin, an interferon-like cytokine, transduces inhibitory signals on B-cell growth through activation of Tyk2, but not Stat1, followed by induction and nuclear translocation of Daxx.
Volume: 31
Issue: 12
Pages: 1317-22
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Publication
17982033 | J:153870
First Author: Sriram U
Year: 2007
Journal: J Immunol
Title: IL-4 suppresses dendritic cell response to type I interferons.
Volume: 179
Issue: 10
Pages: 6446-55
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Publication
21810606 | J:179129
First Author: Wang WB
Year: 2011
Journal: J Immunol
Title: STAT3 negatively regulates type I IFN-mediated antiviral response.
Volume: 187
Issue: 5
Pages: 2578-85
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