Type |
Details |
Score |
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
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Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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•
•
•
•
•
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Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
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•
•
•
•
•
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Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
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•
•
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•
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Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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•
•
•
•
•
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Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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•
•
•
•
•
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Publication |
First Author: |
Shinohara H |
Year: |
2016 |
Journal: |
FEBS Lett |
Title: |
TAK1 adaptor proteins, TAB2 and TAB3, link the signalosome to B-cell receptor-induced IKK activation. |
Volume: |
590 |
Issue: |
18 |
Pages: |
3264-9 |
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•
•
•
•
•
|
Publication |
First Author: |
Kim K |
Year: |
2018 |
Journal: |
Bone |
Title: |
TRIM38 regulates NF-κB activation through TAB2 degradation in osteoclast and osteoblast differentiation. |
Volume: |
113 |
|
Pages: |
17-28 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kulathu Y |
Year: |
2009 |
Journal: |
Nat Struct Mol Biol |
Title: |
Two-sided ubiquitin binding explains specificity of the TAB2 NZF domain. |
Volume: |
16 |
Issue: |
12 |
Pages: |
1328-30 |
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•
•
•
•
•
|
Publication |
First Author: |
Dauvillée D |
Year: |
2003 |
Journal: |
EMBO J |
Title: |
Tab2 is a novel conserved RNA binding protein required for translation of the chloroplast psaB mRNA. |
Volume: |
22 |
Issue: |
23 |
Pages: |
6378-88 |
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•
•
•
•
•
|
Interaction Experiment |
Description: |
TRIM30 alpha negatively regulates TLR-mediated NF-kappa B activation by targeting TAB2 and TAB3 for degradation. |
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•
•
•
•
•
|
Interaction Experiment |
Description: |
Tripartite motif 38 alleviates the pathological process of NAFLD-NASH by promoting TAB2 degradation. |
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•
•
•
•
|
Interaction Experiment |
Description: |
Smad7 binds to the adaptors TAB2 and TAB3 to block recruitment of the kinase TAK1 to the adaptor TRAF2. |
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•
•
•
•
•
|
Publication |
First Author: |
Yao X |
Year: |
2023 |
Journal: |
J Lipid Res |
Title: |
Tripartite motif 38 alleviates the pathological process of NAFLD-NASH by promoting TAB2 degradation. |
Volume: |
64 |
Issue: |
7 |
Pages: |
100382 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hong S |
Year: |
2007 |
Journal: |
Nat Immunol |
Title: |
Smad7 binds to the adaptors TAB2 and TAB3 to block recruitment of the kinase TAK1 to the adaptor TRAF2. |
Volume: |
8 |
Issue: |
5 |
Pages: |
504-13 |
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•
•
•
•
•
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Protein Domain |
Type: |
Domain |
Description: |
This entry represents the N-terminal domain of proteins from photosynthetic organisms including plants and cyanobacteria, such as Tab2 proteins. Tab2 was first identified in Chlamydomonas reinhardtii as a RNA binding protein required for translation of the chloroplast PsaB photosystem I subunit []. Later, the Tab2 homologue (ATAB2) from Arabidopsis was found involved in the signalling pathway of light-controlled synthesis of photosystem proteins during early plant development [], presumably functioning as an activator of translation with targets at PSI and PSII []. |
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•
•
•
•
•
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Publication |
First Author: |
Barneche F |
Year: |
2006 |
Journal: |
EMBO J |
Title: |
ATAB2 is a novel factor in the signalling pathway of light-controlled synthesis of photosystem proteins. |
Volume: |
25 |
Issue: |
24 |
Pages: |
5907-18 |
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•
•
•
•
•
|
Publication |
First Author: |
Belcher S |
Year: |
2015 |
Journal: |
Biochim Biophys Acta |
Title: |
Large-scale genetic analysis of chloroplast biogenesis in maize. |
Volume: |
1847 |
Issue: |
9 |
Pages: |
1004-16 |
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•
•
•
•
•
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Protein Domain |
Type: |
Domain |
Description: |
This entry represents the C-terminal domain of Tab2 from plants and cyanobacteria. Tab2 was first identified in Chlamydomonas reinhardtii ([swissprot]:Q7X8Y6) as a RNA-binding protein required for translation of the chloroplast PsaB photosystem I subunit []. Later, the Tab2 homologue from Arabidopsis (ATAB2) was found involved in the signalling pathway of light-controlled synthesis of photosystem proteins during early plant development, presumably functioning as an activator of translation with targets at PSI and PSII [, ]. Directed mutagenesis experiments carried out in Tab2 from C.reinhardtii indicated the importance of a highly conserved C-terminal tripeptide WLL for normal psaB translation []. |
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•
•
•
•
•
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Publication |
First Author: |
Tian Y |
Year: |
2007 |
Journal: |
J Biol Chem |
Title: |
RBCK1 negatively regulates tumor necrosis factor- and interleukin-1-triggered NF-kappaB activation by targeting TAB2/3 for degradation. |
Volume: |
282 |
Issue: |
23 |
Pages: |
16776-82 |
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•
•
•
•
•
|
Publication |
First Author: |
Takaesu G |
Year: |
2000 |
Journal: |
Mol Cell |
Title: |
TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway. |
Volume: |
5 |
Issue: |
4 |
Pages: |
649-58 |
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•
•
•
•
•
|
Publication |
First Author: |
Ishitani T |
Year: |
2003 |
Journal: |
EMBO J |
Title: |
Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling. |
Volume: |
22 |
Issue: |
23 |
Pages: |
6277-88 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
TAB2 (TGF-beta-activated kinase 1 and MAP3K7-binding protein 2) is an adaptor protein that regulates activation of TAK1, a MAP kinase kinase kinase (MAPKKK), through linking TAK1 to TRAF6 in the Interleukin-1 (IL-1) induced NF-kappaB activation pathway []. TAB3 is a TAB2-like TAK1-binding protein that activates NF-kappaB similar to TAB2 []. It activates TAK1 and regulates its association with TRAF2 and TRAF6. Moreover, TAB3 interacts with TRAF6 and TRAF2 in an IL-1- and a TNF-dependent manner, respectively. TAB2 and TAB3 function redundantly as mediators of TAK1 activation in IL-1 and TNF signal transduction []. Both of them contain an N-terminal CUE domain, a coiled-coil (CC) region, a TAK1-binding domain and a C-terminal Npl4 zinc finger (NZF) ubiquitin-binding domain (UBD) [].This entry represents the CUE domain found in TAB2 and TAB3. |
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•
•
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•
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Protein Domain |
Type: |
Family |
Description: |
Tab2 was first identified in Chlamydomonas reinhardtii as a RNA binding protein required for translation of the chloroplast PsaB photosystem I subunit []. Later, the Tab2 homologue from Arabidopsis was found involved in the signalling pathway of light-controlled synthesis of photosystem proteins during early plant development, that probably functions as an activator of translation with targets at PSI and PSII [, ]. Proteins in this entry are from photosynthetic organisms including plants and cyanobacteria. |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
108
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
553
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Mashima R |
Year: |
2005 |
Journal: |
J Biol Chem |
Title: |
FLN29, a novel interferon- and LPS-inducible gene acting as a negative regulator of toll-like receptor signaling. |
Volume: |
280 |
Issue: |
50 |
Pages: |
41289-97 |
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•
•
•
•
•
|
Publication |
First Author: |
Sardi SP |
Year: |
2006 |
Journal: |
Cell |
Title: |
Presenilin-dependent ErbB4 nuclear signaling regulates the timing of astrogenesis in the developing brain. |
Volume: |
127 |
Issue: |
1 |
Pages: |
185-97 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xia P |
Year: |
2015 |
Journal: |
Nat Immunol |
Title: |
Sox2 functions as a sequence-specific DNA sensor in neutrophils to initiate innate immunity against microbial infection. |
Volume: |
16 |
Issue: |
4 |
Pages: |
366-75 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ji YX |
Year: |
2016 |
Journal: |
Nat Commun |
Title: |
The ubiquitin E3 ligase TRAF6 exacerbates pathological cardiac hypertrophy via TAK1-dependent signalling. |
Volume: |
7 |
|
Pages: |
11267 |
|
•
•
•
•
•
|
Publication |
First Author: |
Grimsey NJ |
Year: |
2015 |
Journal: |
J Cell Biol |
Title: |
Ubiquitin plays an atypical role in GPCR-induced p38 MAP kinase activation on endosomes. |
Volume: |
210 |
Issue: |
7 |
Pages: |
1117-31 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li Z |
Year: |
2023 |
Journal: |
Adv Sci (Weinh) |
Title: |
USP25 Inhibits Neuroinflammatory Responses After Cerebral Ischemic Stroke by Deubiquitinating TAB2. |
Volume: |
10 |
Issue: |
28 |
Pages: |
e2301641 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
716
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
693
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
716
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Hu MM |
Year: |
2015 |
Journal: |
J Immunol |
Title: |
TRIM38 Negatively Regulates TLR3/4-Mediated Innate Immune and Inflammatory Responses by Two Sequential and Distinct Mechanisms. |
Volume: |
195 |
Issue: |
9 |
Pages: |
4415-25 |
|
•
•
•
•
•
|
Publication |
First Author: |
Buchta CM |
Year: |
2014 |
Journal: |
J Immunol |
Title: |
TRAF5 negatively regulates TLR signaling in B lymphocytes. |
Volume: |
192 |
Issue: |
1 |
Pages: |
145-50 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hou P |
Year: |
2021 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
An unconventional role of an ASB family protein in NF-κB activation and inflammatory response during microbial infection and colitis. |
Volume: |
118 |
Issue: |
3 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang H |
Year: |
2022 |
Journal: |
J Immunol |
Title: |
RNF186/EPHB2 Axis Is Essential in Regulating TNF Signaling for Colorectal Tumorigenesis in Colorectal Epithelial Cells. |
Volume: |
209 |
Issue: |
9 |
Pages: |
1796-1805 |
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•
•
•
•
•
|
Publication |
First Author: |
Xia ZP |
Year: |
2009 |
Journal: |
Nature |
Title: |
Direct activation of protein kinases by unanchored polyubiquitin chains. |
Volume: |
461 |
Issue: |
7260 |
Pages: |
114-9 |
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•
•
•
•
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