Type |
Details |
Score |
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
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•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
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•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
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•
•
•
•
•
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Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
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•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7641292 |
Assay Type: |
RT-PCR |
Annotation Date: |
2024-05-21 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:360464 |
|
Stage: |
TS04 |
Assay Id: |
MGI:7641360 |
Age: |
embryonic day 3.5 |
Image: |
1 |
|
Specimen Label: |
Taf5 -/- |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7641292 |
Assay Type: |
RT-PCR |
Annotation Date: |
2024-05-21 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:360464 |
|
Stage: |
TS04 |
Assay Id: |
MGI:7641360 |
Age: |
embryonic day 3.5 |
Image: |
1 |
|
Specimen Label: |
Taf5 -/- |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7641292 |
Assay Type: |
RT-PCR |
Annotation Date: |
2024-05-21 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:360464 |
|
Stage: |
TS04 |
Assay Id: |
MGI:7641360 |
Age: |
embryonic day 3.5 |
Image: |
1 |
|
Specimen Label: |
Taf5 +/- |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7641292 |
Assay Type: |
RT-PCR |
Annotation Date: |
2024-05-21 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:360464 |
|
Stage: |
TS04 |
Assay Id: |
MGI:7641360 |
Age: |
embryonic day 3.5 |
Image: |
1 |
|
Specimen Label: |
Taf5 +/- |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7641291 |
Assay Type: |
RT-PCR |
Annotation Date: |
2024-05-21 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:360464 |
|
Stage: |
TS04 |
Assay Id: |
MGI:7641364 |
Age: |
embryonic day 3.5 |
Image: |
1 |
|
Specimen Label: |
Taf5 -/- |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7641291 |
Assay Type: |
RT-PCR |
Annotation Date: |
2024-05-21 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:360464 |
|
Stage: |
TS04 |
Assay Id: |
MGI:7641364 |
Age: |
embryonic day 3.5 |
Image: |
1 |
|
Specimen Label: |
Taf5 -/- |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7641291 |
Assay Type: |
RT-PCR |
Annotation Date: |
2024-05-21 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:360464 |
|
Stage: |
TS04 |
Assay Id: |
MGI:7641364 |
Age: |
embryonic day 3.5 |
Image: |
1 |
|
Specimen Label: |
Taf5 +/- |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7641291 |
Assay Type: |
RT-PCR |
Annotation Date: |
2024-05-21 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:360464 |
|
Stage: |
TS04 |
Assay Id: |
MGI:7641364 |
Age: |
embryonic day 3.5 |
Image: |
1 |
|
Specimen Label: |
Taf5 +/- |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7641290 |
Assay Type: |
RT-PCR |
Annotation Date: |
2024-05-21 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:360464 |
|
Stage: |
TS04 |
Assay Id: |
MGI:7641365 |
Age: |
embryonic day 3.5 |
Image: |
1 |
|
Specimen Label: |
Taf5 -/- |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7641290 |
Assay Type: |
RT-PCR |
Annotation Date: |
2024-05-21 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:360464 |
|
Stage: |
TS04 |
Assay Id: |
MGI:7641365 |
Age: |
embryonic day 3.5 |
Image: |
1 |
|
Specimen Label: |
Taf5 -/- |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7641290 |
Assay Type: |
RT-PCR |
Annotation Date: |
2024-05-21 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:360464 |
|
Stage: |
TS04 |
Assay Id: |
MGI:7641365 |
Age: |
embryonic day 3.5 |
Image: |
1 |
|
Specimen Label: |
Taf5 +/- |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7641290 |
Assay Type: |
RT-PCR |
Annotation Date: |
2024-05-21 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:360464 |
|
Stage: |
TS04 |
Assay Id: |
MGI:7641365 |
Age: |
embryonic day 3.5 |
Image: |
1 |
|
Specimen Label: |
Taf5 +/- |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bhattacharya S |
Year: |
2007 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Structural analysis and dimerization potential of the human TAF5 subunit of TFIID. |
Volume: |
104 |
Issue: |
4 |
Pages: |
1189-94 |
|
•
•
•
•
•
|
Publication |
First Author: |
Scheer E |
Year: |
2012 |
Journal: |
J Biol Chem |
Title: |
TFIID TAF6-TAF9 complex formation involves the HEAT repeat-containing C-terminal domain of TAF6 and is modulated by TAF5 protein. |
Volume: |
287 |
Issue: |
33 |
Pages: |
27580-92 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Homologous_superfamily |
Description: |
This region is an all-alpha domain associated with the WD40 helical bundle of the TAF5 subunit of transcription factor TFIID. The domain has distant structural similarity to RNA polymerase II CTD interacting factors. It contains several conserved clefts that are likely to be critical for TFIID complex assembly []. The TAF5 subunit is present twice in the TFIID complex and is critical for the function and assembly of the complex, and the NTD2 (second N-terminal domain) and N-terminal domain are crucial for homodimerisation []. TAF5 has a paralogue gene (TAF5L) which has a redundant function [].The TATA Binding Protein (TBP) Associated Factor 5 (TAF5) is one of several TAFs that bind TBP and are involved in forming Transcription Factor IID (TFIID) complex. TFIID plays an important role in the recognition of promoter DNA and assembly of the preinitiation complex. TFIID complex is composed of the TBP and at least 13 TAFs. In yeast and human cells, TAFs have been found as components of other complexes besides TFIID [].The N-terminal domain of TAF5 has a multihelical structure with a C-terminal beta-alpha(2)-beta motif, one central buried helix and parallel β-ribbon. |
|
•
•
•
•
•
|
Publication |
First Author: |
Romier C |
Year: |
2007 |
Journal: |
J Mol Biol |
Title: |
Crystal structure, biochemical and genetic characterization of yeast and E. cuniculi TAF(II)5 N-terminal domain: implications for TFIID assembly. |
Volume: |
368 |
Issue: |
5 |
Pages: |
1292-306 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chistiakov DA |
Year: |
2005 |
Journal: |
Autoimmunity |
Title: |
The TAF5L gene on chromosome 1q42 is associated with type 1 diabetes in Russian affected patients. |
Volume: |
38 |
Issue: |
4 |
Pages: |
283-93 |
|
•
•
•
•
•
|
Allele |
Name: |
TATA-box binding protein associated factor 5; endonuclease-mediated mutation 1, Jackson |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This region is an all-alpha domain associated with the WD40 helical bundle of the TAF5 subunit of transcription factor TFIID. The domain has distant structural similarity to RNA polymerase II CTD interacting factors. It contains several conserved clefts that are likely to be critical for TFIID complex assembly []. The TAF5 subunit is present twice in the TFIID complex and is critical for the function and assembly of the complex, and the NTD2 (second N-terminal domain) and N-terminal domain are crucial for homodimerisation []. TAF5 has a paralogue gene (TAF5L) which has a redundant function [].The TATA Binding Protein (TBP) Associated Factor 5 (TAF5) is one of several TAFs that bind TBP and are involved in forming Transcription Factor IID (TFIID) complex. TFIID plays an important role in the recognition of promoter DNA and assembly of the preinitiation complex. TFIID complex is composed of the TBP and at least 13 TAFs. In yeast and human cells, TAFs have been found as components of other complexes besides TFIID []. |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Taf5/Taf5 |
Background: |
C57BL/6NJ-Taf5/Mmjax |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Taf5/Taf5<+> |
Background: |
C57BL/6NJ-Taf5/Mmjax |
Zygosity: |
ht |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Papai G |
Year: |
2020 |
Journal: |
Nature |
Title: |
Structure of SAGA and mechanism of TBP deposition on gene promoters. |
Volume: |
577 |
Issue: |
7792 |
Pages: |
711-716 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang H |
Year: |
2020 |
Journal: |
Nature |
Title: |
Structure of the transcription coactivator SAGA. |
Volume: |
577 |
Issue: |
7792 |
Pages: |
717-720 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nagy Z |
Year: |
2009 |
Journal: |
Mol Cell Biol |
Title: |
The human SPT20-containing SAGA complex plays a direct role in the regulation of endoplasmic reticulum stress-induced genes. |
Volume: |
29 |
Issue: |
6 |
Pages: |
1649-60 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wu CJ |
Year: |
2021 |
Journal: |
Mol Plant |
Title: |
Three functionally redundant plant-specific paralogs are core subunits of the SAGA histone acetyltransferase complex in Arabidopsis. |
Volume: |
14 |
Issue: |
7 |
Pages: |
1071-1087 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This entry represents the SEP domain found in Spt20 from yeast and human [, , ]. The Spt20 protein is part of the SAGA complex which is a large complex mediating histone deacetylation. Yeast Spt20 has been shown to play a role in structural integrity of the SAGA complex as as no intact SAGA could be purified in spt20 deletion strains. Spt20 is indispensable under endoplasmic reticulum (ER) stress conditions, being involved in the regulation of stress-responsive genes transcription. This domain interacts with LisH motif helices of Taf5 []. This domain is also found in Protein PHYTOCHROME-DEPENDENT LATE-FLOWERING (PHL), which is involved in the phytochrome B-dependent regulation of flowering [, , ]. |
|
•
•
•
•
•
|
Publication |
First Author: |
Green MR |
Year: |
2000 |
Journal: |
Trends Biochem Sci |
Title: |
TBP-associated factors (TAFIIs): multiple, selective transcriptional mediators in common complexes. |
Volume: |
25 |
Issue: |
2 |
Pages: |
59-63 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
530
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
181
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
529
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
141
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
784
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Endo M |
Year: |
2014 |
Journal: |
Plant Signal Behav |
Title: |
Light-dependent destabilization of PHL in Arabidopsis. |
Volume: |
9 |
Issue: |
3 |
Pages: |
e28118 |
|
•
•
•
•
•
|
Publication |
First Author: |
Endo M |
Year: |
2013 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
PHYTOCHROME-DEPENDENT LATE-FLOWERING accelerates flowering through physical interactions with phytochrome B and CONSTANS. |
Volume: |
110 |
Issue: |
44 |
Pages: |
18017-22 |
|
•
•
•
•
•
|