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Search results 201 to 279 out of 279 for Tank

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Type Details Score
Protein Domain
IPR041087 | TBK1_ULD
Type: Domain
Description: This is the ubiquitin-like domain (ULD) found in TANK-binding kinase 1 (TBK1). TBK1 is a serine/threonine kinase and a noncanonical member of the IKK family implicated in diverse cellular functions, including innate immune response as well as tumorigenesis and development []. It has been reported that the ULD of TBK1 regulates kinase activity, playing an important role in signaling and mediating interactions with other molecules in the IFN pathway. Deletion of ULD indicates that it is required for the kinase domain to form an enzymatically active conformation. TBK1 ULD has a ubiquitin-like structure and an Ile44 hydrophobic patch, which is conserved among ULDs and IKK and IKK-related proteins. This hydrophobic patch is involved in ULD-SDD interactions in TBK1 and other IKK and IKK-related proteins [].
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Allele
Tank<em1Smoc> | MGI:7292681
Name: TRAF family member-associated Nf-kappa B activator; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Publication
24696485 | J:236952
First Author: Kang HR
Year: 2014
Journal: J Virol
Title: Murine gammaherpesvirus 68 encoding open reading frame 11 targets TANK binding kinase 1 to negatively regulate the host type I interferon response.
Volume: 88
Issue: 12
Pages: 6832-46
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Publication
25402854 | J:228932
First Author: Rickgauer JP
Year: 2014
Journal: Nat Neurosci
Title: Simultaneous cellular-resolution optical perturbation and imaging of place cell firing fields.
Volume: 17
Issue: 12
Pages: 1816-24
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Publication
9048752 | J:45988
First Author: Osterhout CA
Year: 1997
Journal: J Neurochem
Title: Induction of tyrosine hydroxylase protein and a transgene containing tyrosine hydroxylase 5' flanking sequences by stress in mouse adrenal gland.
Volume: 68
Issue: 3
Pages: 1071-7
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Interaction Experiment
Pomerantz JL (1999)
Description: NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase.
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Strain
MGI:6476417 | C57BL/6JSmoc-Tank<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Publication
15623583 | -
First Author: Loercher AE
Year: 2005
Journal: J Cell Biol
Title: MITF links differentiation with cell cycle arrest in melanocytes by transcriptional activation of INK4A.
Volume: 168
Issue: 1
Pages: 35-40
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Publication
24623780 | J:209602
First Author: Li CL
Year: 2014
Journal: J Neurosci
Title: SRF phosphorylation by glycogen synthase kinase-3 promotes axon growth in hippocampal neurons.
Volume: 34
Issue: 11
Pages: 4027-42
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Publication
34776042 | J:328607
First Author: Koay SA
Year: 2022
Journal: Neuron
Title: Sequential and efficient neural-population coding of complex task information.
Volume: 110
Issue: 2
Pages: 328-349.e11
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Publication
31311934 | J:283084
First Author: Deverett B
Year: 2019
Journal: Nat Commun
Title: Cerebellar disruption impairs working memory during evidence accumulation.
Volume: 10
Issue: 1
Pages: 3128
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Publication
17920014 | J:125132
First Author: Dombeck DA
Year: 2007
Journal: Neuron
Title: Imaging large-scale neural activity with cellular resolution in awake, mobile mice.
Volume: 56
Issue: 1
Pages: 43-57
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Publication
29154129 | J:256104
First Author: Meshulam L
Year: 2017
Journal: Neuron
Title: Collective Behavior of Place and Non-place Neurons in the Hippocampal Network.
Volume: 96
Issue: 5
Pages: 1178-1191.e4
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Publication
20184394 | -
First Author: Kanno Y
Year: 2010
Journal: J Recept Signal Transduct Res
Title: TACI induces cIAP1-mediated ubiquitination of NIK by TRAF2 and TANK to limit non-canonical NF-kappaB signaling.
Volume: 30
Issue: 2
Pages: 121-32
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Publication
28148298 | -
First Author: Oakes JA
Year: 2017
Journal: Mol Brain
Title: TBK1: a new player in ALS linking autophagy and neuroinflammation.
Volume: 10
Issue: 1
Pages: 5
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DO Term
DOID:10518 | beach ear
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Protein
Q3THP3
Organism: Mus musculus/domesticus
Length: 607  
Fragment?: false
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Publication
12154115 | J:103144
First Author: Gross V
Year: 2002
Journal: Hypertension
Title: Heart rate variability and baroreflex function in AT2 receptor-disrupted mice.
Volume: 40
Issue: 2
Pages: 207-13
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Publication
15661972 | J:97731
First Author: Gross V
Year: 2005
Journal: Am J Physiol Regul Integr Comp Physiol
Title: Autonomic nervous system and blood pressure regulation in RGS2-deficient mice.
Volume: 288
Issue: 5
Pages: R1134-42
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Publication
16269576 | J:115763
First Author: Obst M
Year: 2006
Journal: Am J Physiol Regul Integr Comp Physiol
Title: NO-dependent blood pressure regulation in RGS2-deficient mice.
Volume: 290
Issue: 4
Pages: R1012-9
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Publication
30270041 | J:267430
First Author: Gu Y
Year: 2018
Journal: Cell
Title: A Map-like Micro-Organization of Grid Cells in the Medial Entorhinal Cortex.
Volume: 175
Issue: 3
Pages: 736-750.e30
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Publication
19029483 | J:165006
First Author: Goncalves AC
Year: 2009
Journal: Hypertension
Title: Diabetic hypertensive leptin receptor-deficient db/db mice develop cardioregulatory autonomic dysfunction.
Volume: 53
Issue: 2
Pages: 387-92
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Protein
Q9R0T8
Organism: Mus musculus/domesticus
Length: 717  
Fragment?: false
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Protein
Q9WUN2
Organism: Mus musculus/domesticus
Length: 729  
Fragment?: false
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Protein
A1L361
Organism: Mus musculus/domesticus
Length: 729  
Fragment?: false
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Protein
Q3U6P9
Organism: Mus musculus/domesticus
Length: 717  
Fragment?: false
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Protein
Q8CI55
Organism: Mus musculus/domesticus
Length: 693  
Fragment?: false
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Protein
E9PYL6
Organism: Mus musculus/domesticus
Length: 693  
Fragment?: false
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Publication
18711009 | J:154723
First Author: da Costa-Goncalves AC
Year: 2008
Journal: Hypertension
Title: Role of the multidomain protein spinophilin in blood pressure and cardiac function regulation.
Volume: 52
Issue: 4
Pages: 702-7
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Publication
26056265 | J:223767
First Author: Barmada SJ
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Amelioration of toxicity in neuronal models of amyotrophic lateral sclerosis by hUPF1.
Volume: 112
Issue: 25
Pages: 7821-6
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Publication
19412553 | J:148889
First Author: Noh T
Year: 2009
Journal: PLoS One
Title: Lef1 haploinsufficient mice display a low turnover and low bone mass phenotype in a gender- and age-specific manner.
Volume: 4
Issue: 5
Pages: e5438
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Publication
34190355 | J:308503
   
First Author: Maimon R
Year: 2021
Journal: EMBO J
Title: A CRMP4-dependent retrograde axon-to-soma death signal in amyotrophic lateral sclerosis.
Pages: e107586
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Publication
17568778 | -
First Author: Ryzhakov G
Year: 2007
Journal: EMBO J
Title: SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK.
Volume: 26
Issue: 13
Pages: 3180-90
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Protein
Q9QYP6
Organism: Mus musculus/domesticus
Length: 405  
Fragment?: false
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Protein
D3Z7S3
Organism: Mus musculus/domesticus
Length: 178  
Fragment?: true
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Protein
F7A092
Organism: Mus musculus/domesticus
Length: 199  
Fragment?: true
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Protein
F6SY96
Organism: Mus musculus/domesticus
Length: 67  
Fragment?: true
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Protein Domain
IPR024581 | TBD
Type: Domain
Description: The Tbk1/Ikki binding domain (TBD) is a 40 amino acid domain able to bind kinases which is essential for poly(I:C)-induced IRF activation []. The domain is found in the SINTBAD, TANK and NAP1 proteins. This domain is predicted to form an α-helix with residues essential for kinase binding clustering on one side [].
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Publication
33491666 | J:321192
 
First Author: Willmes DM
Year: 2021
Journal: JCI Insight
Title: The longevity gene mIndy (I'm Not Dead, Yet) affects blood pressure through sympathoadrenal mechanisms.
Volume: 6
Issue: 2
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HT Experiment
GSE227670 | The zebrafish heart harbors a thermogenic beige fat depot analog of human epicardial adipose tissue
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
25961942 | J:231784
First Author: Maass PG
Year: 2015
Journal: Nat Genet
Title: PDE3A mutations cause autosomal dominant hypertension with brachydactyly.
Volume: 47
Issue: 6
Pages: 647-53
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Publication
38697117 | J:348311
First Author: Gitlin AD
Year: 2024
Journal: Immunity
Title: N4BP1 coordinates ubiquitin-dependent crosstalk within the IκB kinase family to limit Toll-like receptor signaling and inflammation.
Volume: 57
Issue: 5
Pages: 973-986.e7
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Publication
33152322 | J:300240
First Author: Huh JY
Year: 2020
Journal: Cell Metab
Title: TANK-Binding Kinase 1 Regulates the Localization of Acyl-CoA Synthetase ACSL1 to Control Hepatic Fatty Acid Oxidation.
Volume: 32
Issue: 6
Pages: 1012-1027.e7
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Publication
17157040 | J:116705
First Author: An H
Year: 2006
Journal: Immunity
Title: SHP-2 phosphatase negatively regulates the TRIF adaptor protein-dependent type I interferon and proinflammatory cytokine production.
Volume: 25
Issue: 6
Pages: 919-28
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Publication
29935921 | J:341476
 
First Author: Cruz VH
Year: 2018
Journal: Mol Metab
Title: Loss of Tbk1 kinase activity protects mice from diet-induced metabolic dysfunction.
Volume: 16
Pages: 139-149
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Publication
21617041 | J:222675
First Author: Wild P
Year: 2011
Journal: Science
Title: Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth.
Volume: 333
Issue: 6039
Pages: 228-33
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Protein Domain
IPR044367 | NSP6_betaCoV
Type: Domain
Description: This entry represents the non-structural protein 6 (NSP6) from betacoronavirus. Recently, it was reported that SARS-CoV-2 NSP6 binds TANK binding kinase 1 (TBK1) to suppress interferon regulatory factor 3 (IRF3) phosphorylation which suppresses IFN-I signalling and production more efficiently than SARS-CoV and MERS-CoV [].Coronaviruses (CoV) redirect and rearrange host cell membranes as part of the viral genome replication and transcription machinery; they induce the formation of double-membrane vesicles in infected cells. CoV non-structural protein 6 (NSP6), a transmembrane-containing protein, together with NSP3 and NSP4, have the ability to induce double-membrane vesicles that are similar to those observed in severe acute respiratory syndrome (SARS) coronavirus-infected cells []. By itself, NSP6 can generate autophagosomes from the endoplasmic reticulum. Autophagosomes are normally generated as a cellular response to starvation to carry cellular organelles and long-lived proteins to lysosomes for degradation. Degradation through autophagy may provide an innate defense against virus infection, or conversely, autophagosomes can promote infection by facilitating the assembly of replicase proteins []. In additionto initiating autophagosome formation, NSP6 also limits autophagosome expansion regardless of how they were induced, i.e. whether they were induced directly by NSP6, or indirectly by starvation or chemical inhibition of MTOR signalling. This may favour coronavirus infection by compromising the ability of autophagosomes to deliver viral components to lysosomes for degradation [].
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Publication
10580148 | J:58756
First Author: Miyagawa J
Year: 1999
Journal: Gene
Title: Isolation of the novel cDNA of a gene of which expression is induced by a demethylating stimulus.
Volume: 240
Issue: 2
Pages: 289-95
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Publication
12915444 | J:85961
First Author: Glynn D
Year: 2003
Journal: Hum Mol Genet
Title: Complexin II is essential for normal neurological function in mice.
Volume: 12
Issue: 19
Pages: 2431-48
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Publication
32035058 | J:348715
First Author: Garcia G Jr
Year: 2020
Journal: Am J Pathol
Title: Hippo Signaling Pathway Has a Critical Role in Zika Virus Replication and in the Pathogenesis of Neuroinflammation.
Volume: 190
Issue: 4
Pages: 844-861
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Publication
39434428 | J:360143
First Author: Li Y
Year: 2024
Journal: FEBS J
Title: TBK1 is involved in M-CSF-induced macrophage polarization through mediating the IRF5/IRF4 axis.
Volume: 291
Issue: 23
Pages: 5214-5235
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Publication
24651066 | J:210974
First Author: Zhou L
Year: 2014
Journal: Hum Mol Genet
Title: Lack of seipin in neurons results in anxiety- and depression-like behaviors via down regulation of PPARγ.
Volume: 23
Issue: 15
Pages: 4094-102
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Publication
35343085 | J:334690
First Author: Luo W
Year: 2022
Journal: Clin Transl Med
Title: MD2 deficiency prevents high-fat diet-induced AMPK suppression and lipid accumulation through regulating TBK1 in non-alcoholic fatty liver disease.
Volume: 12
Issue: 3
Pages: e777
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Publication
29963044 | J:265099
 
First Author: Cheng WY
Year: 2018
Journal: Front Immunol
Title: The cGas-Sting Signaling Pathway Is Required for the Innate Immune Response Against Ectromelia Virus.
Volume: 9
Pages: 1297
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Publication
18941247 | J:140714
First Author: Tamassia N
Year: 2008
Journal: J Immunol
Title: Activation of an immunoregulatory and antiviral gene expression program in poly(I:C)-transfected human neutrophils.
Volume: 181
Issue: 9
Pages: 6563-73
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Publication
18439848 | J:136289
First Author: Michallet MC
Year: 2008
Journal: Immunity
Title: TRADD protein is an essential component of the RIG-like helicase antiviral pathway.
Volume: 28
Issue: 5
Pages: 651-61
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Publication
23610142 | J:204786
First Author: Fukasaka M
Year: 2013
Journal: J Immunol
Title: Critical role of AZI2 in GM-CSF-induced dendritic cell differentiation.
Volume: 190
Issue: 11
Pages: 5702-11
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Publication
24244017 | J:207113
First Author: Munitic I
Year: 2013
Journal: J Immunol
Title: Optineurin insufficiency impairs IRF3 but not NF-κB activation in immune cells.
Volume: 191
Issue: 12
Pages: 6231-40
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Publication
34352252 | J:355580
First Author: Hale J
Year: 2021
Journal: Biophys J
Title: αI-spectrin represents evolutionary optimization of spectrin for red blood cell deformability.
Volume: 120
Issue: 17
Pages: 3588-3599
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Publication
11169869 | J:67510
First Author: Cardiff RD
Year: 2001
Journal: Microsc Res Tech
Title: Validity of mouse mammary tumour models for human breast cancer: comparative pathology.
Volume: 52
Issue: 2
Pages: 224-30
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Publication
8916178 | J:37206
First Author: Klapdor K
Year: 1996
Journal: Physiol Behav
Title: The Morris water-escape task in mice: strain differences and effects of intra-maze contrast and brightness.
Volume: 60
Issue: 5
Pages: 1247-54
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Publication
9240474 | J:41930
First Author: Kathmann EC
Year: 1997
Journal: Biochem Biophys Res Commun
Title: Cloning of a cDNA encoding a constitutively expressed rat liver cytosolic aldehyde dehydrogenase.
Volume: 236
Issue: 2
Pages: 527-31
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Publication
15248866 | J:104875
First Author: Brooks SP
Year: 2004
Journal: Genes Brain Behav
Title: Behavioural profiles of inbred mouse strains used as transgenic backgrounds. I: motor tests.
Volume: 3
Issue: 4
Pages: 206-15
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Publication
22851696 | J:189138
First Author: Qu F
Year: 2012
Journal: Mol Cell Biol
Title: TRAF6-dependent Act1 phosphorylation by the IκB kinase-related kinases suppresses interleukin-17-induced NF-κB activation.
Volume: 32
Issue: 19
Pages: 3925-37
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Publication
30420664 | J:268450
First Author: Lafont E
Year: 2018
Journal: Nat Cell Biol
Title: TBK1 and IKKε prevent TNF-induced cell death by RIPK1 phosphorylation.
Volume: 20
Issue: 12
Pages: 1389-1399
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Publication
33741962 | J:303828
First Author: Zhang Y
Year: 2021
Journal: Nat Commun
Title: Cerebellar Kv3.3 potassium channels activate TANK-binding kinase 1 to regulate trafficking of the cell survival protein Hax-1.
Volume: 12
Issue: 1
Pages: 1731
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Publication
37088470 | J:340698
First Author: Guo R
Year: 2023
Journal: ESC Heart Fail
Title: Rnf144b alleviates the inflammatory responses and cardiac dysfunction in sepsis.
Volume: 10
Issue: 4
Pages: 2338-2344
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Publication
21947006 | J:196251
First Author: Burdette DL
Year: 2011
Journal: Nature
Title: STING is a direct innate immune sensor of cyclic di-GMP.
Volume: 478
Issue: 7370
Pages: 515-8
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Publication
31913745 | J:337050
First Author: Lee DH
Year: 2020
Journal: Autophagy
Title: SQSTM1/p62 activates NFE2L2/NRF2 via ULK1-mediated autophagic KEAP1 degradation and protects mouse liver from lipotoxicity.
Volume: 16
Issue: 11
Pages: 1949-1973
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Publication
24335288 | J:205493
First Author: Ono C
Year: 2014
Journal: J Virol
Title: Innate immune response induced by baculovirus attenuates transgene expression in mammalian cells.
Volume: 88
Issue: 4
Pages: 2157-67
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Publication
17055661 | J:116095
First Author: Jankowski MP
Year: 2006
Journal: Neuroscience
Title: SRY-box containing gene 11 (Sox11) transcription factor is required for neuron survival and neurite growth.
Volume: 143
Issue: 2
Pages: 501-14
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Publication
37781354 | J:341362
 
First Author: Yang Y
Year: 2023
Journal: Front Immunol
Title: cGAS-STING signaling pathway in intestinal homeostasis and diseases.
Volume: 14
Pages: 1239142
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Protein
A2A9T0
Organism: Mus musculus/domesticus
Length: 611  
Fragment?: false
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Protein
Z4YKN2
Organism: Mus musculus/domesticus
Length: 610  
Fragment?: false
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Publication
23943763 | -
 
First Author: Angelini MM
Year: 2013
Journal: mBio
Title: Severe acute respiratory syndrome coronavirus nonstructural proteins 3, 4, and 6 induce double-membrane vesicles.
Volume: 4
Issue: 4
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Publication
24991833 | -
First Author: Cottam EM
Year: 2014
Journal: Autophagy
Title: Coronavirus NSP6 restricts autophagosome expansion.
Volume: 10
Issue: 8
Pages: 1426-41
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Publication
21799305 | -
First Author: Cottam EM
Year: 2011
Journal: Autophagy
Title: Coronavirus nsp6 proteins generate autophagosomes from the endoplasmic reticulum via an omegasome intermediate.
Volume: 7
Issue: 11
Pages: 1335-47
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Publication
32979938 | -
First Author: Xia H
Year: 2020
Journal: Cell Rep
Title: Evasion of Type I Interferon by SARS-CoV-2.
Volume: 33
Issue: 1
Pages: 108234
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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