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Search results 201 to 280 out of 280 for Tap2

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Type Details Score
Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
9062964 | J:42303
First Author: Ishihara M
Year: 1997
Journal: Tissue Antigens
Title: Analysis of allelic variation of the TAP2 gene in sarcoidosis.
Volume: 49
Issue: 2
Pages: 107-10
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Publication
8206525 | J:18841
First Author: Joly E
Year: 1994
Journal: Immunogenetics
Title: The distribution of Tap2 alleles among laboratory rat RT1 haplotypes.
Volume: 40
Issue: 1
Pages: 45-53
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Publication
17244610 | J:121131
First Author: Papadopoulos M
Year: 2007
Journal: J Biol Chem
Title: Multiple residues in the transmembrane helix and connecting peptide of mouse tapasin stabilize the transporter associated with the antigen-processing TAP2 subunit.
Volume: 282
Issue: 13
Pages: 9401-10
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Allele
Tap2<em1Smoc> | MGI:7292685
Name: transporter 2, ATP-binding cassette, sub-family B (MDR/TAP); endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:6429639 | C57BL/6JSmoc-Tap2<em1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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HT Experiment
E-MTAB-12265 | Microarrays of flow cytometry sorted neural progenitor populations from SVZ of adult mouse brains
 
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: ArrayExpress
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DO Term
DOID:0060009 | MHC class I deficiency
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GO Term
GO:0042825 | TAP complex
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Allele
Tap2<M4Btlr> | MGI:6286077
Name: transporter 2, ATP-binding cassette, sub-family B (MDR/TAP); mutation 4, Bruce Beutler
Allele Type: Chemically induced (ENU)
Attribute String: Not Specified
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Strain
MGI:6286083 | C57BL/6J-Tap2<M4Btlr>
Attribute String: chemically induced mutation, coisogenic, mutant strain
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Genotype
Genotype
Symbol: Tap2/Tap2
Background: C57BL/6J-Tap2
Zygosity: hm
Has Mutant Allele: true
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Protein Coding Gene
MGI:98483 | Tap1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1201689 | Tapbp
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
10085102 | J:53897
First Author: Li S
Year: 1999
Journal: J Biol Chem
Title: Peptide-bound major histocompatibility complex class I molecules associate with tapasin before dissociation from transporter associated with antigen processing.
Volume: 274
Issue: 13
Pages: 8649-54
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Protein Coding Gene
MGI:95956 | H2-T22
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:95931 | H2-Q2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:95936 | H2-Q7
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1276527 | H2-M10.4
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2676637 | H2-M11
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:95917 | H2-M5
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:95928 | H2-Q1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:95935 | H2-Q6
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:95929 | H2-Q10
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2687364 | H2-M10.6
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:95914 | H2-M2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1276525 | H2-M10.2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1276522 | H2-M10.1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
8342042 | J:231213
First Author: Neefjes JJ
Year: 1993
Journal: Science
Title: Selective and ATP-dependent translocation of peptides by the MHC-encoded transporter.
Volume: 261
Issue: 5122
Pages: 769-71
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Protein Coding Gene
MGI:95896 | H2-D1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:95904 | H2-K1
Type: protein_coding_gene
Organism: mouse, laboratory
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Gene
6890 | TAP1
Type: gene
Organism: human
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Publication
12645939 | J:231206
First Author: Hewitt EW
Year: 2003
Journal: Eur J Immunol
Title: The ABC-transporter signature motif is required for peptide translocation but not peptide binding by TAP.
Volume: 33
Issue: 2
Pages: 422-7
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Publication
7809164 | J:22079
First Author: Schumacher TN
Year: 1994
Journal: Proc Natl Acad Sci U S A
Title: Transporters from H-2b, H-2d, H-2s, H-2k, and H-2g7 (NOD/Lt) haplotype translocate similar sets of peptides.
Volume: 91
Issue: 26
Pages: 13004-8
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Publication
10471785 | J:57293
First Author: Yamaguchi Y
Year: 1999
Journal: FEBS Lett
Title: An ABC transporter homologous to TAP proteins.
Volume: 457
Issue: 2
Pages: 231-6
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Publication
9271576 | -
First Author: Ortmann B
Year: 1997
Journal: Science
Title: A critical role for tapasin in the assembly and function of multimeric MHC class I-TAP complexes.
Volume: 277
Issue: 5330
Pages: 1306-9
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Publication
10382748 | -
First Author: Bangia N
Year: 1999
Journal: Eur J Immunol
Title: The N-terminal region of tapasin is required to stabilize the MHC class I loading complex.
Volume: 29
Issue: 6
Pages: 1858-70
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Publication
10636848 | -
First Author: Li S
Year: 2000
Journal: J Biol Chem
Title: Tapasin is required for efficient peptide binding to transporter associated with antigen processing.
Volume: 275
Issue: 3
Pages: 1581-6
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Publication
9238042 | -
First Author: Li S
Year: 1997
Journal: Proc Natl Acad Sci U S A
Title: Cloning and functional characterization of a subunit of the transporter associated with antigen processing.
Volume: 94
Issue: 16
Pages: 8708-13
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Protein Domain
IPR008056 | Tapasin
Type: Family
Description: Major histocompatibility complex (MHC) class I molecules present antigenic peptides to CD8 T cells. The majority of peptides found associated with class I molecules are derived from nuclear and cytosolic proteins, and they are generated largely by the proteasome complex. These peptides are transported from cytosol into the lumen of the endoplasmic reticulum (ER) by a peptide transporter, which is known as the transporter associated with antigen processing (TAP). TAP is a trimeric complex consisting of TAP1, TAP2 and tapasin (TAP-A). TAP1 and TAP2 are required for peptide transport. Tapasin, which actually serves as a docking site on the TAP complex specific for interaction with class I MHC molecules, is essential for peptide loading (up to four MHC class I-tapasin complexes have beenfound to bind to each TAP molecule). However, since the exact mechanisms oftapasin functions are still unknown, it has also been speculated thattapasin may regulate the MHC class I release from the ER rather than directly loading peptides onto MHC class I molecules [, , , ].In studies of the interaction between MHC class I and TAP, it was found that TAP1, but not TAP2, is required for the association of TAP with class I molecules. Because tapasin is essential for the association of MHC class I to TAP, tapasin may directly interact with TAP1. Thus the predicted order of interaction between different molecules in the TAP complex is TAP2 to TAP1, TAP1 to tapasin, and tapasin to MHC class I molecules. Thus, by these linked events, the translocation and loading of peptides rapidly and efficientlyproceed in the same microenvironment [, ].Tapasin is a type I transmembrane (TM) glycoprotein with a double lysinemotif that is thought to be involved with mediating the retrieval of proteins back from the cis-Golgi, thus maintaining membrane proteins in theER []. It is encoded by an MHC-linked gene and is a member of theimmunoglobulin superfamily. Binding to TAP is mediated by the C-terminalregion, whereas its N-terminal 50 residues constitute the key element thatconverts the MHC class I molecules and TAP weak interactions into a stablecomplex [, ].
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Protein Domain
IPR005293 | Tap2/ABCB3
Type: Family
Description: The ABC transporter family is a group of membrane proteins that use the hydrolysis of ATP to power the translocation of a wide variety of substrates across cellular membranes. ABC transporters minimally consist of two conserved regions: a highly conserved nucleotide-binding domain (NBD) and a less conserved transmembrane domain (TMD). Eukaryotic ABC proteins are usually organised either as full transporters (containing two NBDs and two TMDs), or as half transporters (containing one NBD and one TMD), that have to form homo- or heterodimers in order to constitute a functional protein [].This entry represents Tap2 (also known as antigen peptide transporter 2), which is an eukaryotic protein belonging to the ABC transporter family. It plays a crucial role in the processing and presentation of the MHC class I-restricted antigens. It is a half transporter that forms a complex with Tap1. This complex translocates antigens from the cytoplasm to the endoplasmic reticulum for loading onto MHC class I molecules [].
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Protein
Q5XW46
Organism: Mus musculus/domesticus
Length: 143  
Fragment?: true
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Publication
10846095 | J:126435
First Author: Kimura T
Year: 2000
Journal: J Virol
Title: The role of CD8(+) T cells and major histocompatibility complex class I expression in the central nervous system of mice infected with neurovirulent Sindbis virus.
Volume: 74
Issue: 13
Pages: 6117-25
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Publication
9317117 | J:43092
First Author: Salazar-Onfray F
Year: 1997
Journal: J Immunol
Title: Down-regulation of the expression and function of the transporter associated with antigen processing in murine tumor cell lines expressing IL-10.
Volume: 159
Issue: 7
Pages: 3195-202
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Publication
9521053 | J:46195
First Author: Herberg JA
Year: 1998
Journal: Eur J Immunol
Title: Genomic analysis of the Tapasin gene, located close to the TAP loci in the MHC.
Volume: 28
Issue: 2
Pages: 459-67
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Publication
15302165 | J:92342
First Author: Prasanna SJ
Year: 2004
Journal: Mol Immunol
Title: The MHC-encoded class I molecule, H-2Kk, demonstrates distinct requirements of assembly factors for cell surface expression: roles of TAP, Tapasin and beta2-microglobulin.
Volume: 41
Issue: 10
Pages: 1029-45
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Protein
Q5XW47
Organism: Mus musculus/domesticus
Length: 116  
Fragment?: true
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Publication
21205905 | -
First Author: Herget M
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Conformation of peptides bound to the transporter associated with antigen processing (TAP).
Volume: 108
Issue: 4
Pages: 1349-54
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Protein
Q9R233
Organism: Mus musculus/domesticus
Length: 465  
Fragment?: false
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Protein
Q91WI5
Organism: Mus musculus/domesticus
Length: 466  
Fragment?: false
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Protein
Q5XW49
Organism: Mus musculus/domesticus
Length: 464  
Fragment?: true
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Protein
Q3U7C1
Organism: Mus musculus/domesticus
Length: 291  
Fragment?: true
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Protein
Q5XW52
Organism: Mus musculus/domesticus
Length: 430  
Fragment?: true
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Protein
Q9D679
Organism: Mus musculus/domesticus
Length: 466  
Fragment?: false
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Protein
Q3TED6
Organism: Mus musculus/domesticus
Length: 465  
Fragment?: false
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Protein
Q8C6N4
Organism: Mus musculus/domesticus
Length: 260  
Fragment?: true
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Protein
Q5XW51
Organism: Mus musculus/domesticus
Length: 430  
Fragment?: true
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Protein
Q5XW48
Organism: Mus musculus/domesticus
Length: 454  
Fragment?: true
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Protein
A0A068BIS1
Organism: Mus musculus/domesticus
Length: 466  
Fragment?: false
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Protein
Q3U9A3
Organism: Mus musculus/domesticus
Length: 465  
Fragment?: false
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Protein
Q3TCU5
Organism: Mus musculus/domesticus
Length: 466  
Fragment?: false
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Protein
A6X8J6
Organism: Mus musculus/domesticus
Length: 91  
Fragment?: true
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Protein Coding Gene
MGI:95834 | Pdia3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P36371
Organism: Mus musculus/domesticus
Length: 702  
Fragment?: false
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Protein
Q3UA79
Organism: Mus musculus/domesticus
Length: 701  
Fragment?: false
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Protein
Q80WF7
Organism: Mus musculus/domesticus
Length: 702  
Fragment?: false
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Protein
Q3TXM1
Organism: Mus musculus/domesticus
Length: 702  
Fragment?: false
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Protein
A0A068BGU5
Organism: Mus musculus/domesticus
Length: 703  
Fragment?: false
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Publication
11441126 | -
First Author: Dean M
Year: 2001
Journal: J Lipid Res
Title: The human ATP-binding cassette (ABC) transporter superfamily.
Volume: 42
Issue: 7
Pages: 1007-17
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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