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Search results 201 to 293 out of 293 for Tdg

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Type Details Score
GXD Expression
GXD Expression
 
Probe: MGI:5304407
Assay Type: RNA in situ
Annotation Date: 2012-02-01
Strength: Strong
Sex: Male
Emaps: EMAPS:1929028
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:5304437
Age: postnatal day 40
Note: Expression is in the epithelium.
Specimen Label: 4C
Detected: true
Specimen Num: 17
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GXD Expression
GXD Expression
   
Probe: MGI:5829716
Assay Type: RNA in situ
Annotation Date: 2017-03-28
Strength: Absent
Sex: Male
Emaps: EMAPS:3273522
Stage: TS22
Assay Id: MGI:5829753
Age: embryonic day 14.5
Note: No staining was detected in the neural crest derivatives of the pelvic urethra.
Specimen Label: Supplementary Table E14.5 male
Detected: false
Specimen Num: 7
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•
GXD Expression
GXD Expression
   
Probe: MGI:5829716
Assay Type: RNA in situ
Annotation Date: 2017-03-28
Strength: Absent
Sex: Female
Emaps: EMAPS:3273522
Stage: TS22
Assay Id: MGI:5829753
Age: embryonic day 14.5
Note: No staining was detected in the neural crest derivatives of the pelvic urethra.
Specimen Label: Supplementary Table E14.5 female
Detected: false
Specimen Num: 8
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•
GXD Expression
GXD Expression
     
Probe: MGI:5304407
Assay Type: RNA in situ
Annotation Date: 2012-02-01
Strength: Absent
Sex: Female
Emaps: EMAPS:3102528
Stage: TS28
Assay Id: MGI:5304437
Age: postnatal day 40
Specimen Label: 4D
Detected: false
Specimen Num: 18
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•
GXD Expression
GXD Expression
   
Probe: MGI:5829716
Assay Type: RNA in situ
Annotation Date: 2017-03-28
Strength: Moderate
Sex: Female
Emaps: EMAPS:3610525
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:5829753
Age: embryonic day 17.5
Specimen Label: Supplementary Table E17.5 female
Detected: true
Specimen Num: 10
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•
GXD Expression
GXD Expression
   
Probe: MGI:5829716
Assay Type: RNA in situ
Annotation Date: 2017-03-28
Strength: Moderate
Sex: Female
Emaps: EMAPS:3610528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5829753
Age: postnatal day 5
Specimen Label: Supplementary Table P5 female
Detected: true
Specimen Num: 12
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•
GXD Expression
GXD Expression
     
Probe: MGI:5829716
Assay Type: RNA in situ
Annotation Date: 2017-03-28
Strength: Absent
Sex: Female
Emaps: EMAPS:3100328
Stage: TS28
Assay Id: MGI:5829753
Age: postnatal day 5
Specimen Label: Supplementary Table P5 female
Detected: false
Specimen Num: 12
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•
GXD Expression
GXD Expression
   
Probe: MGI:5304407
Assay Type: RNA in situ
Annotation Date: 2012-02-01
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1757722
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:5304437
Age: embryonic day 14.5
Specimen Label: 1A
Detected: true
Specimen Num: 3
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•
GXD Expression
GXD Expression
   
Probe: MGI:5304407
Assay Type: RNA in situ
Annotation Date: 2012-02-01
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1757726
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:5304437
Age: embryonic day 18.5
Specimen Label: 2B
Detected: true
Specimen Num: 8
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•
GXD Expression
GXD Expression
   
Probe: MGI:5304407
Assay Type: RNA in situ
Annotation Date: 2012-02-01
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1760522
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:5304437
Age: embryonic day 14.5
Specimen Label: 1A
Detected: true
Specimen Num: 3
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•
GXD Expression
GXD Expression
   
Probe: MGI:5304407
Assay Type: RNA in situ
Annotation Date: 2012-02-01
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3287322
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:5304437
Age: embryonic day 14.5
Specimen Label: 1D
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
 
Probe: MGI:5304407
Assay Type: RNA in situ
Annotation Date: 2012-02-01
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3287326
Pattern: Regionally restricted
Stage: TS26
Assay Id: MGI:5304437
Age: embryonic day 18.5
Note: Expression is in the most basal cell layer with the strongest expression is in crypt cells.
Specimen Label: 2B
Detected: true
Specimen Num: 8
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•
GXD Expression
GXD Expression
 
Probe: MGI:5304407
Assay Type: RNA in situ
Annotation Date: 2012-02-01
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3287326
Pattern: Regionally restricted
Stage: TS26
Assay Id: MGI:5304437
Age: embryonic day 18.5
Note: Expression is in the most basal cell layer with the strongest expression is in crypt cells.
Specimen Label: 3D
Detected: true
Specimen Num: 12
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GXD Expression
GXD Expression
   
Probe: MGI:5304407
Assay Type: RNA in situ
Annotation Date: 2012-02-01
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:5304437
Age: embryonic day 18.5
Specimen Label: 2B
Detected: true
Specimen Num: 8
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•
GXD Expression
GXD Expression
 
Probe: MGI:5829716
Assay Type: RNA in situ
Annotation Date: 2017-03-28
Strength: Weak
Sex: Male
Emaps: EMAPS:3090322
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5829753
Age: embryonic day 14.5
Note: Low expression was detected in the lamina propria, muscularis mucosa, submucosa, and muscularis propria.
Specimen Label: Supplementary Table E14.5 male
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
 
Probe: MGI:5829716
Assay Type: RNA in situ
Annotation Date: 2017-03-28
Strength: Weak
Sex: Female
Emaps: EMAPS:3090322
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5829753
Age: embryonic day 14.5
Note: Low expression was detected in the lamina propria, muscularis mucosa, submucosa, and muscularis propria.
Specimen Label: Supplementary Table E14.5 female
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
   
Probe: MGI:5829716
Assay Type: RNA in situ
Annotation Date: 2017-03-28
Strength: Moderate
Sex: Male
Emaps: EMAPS:2978625
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:5829753
Age: embryonic day 17.5
Specimen Label: Supplementary Table E17.5 male
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
   
Probe: MGI:5829716
Assay Type: RNA in situ
Annotation Date: 2017-03-28
Strength: Moderate
Sex: Male
Emaps: EMAPS:2978628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5829753
Age: postnatal day 5
Specimen Label: Supplementary Table P5 male
Detected: true
Specimen Num: 11
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GXD Expression
GXD Expression
     
Probe: MGI:5829716
Assay Type: RNA in situ
Annotation Date: 2017-03-28
Strength: Absent
Sex: Male
Emaps: EMAPS:3226225
Stage: TS25
Assay Id: MGI:5829753
Age: embryonic day 17.5
Specimen Label: Supplementary Table E17.5 male
Detected: false
Specimen Num: 9
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•
GXD Expression
GXD Expression
     
Probe: MGI:5829716
Assay Type: RNA in situ
Annotation Date: 2017-03-28
Strength: Absent
Sex: Male
Emaps: EMAPS:3226228
Stage: TS28
Assay Id: MGI:5829753
Age: postnatal day 5
Specimen Label: Supplementary Table P5 male
Detected: false
Specimen Num: 11
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GXD Expression
GXD Expression
     
Probe: MGI:5829716
Assay Type: RNA in situ
Annotation Date: 2017-03-28
Strength: Absent
Sex: Male
Emaps: EMAPS:3612625
Stage: TS25
Assay Id: MGI:5829753
Age: embryonic day 17.5
Specimen Label: Supplementary Table E17.5 male
Detected: false
Specimen Num: 9
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•
GXD Expression
GXD Expression
   
Probe: MGI:5829716
Assay Type: RNA in situ
Annotation Date: 2017-03-28
Strength: Weak
Sex: Male
Emaps: EMAPS:3612628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5829753
Age: postnatal day 5
Specimen Label: Supplementary Table P5 male
Detected: true
Specimen Num: 11
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GXD Expression
GXD Expression
   
Probe: MGI:5304407
Assay Type: RNA in situ
Annotation Date: 2012-02-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2672026
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:5304437
Age: embryonic day 18.5
Specimen Label: 2B
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
   
Probe: MGI:5304407
Assay Type: RNA in situ
Annotation Date: 2012-02-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2672026
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:5304437
Age: embryonic day 18.5
Specimen Label: 3B
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
   
Probe: MGI:5829716
Assay Type: RNA in situ
Annotation Date: 2017-03-28
Strength: Ambiguous
Sex: Female
Emaps: EMAPS:3816128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5829753
Age: postnatal day 5
Image: 5F
Specimen Label: 5F
Specimen Num: 6
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Publication
28426967 | J:256153
First Author: Weng YL
Year: 2017
Journal: Neuron
Title: An Intrinsic Epigenetic Barrier for Functional Axon Regeneration.
Volume: 94
Issue: 2
Pages: 337-346.e6
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Publication
24838012 | J:334511
First Author: Pfaffeneder T
Year: 2014
Journal: Nat Chem Biol
Title: Tet oxidizes thymine to 5-hydroxymethyluracil in mouse embryonic stem cell DNA.
Volume: 10
Issue: 7
Pages: 574-81
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Publication
15569683 | J:96947
First Author: Takahashi H
Year: 2005
Journal: J Biol Chem
Title: Noncovalent SUMO-1 binding activity of thymine DNA glycosylase (TDG) is required for its SUMO-1 modification and colocalization with the promyelocytic leukemia protein.
Volume: 280
Issue: 7
Pages: 5611-21
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Publication
20595612 | J:161356
First Author: Hajkova P
Year: 2010
Journal: Science
Title: Genome-wide reprogramming in the mouse germ line entails the base excision repair pathway.
Volume: 329
Issue: 5987
Pages: 78-82
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Publication
1631061 | J:33282
First Author: Chevray PM
Year: 1992
Journal: Proc Natl Acad Sci U S A
Title: Protein interaction cloning in yeast: identification of mammalian proteins that react with the leucine zipper of Jun.
Volume: 89
Issue: 13
Pages: 5789-93
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
23920106 | J:202864
First Author: Keil KP
Year: 2013
Journal: Gene Expr Patterns
Title: Catalog of mRNA expression patterns for DNA methylating and demethylating genes in developing mouse lower urinary tract.
Volume: 13
Issue: 8
Pages: 413-24
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Publication
- | J:73065
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
- | J:72245
       
First Author: GOA curators, MGI curators
Year: 2001
Title: Gene Ontology annotation based on Enzyme Commission mapping
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Publication
- | J:81858
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: Data Curation Using Mouse Genome Assembly
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
24529596 | J:266625
First Author: Hu X
Year: 2014
Journal: Cell Stem Cell
Title: Tet and TDG mediate DNA demethylation essential for mesenchymal-to-epithelial transition in somatic cell reprogramming.
Volume: 14
Issue: 4
Pages: 512-22
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Pathway
R-MMU-5221030 | TET1,2,3 and TDG demethylate DNA
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Protein
P56581
Organism: Mus musculus/domesticus
Length: 421  
Fragment?: false
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Pseudogene
MGI:3645587 | Tdg-ps
Type: pseudogene
Organism: mouse, laboratory
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Pseudogene
MGI_C57BL6J_3645587 | -
Type: pseudogene
Organism: mouse, laboratory
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HT Experiment
E-MTAB-6271 | DNA- and RNA-seq to study the impact of 5-formylcytosine on nucleosome organization and gene expression in embryonic mouse tissues and stem cells
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
GSE259242 | DCAF2 regulates the proliferation and differentiation of mouse progenitor spermatogonia by targeting p21 and thymine DNA glycosylase
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Protein Domain
IPR015637 | MUG/TDG
Type: Family
Description: G:U mismatches resulting from deamination of cytosine are the most common pro-mutagenic lesions occurring in DNA. Uracil is removed in a base-excision repair pathway by uracil DNA-glycosylase (UDG), which excises uracil from both single- and double-stranded DNA. The uracil DNA glycosylase family 2 consists of thymine DNA glycosylase (TDG) from eukaryotes and mismatch-specific uracil DNA glycosylase (MUG) from prokaryotes. Thymine DNA glycosylases (TDG) in eukaryotic organisms are known for their double-stranded glycosylase activity on guanine/uracil (G/U) base pairs []. In human TDG removes uracil and thymine from G:U and G:T mismatches in double-stranded DNA [, ]. In E. coli MUG is highly specific to G:U mismatches but also repairs G:T mismatches at high enzyme concentration. Structural studies of E. coli MUG reveal its structural homology to UDG despite low sequence identity. It has a specific uracil-binding pocket located in a DNA-binding groove and this specificity is likely the result of a multistep lesion recognition process [].
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Publication
24114270 | J:201964
First Author: Fu X
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: MicroRNA-26a targets ten eleven translocation enzymes and is regulated during pancreatic cell differentiation.
Volume: 110
Issue: 44
Pages: 17892-7
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Publication
26620559 | J:228936
First Author: Xue JH
Year: 2016
Journal: J Biol Chem
Title: Uracil-DNA Glycosylase UNG Promotes Tet-mediated DNA Demethylation.
Volume: 291
Issue: 2
Pages: 731-8
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Publication
32510763 | J:306854
First Author: Feng C
Year: 2020
Journal: EMBO Rep
Title: TCF20 dysfunction leads to cortical neurogenesis defects and autistic-like behaviors in mice.
Volume: 21
Issue: 8
Pages: e49239
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Publication
20696907 | J:163687
First Author: Hu XV
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Identification of RING finger protein 4 (RNF4) as a modulator of DNA demethylation through a functional genomics screen.
Volume: 107
Issue: 34
Pages: 15087-92
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Publication
19909758 | -
First Author: Zharkov DO
Year: 2010
Journal: Mutat Res
Title: Uracil-DNA glycosylase: Structural, thermodynamic and kinetic aspects of lesion search and recognition.
Volume: 685
Issue: 1-2
Pages: 11-20
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Publication
18789404 | -
First Author: Dong L
Year: 2008
Journal: DNA Repair (Amst)
Title: Repair of deaminated base damage by Schizosaccharomyces pombe thymine DNA glycosylase.
Volume: 7
Issue: 12
Pages: 1962-72
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Publication
22962365 | -
First Author: Hashimoto H
Year: 2012
Journal: Nucleic Acids Res
Title: Excision of 5-hydroxymethyluracil and 5-carboxylcytosine by the thymine DNA glycosylase domain: its structural basis and implications for active DNA demethylation.
Volume: 40
Issue: 20
Pages: 10203-14
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Publication
22327402 | -
First Author: Zhang L
Year: 2012
Journal: Nat Chem Biol
Title: Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA.
Volume: 8
Issue: 4
Pages: 328-30
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Protein Domain
IPR003310 | TDG-like_euk
Type: Family
Description: This entry includes a group of eukaryotic G/U mismatch-specific DNA glycosylases, including the uracil DNA glycosylase from fission yeasts and the thymine DNA glycosylase from animals. They excise the mismatched base from G:X mismatches, where X is uracil, thymine or 5-hydroxymethyluracil (5hmU). The mammalian thymine DNA glycosylase (TDG) may be involved in active DNA demethylation via the base excision repair pathway [, , ]. It can also act as a transcriptional co-activator or co-repressor [].G:U mismatches resulting from deamination of cytosine are the most common pro-mutagenic lesions occurring in DNA. Uracil is removed in a base-excision repair pathway by uracil DNA-glycosylase (UDG), which excises uracil from both single- and double-stranded DNA. The uracil DNA glycosylase family 2 consists of thymine DNA glycosylase (TDG) from eukaryotes and mismatch-specific uracil DNA glycosylase (MUG) from prokaryotes. Thymine DNA glycosylases (TDG) in eukaryotic organisms are known for their double-stranded glycosylase activity on guanine/uracil (G/U) base pairs []. In human TDG removes uracil and thymine from G:U and G:T mismatches in double-stranded DNA [, ]. In E. coli MUG is highly specific to G:U mismatches but also repairs G:T mismatches at high enzyme concentration. Structural studies of E. coli MUG reveal its structural homology to UDG despite low sequence identity. It has a specific uracil-binding pocket located in a DNA-binding groove and this specificity is likely the result of a multistep lesion recognition process [].
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Protein Domain
IPR023502 | MUG_bact
Type: Family
Description: G:U mismatches resulting from deamination of cytosine are the most common pro-mutagenic lesions occurring in DNA. Uracil is removed in a base-excision repair pathway by uracil DNA-glycosylase (UDG),which excises uracil from both single- and double-stranded DNA. The uracil DNA glycosylase family 2 consists of thymine DNA glycosylase (TDG) from eukaryotes and mismatch-specific uracil DNA glycosylase (MUG) from prokaryotes. Thymine DNA glycosylases (TDG) in eukaryotic organisms are known for their double-stranded glycosylase activity on guanine/uracil (G/U) base pairs []. In human TDG removes uracil and thymine from G:U and G:T mismatches in double-stranded DNA [, ]. In E. coli MUG is highly specific to G:U mismatches but also repairs G:T mismatches at high enzyme concentration. Structural studies of E. coli MUG reveal its structural homology to UDG despite low sequence identity. It has a specific uracil-binding pocket located in a DNA-binding groove and this specificity is likely the result of a multistep lesion recognition process [].This family represents the bacterial G/U mismatch-specific DNA glycosylase MUG.
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Publication
38837535 | J:361100
First Author: Wei H
Year: 2024
Journal: Cell Prolif
Title: DCAF2 regulates the proliferation and differentiation of mouse progenitor spermatogonia by targeting p21 and thymine DNA glycosylase.
Volume: 57
Issue: 10
Pages: e13676
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Publication
25845601 | J:231859
First Author: Li Z
Year: 2015
Journal: Nucleic Acids Res
Title: Gadd45a promotes DNA demethylation through TDG.
Volume: 43
Issue: 8
Pages: 3986-97
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Protein
Q9Z1T3
Organism: Mus musculus/domesticus
Length: 338  
Fragment?: true
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Protein
H3BJJ4
Organism: Mus musculus/domesticus
Length: 196  
Fragment?: true
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Publication
9489705 | -
First Author: Barrett TE
Year: 1998
Journal: Cell
Title: Crystal structure of a G:T/U mismatch-specific DNA glycosylase: mismatch recognition by complementary-strand interactions.
Volume: 92
Issue: 1
Pages: 117-29
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Publication
17590428 | J:125801
First Author: Sousa MM
Year: 2007
Journal: Mol Aspects Med
Title: DNA-uracil and human pathology.
Volume: 28
Issue: 3-4
Pages: 276-306
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Protein
H3BL22
Organism: Mus musculus/domesticus
Length: 208  
Fragment?: true
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Protein
D3Z417
Organism: Mus musculus/domesticus
Length: 186  
Fragment?: true
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Protein
H3BLR1
Organism: Mus musculus/domesticus
Length: 111  
Fragment?: true
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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