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Search results 201 to 300 out of 305 for Tlr6

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Type Details Score
Publication
26283364 | J:226711
First Author: Koymans KJ
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Structural basis for inhibition of TLR2 by staphylococcal superantigen-like protein 3 (SSL3).
Volume: 112
Issue: 35
Pages: 11018-23
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Publication
16785551 | J:134440
First Author: Jeyaseelan S
Year: 2006
Journal: J Immunol
Title: Toll/IL-1R domain-containing adaptor protein (TIRAP) is a critical mediator of antibacterial defense in the lung against Klebsiella pneumoniae but not Pseudomonas aeruginosa.
Volume: 177
Issue: 1
Pages: 538-47
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Publication
24723682 | J:213131
First Author: Hope C
Year: 2014
Journal: Blood
Title: TPL2 kinase regulates the inflammatory milieu of the myeloma niche.
Volume: 123
Issue: 21
Pages: 3305-15
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Publication
32052456 | J:304269
First Author: Zahoor A
Year: 2020
Journal: J Cell Physiol
Title: Gas6 negatively regulates the Staphylococcus aureus-induced inflammatory response via TLR signaling in the mouse mammary gland.
Volume: 235
Issue: 10
Pages: 7081-7093
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Publication
28684329 | J:252734
First Author: Jang YH
Year: 2017
Journal: J Invest Dermatol
Title: House Dust Mite Increases pro-Th2 Cytokines IL-25 and IL-33 via the Activation of TLR1/6 Signaling.
Volume: 137
Issue: 11
Pages: 2354-2361
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Publication
24778236 | J:211069
First Author: Huh JW
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: UNC93B1 is essential for the plasma membrane localization and signaling of Toll-like receptor 5.
Volume: 111
Issue: 19
Pages: 7072-7
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Publication
11739561 | J:114018
First Author: McCurdy JD
Year: 2001
Journal: J Leukoc Biol
Title: Toll-like receptor 4-mediated activation of murine mast cells.
Volume: 70
Issue: 6
Pages: 977-84
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Publication
18187448 | J:131083
First Author: Rousseau S
Year: 2008
Journal: J Cell Sci
Title: TPL2-mediated activation of ERK1 and ERK2 regulates the processing of pre-TNF alpha in LPS-stimulated macrophages.
Volume: 121
Issue: Pt 2
Pages: 149-54
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Publication
17312161 | J:144304
First Author: Mayer AK
Year: 2007
Journal: J Immunol
Title: Differential recognition of TLR-dependent microbial ligands in human bronchial epithelial cells.
Volume: 178
Issue: 5
Pages: 3134-42
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Publication
17082324 | J:144455
First Author: Satta N
Year: 2007
Journal: Blood
Title: The role of TLR2 in the inflammatory activation of mouse fibroblasts by human antiphospholipid antibodies.
Volume: 109
Issue: 4
Pages: 1507-14
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Publication
20347487 | J:160633
First Author: Pore D
Year: 2010
Journal: Mol Immunol
Title: 34 kDa MOMP of Shigella flexneri promotes TLR2 mediated macrophage activation with the engagement of NF-kappaB and p38 MAP kinase signaling.
Volume: 47
Issue: 9
Pages: 1739-46
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Publication
22451944 | J:183538
First Author: Schroder K
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages.
Volume: 109
Issue: 16
Pages: E944-53
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Publication
21385270 | J:187557
First Author: Rose JA
Year: 2011
Journal: Am J Reprod Immunol
Title: Peptidoglycan induces necrosis and regulates cytokine production in murine trophoblast stem cells.
Volume: 66
Issue: 3
Pages: 209-22
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Publication
26786104 | J:233729
First Author: Westwell-Roper C
Year: 2016
Journal: J Biol Chem
Title: Differential Activation of Innate Immune Pathways by Distinct Islet Amyloid Polypeptide (IAPP) Aggregates.
Volume: 291
Issue: 17
Pages: 8908-17
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Publication
34866574 | J:317266
   
First Author: Khan S
Year: 2021
Journal: Elife
Title: SARS-CoV-2 spike protein induces inflammation via TLR2-dependent activation of the NF-κB pathway.
Volume: 10
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Publication
10426995 | -
First Author: Brightbill HD
Year: 1999
Journal: Science
Title: Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors.
Volume: 285
Issue: 5428
Pages: 732-6
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Publication
21813774 | J:179271
First Author: Mattos KA
Year: 2011
Journal: J Immunol
Title: TLR6-driven lipid droplets in Mycobacterium leprae-infected Schwann cells: immunoinflammatory platforms associated with bacterial persistence.
Volume: 187
Issue: 5
Pages: 2548-58
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Publication
32747017 | J:303590
First Author: Zahoor A
Year: 2020
Journal: Immunobiology
Title: MerTK negatively regulates Staphylococcus aureus induced inflammatory response via SOCS1/SOCS3 and Mal.
Volume: 225
Issue: 4
Pages: 151960
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Publication
17040905 | J:117607
First Author: Wang J
Year: 2006
Journal: J Biol Chem
Title: The functional effects of physical interactions among Toll-like receptors 7, 8, and 9.
Volume: 281
Issue: 49
Pages: 37427-34
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Publication
18931363 | J:143565
First Author: Banerjee P
Year: 2008
Journal: Int Immunol
Title: Porin-incorporated liposome induces Toll-like receptors 2- and 6-dependent maturation and type 1 response of dendritic cell.
Volume: 20
Issue: 12
Pages: 1551-63
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Publication
17457343 | -
First Author: O'Neill LA
Year: 2007
Journal: Nat Rev Immunol
Title: The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling.
Volume: 7
Issue: 5
Pages: 353-64
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Publication
18227810 | -
First Author: Leulier F
Year: 2008
Journal: Nat Rev Genet
Title: Toll-like receptors--taking an evolutionary approach.
Volume: 9
Issue: 3
Pages: 165-78
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Publication
16822173 | -
 
First Author: West AP
Year: 2006
Journal: Annu Rev Cell Dev Biol
Title: Recognition and signaling by toll-like receptors.
Volume: 22
Pages: 409-37
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Publication
9039775 | -
First Author: Medzhitov R
Year: 1997
Journal: Curr Opin Immunol
Title: Innate immunity: impact on the adaptive immune response.
Volume: 9
Issue: 1
Pages: 4-9
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Publication
16675322 | -
First Author: Kaisho T
Year: 2006
Journal: J Allergy Clin Immunol
Title: Toll-like receptor function and signaling.
Volume: 117
Issue: 5
Pages: 979-87; quiz 988
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Publication
21741580 | -
First Author: Moresco EM
Year: 2011
Journal: Curr Biol
Title: Toll-like receptors.
Volume: 21
Issue: 13
Pages: R488-93
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Publication
2449285 | -
First Author: Hashimoto C
Year: 1988
Journal: Cell
Title: The Toll gene of Drosophila, required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein.
Volume: 52
Issue: 2
Pages: 269-79
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Publication
2124970 | -
First Author: Keith FJ
Year: 1990
Journal: EMBO J
Title: The Drosophila membrane receptor Toll can function to promote cellular adhesion.
Volume: 9
Issue: 13
Pages: 4299-306
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Publication
8808632 | -
First Author: Lemaitre B
Year: 1996
Journal: Cell
Title: The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults.
Volume: 86
Issue: 6
Pages: 973-83
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Publication
12872120 | -
First Author: Weber AN
Year: 2003
Journal: Nat Immunol
Title: Binding of the Drosophila cytokine Spätzle to Toll is direct and establishes signaling.
Volume: 4
Issue: 8
Pages: 794-800
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Publication
11135568 | -
First Author: Beutler B
Year: 2001
Journal: Nat Immunol
Title: Toll we meet again....
Volume: 2
Issue: 1
Pages: 9-10
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Publication
12888789 | -
First Author: Underhill D
Year: 2003
Journal: Nat Immunol
Title: Toll gets tied in a knot.
Volume: 4
Issue: 8
Pages: 723-4
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Protein Domain
IPR017241 | Toll-like_receptor
Type: Family
Description: This entry represents toll-like receptors (TLRs), which are key regulators of immune responses. They recognise pathogen-associated molecular patterns (PAMPs) such as bacterial lipopeptides (TLR1/2/6), bacterial flagellin (TLR5), and lipopolysaccharide (TLR4) []. In highervertebrates, TLRs are essential not only for sensing microbes by the innate immune system, but also for inducing adaptive immune system responses mediated by B and T cells [].TLRs are expressed at the cell membrane and in subcellular compartments such as the endosome. TLRs are type-I transmembrane proteins with extracellular leucine-rich repeat (LRR) motifs and an intracellular Toll/interleukin-1 receptor (TIR) domain. Members of the TLR family contribute both to cell-cell interactions and to signalling, linking extracellular signals to specific gene-expression programmes [, ]. Binding of ligands to the extracellular domains causes rearrangement of the receptor complexes and triggers the recruitment of specific adaptor proteins to the intracellular TIR domain, leading to nuclear factor-kappa B (NF-kappaB) activation and initiation of both innate and adaptive immune responses. Signalling by TLRs involves five adaptor proteins known as MyD88, MAL, TRIF, TRAM and SARM []. TLRs form homodimers or heterodimers induced by the binding of ligands to residues in the LRRs of distinct receptor chains. In mice and humans combined there are 13 paralogous TLRs; 10 in humans and 12 in mice. TLR10 is only present in humans, and TLR11-13 are only present in mice []. This entry represents some toll-like receptors, which includes TLR1, TLR2, TLR4, TLR5, TLR6 and TLR10.In Drosophila, the Toll receptor plays a role in development as well as immunity [, ]. Toll is a component of the extracellular signaling pathway that establishes the dorsal-ventral pathway of the embryo []. Three proteases; ndl, gd and snk process easter to create active easter. Active easter defines cell identities along the dorsal-ventral continuum by activating the Spz ligand for the Tl receptor in the ventral region of the embryo []. Toll promotes heterophilic cellular adhesion []. The Drosophila Toll receptor is essential in initiating innate immune defenses to fungi and Gram-positive bacteria in adult flies []. Spz C-106 in the hemolymph controls expression of the antifungal peptide Drosomycin (Drs) by acting as a ligand of Tl and inducing an intracellular signaling pathway [].
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Protein
F2Z425
Organism: Mus musculus/domesticus
Length: 86  
Fragment?: false
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Protein
E9Q009
Organism: Mus musculus/domesticus
Length: 105  
Fragment?: false
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Protein
A2BHU8
Organism: Mus musculus/domesticus
Length: 154  
Fragment?: false
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Protein
Q9QUN7
Organism: Mus musculus/domesticus
Length: 784  
Fragment?: false
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Protein
Q811T5
Organism: Mus musculus/domesticus
Length: 784  
Fragment?: false
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Protein
Q8K3D9
Organism: Mus musculus/domesticus
Length: 784  
Fragment?: false
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Protein
G3X8Y8
Organism: Mus musculus/domesticus
Length: 784  
Fragment?: false
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Protein
Q62192
Organism: Mus musculus/domesticus
Length: 661  
Fragment?: false
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Protein
Q3U0U7
Organism: Mus musculus/domesticus
Length: 661  
Fragment?: false
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Protein
Q8C2X8
Organism: Mus musculus/domesticus
Length: 180  
Fragment?: true
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Protein
Q6R5N8
Organism: Mus musculus/domesticus
Length: 991  
Fragment?: false
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Protein
Q99MB1
Organism: Mus musculus/domesticus
Length: 905  
Fragment?: false
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Protein
Q6R5P0
Organism: Mus musculus/domesticus
Length: 926  
Fragment?: false
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Protein
Q9EPQ1
Organism: Mus musculus/domesticus
Length: 795  
Fragment?: false
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Protein
Q9QUK6
Organism: Mus musculus/domesticus
Length: 835  
Fragment?: false
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Protein
Q6QNU9
Organism: Mus musculus/domesticus
Length: 906  
Fragment?: false
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Protein
Q9JLF7
Organism: Mus musculus/domesticus
Length: 859  
Fragment?: false
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Protein
U5LHT3
Organism: Mus musculus/domesticus
Length: 749  
Fragment?: true
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Protein
V9PC74
Organism: Mus musculus/domesticus
Length: 748  
Fragment?: true
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Protein
U5LIX2
Organism: Mus musculus/domesticus
Length: 749  
Fragment?: true
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Protein
V9PCB9
Organism: Mus musculus/domesticus
Length: 748  
Fragment?: true
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Protein
U5LIT5
Organism: Mus musculus/domesticus
Length: 749  
Fragment?: true
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Protein
U5LL62
Organism: Mus musculus/domesticus
Length: 749  
Fragment?: true
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Protein
V9PC79
Organism: Mus musculus/domesticus
Length: 748  
Fragment?: true
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Protein
V9PCD3
Organism: Mus musculus/domesticus
Length: 748  
Fragment?: true
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Protein
V9PC30
Organism: Mus musculus/domesticus
Length: 748  
Fragment?: true
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Protein
V9PC06
Organism: Mus musculus/domesticus
Length: 748  
Fragment?: true
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Protein
V9PCB6
Organism: Mus musculus/domesticus
Length: 748  
Fragment?: true
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Protein
V9PC22
Organism: Mus musculus/domesticus
Length: 748  
Fragment?: true
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Protein
V9PC08
Organism: Mus musculus/domesticus
Length: 748  
Fragment?: true
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Protein
Q05AH3
Organism: Mus musculus/domesticus
Length: 859  
Fragment?: false
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Protein
Q3U4D4
Organism: Mus musculus/domesticus
Length: 835  
Fragment?: false
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Protein
U5LIT9
Organism: Mus musculus/domesticus
Length: 749  
Fragment?: true
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Protein
V9PBW6
Organism: Mus musculus/domesticus
Length: 748  
Fragment?: true
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Protein
Q3TM31
Organism: Mus musculus/domesticus
Length: 905  
Fragment?: false
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Protein
V9PBV4
Organism: Mus musculus/domesticus
Length: 748  
Fragment?: true
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Protein
U5LL15
Organism: Mus musculus/domesticus
Length: 749  
Fragment?: true
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Protein
A0A0A6YVY4
Organism: Mus musculus/domesticus
Length: 873  
Fragment?: false
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Protein
Q499F3
Organism: Mus musculus/domesticus
Length: 905  
Fragment?: false
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Protein
L0CL36
Organism: Mus musculus/domesticus
Length: 835  
Fragment?: false
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Protein
V9PC21
Organism: Mus musculus/domesticus
Length: 748  
Fragment?: true
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Protein
V9PBW8
Organism: Mus musculus/domesticus
Length: 748  
Fragment?: true
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Protein
V9PC89
Organism: Mus musculus/domesticus
Length: 748  
Fragment?: true
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Protein
U5LHT6
Organism: Mus musculus/domesticus
Length: 749  
Fragment?: true
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Protein
Q32ME8
Organism: Mus musculus/domesticus
Length: 926  
Fragment?: false
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Protein
Q6A0E8
Organism: Mus musculus/domesticus
Length: 727  
Fragment?: true
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Protein
L0CMZ8
Organism: Mus musculus/domesticus
Length: 835  
Fragment?: false
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Protein
Q8K2T5
Organism: Mus musculus/domesticus
Length: 835  
Fragment?: false
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Protein
Q8CB40
Organism: Mus musculus/domesticus
Length: 853  
Fragment?: true
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Protein
V9GWT0
Organism: Mus musculus/domesticus
Length: 931  
Fragment?: false
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Protein
A2RRZ9
Organism: Mus musculus/domesticus
Length: 906  
Fragment?: false
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Protein
V9PC13
Organism: Mus musculus/domesticus
Length: 748  
Fragment?: true
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Protein
V9PC15
Organism: Mus musculus/domesticus
Length: 748  
Fragment?: true
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Protein
Q3UPN5
Organism: Mus musculus/domesticus
Length: 604  
Fragment?: true
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Protein
V9PBZ6
Organism: Mus musculus/domesticus
Length: 748  
Fragment?: true
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Protein
B9EJ46
Organism: Mus musculus/domesticus
Length: 795  
Fragment?: false
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Protein
V9PCC9
Organism: Mus musculus/domesticus
Length: 748  
Fragment?: true
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Protein
U5LL67
Organism: Mus musculus/domesticus
Length: 749  
Fragment?: true
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Protein
Q1ZZX0
Organism: Mus musculus/domesticus
Length: 859  
Fragment?: false
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Protein
V9PCD6
Organism: Mus musculus/domesticus
Length: 748  
Fragment?: true
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Protein
V9PC69
Organism: Mus musculus/domesticus
Length: 748  
Fragment?: true
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Protein
V9PCC4
Organism: Mus musculus/domesticus
Length: 748  
Fragment?: true
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Protein
V9PC34
Organism: Mus musculus/domesticus
Length: 748  
Fragment?: true
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Protein
V9PC11
Organism: Mus musculus/domesticus
Length: 748  
Fragment?: true
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Protein
V9PC02
Organism: Mus musculus/domesticus
Length: 748  
Fragment?: true
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Protein
V9PBW5
Organism: Mus musculus/domesticus
Length: 748  
Fragment?: true
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Protein
V9PC40
Organism: Mus musculus/domesticus
Length: 748  
Fragment?: true
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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Cambridge CB2 3EH, United Kingdom