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Search results 201 to 254 out of 254 for Tmem106b

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Type Details Score
Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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HT Experiment
GSE165105 | Loss of Tmem106b leads to cerebellum Purkinje cell death and motor deficits
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
27126638 | J:236991
First Author: Busch JI
Year: 2016
Journal: Hum Mol Genet
Title: Increased expression of the frontotemporal dementia risk factor TMEM106B causes C9orf72-dependent alterations in lysosomes.
Volume: 25
Issue: 13
Pages: 2681-2697
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Allele
Tmem106b<em1Smoc> | MGI:7292832
Name: transmembrane protein 106B; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Publication
34347309 | -
First Author: Levine TP
Year: 2022
Journal: Proteins
Title: TMEM106B in humans and Vac7 and Tag1 in yeast are predicted to be lipid transfer proteins.
Volume: 90
Issue: 1
Pages: 164-175
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Publication
24357581 | -
First Author: Schwenk BM
Year: 2014
Journal: EMBO J
Title: The FTLD risk factor TMEM106B and MAP6 control dendritic trafficking of lysosomes.
Volume: 33
Issue: 5
Pages: 450-67
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Strain
MGI:6771218 | C57BL/6JSmoc-Tmem106b<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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DO Term
DOID:0070405 | hypomyelinating leukodystrophy 16
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Protein
Q8VC04
Organism: Mus musculus/domesticus
Length: 261  
Fragment?: false
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Protein
Q80X71
Organism: Mus musculus/domesticus
Length: 275  
Fragment?: false
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Protein
Q80VP8
Organism: Mus musculus/domesticus
Length: 260  
Fragment?: false
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Protein
D3Z0M2
Organism: Mus musculus/domesticus
Length: 93  
Fragment?: true
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Protein
D3Z191
Organism: Mus musculus/domesticus
Length: 185  
Fragment?: true
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Protein
A2A4M9
Organism: Mus musculus/domesticus
Length: 156  
Fragment?: true
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Protein
A2A4N0
Organism: Mus musculus/domesticus
Length: 171  
Fragment?: true
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Protein
A0A2R8W6L2
Organism: Mus musculus/domesticus
Length: 116  
Fragment?: true
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Protein
Q9D3D8
Organism: Mus musculus/domesticus
Length: 121  
Fragment?: false
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Protein
A0A2R8VJM7
Organism: Mus musculus/domesticus
Length: 165  
Fragment?: true
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Protein
A0A2R8VHS8
Organism: Mus musculus/domesticus
Length: 166  
Fragment?: true
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Protein
D3Z6E0
Organism: Mus musculus/domesticus
Length: 70  
Fragment?: true
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Publication
29131025 | -
First Author: Wu C
Year: 2017
Journal: Kidney Blood Press Res
Title: TMEM106a is a Novel Tumor Suppressor in Human Renal Cancer.
Volume: 42
Issue: 5
Pages: 853-864
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Publication
30456879 | -
     
First Author: Liu J
Year: 2018
Journal: J Cell Biochem
Title: TMEM106A inhibits cell proliferation, migration, and induces apoptosis of lung cancer cells.
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Publication
23136129 | -
First Author: Brady OA
Year: 2013
Journal: Hum Mol Genet
Title: The frontotemporal lobar degeneration risk factor, TMEM106B, regulates lysosomal morphology and function.
Volume: 22
Issue: 4
Pages: 685-95
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Protein Domain
IPR009790 | TMEM106
Type: Family
Description: This family includes Transmembrane protein 106A/B/C, type II transmembrane proteins which have homology to the late embryogenesis abundant-2 (LEA-2) domain []. TMEM106A has been identified as a key factor to regulate macrophage activation and a tumor suppressor in gastric, renal cancer and nonsmall-cell lung carcinoma (NSCLC), being an interesting therapeutic target for the management of NSCLC [, ]. TMEM106B localises to late endosomes and lysosomes, and it is involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with MAP6 []. Its overexpression is associated with familial frontotemporal lobar degeneration []. It has also been identified as a protein required for productive SARS-CoV-2 infection []. Structural analysis of LEA-2 domains revealed that they have a long, conserved lipid-binding groove, implying that TMEM106B and its homologues, Vac7 and Tag1 from yeast, may all be lipid transfer proteins in the lumen of late endocytic organelles.
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Publication
9372916 | -
First Author: Bonangelino CJ
Year: 1997
Journal: Mol Cell Biol
Title: Vac7p, a novel vacuolar protein, is required for normal vacuole inheritance and morphology.
Volume: 17
Issue: 12
Pages: 6847-58
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Publication
11950935 | -
First Author: Gary JD
Year: 2002
Journal: Mol Biol Cell
Title: Regulation of Fab1 phosphatidylinositol 3-phosphate 5-kinase pathway by Vac7 protein and Fig4, a polyphosphoinositide phosphatase family member.
Volume: 13
Issue: 4
Pages: 1238-51
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Publication
23267013 | J:194595
First Author: Beisner DR
Year: 2013
Journal: J Exp Med
Title: The intramembrane protease Sppl2a is required for B cell and DC development and survival via cleavage of the invariant chain.
Volume: 210
Issue: 1
Pages: 23-30
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Publication
24872421 | -
First Author: Brady OA
Year: 2014
Journal: J Biol Chem
Title: Regulated intramembrane proteolysis of the frontotemporal lobar degeneration risk factor, TMEM106B, by signal peptide peptidase-like 2a (SPPL2a).
Volume: 289
Issue: 28
Pages: 19670-80
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Protein Domain
IPR024260 | Vac7
Type: Family
Description: Vac7 is localised at the vacuole membrane, a location which is consistent with its involvement in vacuole morphology and inheritance []. Vac7 has been shown to function as an upstream regulator of the Fab1 lipid kinase pathway []. The Fab1 lipid pathway is important for correct regulation of membrane trafficking events. It has been identified as a LEA-2homologue together with TMEM106B from humans and Tag1 in yeast, all predicted to be lipid transfer proteins [].
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Protein Domain
IPR033151 | SPPL2a
Type: Family
Description: Signal peptide peptidase-like 2a (MEROPS identifier A22.007) is an intramembrane peptidase that performs regulated intramembrane proteolysis, particularly on single pass type II transmembrane proteins. It is predominantly localized to late endosomes and lysosomes because of a C-terminal tyrosine motif []. SPPL2a cleaves the N-terminal fragment of the invariant chain, and is essential for B-cell development []. The membrane stump, following shedding of the ectodomain, of frontotemporal lobar degeneration risk factor TMEM106B is also a substrate [].
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Publication
33536246 | -
 
First Author: Kira S
Year: 2021
Journal: J Cell Sci
Title: Vacuolar protein Tag1 and Atg1-Atg13 regulate autophagy termination during persistent starvation in S. cerevisiae.
Volume: 134
Issue: 4
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Protein Domain
IPR046368 | Tag1
Type: Family
Description: This fungal family includes Tag1 (also known as YLR173W), a vacuolar membrane protein involved in termination of autophagy. It regulates autophagy termination during persistent nitrogen starvation through Atg1p-mediated re-phosphorylation of Atg13p and PAS disassembly [, ]. This is a type II membrane protein containing a hydrophobic transmembrane region, with the N-terminal region oriented toward the cytosol and the C-terminal inside the lumen, which is glycosylated. Tag1, together with Vac7 from yeast and TMEM106B from humans, has homology with LEA-2 domain. It has three tandemly repeated LEA-2 domains [].
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Publication
12231625 | J:79099
First Author: Andrieux A
Year: 2002
Journal: Genes Dev
Title: The suppression of brain cold-stable microtubules in mice induces synaptic defects associated with neuroleptic-sensitive behavioral disorders.
Volume: 16
Issue: 18
Pages: 2350-64
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Publication
28521134 | J:250438
First Author: Tortosa E
Year: 2017
Journal: Neuron
Title: Dynamic Palmitoylation Targets MAP6 to the Axon to Promote Microtubule Stabilization during Neuronal Polarization.
Volume: 94
Issue: 4
Pages: 809-825.e7
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Protein
Q7TSJ2
Organism: Mus musculus/domesticus
Length: 906  
Fragment?: false
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Protein
Q14BB9
Organism: Mus musculus/domesticus
Length: 191  
Fragment?: false
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Protein
D3Z6W1
Organism: Mus musculus/domesticus
Length: 509  
Fragment?: false
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Protein
A0A140LIT9
Organism: Mus musculus/domesticus
Length: 703  
Fragment?: false
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Publication
16806091 | -
First Author: Andrieux A
Year: 2006
Journal: Biol Psychiatry
Title: Microtubule stabilizer ameliorates synaptic function and behavior in a mouse model for schizophrenia.
Volume: 60
Issue: 11
Pages: 1224-30
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Protein Domain
IPR007882 | MAP6
Type: Family
Description: Microtubule-associated protein6 (MAP6) is a calmodulin binding protein that is involved in microtubule stabilisation []. Neurons contain abundant subsets of highly stable microtubules that resist de-polymerising conditions such as exposure to the cold. Stable microtubules are thought to be essential for neuronal development, maintenance, and function. MAP6 is a major factor responsible for the intriguing stability properties of neuronal microtubules and is important for synaptic plasticity []. It regulates axonal growth during neuron polarization, which is controlled by a palmitoylation cycle []. MAP6 interacts with TMEM106B, and this interaction is crucial for controlling dendritic trafficking of lysosomes, presumably by acting as a molecular brake for retrograde transport []. TMEM106B is a major risk factor for frontotemporal lobar degeneration with TDP-43 pathology.
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Publication
26358247 | J:288981
First Author: Clayton EL
Year: 2015
Journal: Acta Neuropathol
Title: Frontotemporal dementia caused by CHMP2B mutation is characterised by neuronal lysosomal storage pathology.
Volume: 130
Issue: 4
Pages: 511-23
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Publication
21896273 | J:176424
First Author: Behnke J
Year: 2011
Journal: FEBS Lett
Title: Signal-peptide-peptidase-like 2a (SPPL2a) is targeted to lysosomes/late endosomes by a tyrosine motif in its C-terminal tail.
Volume: 585
Issue: 19
Pages: 2951-7
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Protein
F6RJQ8
Organism: Mus musculus/domesticus
Length: 253  
Fragment?: true
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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