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Search results 201 to 241 out of 241 for Tnfrsf4

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0.019s

Type

Details

Score

Publication

- | J:90438

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2005

Title:	Obtaining and loading genome assembly coordinates from NCBI annotations

•

Publication

- | J:144087

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2009
Journal:	Database Download
Title:	Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform

•

Allele

Tg(Tnfrsf4-cre)1Nik | MGI:3487294

Name:	transgene insertion 1, Nigel Killeen
Allele Type:	Transgenic
Attribute String:	Recombinase

•

Allele

Tnfrsf4<em2Smoc> | MGI:7292891

Name:	tumor necrosis factor receptor superfamily, member 4; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type:	Endonuclease-mediated
Attribute String:	Null/knockout

•

Strain

MGI:6355290 | C57BL/6JSmoc-Tnfrsf4<em2Smoc>/Smoc

Attribute String:

coisogenic, mutant strain, endonuclease-mediated mutation

•

DO Term

DOID:0111935 | immunodeficiency 16

•

Allele

Tnfrsf4<tm1Nik> | MGI:1859871

Name:	tumor necrosis factor receptor superfamily, member 4; targeted mutation 1, Nigel Killeen
Allele Type:	Targeted
Attribute String:	Null/knockout

•

Genotype

Symbol:	Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Tnfrsf4-cre)1Nik/?
Background:	B6.129-Tnfrsf4 Gt(ROSA)26Sor
Zygosity:	cn
Has Mutant Allele:	true

•

Strain

MGI:4442212 | B6.129S4-Tnfrsf4<tm1Nik>/J

Attribute String:

targeted mutation, mutant strain, congenic

•

Genotype

Symbol:	Tnfrsf4/Tnfrsf4
Background:	involves: 129S4/SvJae * C57BL/6
Zygosity:	hm
Has Mutant Allele:	true

•

Genotype

Symbol:	Gata3/Gata3 Tg(Tnfrsf4-cre)1Nik/?
Background:	involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity:	cn
Has Mutant Allele:	true

•

Publication

24167278 | J:202891

First Author:	Hosokawa H
Year:	2013
Journal:	Proc Natl Acad Sci U S A
Title:	Gata3/Ruvbl2 complex regulates T helper 2 cell proliferation via repression of Cdkn2c expression.
Volume:	110
Issue:	46
Pages:	18626-31

•

Publication

18059267 | -

First Author:	Cunninghame Graham DS
Year:	2008
Journal:	Nat Genet
Title:	Polymorphism at the TNF superfamily gene TNFSF4 confers susceptibility to systemic lupus erythematosus.
Volume:	40
Issue:	1
Pages:	83-9

•

Protein Domain

IPR042338 | TNFSF4

Type:

Family

Description:

TNFSF4 (also known as OX40L) is a cytokine that binds to its unique receptor, TNFRSF4 [].Cytokines can be grouped into a family on the basis of sequence, functional and structural similarities [, , ]. Tumor necrosis factor (TNF) (also known as TNF-alpha or cachectin) is a monocyte-derived cytotoxin that has been implicated in tumour regression, septic shock and cachexia [, ]. The protein is synthesised as a prohormone with an unusually long and atypical signal sequence, which is absent from the mature secreted cytokine []. A short hydrophobic stretch of amino acids serves to anchor the prohormone in lipid bilayers []. Both the mature protein and a partially-processed form of the hormone are secreted after cleavage of the propeptide [].There are a number of different families of TNF, but all these cytokines seem to form homotrimeric (or heterotrimeric in the case of LT-alpha/beta) complexes that are recognised by their specific receptors.

•

Publication

18178845 | J:130983

First Author:	Pai SY
Year:	2008
Journal:	J Immunol
Title:	Distinct structural requirements of GATA-3 for the regulation of thymocyte and Th2 cell differentiation.
Volume:	180
Issue:	2
Pages:	1050-9

•

Publication

18498346 | J:144443

First Author:	Moncrieffe H
Year:	2008
Journal:	Immunology
Title:	The influence of CD4 T-cell subsets on control of CD4 T-cell-mediated graft-versus-host disease.
Volume:	125
Issue:	4
Pages:	459-68

•

Publication

19760068 | -

First Author:	Gough MJ
Year:	2009
Journal:	Adv Exp Med Biol
Title:	OX40 (CD134) and OX40L.
Volume:	647

Pages:	94-107

•

Publication

15173831 | -

First Author:	Sugamura K
Year:	2004
Journal:	Nat Rev Immunol
Title:	Therapeutic targeting of the effector T-cell co-stimulatory molecule OX40.
Volume:	4
Issue:	6
Pages:	420-31

•

Publication

9488716 | J:46205

First Author:	Kawamata S
Year:	1998
Journal:	J Biol Chem
Title:	Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-associated factor (TRAF) 2- and TRAF5-mediated NF-kappaB activation.
Volume:	273
Issue:	10
Pages:	5808-14

•

Publication

27519474 | -

First Author:	Chua KH
Year:	2016
Journal:	Int J Immunogenet
Title:	TNFSF4 polymorphisms are associated with systemic lupus erythematosus in the Malaysian population.
Volume:	43
Issue:	5
Pages:	303-9

•

Protein Domain

IPR034022 | TNFRSF4_N

Type:

Domain

Description:

Tumor necrosis factor receptor superfamily member 4 (TNFRSF4), also known as OX40, ACT35, CD134, IMD16 or TXGP1L, activates NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5 []. It also promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis []. It is primarily expressed on activated CD4+ and CD8+ T cells, where it is transiently expressed and upregulated on the most recently antigen-activated T cells within inflammatory lesions. This makes it an attractive target to modulate immune responses, i.e. TNFRSF4 (OX40) blocking agents to inhibit adverse inflammation or agonists to enhance immune responses [, ]. An artificially created biologic fusion protein, OX40-immunoglobulin (OX40-Ig), prevents OX40 from reaching the T-cell receptors, thus reducing the T-cell response. Some single nucleotide polymorphisms (SNPs) of its natural ligand OX40 ligand (OX40L, CD252), which is also found on activated T cells, have been associated with systemic lupus erythematosus [].This entry represents the N-terminal domain of TNFRSF4. TNF-receptors are modular proteins. The N-terminal extracellular part contains a cysteine-rich region responsible for ligand-binding. This region is composed of small modules of about 40 residues containing 6 conserved cysteines; the number of modules can vary in number and type in different members of the family [, , ].

•

Publication

15475959 | J:93538

First Author:	Zhu J
Year:	2004
Journal:	Nat Immunol
Title:	Conditional deletion of Gata3 shows its essential function in T(H)1-T(H)2 responses.
Volume:	5
Issue:	11
Pages:	1157-65

•

Publication

34234346 | J:326195

First Author:	Fu G
Year:	2021
Journal:	Nature
Title:	Metabolic control of T_FH cells and humoral immunity by phosphatidylethanolamine.
Volume:	595
Issue:	7869
Pages:	724-729

•

Publication

29180433 | J:254441

First Author:	Ciucci T
Year:	2017
Journal:	Proc Natl Acad Sci U S A
Title:	A STAT3-dependent transcriptional circuitry inhibits cytotoxic gene expression in T cells.
Volume:	114
Issue:	50
Pages:	13236-13241

•

Publication

21965331 | J:178459

First Author:	Wohlfert EA
Year:	2011
Journal:	J Clin Invest
Title:	GATA3 controls Foxp3⁺ regulatory T cell fate during inflammation in mice.
Volume:	121
Issue:	11
Pages:	4503-15

•

Protein

P47741

Organism:	Mus musculus/domesticus
Length:	272
Fragment?:	false

•

Protein

B1ASL3

Organism:	Mus musculus/domesticus
Length:	272
Fragment?:	false

•

Publication

31422869 | J:282482

First Author:	Vacchio MS
Year:	2019
Journal:	Immunity
Title:	A Thpok-Directed Transcriptional Circuitry Promotes Bcl6 and Maf Expression to Orchestrate T Follicular Helper Differentiation.
Volume:	51
Issue:	3
Pages:	465-478.e6

•

Publication

30638736 | J:282390

First Author:	Ciucci T
Year:	2019
Journal:	Immunity
Title:	The Emergence and Functional Fitness of Memory CD4⁺ T Cells Require the Transcription Factor Thpok.
Volume:	50
Issue:	1
Pages:	91-105.e4

•

Protein

P43488

Organism:	Mus musculus/domesticus
Length:	198
Fragment?:	false

•

Protein

B6DXE3

Organism:	Mus musculus/domesticus
Length:	198
Fragment?:	false

•

Publication

1377364 | -

First Author:	Farrah T
Year:	1992
Journal:	Nature
Title:	Emerging cytokine family.
Volume:	358
Issue:	6381
Pages:	26

•

Publication

8095800 | -

First Author:	Peitsch MC
Year:	1993
Journal:	Int Immunol
Title:	A 3-D model for the CD40 ligand predicts that it is a compact trimer similar to the tumor necrosis factors.
Volume:	5
Issue:	2
Pages:	233-8

•

Publication

2989794 | J:20071

First Author:	Fransen L
Year:	1985
Journal:	Nucleic Acids Res
Title:	Molecular cloning of mouse tumour necrosis factor cDNA and its eukaryotic expression.
Volume:	13
Issue:	12
Pages:	4417-29

•

Publication

2777790 | -

First Author:	Cseh K
Year:	1989
Journal:	J Biol Chem
Title:	Alternative cleavage of the cachectin/tumor necrosis factor propeptide results in a larger, inactive form of secreted protein.
Volume:	264
Issue:	27
Pages:	16256-60

•

Publication

2268312 | -

First Author:	Sherry B
Year:	1990
Journal:	Biochem Biophys Res Commun
Title:	Characterization of high molecular weight glycosylated forms of murine tumor necrosis factor.
Volume:	173
Issue:	3
Pages:	1072-8

•

Publication

3349526 | -

First Author:	Kriegler M
Year:	1988
Journal:	Cell
Title:	A novel form of TNF/cachectin is a cell surface cytotoxic transmembrane protein: ramifications for the complex physiology of TNF.
Volume:	53
Issue:	1
Pages:	45-53

•

Publication

15335677 | -

First Author:	Bazan JF
Year:	1993
Journal:	Curr Biol
Title:	Emerging families of cytokines and receptors.
Volume:	3
Issue:	9
Pages:	603-6

•

Publication

9538693 | -

First Author:	Naismith JH
Year:	1998
Journal:	Trends Biochem Sci
Title:	Modularity in the TNF-receptor family.
Volume:	23
Issue:	2
Pages:	74-9

•

Publication

11796220 | -

First Author:	Bodmer JL
Year:	2002
Journal:	Trends Biochem Sci
Title:	The molecular architecture of the TNF superfamily.
Volume:	27
Issue:	1
Pages:	19-26

•

Publication

8387891 | -

First Author:	Banner DW
Year:	1993
Journal:	Cell
Title:	Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation.
Volume:	73
Issue:	3
Pages:	431-45

•

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