|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 201 to 300 out of 419 for Tpo

<< First    < Previous  |  Next >    Last >>
0.029s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Publication
8390965 | J:4958
First Author: Taylor BA
Year: 1993
Journal: Genomics
Title: The MEV mouse linkage testing stock: mapping 30 novel proviral insertions and establishment of an improved stock.
Volume: 16
Issue: 2
Pages: 380-94
•
•
•
•
•
Publication
14651853 | J:86816
First Author: Mootha VK
Year: 2003
Journal: Cell
Title: Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria.
Volume: 115
Issue: 5
Pages: 629-40
•
•
•
•
•
Publication
- | J:342601
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniPathway vocabulary mapping
•
•
•
•
•
Publication
- | J:342608
       
First Author: GO Central curators, GOA curators, Rhea curators
Year: 2020
Title: Automatic Gene Ontology annotation based on Rhea mapping
•
•
•
•
•
Publication
- | J:72245
       
First Author: GOA curators, MGI curators
Year: 2001
Title: Gene Ontology annotation based on Enzyme Commission mapping
•
•
•
•
•
Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
•
•
•
•
•
Publication
- | J:346132
       
First Author: The Gene Ontology Consortium
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
•
•
•
•
•
Publication
14681479 | J:122989
First Author: Visel A
Year: 2004
Journal: Nucleic Acids Res
Title: GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Volume: 32
Issue: Database issue
Pages: D552-6
•
•
•
•
•
Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
•
•
•
•
•
Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
•
•
•
•
•
Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
•
•
•
•
•
Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
•
•
•
•
•
Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
•
•
•
•
•
Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
•
•
•
•
•
Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
•
•
•
•
•
Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
•
•
•
•
•
Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
•
•
•
•
•
Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
•
•
•
•
•
Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
•
•
•
•
•
Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
•
•
•
•
•
Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
•
•
•
•
•
Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
•
•
•
•
•
Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
•
•
•
•
•
Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
•
•
•
•
•
Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
•
•
•
•
•
Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
•
•
•
•
•
Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
•
•
•
•
•
Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
•
•
•
•
•
Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
•
•
•
•
•
Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
•
•
•
•
•
Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
•
•
•
•
•
Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
•
•
•
•
•
Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
•
•
•
•
•
Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
•
•
•
•
•
Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
•
•
•
•
•
Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
•
•
•
•
•
Publication
12855555 | J:115674
First Author: Kirito K
Year: 2003
Journal: Blood
Title: Thrombopoietin stimulates Hoxb4 expression: an explanation for the favorable effects of TPO on hematopoietic stem cells.
Volume: 102
Issue: 9
Pages: 3172-8
•
•
•
•
•
Publication
8781421 | J:35036
First Author: Cocault L
Year: 1996
Journal: Blood
Title: Ectopic expression of murine TPO receptor (c-mpl) in mice is pathogenic and induces erythroblastic proliferation.
Volume: 88
Issue: 5
Pages: 1656-65
•
•
•
•
•
GO Term
GO:0004447 | iodide peroxidase activity
•
•
•
•
•
DO Term
DOID:0112186 | thyroid dyshormonogenesis 2A
•
•
•
•
•
Protein Coding Gene
MGI:101875 | Thpo
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Publication
10582337 | J:59863
First Author: Alexander WS
Year: 1999
Journal: Int J Biochem Cell Biol
Title: Thrombopoietin and the c-Mpl receptor: insights from gene targeting.
Volume: 31
Issue: 10
Pages: 1027-35
•
•
•
•
•
Publication
8440133 | J:4209
First Author: Barnett PS
Year: 1993
Journal: Cytogenet Cell Genet
Title: Regional sublocalization of the human thyroid peroxidase gene (TPO) by tritium and fluorescence in situ hybridization to chromosome 2p25-->p24.
Volume: 62
Issue: 4
Pages: 188-9
•
•
•
•
•
Publication
8202158 | J:18896
First Author: Lok S
Year: 1994
Journal: Nature
Title: Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo.
Volume: 369
Issue: 6481
Pages: 565-8
•
•
•
•
•
Publication
10377897 | -
First Author: Kaushansky K
Year: 1999
Journal: Bioessays
Title: The enigmatic megakaryocyte gradually reveals its secrets.
Volume: 21
Issue: 4
Pages: 353-60
•
•
•
•
•
Publication
9417073 | -
First Author: Park H
Year: 1998
Journal: J Biol Chem
Title: Identification of functionally important residues of human thrombopoietin.
Volume: 273
Issue: 1
Pages: 256-61
•
•
•
•
•
Protein Domain
IPR019767 | EPO/TPO_CS
Type: Conserved_site
Description: Erythropoietin, a plasma glycoprotein, is the primary physiological mediator of erythropoiesis []. Itis involved in the regulation of the level of peripheral erythrocytes by stimulating the differentiation of erythroid progenitor cells, found in the spleen and bone marrow, into mature erythrocytes []. It is primarily produced in adult kidneys and foetal liver, acting by attachment to specific binding sites on erythroid progenitor cells, stimulating their differentiation []. Severe kidney dysfunction causes reduction in the plasma levels of erythropoietin,resulting in chronic anaemia - injection of purified erythropoietin into the blood stream can help to relieve this type of anaemia. Levels of erythropoietin in plasma fluctuate with varying oxygen tension of the blood, but androgens and prostaglandins also modulate the levels to some extent []. Erythropoietin glycoprotein sequences are well conserved, a consequence of which is that the hormones are cross-reactive among mammals,i.e. that from one species, say human, can stimulate erythropoiesis inother species, say mouse or rat []. Thrombopoeitin (TPO), a glycoprotein, is the mammalian0 hormone which functions as a megakaryocytic lineage specific growth and differentiation factor affecting the proliferation and maturation from their committed progenitor cells acting at a late stage of megakaryocyte development. It acts as a circulating regulator of platelet numbers.EPO and TPO are evolutionary related. As a signature pattern, this entry represents a conserved region located at the N-terminal extremity of mature EPO and TPO and that includes two cysteines which have been shown, in human EPO, to be implicated in disulphide bonds.
•
•
•
•
•
Protein Domain
IPR003978 | Thrombopoietin
Type: Family
Description: Megakaryocytes are large cells found in the bone marrow that, uponmaturation, fragment into platelets. The term thrombopoietin (TPO) wascoined in 1958 to describe a possible humoral entity that stimulatesmegakaryocyte development into platelets. The discovery of a novelhaemopoietic cytokine receptor encoded by the proto-oncogene c-mpl raisedspeculation that this was the receptor for thrombopoietin, and prompted asearch for the endogenous ligand []. The ligand was cloned and in vivo-administration of the recombinant protein to mice produced a 4-fold increasein circulating platelets. These results suggested that the c-mpl ligand wasin fact thrombopoietin [].More recent studies have shown that TPO is expressed in hepatocytes, therenal proximal tubules, muscle cells and stromal cells in haemopoieticorgans []. TPO is a 332-residue protein with a 2-domain structure. Thedomain at the N terminus is 153 amino acids long, shares similarity witherythropoietin and can itself stimulate megakaryopoiesis in vitro. A four-α-helical structure is predicted, which is typical of many haemopoieticregulators. The C-terminal domain is 179 amino acids long, is highly variable across species and is not required for the binding of c-mpl [].
•
•
•
•
•
Publication
25485912 | J:227944
First Author: Grozovsky R
Year: 2015
Journal: Nat Med
Title: The Ashwell-Morell receptor regulates hepatic thrombopoietin production via JAK2-STAT3 signaling.
Volume: 21
Issue: 1
Pages: 47-54
•
•
•
•
•
Publication
28550162 | J:244489
First Author: Kim E
Year: 2017
Journal: J Exp Med
Title: Rb family proteins enforce the homeostasis of quiescent hematopoietic stem cells by repressing Socs3 expression.
Volume: 214
Issue: 7
Pages: 1901-1912
•
•
•
•
•
Publication
15282748 | J:92293
First Author: Kusakabe T
Year: 2004
Journal: Genesis
Title: Thyrocyte-specific expression of Cre recombinase in transgenic mice.
Volume: 39
Issue: 3
Pages: 212-6
•
•
•
•
•
Publication
8073287 | J:83264
First Author: Gurney AL
Year: 1994
Journal: Science
Title: Thrombocytopenia in c-mpl-deficient mice.
Volume: 265
Issue: 5177
Pages: 1445-7
•
•
•
•
•
Publication
7849319 | J:22988
First Author: Gurney AL
Year: 1995
Journal: Blood
Title: Genomic structure, chromosomal localization, and conserved alternative splice forms of thrombopoietin.
Volume: 85
Issue: 4
Pages: 981-8
•
•
•
•
•
Publication
11785982 | J:73925
First Author: Oda M
Year: 2002
Journal: Biochem Biophys Res Commun
Title: Isolation and characterization of mouse homolog of the neutrophil activating peptide-2.
Volume: 290
Issue: 2
Pages: 865-8
•
•
•
•
•
Publication
23246483 | J:194947
First Author: de Laval B
Year: 2013
Journal: Cell Stem Cell
Title: Thrombopoietin-increased DNA-PK-dependent DNA repair limits hematopoietic stem and progenitor cell mutagenesis in response to DNA damage.
Volume: 12
Issue: 1
Pages: 37-48
•
•
•
•
•
Publication
30104364 | J:264604
First Author: Kanaji T
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Tyrosyl-tRNA synthetase stimulates thrombopoietin-independent hematopoiesis accelerating recovery from thrombocytopenia.
Volume: 115
Issue: 35
Pages: E8228-E8235
•
•
•
•
•
Publication
31953383 | J:284931
First Author: Giannini S
Year: 2020
Journal: Nat Commun
Title: β4GALT1 controls β1 integrin function to govern thrombopoiesis and hematopoietic stem cell homeostasis.
Volume: 11
Issue: 1
Pages: 356
•
•
•
•
•
Publication
24711413 | J:208120
First Author: Ng AP
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Mpl expression on megakaryocytes and platelets is dispensable for thrombopoiesis but essential to prevent myeloproliferation.
Volume: 111
Issue: 16
Pages: 5884-9
•
•
•
•
•
Publication
9531584 | J:47462
First Author: Gainsford T
Year: 1998
Journal: Blood
Title: Cytokine production and function in c-mpl-deficient mice: no physiologic role for interleukin-3 in residual megakaryocyte and platelet production.
Volume: 91
Issue: 8
Pages: 2745-52
•
•
•
•
•
Publication
30733282 | J:275337
First Author: Malara A
Year: 2019
Journal: J Exp Med
Title: EDA fibronectin-TLR4 axis sustains megakaryocyte expansion and inflammation in bone marrow fibrosis.
Volume: 216
Issue: 3
Pages: 587-604
•
•
•
•
•
Publication
21115812 | J:167138
First Author: de Graaf CA
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Regulation of hematopoietic stem cells by their mature progeny.
Volume: 107
Issue: 50
Pages: 21689-94
•
•
•
•
•
Publication
8627177 | J:83262
First Author: de Sauvage FJ
Year: 1996
Journal: J Exp Med
Title: Physiological regulation of early and late stages of megakaryocytopoiesis by thrombopoietin.
Volume: 183
Issue: 2
Pages: 651-6
•
•
•
•
•
Publication
26912146 | J:251761
 
First Author: Liu HD
Year: 2016
Journal: J Hematol Oncol
Title: H2S protects against fatal myelosuppression by promoting the generation of megakaryocytes/platelets.
Volume: 9
Pages: 13
•
•
•
•
•
Publication
25115888 | J:218722
First Author: Meyer SC
Year: 2014
Journal: Blood
Title: Genetic studies reveal an unexpected negative regulatory role for Jak2 in thrombopoiesis.
Volume: 124
Issue: 14
Pages: 2280-4
•
•
•
•
•
Publication
32954656 | J:329627
First Author: Märklin M
Year: 2020
Journal: J Cell Mol Med
Title: C-Cbl regulates c-MPL receptor trafficking and its internalization.
Volume: 24
Issue: 21
Pages: 12491-12503
•
•
•
•
•
Publication
21262827 | J:168301
First Author: Rongvaux A
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Human thrombopoietin knockin mice efficiently support human hematopoiesis in vivo.
Volume: 108
Issue: 6
Pages: 2378-83
•
•
•
•
•
Publication
31818938 | J:285912
     
First Author: Badami E
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Activation-induced cell death of self-reactive regulatory T cells drives autoimmunity.
•
•
•
•
•
Publication
29471321 | J:283456
First Author: Tan YX
Year: 2018
Journal: Glycobiology
Title: Overexpression of heparanase in mice promoted megakaryopoiesis.
Volume: 28
Issue: 5
Pages: 269-275
•
•
•
•
•
Publication
9214635 | J:41061
First Author: Zannini M
Year: 1997
Journal: EMBO J
Title: TTF-2, a new forkhead protein, shows a temporal expression in the developing thyroid which is consistent with a role in controlling the onset of differentiation.
Volume: 16
Issue: 11
Pages: 3185-97
•
•
•
•
•
Publication
15642952 | J:96497
First Author: Ehrenreich H
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: A hematopoietic growth factor, thrombopoietin, has a proapoptotic role in the brain.
Volume: 102
Issue: 3
Pages: 862-7
•
•
•
•
•
Publication
17464207 | J:136607
First Author: Kim MO
Year: 2007
Journal: Mol Cells
Title: Human erythropoietin induces lung failure and erythrocytosis in transgenic mice.
Volume: 23
Issue: 1
Pages: 17-22
•
•
•
•
•
Publication
26140605 | J:224848
First Author: Wu Z
Year: 2015
Journal: Cell Stem Cell
Title: TPO-Induced Metabolic Reprogramming Drives Liver Metastasis of Colorectal Cancer CD110+ Tumor-Initiating Cells.
Volume: 17
Issue: 1
Pages: 47-59
•
•
•
•
•
Publication
29622652 | J:272167
First Author: Decker M
Year: 2018
Journal: Science
Title: Hepatic thrombopoietin is required for bone marrow hematopoietic stem cell maintenance.
Volume: 360
Issue: 6384
Pages: 106-110
•
•
•
•
•
Publication
33384332 | J:299637
 
First Author: Cui L
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: Tuning MPL signaling to influence hematopoietic stem cell differentiation and inhibit essential thrombocythemia progenitors.
Volume: 118
Issue: 2
•
•
•
•
•
Protein
P40226
Organism: Mus musculus/domesticus
Length: 356  
Fragment?: false
•
•
•
•
•
Protein
A0A338P6C8
Organism: Mus musculus/domesticus
Length: 231  
Fragment?: true
•
•
•
•
•
Protein
A0A338P6S5
Organism: Mus musculus/domesticus
Length: 385  
Fragment?: false
•
•
•
•
•
Protein
Q543R9
Organism: Mus musculus/domesticus
Length: 356  
Fragment?: false
•
•
•
•
•
Publication
1420369 | -
First Author: Nagao M
Year: 1992
Journal: Biochim Biophys Acta
Title: Nucleotide sequence of rat erythropoietin.
Volume: 1171
Issue: 1
Pages: 99-102
•
•
•
•
•
Publication
2877922 | -
First Author: Lin FK
Year: 1986
Journal: Gene
Title: Monkey erythropoietin gene: cloning, expression and comparison with the human erythropoietin gene.
Volume: 44
Issue: 2-3
Pages: 201-9
•
•
•
•
•
Publication
3346214 | -
First Author: Takeuchi M
Year: 1988
Journal: J Biol Chem
Title: Comparative study of the asparagine-linked sugar chains of human erythropoietins purified from urine and the culture medium of recombinant Chinese hamster ovary cells.
Volume: 263
Issue: 8
Pages: 3657-63
•
•
•
•
•
Publication
14726379 | J:90545
First Author: Lannutti BJ
Year: 2004
Journal: Blood
Title: Lyn tyrosine kinase regulates thrombopoietin-induced proliferation of hematopoietic cell lines and primary megakaryocytic progenitors.
Volume: 103
Issue: 10
Pages: 3736-43
•
•
•
•
•
Publication
22128142 | J:181770
First Author: Kostyak JC
Year: 2012
Journal: Blood
Title: Calcium- and integrin-binding protein 1 regulates megakaryocyte ploidy, adhesion, and migration.
Volume: 119
Issue: 3
Pages: 838-46
•
•
•
•
•
Publication
15138166 | J:92703
First Author: Antonchuk J
Year: 2004
Journal: Blood
Title: Synergistic effects on erythropoiesis, thrombopoiesis, and stem cell competitiveness in mice deficient in thrombopoietin and steel factor receptors.
Volume: 104
Issue: 5
Pages: 1306-13
•
•
•
•
•
Publication
16648859 | J:109523
First Author: Jin DK
Year: 2006
Journal: Nat Med
Title: Cytokine-mediated deployment of SDF-1 induces revascularization through recruitment of CXCR4+ hemangiocytes.
Volume: 12
Issue: 5
Pages: 557-67
•
•
•
•
•
Publication
16418722 | J:144143
First Author: Lannutti BJ
Year: 2006
Journal: Oncogene
Title: Increased megakaryocytopoiesis in Lyn-deficient mice.
Volume: 25
Issue: 23
Pages: 3316-24
•
•
•
•
•
Publication
8799165 | J:35594
First Author: Kieran MW
Year: 1996
Journal: Proc Natl Acad Sci U S A
Title: Thrombopoietin rescues in vitro erythroid colony formation from mouse embryos lacking the erythropoietin receptor.
Volume: 93
Issue: 17
Pages: 9126-31
•
•
•
•
•
Publication
16081633 | J:129450
First Author: Guo J
Year: 2005
Journal: Endocrinology
Title: Relationship between thyroid peroxidase T cell epitope restriction and antibody recognition of the autoantibody immunodominant region in human leukocyte antigen DR3 transgenic mice.
Volume: 146
Issue: 11
Pages: 4961-7
•
•
•
•
•
Publication
29802222 | J:264753
First Author: Chen S
Year: 2018
Journal: Blood
Title: IGF-1 facilitates thrombopoiesis primarily through Akt activation.
Volume: 132
Issue: 2
Pages: 210-222
•
•
•
•
•
Publication
39499573 | J:360800
 
First Author: Everett LA
Year: 2024
Journal: JCI Insight
Title: LMAN1 serves as a cargo receptor for thrombopoietin.
Volume: 9
Issue: 24
•
•
•
•
•
Publication
11986210 | J:76579
First Author: Kaushansky K
Year: 2002
Journal: Blood
Title: Lineage-specific growth factors can compensate for stem and progenitor cell deficiencies at the postprogenitor cell level: an analysis of doubly TPO- and G-CSF receptor-deficient mice.
Volume: 99
Issue: 10
Pages: 3573-8
•
•
•
•
•
Publication
22096247 | J:181799
First Author: Umemoto T
Year: 2012
Journal: Blood
Title: Integrin-αvβ3 regulates thrombopoietin-mediated maintenance of hematopoietic stem cells.
Volume: 119
Issue: 1
Pages: 83-94
•
•
•
•
•
Publication
29794068 | J:266091
First Author: Xu M
Year: 2018
Journal: Blood
Title: GPIbα is required for platelet-mediated hepatic thrombopoietin generation.
Volume: 132
Issue: 6
Pages: 622-634
•
•
•
•
•
Publication
26972179 | J:238116
First Author: Damnernsawad A
Year: 2016
Journal: Stem Cells
Title: Kras is Required for Adult Hematopoiesis.
Volume: 34
Issue: 7
Pages: 1859-71
•
•
•
•
•
Publication
31301081 | J:291132
First Author: Tanaka H
Year: 2019
Journal: Cancer Sci
Title: Overproduction of thrombopoietin by BRAFV600E-mutated mouse hepatocytes and contribution of thrombopoietin to hepatocarcinogenesis.
Volume: 110
Issue: 9
Pages: 2748-2759
•
•
•
•
•
Publication
38603632 | J:351065
First Author: Sun Y
Year: 2024
Journal: Blood
Title: Notch1 regulates hepatic thrombopoietin production.
Volume: 143
Issue: 26
Pages: 2778-2790
•
•
•
•
•
Publication
15665119 | J:98976
First Author: Vannucchi AM
Year: 2005
Journal: Blood
Title: A pathobiologic pathway linking thrombopoietin, GATA-1, and TGF-beta1 in the development of myelofibrosis.
Volume: 105
Issue: 9
Pages: 3493-501
•
•
•
•
•
Publication
28622305 | J:276266
First Author: Zingariello M
Year: 2017
Journal: Blood Cancer J
Title: The thrombopoietin/MPL axis is activated in the Gata1low mouse model of myelofibrosis and is associated with a defective RPS14 signature.
Volume: 7
Issue: 6
Pages: e572
•
•
•
•
•
Publication
12506018 | J:82928
First Author: Chagraoui H
Year: 2003
Journal: Blood
Title: Stimulation of osteoprotegerin production is responsible for osteosclerosis in mice overexpressing TPO.
Volume: 101
Issue: 8
Pages: 2983-9
•
•
•
•
•
Publication
18456388 | J:136990
First Author: Takizawa H
Year: 2008
Journal: Exp Hematol
Title: Growth and maturation of megakaryocytes is regulated by Lnk/Sh2b3 adaptor protein through crosstalk between cytokine- and integrin-mediated signals.
Volume: 36
Issue: 7
Pages: 897-906
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom